التفاصيل البيبلوغرافية
| العنوان: |
Mapping the risk of infections in patients with multiple sclerosis: A multi-database study in the United Kingdom Clinical Practice Research Datalink GOLD and Aurum |
| المؤلفون: |
Leung, Melissa Wy, Bazelier, Marloes T, Souverein, Patrick C, Uitdehaag, Bernard Mj, Klungel, Olaf H, Leufkens, Hubert Gm, Pajouheshnia, Romin |
| المساهمون: |
Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, PECP - Centre for Pharmacoepidemiology, PECP - Centre for Pharmaceutical Policy and Regulation |
| سنة النشر: |
2022 |
| مصطلحات موضوعية: |
Multiple sclerosis infections, United Kingdom Clinical Practice Research Datalink GOLD and Aurum, multiple outcomes multi-database study, urinary tract infection, Neurology, Clinical Neurology |
| الوصف: |
BACKGROUND: People with multiple sclerosis (pwMS) have an increased risk of infections; risk factors include underlying disease, physical impairment and use of some disease-modifying treatments. OBJECTIVE: To quantify changes in population-level infection rates among pwMS and compare these to the general population and people with rheumatoid arthritis (pwRA), and identify patient characteristics predictive of infections after MS diagnosis. METHODS: We conducted a multi-database study using data on 23,226 people with MS diagnosis from the UK Clinical Practice Research Datalink Aurum and GOLD (January 2000-December 2020). PwMS were matched to MS-free controls and pwRA. We calculated infection rates, and estimated incidence rate ratios (IRR) and 95% confidence intervals (CI) of predictors for infections ⩽ 5 years after MS diagnosis using Poisson regression. RESULTS: Among pwMS, overall infection rates remained stable - 1.51-fold (1.49-1.52) that in MS-free controls and 0.87-fold (0.86-0.88) that in pwRA - although urinary tract infection rate per 1000 person-years increased from 98.7 (96.1-101) (2000-2010) to 136 (134-138) (2011-2020). Recent infection before MS diagnosis was most predictive of infections (1 infection: IRR 1.92 (1.86-1.97); ⩾2 infections: IRR 3.00 (2.89-3.10)). CONCLUSION: The population-level elevated risk of infection among pwMS has remained stable despite the introduction of disease-modifying treatments. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
1352-4585 |
| العلاقة: |
https://dspace.library.uu.nl/handle/1874/423076Test |
| الإتاحة: |
https://dspace.library.uu.nl/handle/1874/423076Test |
| حقوق: |
info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: |
edsbas.F71EA31E |
| قاعدة البيانات: |
BASE |
