المؤلفون: Patrik Johansson, Cecilia Krona, Soumi Kundu, Milena Doroszko, Sathishkumar Baskaran, Linnéa Schmidt, Claire Vinel, Elin Almstedt, Ramy Elgendy, Ludmila Elfineh, Caroline Gallant, Sara Lundsten, Fernando J. Ferrer Gago, Aleksi Hakkarainen, Petra Sipilä, Maria Häggblad, Ulf Martens, Bo Lundgren, Melanie M. Frigault, David P. Lane, Fredrik J. Swartling, Lene Uhrbom, Marika Nestor, Silvia Marino, Sven Nelander

المصدر: Cell Reports, Vol 32, Iss 2, Pp 107897- (2020)

مصطلحات موضوعية: biobank, combination therapy, data integration, glioblastoma, multi-omics, p53 reactivators, Biology (General), QH301-705.5

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2211124720308780Test; https://doaj.org/toc/2211-1247Test

الوصول الحر: https://doaj.org/article/cc573e6ed9f44191ba0a80782a5d717eTest

المؤلفون: Jordi Carreras-Puigvert, Marinka Zitnik, Ann-Sofie Jemth, Megan Carter, Judith E. Unterlass, Björn Hallström, Olga Loseva, Zhir Karem, José Manuel Calderón-Montaño, Cecilia Lindskog, Per-Henrik Edqvist, Damian J. Matuszewski, Hammou Ait Blal, Ronnie P. A. Berntsson, Maria Häggblad, Ulf Martens, Matthew Studham, Bo Lundgren, Carolina Wählby, Erik L. L. Sonnhammer, Emma Lundberg, Pål Stenmark, Blaz Zupan, Thomas Helleday

المصدر: Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/6564fe588369406e87c0d1e279e7b8c4Test

المؤلفون: Nadilly Bonagas, Nina M. S. Gustafsson, Martin Henriksson, Petra Marttila, Robert Gustafsson, Elisée Wiita, Sanjay Borhade, Alanna C. Green, Karl S. A. Vallin, Antonio Sarno, Richard Svensson, Camilla Göktürk, Therese Pham, Ann-Sofie Jemth, Olga Loseva, Victoria Cookson, Nicole Kiweler, Lars Sandberg, Azita Rasti, Judith E. Unterlass, Martin Haraldsson, Yasmin Andersson, Emma R. Scaletti, Christoffer Bengtsson, Cynthia B. J. Paulin, Kumar Sanjiv, Eldar Abdurakhmanov, Linda Pudelko, Ben Kunz, Matthieu Desroses, Petar Iliev, Katarina Färnegårdh, Andreas Krämer, Neeraj Garg, Maurice Michel, Sara Häggblad, Malin Jarvius, Christina Kalderén, Amanda Bögedahl Jensen, Ingrid Almlöf, Stella Karsten, Si Min Zhang, Maria Häggblad, Anders Eriksson, Jianping Liu, Björn Glinghammar, Natalia Nekhotiaeva, Fredrik Klingegård, Tobias Koolmeister, Ulf Martens, Sabin Llona-Minguez, Ruth Moulson, Helena Nordström, Vendela Parrow, Leif Dahllund, Birger Sjöberg, Irene L. Vargas, Duy Duc Vo, Johan Wannberg, Stefan Knapp, Hans E. Krokan, Per I. Arvidsson, Martin Scobie, Johannes Meiser, Pål Stenmark, Ulrika Warpman Berglund, Evert J. Homan, Thomas Helleday

المصدر: Nature Cancer

مصطلحات موضوعية: Methylenetetrahydrofolate Dehydrogenase (NADP), Cancer och onkologi, Leukemia, Myeloid, Acute, Cancer Research, Oncology, Cellbiologi, Aminohydrolases, Hydrolases, Cancer and Oncology, Humans, Cell Biology, Multifunctional Enzymes, Thymidine

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc803a4ce48681e11987b33fd0a94afTest
https://doi.org/10.1038/s43018-022-00331-yTest

المؤلفون: Nadilly Bonagas, Nina Gustafsson, Martin Henriksson, Petra Marttila, Robert Gustafsson, Elisée Wiita, Sanjay Borhade, Alanna Green, Karl Vallin, Antonio Sarno, Richard Svensson, Camilla Göktürk, Therese Pham, Ann-Sofie Jemth, Olga Loseva, Victoria Cookson, Nicole Kiweler, Lars Sandberg, Azita Rasti, Judith Unterlass, Martin Haraldsson, Yasmin Andersson, Emma Scaletti, Christoffer Bengtsson, Cynthia Paulin, Kumar Sanjiv, Eldar Abdurakhmanov, Linda Pudelko, Ben Kunz, Matthieu Desroses, Petar Iliev, Katarina Färnegårdh, Andreas Krämer, Neeraj Garg, Maurice Michel, Sara Häggblad, Malin Jarvius, Christina Kalderén, Amanda Bögedahl Jensen, Ingrid Almlöf, Stella Karsten, Si Min Zhang, Maria Häggblad, Anders Eriksson, Jianping Liu, Björn Glinghammar, Natalia Nekhotiaeva, Fredrik Klingegård, Tobias Koolmeister, Ulf Martens, Sabin Llona-Minguez, Ruth Moulson, Helena Nordström, Vendela Parrow, Leif Dahllund, Birger Sjöberg, Irene Vargas, Duy Duc Vo, Johan Wannberg, Stefan Knapp, Hans Krokan, Per Arvidsson, Martin Scobie, Johannes Meiser, Pål Stenmark, Ulrika Warpman Berglund, Evert Homan, Thomas Helleday

مصطلحات موضوعية: hemic and lymphatic diseases

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::032514cb5181fdda8fdfefd73848c5d0Test
https://doi.org/10.21203/rs.3.pex-1730/v1Test

المؤلفون: Patrik, Johansson, Cecilia, Krona, Soumi, Kundu, Milena, Doroszko, Sathishkumar, Baskaran, Linnéa, Schmidt, Claire, Vinel, Elin, Almstedt, Ramy, Elgendy, Ludmila, Elfineh, Caroline, Gallant, Sara, Lundsten, Fernando J, Ferrer Gago, Aleksi, Hakkarainen, Petra, Sipilä, Maria, Häggblad, Ulf, Martens, Bo, Lundgren, Melanie M, Frigault, David P, Lane, Fredrik J, Swartling, Lene, Uhrbom, Marika, Nestor, Silvia, Marino, Sven, Nelander

المصدر: Cell Reports, Vol 32, Iss 2, Pp 107897-(2020)

مصطلحات موضوعية: Cellbiologi, Cell- och molekylärbiologi, Antineoplastic Agents, combination therapy, Bortezomib, Genetic Heterogeneity, Tumor Cells, Cultured, Animals, Humans, Gene Regulatory Networks, Molecular Targeted Therapy, Precision Medicine, data integration, lcsh:QH301-705.5, Cyclin-Dependent Kinase Inhibitor p16, Cell Proliferation, Cyclin-Dependent Kinase Inhibitor p15, Mice, Inbred BALB C, Genome, Human, glioblastoma, p53 reactivators, Cell Biology, multi-omics, biobank, lcsh:Biology (General), Mutation, Tumor Suppressor Protein p53, Proteasome Inhibitors, Cell and Molecular Biology

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::224df7b0a96b217a92523ab1aef4f7eaTest
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-419794Test

المؤلفون: Mark R. Southern, M. Otrocka, Ulf Martens, Vicente Martínez-Redondo, Igor Cervenka, Bo Lundgren, Jorge C. Correia, Amanda T. Pettersson-Klein, Daniel Ferreira, Patrick R. Griffin, Theodore M. Kamenecka, A. Jenmalm-Jensen, Manizheh Izadi, Michael D. Cameron, Leandro Z. Agudelo, Jorge L. Ruas, Margareta Porsmyr-Palmertz

المصدر: Molecular Metabolism
Molecular Metabolism, Vol 9, Iss, Pp 28-42 (2018)

مصطلحات موضوعية: 0301 basic medicine, Adipose tissue, PPAR, peroxisome proliferator-activated receptor, Protein stabilization, Brown adipose tissue, Mice, chemistry.chemical_compound, Adipocyte, PGC, peroxisome proliferator-activated receptor-γ coactivator, FCCP, carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone, Uncoupling Protein 1, Protein Stability, Chemistry, Peroxisome, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Small molecule, PGC-1alpha, Mitochondria, Cell biology, PGC-1alpha1, C/EBP, CCAAT-enhancer-binding proteins, XBP1, X-box binding protein 1, Adipocytes, Brown, medicine.anatomical_structure, PGC-1a, Original Article, HNF, hepatocyte nuclear factor, Mitochondrial respiration, lcsh:Internal medicine, Small molecule screening, UCP1, Cell Respiration, Alpha (ethology), IDP, intrinsically disordered protein, NRF2, nuclear respiratory factors 2, MEF2, myocyte enhancer factor 2, Small Molecule Libraries, HEK, human embryonic kidney, 03 medical and health sciences, ROS, reactive oxygen species, UCP1, uncoupling protein 1, medicine, Animals, Humans, lcsh:RC31-1245, Molecular Biology, Gene, Uncoupling Agents, SREBP1, sterol regulatory element-binding protein 1, Cell Biology, HEK293 Cells, 030104 developmental biology, Anti-Obesity Agents, PTM, post-translational modifications, HPRT, hypoxanthine-guanine phosphoribosyltransferase

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8adef5e0e4e4795105a62227894df6cTest
https://doi.org/10.1016/j.molmet.2018.01.017Test

المؤلفون: Kristmundur Sigmundsson, Lars Johansson, Ulf Martens, Thomas Helleday, Annika Jenmalm Jensen, Maria Häggblad, Thomas Lundbäck, Bo Lundgren, Olga Loseva, Sabin Llona-Minguez, Ann-Sofie Jemth, Martin Scobie

المصدر: Bioorganic & Medicinal Chemistry Letters. 27:3219-3225

مصطلحات موضوعية: 0301 basic medicine, Pyridones, Stereochemistry, Clinical Biochemistry, Chemical biology, Pharmaceutical Science, Pyrimidinones, Ligands, Biochemistry, 2-Pyridone, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Drug Discovery, Humans, Pyrimidone, DCTP pyrophosphatase 1, Enzyme Inhibitors, Pyrophosphatases, Molecular Biology, Ligand efficiency, biology, Chemistry, Organic Chemistry, Nucleotide Metabolism, 030104 developmental biology, biology.protein, Molecular Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::732fafcf910631bc9de420df40e9c8caTest
https://doi.org/10.1016/j.bmcl.2017.06.039Test

المؤلفون: Evert Homan, Elisee Wiita, Cindy Cazares-Körner, Sabin Llona-Minguez, Andreas Höglund, Per Artursson, Bo Lundgren, Martin Scobie, Olga Loseva, Ann-Sofie Jemth, Ulrika Warpman Berglund, Ingrid Almlöf, José Manuel Calderón-Montaño, Ulf Martens, Thomas Helleday, Annika Jenmalm Jensen, Maria Häggblad, André Mateus, Pawel Baranczewski, Thomas Lundbäck

المصدر: Journal of Medicinal Chemistry. 60:2148-2154

مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, biology, Target engagement, High-Throughput Screening Assays, Cell biology, Molecular Docking Simulation, 03 medical and health sciences, 030104 developmental biology, Enzyme, Biochemistry, chemistry, Thiadiazoles, Drug Discovery, biology.protein, Humans, Molecular Medicine, DCTP pyrophosphatase 1, Enzyme Inhibitors, Pyrophosphatases, Pharmaceutical sciences

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb68528e3203ee1a731b126d855a9f9dTest
https://doi.org/10.1021/acs.jmedchem.6b01786Test

المؤلفون: Ludmila Elfineh, Ulf Martens, Ida-Maria Sintorn, Shimei Wee, Narendra Padhan, Sathishkumar Baskaran, Linnéa Schmidt, Maria Häggblad, Karin Forsberg-Nilsson, Bengt Westermark, Patrik Johansson, Ingrid Lönnstedt, Michael Andäng, Lydia C. Green, Lene Uhrbom, Sven Nelander, Lena Claesson-Welsh, Bo Lundgren, Damian J. Matuszewski, Cecilia Krona

المصدر: Oncotarget

مصطلحات موضوعية: Male, 0301 basic medicine, Pterostilbene, Cell, Pharmacology, stilbenoids, chemistry.chemical_compound, Antineoplastic Combined Chemotherapy Protocols, Stilbenes, EGFR inhibitors, Aged, 80 and over, drug repurposing, Brain Neoplasms, Cell Cycle, Drug Synergism, Gefitinib, Middle Aged, Cell cycle, Phenotype, medicine.anatomical_structure, Oncology, Gene Knockdown Techniques, Chromosomal region, Female, TXNIP, Research Paper, medicine.drug, DNA Copy Number Variations, MAP Kinase Signaling System, cancer therapeutics, 03 medical and health sciences, Cell Line, Tumor, medicine, glioblastoma initiating cells, Humans, Protein Kinase Inhibitors, Aged, Cell Proliferation, Cell growth, business.industry, Gene Expression Profiling, glioblastoma, Antineoplastic Agents, Phytogenic, 030104 developmental biology, chemistry, Mutation, Quinazolines, Transcriptome, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a090c37376c7b084e8c6c8b00ddb8f5Test
https://doi.org/10.18632/oncotarget.12298Test

المؤلفون: Judith E. Unterlass, Thomas Helleday, Olga Loseva, Ulf Martens, Hammou Ait Blal, José Manuel Calderón-Montaño, Carolina Wählby, Jordi Carreras-Puigvert, Blaz Zupan, Ronnie P.-A. Berntsson, Cecilia Lindskog, Zhir Karem, Erik L. L. Sonnhammer, Maria Häggblad, Per-Henrik Edqvist, Pål Stenmark, Emma Lundberg, Björn M. Hallström, Matthew Studham, Marinka Zitnik, Megan Carter, Ann-Sofie Jemth, Bo Lundgren, Damian J. Matuszewski

المصدر: Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, Science, Gene regulatory network, General Physics and Astronomy, Sequence alignment, macromolecular substances, Computational biology, Biology, Nudix hydrolase, Article, Gene Expression Regulation, Enzymologic, General Biochemistry, Genetics and Molecular Biology, Cell Line, Substrate Specificity, 03 medical and health sciences, 0302 clinical medicine, RNA interference, Phylogenetics, Cell Line, Tumor, Humans, Gene Regulatory Networks, Pyrophosphatases, lcsh:Science, Phylogeny, chemistry.chemical_classification, Regulation of gene expression, Bioinformatics (Computational Biology), Gene knockdown, Multidisciplinary, Gene Expression Profiling, General Chemistry, Gene Expression Regulation, Neoplastic, 030104 developmental biology, Enzyme, chemistry, A549 Cells, Multigene Family, 030220 oncology & carcinogenesis, MCF-7 Cells, Bioinformatik (beräkningsbiologi), RNA Interference, lcsh:Q

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bdfe6a3975841a5922701e68d4c166dTest
https://doi.org/10.1038/s41467-017-01642-wTest