المؤلفون: Lu, Chanyi, Lin, Xiaoli, Yamashita, Jumpei, Xi, Ranhui, Zhou, Minliang, Zhang, Yali V., Wang, Hong, Margolskee, Robert F., Koo, Bon Kyoung, Clevers, Hans, Matsumoto, Ichiro, Jiang, Peihua

المساهمون: Hubrecht Institute with UMC

مصطلحات موضوعية: LGR5, R-spondin, RNF43, taste stem cells, WNT, ZNRF3, Epithelium/metabolism, Mice, Inbred C57BL, Wnt Signaling Pathway/drug effects, Ubiquitin-Protein Ligases/deficiency, Knockout, Taste Buds/metabolism, Animals, Tongue/cytology, Benzeneacetamides/pharmacology, Taste/physiology, Stem Cells/cytology, Glossopharyngeal Nerve/surgery, Pyridines/pharmacology, Genetics, Biochemistry, Cell Biology, Developmental Biology, Journal Article, Research Support, N.I.H., Extramural

وصف الملف: application/pdf

العلاقة: https://dspace.library.uu.nl/handle/1874/446394Test

الإتاحة: https://dspace.library.uu.nl/handle/1874/446394Test

المؤلفون: Nakagawa, M.M., Davis, H., Rathinam, C.V.

مصطلحات موضوعية: Hematopoietic Stem Cells, Ubiquitin-Protein Ligases--deficiency

العلاقة: Stem Cell Research; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85056601601&doi=10.1016%2fj.scr.2018.10.020&partnerID=40&md5=95811b47849374e41ed4c272bb0c4248Test; http://hdl.handle.net/10713/8829Test

الإتاحة: https://doi.org/10.1016/j.scr.2018.10.020Test
http://hdl.handle.net/10713/8829Test

المؤلفون: Zakaria, Chadi, Sean, Polen, Hoang, Huy-Dung, Leroux, Louis-Phillipe, Watson, Margaret, Workenhe, Samuel Tekeste, Hearnden, Jaclyn, Pearl, Dana, Truong, Vinh Tai, Robichaud, Nathaniel, Yanagiya, Akiko, Tahmasebi, Soroush, Jafarnejad, Seyed Mehdi, Jia, Jian-Jun, Pelin, Adrian, Diallo, Jean-Simon, Le Boeuf, Fabrice, Bell, John Cameron, Mossman, Karen Louise, Graber, Tyson Ernst, Jaramillo, Maritza, Sonenberg, Nahum, Alain, Tommy

المساهمون: McGill University = Université McGill Montréal, Canada, University of Ottawa Ottawa, Institut Armand Frappier (INRS-IAF), Institut National de la Recherche Scientifique Québec (INRS)-Réseau International des Instituts Pasteur (RIIP), McMaster University Hamilton, Ontario, Ottawa Hospital Research Institute Ottawa (OHRI), This research was funded by grants from the Terry Fox Research Institute to NS and TA, and the CHEO Foundation, the Cancer Research Society / Stephen E. Drabin Research Fund, the Brain Tumour Foundation of Canada, and the Canadian Breast Cancer Foundation to TA. The funders had no role in study design, data collection and analysis, Decision to publish, or preparation of the manuscript, We thank Isabelle Harvey and Lynn Kyte for technical assistance, Xu Zhang and Sebastian Morales for help with experiments, and William Muller (McGill) for the mouse mammary epithelial cells.

المصدر: ISSN: 1553-7366.

مصطلحات موضوعية: MESH: Adaptator Proteins, Signal Transducing/genetics, Signal Transducing/metabolism, MESH: Mice, MESH: Neoplasms/complications, MESH: Animals, MESH: Neoplasms/genetics, MESH: Neoplasms/pathology, MESH: Neoplasms/virology, MESH: Organisms, Genetically Modified, MESH: Phosphoproteins/genetics, MESH: Phosphoproteins/metabolims, MESH: Protein Kinase Inhibitors/pharmacology, MESH: Herpes Simplex/complications, MESH: Signal Transduction/genetics, MESH: TOR Serine-Threonine Kinases/antagonists & inhibitiors, MESH: TOR Serine-Threonine Kinases/chemistry, MESH: Catalytic Domain/drug effects, MESH: Ubiquitin-Protein Ligases/deficiency, MESH: Ubiquitin-Protein Ligases/genetics, MESH: Vero Cells, MESH: Cells, Cultured, MESH: Cercopithecus aethiops, MESH: Eukaryotic Initiation Factor-4E/genetics, MESH: Herpes Simplex/genetics, MESH: Eukaryotic Initiation Factor-4E/metabolism, MESH: Gene Expression Regulation, Neoplastic/drug effects

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/30138450; pasteur-02136237; https://riip.hal.science/pasteur-02136237Test; https://riip.hal.science/pasteur-02136237/documentTest; https://riip.hal.science/pasteur-02136237/file/Active_site_mTOR_inhibitors_augment_HSV1_dICP0_infection_in_a_cancer_cells.pdfTest; PUBMED: 30138450; PUBMEDCENTRAL: PMC6124814

الإتاحة: https://doi.org/10.1371/journal.ppat.1007264Test
https://riip.hal.science/pasteur-02136237Test
https://riip.hal.science/pasteur-02136237/documentTest
https://riip.hal.science/pasteur-02136237/file/Active_site_mTOR_inhibitors_augment_HSV1_dICP0_infection_in_a_cancer_cells.pdfTest

المساهمون: College of Medicine, Dept. of Life Science, Youngsoo Kim, Seong Hun Kim, Kook Hwan Kim, SujinChae, Chanki Kim, Jeongjin Kim, Hee-Sup Shin, Myung-Shik Lee, Daesoo Kim, Lee, Myung Shik

مصطلحات موضوعية: Age Factors, Animals, Ataxia/congenital, Ataxia/genetics, Ataxia/physiopathology, Gait/genetics, Gait/physiology, Humans, Mice, Knockout, Ubiquitin-Protein Ligases/deficiency, Ubiquitin-Protein Ligases/genetics

العلاقة: HUMAN MOLECULAR GENETICS; J01008; OAK-2015-06210; https://ir.ymlib.yonsei.ac.kr/handle/22282913/156913Test; T201504923; HUMAN MOLECULAR GENETICS, Vol.24(25) : 7196-7206, 2015

الإتاحة: https://doi.org/10.1093/hmg/ddv417Test
https://ir.ymlib.yonsei.ac.kr/handle/22282913/156913Test

المؤلفون: Chanyi Lu, Xiaoli Lin, Jumpei Yamashita, Ranhui Xi, Minliang Zhou, Yali V. Zhang, Hong Wang, Robert F. Margolskee, Bon-Kyoung Koo, Hans Clevers, Ichiro Matsumoto, Peihua Jiang

المساهمون: Hubrecht Institute for Developmental Biology and Stem Cell Research

المصدر: Stem Cell Reports, 17(2), 369-383. Cell Press

مصطلحات موضوعية: Glossopharyngeal Nerve/surgery, Pyridines, Knockout, Ubiquitin-Protein Ligases, Benzeneacetamides, Inbred C57BL, Taste Buds/metabolism, Biochemistry, Epithelium, Mice, Tongue, Wnt Signaling Pathway/drug effects, Genetics, Stem Cells/cytology, Animals, Wnt Signaling Pathway, Ubiquitin-Protein Ligases/deficiency, Glossopharyngeal Nerve, Tongue/cytology, Pyridines/pharmacology, Mice, Knockout, Taste/physiology, Stem Cells, Cell Biology, Benzeneacetamides/pharmacology, Taste Buds, Epithelium/metabolism, Mice, Inbred C57BL, Taste, Developmental Biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2fbbb32fc7ce9e25325c3bf90b0952aTest
https://pubmed.ncbi.nlm.nih.gov/34995498Test

المؤلفون: Chen, HT, Nussenzweig, A, Chen, J, Nussenzweig, MC, FernandezCapetillo, O, Barbancho, JLR, Wong, N, Klein, IA, LópezContreras, AJ, Jankovic, M, Huen, MSY, Santos, MA

مصطلحات موضوعية: Meiosis - genetics - physiology, Chromatin - metabolism, Animals, Ubiquitin-Protein Ligases - deficiency - genetics - physiology, Immunoglobulin Class Switching - genetics - physiology

العلاقة: Journal of Experimental Medicine; http://www.scopus.com/mlt/select.url?eid=2-s2.0-77952294873&selection=ref&src=s&origin=recordpageTest; Journal Of Experimental Medicine, 2010, v. 207 n. 5, p. 973-981; 981; 170401; WOS:000277452100010; http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-1007&volume=207&issue=5&spage=973&epage=981&date=2010&atitle=Class+switching+and+meiotic+defects+in+mice+lacking+the+E3Test+ubiquitin+ligase+RNF8; PMC2867275; eid_2-s2.0-77952294873; 973; http://hdl.handle.net/10722/65449Test; 207

الإتاحة: https://doi.org/10.1084/jem.20092308Test
http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-1007&volume=207&issue=5&spage=973&epage=981&date=2010&atitle=Class+switching+and+meiotic+defects+in+mice+lacking+the+E3Test+ubiquitin+ligase+RNF8
http://hdl.handle.net/10722/65449Test

المؤلفون: Samuel T Workenhe, Akiko Yanagiya, Huy-Dung Hoang, Soroush Tahmasebi, Dana Pearl, Adrian Pelin, John C. Bell, Chadi Zakaria, Karen L. Mossman, Tyson E. Graber, Jaclyn Hearnden, Polen Sean, Tommy Alain, Jian-Jun Jia, Margaret Watson, Louis-Phillipe Leroux, Seyed Mehdi Jafarnejad, Jean-Simon Diallo, Nahum Sonenberg, Maritza Jaramillo, Nathaniel Robichaud, Vinh Tai Truong, Fabrice Le Boeuf

المساهمون: McGill University = Université McGill [Montréal, Canada], University of Ottawa [Ottawa], Institut Armand Frappier (INRS-IAF), Réseau International des Instituts Pasteur (RIIP)-Institut National de la Recherche Scientifique [Québec] (INRS), McMaster University [Hamilton, Ontario], Ottawa Hospital Research Institute [Ottawa] (OHRI), This research was funded by grants from the Terry Fox Research Institute to NS and TA, and the CHEO Foundation, the Cancer Research Society / Stephen E. Drabin Research Fund, the Brain Tumour Foundation of Canada, and the Canadian Breast Cancer Foundation to TA. The funders had no role in study design, data collection and analysis, Decision to publish, or preparation of the manuscript, We thank Isabelle Harvey and Lynn Kyte for technical assistance, Xu Zhang and Sebastian Morales for help with experiments, and William Muller (McGill) for the mouse mammary epithelial cells.

المصدر: Zakaria, C, Sean, P, Hoang, H-D, Leroux, L-P, Watson, M, Workenhe, S T, Hearnden, J, Pearl, D, Truong, V T, Robichaud, N, Yanagiya, A, Tahmasebi, S, Jafarnejad, S M, Jia, J-J, Pelin, A, Diallo, J-S, Le Boeuf, F, Bell, J C, Mossman, K L, Graber, T E, Jaramillo, M, Sonenberg, N & Alain, T 2018, ' Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP axis ', PLoS Pathogens, vol. 14, no. 8, e1007264 . https://doi.org/10.1371/journal.ppat.1007264Test
PLoS Pathogens
PLoS Pathogens, Public Library of Science, 2018, 14 (8), pp.e1007264. ⟨10.1371/journal.ppat.1007264⟩
PLoS Pathogens, Vol 14, Iss 8, p e1007264 (2018)

مصطلحات موضوعية: 0301 basic medicine, Cell Cycle Proteins, mTORC1, Herpesvirus 1, Human, MESH: Eukaryotic Initiation Factor-4E/genetics, mTORC2, MESH: Immediate-Early Proteins/genetics, Mice, MESH: Immediate-Early Proteins/deficiency, MESH: Catalytic Domain/drug effects, Catalytic Domain, Neoplasms, MESH: Ubiquitin-Protein Ligases/genetics, Chlorocebus aethiops, MESH: Herpes Simplex/genetics, MESH: Ubiquitin-Protein Ligases/deficiency, MESH: Animals, MESH: Signal Transduction/genetics, Biology (General), MESH: Phosphoproteins/genetics, MESH: Eukaryotic Initiation Factor-4E/metabolism, Cells, Cultured, MESH: Phosphoproteins/metabolims, MESH: TOR Serine-Threonine Kinases/chemistry, TOR Serine-Threonine Kinases, MESH: Neoplasms/pathology, EIF4E, MESH: Herpes Simplex/complications, MESH: Herpes Simplex/pathology, 3. Good health, Gene Expression Regulation, Neoplastic, MESH: HEK293 Cells, MESH: Cells, Cultured, Signal Transduction, MESH: Organisms, Genetically Modified, QH301-705.5, Ubiquitin-Protein Ligases, Immunology, MESH: Gene Expression Regulation, Neoplastic/drug effects, MESH: Vero Cells, [SDV.CAN]Life Sciences [q-bio]/Cancer, MESH: Herpesvirus 1, Human/drug effects, Biology, MESH: Neoplasms/virology, Microbiology, MESH: TOR Serine-Threonine Kinases/antagonists & inhibitiors, Immediate-Early Proteins, MESH: Protein Kinase Inhibitors/pharmacology, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Virology, Genetics, medicine, Animals, Humans, MESH: Mice, Molecular Biology, Protein Kinase Inhibitors, Vero Cells, PI3K/AKT/mTOR pathway, Adaptor Proteins, Signal Transducing, MESH: Herpesvirus 1, Human/genetics, MESH: Adaptator Proteins, Signal Transducing/metabolism, MESH: Humans, Organisms, Genetically Modified, Cancer, Herpes Simplex, RC581-607, medicine.disease, Phosphoproteins, MESH: Cercopithecus aethiops, MESH: Neoplasms/complications, Oncolytic virus, 030104 developmental biology, Eukaryotic Initiation Factor-4E, HEK293 Cells, Viral replication, Cancer cell, Cancer research, Parasitology, Immunologic diseases. Allergy, MESH: Neoplasms/genetics, MESH: Adaptator Proteins, Signal Transducing/genetics

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c92dee5a0216e1929b4920ce8f0aa3Test
https://pubmed.ncbi.nlm.nih.gov/30138450Test

المؤلفون: André Nussenzweig, Hua Tang Chen, Margarida A. Santos, Nancy Wong, Isaac A. Klein, Junjie Chen, Juan L R Barbancho, Michel C. Nussenzweig, Andrés J. López-Contreras, Oscar Fernandez-Capetillo, Michael S.Y. Huen, Mila Jankovic

المصدر: The Journal of Experimental Medicine
The Journal of Cell Biology

مصطلحات موضوعية: Transcription, Genetic, Chromosomal Proteins, Non-Histone, DNA damage, Ubiquitin-Protein Ligases, Immunology, Ubiquitin-Protein Ligases - deficiency - genetics - physiology, 030204 cardiovascular system & hematology, Chromatin - metabolism, DNA-binding protein, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Ubiquitin, Lymphopenia, Animals, Immunology and Allergy, DNA Breaks, Double-Stranded, RNA, Messenger, 030304 developmental biology, Mice, Knockout, Recombination, Genetic, 0303 health sciences, biology, Brief Definitive Report, Intracellular Signaling Peptides and Proteins, Immunoglobulin Class Switching - genetics - physiology, Cell Biology, Immunoglobulin Class Switching, Meiosis - genetics - physiology, Molecular biology, Chromatin, 3. Good health, Ubiquitin ligase, DNA-Binding Proteins, Meiosis, Histone, Immunoglobulin class switching, chemistry, 030220 oncology & carcinogenesis, biology.protein, Tumor Suppressor p53-Binding Protein 1, DNA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::316f5bc20b0a346c139d4e53b2adef83Test
https://doi.org/10.1084/jem.20092308Test

المؤلفون: Meka, Durga Praveen, Müller-Rischart, Anne Kathrin, Miesbauer, Margit, Rotermund, Natalie, Lohr, Christian, Tatzelt, Jörg, Winklhofer, Konstanze F, Kramer, Edgar R, Nidadavolu, Prakash, Mohammadi, Behnam, Motori, Elisa, Ponna, Srinivas Kumar, Aboutalebi, Helia, Bassal, Mahmoud, Annamneedi, Anil, Finckh, Barbara

المصدر: The journal of clinical investigation 125(5), 1873-1885 (2015). doi:10.1172/JCI79300

مصطلحات موضوعية: info:eu-repo/classification/ddc/610, Adenosine Triphosphate: biosynthesis, Animals, Anxiety: genetics, Cell Line, Cell Size, Disease Progression, Dopaminergic Neurons: pathology, Exploratory Behavior, Glial Cell Line-Derived Neurotrophic Factor: deficiency, Glial Cell Line-Derived Neurotrophic Factor: genetics, Glial Cell Line-Derived Neurotrophic Factor: physiology, Mice, Knockout, Transgenic, Mitochondria: pathology, NF-kappa B: physiology, Nerve Degeneration: pathology, Parkinsonian Disorders: genetics, Parkinsonian Disorders: pathology, Phosphatidylinositol 3-Kinases: physiology, Proto-Oncogene Proteins c-ret: deficiency, Proto-Oncogene Proteins c-ret: genetics, Proto-Oncogene Proteins c-ret: physiology, Recombinant Fusion Proteins: metabolism, Rotarod Performance Test, Signal Transduction, Substantia Nigra: pathology, Ubiquitin-Protein Ligases: deficiency, Ubiquitin-Protein Ligases: genetics

جغرافية الموضوع: DE

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/pmid:25822020; info:eu-repo/semantics/altIdentifier/issn/0021-9738; info:eu-repo/semantics/altIdentifier/issn/1558-8238; https://pub.dzne.de/record/137919Test; https://pub.dzne.de/search?p=id:%22DZNE-2020-04241%22Test

الإتاحة: https://doi.org/10.1172/JCI79300Test
https://pub.dzne.de/record/137919Test
https://pub.dzne.de/search?p=id:%22DZNE-2020-04241%22Test

المؤلفون: Ronzaud, C., Loffing-Cueni, D., Hausel, P., Debonneville, A., Malsure, S.R., Fowler-Jaeger, N., Boase, N.A., Perrier, R., Maillard, M., Yang, B., Stokes, J.B., Koesters, R., Kumar, S., Hummler, E., Loffing, J., Staub, O.

المصدر: Journal of Clinical Investigation, vol. 123, no. 2, pp. 657-665

مصطلحات موضوعية: Animals, Blood Pressure, Disease Models, Animal, Endosomal Sorting Complexes Required for Transport/deficiency, Endosomal Sorting Complexes Required for Transport/genetics, Epithelial Sodium Channels/metabolism, Humans, Hypertension/etiology, Hypertension/genetics, Kidney Tubules/physiopathology, Liddle Syndrome/etiology, Liddle Syndrome/genetics, Mice, Knockout, Potassium/blood, Potassium/urine, Potassium Channels, Inwardly Rectifying/metabolism, Receptors, Drug/metabolism, Sodium/blood, Sodium/urine, Sodium, Dietary/administration & dosage, Dietary/adverse effects, Symporters/metabolism, Ubiquitin-Protein Ligases/deficiency, Ubiquitin-Protein Ligases/genetics

وصف الملف: application/pdf

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/23348737; info:eu-repo/semantics/altIdentifier/eissn/1558-8238; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_218B3682F1561; https://serval.unil.ch/notice/serval:BIB_218B3682F156Test; urn:issn:0021-9738; https://serval.unil.ch/resource/serval:BIB_218B3682F156.P001/REF.pdfTest; http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_218B3682F1561Test

الإتاحة: https://doi.org/10.1172/JCI61110Test
https://serval.unil.ch/notice/serval:BIB_218B3682F156Test
https://serval.unil.ch/resource/serval:BIB_218B3682F156.P001/REF.pdfTest
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_218B3682F1561Test