المؤلفون: Natalie E. Farrawell, Justin J. Yerbury

المصدر: Frontiers in Molecular Neuroscience, Vol 14 (2021)

مصطلحات موضوعية: ALS, SOD1, UPR – unfolded protein response, UPS – ubiquitin proteasome system, proteome homeostasis, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fnmol.2021.771911/fullTest; https://doaj.org/toc/1662-5099Test

الوصول الحر: https://doaj.org/article/cb509023f6e049ed9739bbae0164f696Test

المؤلفون: Lu Feng, Kai Zhang, Bo Liu, Tingting Jiang, Liang Ouyang, Guan Wang, Jiamei Li, Shiou Zhu, Junping Pei

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 3015-3034 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: Target, ONRs, orphan nuclear receptors, Parkinson's disease, Small-molecule compound, MPP+, 1-methyl-4-phenylpyridinium, Autolysosome, GAPDH, glyceraldehyde 3-phosphate dehydrogenase, GBA, glucocerebrosidase β acid, Review, MPTP, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine, Disease, mTORC1, mTOR, the mammalian target of rapamycin, PD, Parkinson's disease, 0302 clinical medicine, CL, clearance rate, DAT, dopamine transporter, HDAC6, histone deacetylase 6, PD therapy, A2A, adenosine 2A, MYCBP2, MYC-binding protein 2, TFEB, transcription factor EB, AUTAC, autophagy targeting chimera, General Pharmacology, Toxicology and Pharmaceutics, SAS, solvent accessible surface, 0303 health sciences, α-syn, α-synuclein, ALP, autophagy-lysosomal pathway, AADC, aromatic amino acid decarboxylase, DJ-1, Parkinson protein 7, PI3K, phosphatidylinositol 3-kinase, COMT, catechol-O-methyltransferase, LUHMES, lund human mesencephalic, LRRK2, CMA, chaperone-mediated autophagy, KI, knockin, 030220 oncology & carcinogenesis, LRS, leucyl-tRNA synthetase, BBB, blood−brain barrier, SN, substantia nigra, IMPase, inositol monophosphatase, IPPase, inositol polyphosphate 1-phosphatase, HSPA8, heat shock 70 kDa protein 8, MAO-B, monoamine oxidase B, PREP, prolyl oligopeptidase, Parkinson's disease (PD), DR, dopamine receptor, PDE4, phosphodiesterase 4, AMPK, 5ʹAMP-activated protein kinase, 5-HT2C, serotonin 2C, SNCA, α-synuclein gene, TSC2, tuberous sclerosis complex 2, RM1-950, LIMP-2, lysosomal integrated membrane protein-2, CNS, central nervous system, 5-HT2A, Serotonin 2A, ER, endoplasmic reticulum, ATG, autophagy related protein, 03 medical and health sciences, PLC, phospholipase C, ROS, reactive oxygen species, ERRα, estrogen-related receptor alpha, SAR, structure–activity relationship, ULK1, UNC-51-like kinase 1, medicine, Autophagy, NMDA, N-methyl-d-aspartic acid, mAChR, muscarinic acetylcholine receptor, GWAS, genome-wide association study, LAMP2A, lysosome-associated membrane protein 2 A, Lamp2a, type 2A lysosomal-associated membrane protein, 030304 developmental biology, Parkin, parkin RBR E3 ubiquitin−protein ligase, PINK1, PTEN-induced kinase 1, ATTEC, autophagosome-tethering compound, ATP13A2, ATPase cation transporting 13A2, business.industry, ULK1, medicine.disease, LC3, light chain 3, PI3P, phosphatidylinositol 3-phosphate, SYT11, synaptotagmin 11, AUC, the area under the curve, UPS, ubiquitin−proteasome system, TFEB, DA, dopamine, Therapeutics. Pharmacology, business, BAF, bafilomycinA1, HSC70, heat shock cognate 71 kDa protein, Neuroscience, 3-MA, 3-methyladenine, F, oral bioavailability, LRRK2, leucine-rich repeat sequence kinase 2

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d12dab43aca56bfd6a912c2aa71297ffTest
http://www.sciencedirect.com/science/article/pii/S2211383521000642Test

المؤلفون: Arun Upadhyay

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 2995-3014 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: Ubiquitin proteasome system, CASA, chaperone-assisted selective autophagy, DUBs, deubiquitinases, Review, 0302 clinical medicine, Ubiquitin, Natural molecules, Chaperones, General Pharmacology, Toxicology and Pharmaceutics, Ub, ubiquitin, Cancer, CAP, chaperone-assisted proteasomal degradation, EGCG, epigallocatechin-3-gallate, 0303 health sciences, biology, Drug discovery, Chemistry, HECT, homologous to the E6-AP carboxyl terminus, Neurodegeneration, CELL DEBRIS, CMA, chaperone-mediated autophagy, Cell biology, 030220 oncology & carcinogenesis, Proteinopathies, HSP, heat shock protein, LAMP2a, lysosome-associated membrane protein 2a, UPS, ubiquitin–proteasome system, 17-AAG, 17-allylamino-geldanamycin, BAG, BCL2-associated athanogene, HSF1, heat shock factor 1, RM1-950, RING, really interesting new gene, 03 medical and health sciences, ESCRT, endosomal sorting complexes required for transport, CHIP, carboxy-terminus of HSC70 interacting protein, medicine, Autophagy, HSC70, heat shock cognate 70, PQC, protein quality control, 030304 developmental biology, APC, anaphase-promoting complex, medicine.disease, NBR1, next to BRCA1 gene 1, KFERQ, lysine-phenylalanine-glutamate-arginine-glutamine, LC3, light chain 3, Ageing, Proteostasis, Proteasome, biology.protein, Therapeutics. Pharmacology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5576b50a2ff37b0f37fd10602f606f6cTest
http://www.sciencedirect.com/science/article/pii/S2211383521000095Test

المؤلفون: Theodore S. Lawrence, May San Martinho, Derek J. Nancarrow, Dipankar Ray, David G. Beer

المصدر: Cellular and Molecular Gastroenterology and Hepatology

مصطلحات موضوعية: p53, 0301 basic medicine, Mutant, Review, UPS, 0302 clinical medicine, Ubiquitin, GOF, gain-of-function, HSP, Medicine, MVP, mevalonate-5-phosphate, EAC, esophageal adenocarcinoma, Molecular Targeted Therapy, Gastrointestinal Neoplasms, biology, Protein Stability, Gastroenterology, GI, gastrointestinal, Ubiquitin ligase, RE, responsive element, Mdm2, HSP, heat shock protein, 030211 gastroenterology & hepatology, HOP, Hsp70/Hsp90 organizing protein, Ubiquitin-Protein Ligases, Antineoplastic Agents, Heat Shock Protein, 03 medical and health sciences, UPS, ubiquitin proteasome system, Heat shock protein, BE, Barrett’s esophagus, Ubiquitin Proteasome System, LGD, low-grade dysplasia, Humans, HGD, high-grade dysplasia, LOH, loss of heterozygosity, Hepatology, business.industry, WT, wild-type, RNF128/GRAIL, 030104 developmental biology, Proteasome, Chaperone (protein), Mutation, Proteolysis, Cancer cell, biology.protein, Cancer research, Tumor Suppressor Protein p53, HCC, hepatocellular carcinoma, business, Molecular Chaperones

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fb8b4a5877a31843d9d41138bf96cb2Test
https://doi.org/10.1016/j.jcmgh.2020.10.012Test

المؤلفون: Pedrycz Agnieszka, Kramkowska Agnieszka

المصدر: Current Problems of Psychiatry, Vol 17, Iss 1, Pp 47-57 (2016)

مصطلحات موضوعية: proteasome, lysosome, UPS – ubiquitin-proteasome system, Psychiatry, RC435-571

العلاقة: http://www.degruyter.com/view/j/cpp.2016.17.issue-1/cpp-2016-0007/cpp-2016-0007.xml?format=INTTest; https://doaj.org/toc/2353-8627Test; https://doaj.org/article/baaacecddfb94bfa8d57dd49bf0bf48fTest

الإتاحة: https://doi.org/10.1515/cpp-2016-0007Test
https://doaj.org/article/baaacecddfb94bfa8d57dd49bf0bf48fTest

المؤلفون: Justin J. Yerbury, Natalie E. Farrawell

المصدر: Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience, Vol 14 (2021)

مصطلحات موضوعية: animal diseases, UPS – ubiquitin proteasome system, Mutant, SOD1, Neurosciences. Biological psychiatry. Neuropsychiatry, Protein degradation, Cellular and Molecular Neuroscience, medicine, Amyotrophic lateral sclerosis, proteome homeostasis, Molecular Biology, Mutant sod1, UPR – unfolded protein response, Chemistry, Cu-Zn Superoxide Dismutase, nutritional and metabolic diseases, Brief Research Report, medicine.disease, Cell biology, nervous system diseases, nervous system, Degradation (geology), ALS, RC321-571, Neuroscience

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b6324383aa8f9c04e5b790af47234eeTest
https://pubmed.ncbi.nlm.nih.gov/34803609Test

المؤلفون: Oded Kleifeld, Prasad Sulkshane, Michael H. Glickman, Anita Thakur, Noa Reis, Jonathan Ram

المصدر: Redox Biology, Vol 45, Iss, Pp 102047-(2021)
Redox Biology

مصطلحات موضوعية: 0301 basic medicine, Medicine (General), PolyUb, polyubiquitin, QH301-705.5, Clinical Biochemistry, HIF-1α, Mitochondrion, Biochemistry, Parkin, 03 medical and health sciences, 0302 clinical medicine, R5-920, Ubiquitin, Mitophagy, MFN1, Humans, OMM, Outer Mitochondrial Membrane, OCR, oxygen consumption rate, NAC, N-Acetyl Cysteine, Biology (General), Hypoxia, OXPHOS, Oxidative Phosphorylation, MAD, Mitochondria-Associated Degradation, biology, Proteasome, Chemistry, Organic Chemistry, Autophagy, Ubiquitination, Ub, Ubiquitin, Ubiquitin ligase, Cell biology, Mitochondria, Oxidative Stress, 030104 developmental biology, biology.protein, UPS, Ubiquitin Proteasome System, PHD, Prolyl Hydroxylase, MitoQ, Mitoquinone, 030217 neurology & neurosurgery, Research Paper, ROS, Reactive Oxygen Species, HeLa Cells

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36dfe538d50d5a83c423b9365c089170Test
http://www.sciencedirect.com/science/article/pii/S2213231721002068Test

المؤلفون: Zhenyu Luo, Cuifu Yu, Renjie Chai, Hongbiao Huang, Yangshuo Jin, Ningning Liu, Xiaohong Xia, Tumei Hu, Bijun Du, Jielei Gu, Qiong Xu, Shiming Liu, Wenchao Ou, Xiaolin Liu

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: Neointima, Cell cycle checkpoint, Vascular smooth muscle, Immunoprecipitation, proliferation, Myocytes, Smooth Muscle, Cycloheximide, Biochemistry, VSMC, vascular smooth muscle cell, Muscle, Smooth, Vascular, Cell Line, chemistry.chemical_compound, CHX, cycloheximide, HE, hematoxylin-eosin, Cyclin-dependent kinase, Cell Movement, medicine.artery, medicine, Thoracic aorta, UPS, ubiquitin-proteasome system, USP10, ubiquitin-specific peptidase 10, Humans, Molecular Biology, S-Phase Kinase-Associated Proteins, CDK, cyclin-dependent kinase, Cell Proliferation, HASMC, human aortic smooth muscle cell, biology, Protein Stability, Co-IP, coimmunoprecipitation, DUB, deubiquitinase, Cell Biology, Cell biology, chemistry, Proteasome, biology.protein, cardiovascular system, ubiquitin-specific peptidase 10 (USP10), Skp2, vascular smooth muscle cell (VSMC), carotid ligation, Ubiquitin Thiolesterase, IHC, immunohistochemistry, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b3a7a44021dfe977b403f744520a584Test
http://europepmc.org/articles/PMC8524199Test

المؤلفون: Gustavo M. Silva, Nathan A. Snyder

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: translation, Ubiquitin C-Terminal Hydrolase, CYLD, conserved cylindromatosis, SUMO, small ubiquitin-like modifier, Biochemistry, MJD, Machado–Josephin domain, Deubiquitinating enzyme, TRAF6, tumor necrosis factor (TNF) receptor associated factor 6, RTU, redox control of translation by ubiquitin, USP, ubiquitin-specific protease, Ubiquitin, oxidative stress, Homeostasis, deubiquitination, BER, base excision repair, TNF, tumor necrosis factor, biology, Deubiquitinating Enzymes, Chemistry, OTU, ovarian tumor domain, Cell biology, AMSH, associated molecule with the SH3 domain of STAM, Mdm2, Polβ, DNA polymerase beta, Ubp, ubiquitin-binding protein, Oxidation-Reduction, Deubiquitination, Signal Transduction, TRAF2, tumor necrosis factor (TNF) receptor associated factor 2, PCNA, proliferating cell nuclear antigen, OTUB, varian tumor deubiquitinase, ubiquitin aldehyde binding, DUB, A20, tumor necrosis factor alpha–induced protein 3, MIC-CAP, microcephaly-capillary malformation, ROS, reactive oxygen species, ESCRT, endosomal sorting complexes required for transport, MDM2, Mouse double minute 2, ubiquitin, TGF-β, transforming growth factor beta, Endopeptidases, ATXN, ataxin, Integrated stress response, UPS, ubiquitin-proteasome system, Animals, Humans, redox signaling, Molecular Biology, enzymatic regulation, ISR, integrated stress response, BAP1, BRCA1-associated protein 1, JBC Reviews, Ubiquitination, WDR48, WD repeat domain 48, Tumor Necrosis Factor alpha-Induced Protein 3, Cell Biology, RPN11, regulatory particle non-ATPase 11, EGFR, epidermal growth factor receptor, CK2, casein kinase 2, QC, quality control, MINDY, motif interacting with Ub-containing novel DUB, FOXO4, forkhead box O4, Proteasome, DTT, dithiothreitol, NLS, nuclear localization signal, UCH, ubiquitin C-terminal hydrolase, biology.protein, RQC, ribosome-associated quality control, PTM, posttranslational modification, UIM, ubiquitin interacting motif, OTUD, ovarian tumor deubiquitinase, Reactive Oxygen Species, Protein Processing, Post-Translational, DUB, deubiquitinating enzyme or deubiquitinase

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9c743630c2855f90492c29a0b696db4Test
http://europepmc.org/articles/PMC8424594Test

المؤلفون: Saikat Bhattacharya, Michaella J. Levy, Michael P. Washburn, Jeffrey J. Lange, Laurence Florens, Jerry L. Workman

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: hnRNP, heterogeneous ribonucleoprotein, FDR, false discovery rate, ROI, region of interest, RNA polymerase II, histone, Protein degradation, Biochemistry, Methylation, Mass Spectrometry, Histones, Histone H3, Structure-Activity Relationship, CHX, cycloheximide, Humans, UPS, ubiquitin-proteasome system, SRI, Set2-Rpb1 Interaction, Molecular Biology, biology, Chemistry, Protein Stability, Fluorescence recovery after photobleaching, FRAP, fluorescence recovery after photobleaching, APC, anaphase-promoting complex, Cell Biology, Histone-Lysine N-Methyltransferase, Methyltransferases, intrinsically disordered protein, Chromatin, Cell biology, Intrinsically Disordered Proteins, IDR, intrinsically disordered region, Histone, HEK293 Cells, proteasome, Proteasome, SHI, SETD2-hnRNP Interaction, SET, Su(var)3 to 9, Enhancer-of-zeste and Trithorax, RNA splicing, Proteolysis, biology.protein, protein degradation, chromatin, Protein Processing, Post-Translational, MudPIT, multidimensional protein identification technology, Fluorescence Recovery After Photobleaching, Protein Binding, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7440a573ed0fc2395bff62aede8af8beTest
https://pubmed.ncbi.nlm.nih.gov/34391778Test