المؤلفون: Taghavi, Taraneh, St.Helen, Gideon, Benowitz, Neal L, Tyndale, Rachel F

المصدر: Pharmacogenetics and Genomics. 27(4)

مصطلحات موضوعية: Pharmacology and Pharmaceutical Sciences, Biological Sciences, Biomedical and Clinical Sciences, Genetics, Tobacco Smoke and Health, Tobacco, Cancer, Good Health and Well Being, Administration, Intravenous, Black or African American, Cotinine, Genotype, Glucuronosyltransferase, Humans, Minor Histocompatibility Antigens, Mixed Function Oxygenases, Nicotine, Organic Cation Transport Proteins, Organic Cation Transporter 2, Pharmacogenomic Variants, Polymorphism, Single Nucleotide, Smoking, African American, cotinine, FMO3, glucuronidation, nicotine, OCT2, pharmacokinetics, UGT2B10, UGT2B17, Pharmacology & Pharmacy, Pharmacology and pharmaceutical sciences

الوصول الحر: https://escholarship.org/uc/item/4df9k4nzTest

المؤلفون: Itkonen, Matti K., Tornio, Aleksi, Neuvonen, Mikko, Neuvonen, Pertti J., Niemi, Mikko, Backman, Janne T.

المساهمون: HUSLAB, Department of Clinical Pharmacology, Medicum, University of Helsinki, Clinicum, Janne Backman / Principal Investigator

مصطلحات موضوعية: DRUG-DRUG INTERACTION, TRANSPORTING POLYPEPTIDE 1B1, PLASMA-CONCENTRATIONS, DEPENDENT INHIBITOR, MARKEDLY INCREASES, UGT2B10 GENOTYPE, CYP2C8, PHARMACOKINETICS, GLUCURONIDATION, METABOLISM, 317 Pharmacy, 3111 Biomedicine

وصف الملف: application/pdf

العلاقة: This study was supported by grants from the Academy of Finland [Grant decision 278123, 2014] and by State funding for university-level health research [Hospital District of Helsinki and Uusimaa, Finland].; Itkonen , M K , Tornio , A , Neuvonen , M , Neuvonen , P J , Niemi , M & Backman , J T 2019 , ' Clopidogrel and Gemfibrozil Strongly Inhibit the CYP2C8-Dependent Formation of 3-Hydroxydesloratadine and Increase Desloratadine Exposure In Humans ' , Drug Metabolism and Disposition , vol. 47 , no. 4 , pp. 377-385 . https://doi.org/10.1124/dmd.118.084665Test; ORCID: /0000-0002-9577-2788/work/56620207; ORCID: /0000-0003-3631-9411/work/56620749; ORCID: /0000-0001-5713-5692/work/56620937; 85063688828; c07f551a-ad5f-4961-8c08-42e8f3efe377; http://hdl.handle.net/10138/300947Test; 000462570400004

الإتاحة: http://hdl.handle.net/10138/300947Test

المؤلفون: Ware, Jennifer J., Chen, Xiangning, Vink, Jacqueline, Loukola, Anu, Minica, Camelia, Pool, Rene, Milaneschi, Yuri, Mangino, Massimo, Menni, Cristina, Chen, Jingchun, Peterson, Roseann E., Auro, Kirsi, Lyytikainen, Leo-Pekka, Wedenoja, Juho, Stiby, Alexander I., Hemani, Gibran, Willemsen, Gonneke, Hottenga, Jouke Jan, Korhonen, Tellervo, Heliovaara, Markku, Perola, Markus, Rose, Richard J., Paternoster, Lavinia, Timpson, Nic, Wassenaar, Catherine A., Zhu, Andy Z. X., Smith, George Davey, Raitakari, Olli T., Lehtimaki, Terho, Kahonen, Mika, Koskinen, Seppo, Spector, Timothy, Penninx, Brenda W. J. H., Salomaa, Veikko, Boomsma, Dorret I., Tyndale, Rachel F., Kaprio, Jaakko, Munafo, Marcus R.

المساهمون: Department of Public Health, Clinicum, Institute for Molecular Medicine Finland, Jaakko Kaprio / Principal Investigator, Quantitative Genetics, Genetic Epidemiology

مصطلحات موضوعية: NICOTINE GLUCURONIDATION, CARCINOGEN EXPOSURE, SMOKING-BEHAVIOR, SERUM COTININE, CYP2A6, ASSOCIATION, UGT2B10, PLASMA, URINE, METABOLITES, 3142 Public health care science, environmental and occupational health

وصف الملف: application/pdf

العلاقة: JJW is supported by a Post-Doctoral Research Fellowship from the Oak Foundation (http://www.oakfnd.orgTest/). JJW, GH, LP, NT, GDS and MRM are members of the Medical Research Council (MRC) Integrative Epidemiology Unit: support from the MRC is gratefully acknowledged (MC_UU_12013/6). JJW and MRM are members of the UK Centre for Tobacco and Alcohol Studies, a UK Clinical Research Council Public Health Research: Centre of Excellence. Funding from British Heart Foundation, Cancer Research UK, Economic and Social Research Council, Medical Research Council, and the National Institute for Health Research, under the auspices of the UK Clinical Research Collaboration, is gratefully acknowledged. XC, JC and REP acknowledge support from the National Institute on Drug Abuse (NIDA) (R01DA032246). REP also acknowledges support from NIDA (R25 DA26119) and National Institute of Mental Health (NIMH) (T32 MH20030). AIS is supported by a Wellcome Trust 4-year PhD studentship in molecular, genetic, and lifecourse epidemiology (WT083431MA). LP is funded by a UK MRC Population Health Scientist fellowship (MR/J012165/1). VS was funded by the Academy of Finland (139635) and the Finnish Foundation for Cardiovascular Research. RJR acknowledges support from National Institute on Alcohol Abuse and Alcoholism (AA-12502). KA received sponsorship from the Finnish Medical Association. MP acknowledges EU FP7 Grants BBMRI-Large Prospective Cohorts (313010), and BioSHaRE (261433). YM is supported by GGZinGeest, the mental health care organization supporting NESDA. CM is supported by European Research Council (ERC) starting grant 284167 (P.I. JV). DB also acknowledges ERC support (230374). CW is supported by a Canadian Institutes of Health Research (CIHR) doctoral award. MM receives support from the National Institute for Health Research (NIHR) BioResource Clinical Research Facility and Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust and King's College London. RFT is an Endowed Chair in Addiction for the Department of Psychiatry at the University of Toronto (CIHR grant TMH109787, NIH PGRN grant DA020830). JK is supported by Academy of Finland grants 265240 and 263278. Acknowledgements specific to individual cohorts are listed in Supplementary Information.; Ware , J J , Chen , X , Vink , J , Loukola , A , Minica , C , Pool , R , Milaneschi , Y , Mangino , M , Menni , C , Chen , J , Peterson , R E , Auro , K , Lyytikainen , L-P , Wedenoja , J , Stiby , A I , Hemani , G , Willemsen , G , Hottenga , J J , Korhonen , T , Heliovaara , M , Perola , M , Rose , R J , Paternoster , L , Timpson , N , Wassenaar , C A , Zhu , A Z X , Smith , G D , Raitakari , O T , Lehtimaki , T , Kahonen , M , Koskinen , S , Spector , T , Penninx , B W J H , Salomaa , V , Boomsma , D I , Tyndale , R F , Kaprio , J & Munafo , M R 2016 , ' Genome-Wide Meta-Analysis of Cotinine Levels in Cigarette Smokers Identifies Locus at 4q13.2 ' , Scientific Reports , vol. 6 , 20092 . https://doi.org/10.1038/srep20092Test; ORCID: /0000-0003-0542-5967/work/28947738; ORCID: /0000-0002-6155-0378/work/29980082; ORCID: /0000-0003-2838-3085/work/30248861; http://hdl.handle.net/10138/160992Test; b569eee5-1c6d-40cc-ae39-a39f731c0d4d; 84957557668; 000368995100001

الإتاحة: http://hdl.handle.net/10138/160992Test

المؤلفون: Uppugunduri Satyanarayana, Chakradhara Rao, Robin, Shannon, Ben Hassine, Khalil

مصطلحات موضوعية: MD, UGT2B10, GROMACS

وصف الملف: application/octet-stream; text/plain; audio/mpeg; video/mpeg; application/vnd.openxmlformats-officedocument.wordprocessingml.document; text/xml

العلاقة: handle:ba8e6d29-7433-455a-a47c-4935af4d8f8e; https://yareta.unige.ch/archives/5289c100-bc49-4535-89db-2d3c52a8da5aTest

الإتاحة: https://doi.org/10.26037/yareta:o7au7wijvrglnb6nu2k4azkmmyTest
https://yareta.unige.ch/archives/5289c100-bc49-4535-89db-2d3c52a8da5aTest

المؤلفون: Matti K. Itkonen, Mikko Niemi, Mikko Neuvonen, Janne T. Backman, Pertti J. Neuvonen, Aleksi Tornio

المساهمون: HUSLAB, Department of Clinical Pharmacology, Medicum, University of Helsinki, Clinicum, Janne Backman / Principal Investigator

المصدر: Drug Metabolism and Disposition. 47:377-385

مصطلحات موضوعية: Adult, Male, CYP2C8, PHARMACOKINETICS, PLASMA-CONCENTRATIONS, Genotype, TRANSPORTING POLYPEPTIDE 1B1, Glucuronidation, Cmax, Pharmaceutical Science, MARKEDLY INCREASES, METABOLISM, Pharmacology, 030226 pharmacology & pharmacy, UGT2B10 GENOTYPE, Cytochrome P-450 CYP2C8, Young Adult, 03 medical and health sciences, Glucuronides, 0302 clinical medicine, Pharmacokinetics, medicine, Humans, Gemfibrozil, Drug Interactions, Biotransformation, Hypolipidemic Agents, GLUCURONIDATION, DRUG-DRUG INTERACTION, Desloratadine, Cross-Over Studies, Chemistry, Loratadine, Clopidogrel, Crossover study, 3. Good health, Cytochrome P-450 CYP2C8 Inhibitors, 317 Pharmacy, Area Under Curve, 030220 oncology & carcinogenesis, Female, Aryl Hydrocarbon Hydroxylases, 3111 Biomedicine, DEPENDENT INHIBITOR, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d3feef04e577c0368de75157b976c99Test
https://doi.org/10.1124/dmd.118.084665Test

المؤلفون: Cristina Menni, Lavinia Paternoster, Alexander I. Stiby, Veikko Salomaa, Jingchun Chen, Rachel F. Tyndale, Leo-Pekka Lyytikäinen, Roseann E. Peterson, Jacqueline M. Vink, Kirsi Auro, Gonneke Willemsen, René Pool, Terho Lehtimäki, Brenda W. J. H. Penninx, Yuri Milaneschi, Dorret I. Boomsma, Xiangning Chen, Mika Kähönen, Markus Perola, Massimo Mangino, Olli T. Raitakari, Seppo Koskinen, Richard J. Rose, Jaakko Kaprio, Juho Wedenoja, Camelia C. Minică, George Davey Smith, Catherine A. Wassenaar, Tim D. Spector, Markku Heliövaara, Tellervo Korhonen, Nicholas J. Timpson, Gibran Hemani, Jouke-Jan Hottenga, Anu Loukola, Andy Z. X. Zhu, Jennifer J. Ware, Marcus R. Munafò

المساهمون: Department of Public Health, Clinicum, Institute for Molecular Medicine Finland, Jaakko Kaprio / Principal Investigator, Quantitative Genetics, Genetic Epidemiology, Biological Psychology, EMGO+ - Lifestyle, Overweight and Diabetes, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, EMGO+ - Mental Health, Sociology and Social Gerontology, Psychiatry, EMGO - Mental health, Amsterdam Neuroscience - Complex Trait Genetics

المصدر: Scientific Reports
Ware, J J, Chen, X, Vink, J, Loukola, A, Minica, C, Pool, R, Milaneschi, Y, Mangino, M, Menni, C, Chen, J, Peterson, R E, Auro, K, Lyytikainen, L-P, Wedenoja, J, Stiby, A I, Hemani, G, Willemsen, G, Hottenga, J J, Korhonen, T, Heliovaara, M, Perola, M, Rose, R J, Paternoster, L, Timpson, N, Wassenaar, C A, Zhu, A Z X, Smith, G D, Raitakari, O T, Lehtimaki, T, Kahonen, M, Koskinen, S, Spector, T, Penninx, B W J H, Salomaa, V, Boomsma, D I, Tyndale, R F, Kaprio, J & Munafo, M R 2016, ' Genome-Wide Meta-Analysis of Cotinine Levels in Cigarette Smokers Identifies Locus at 4q13.2 ', Scientific Reports, vol. 6 . https://doi.org/10.1038/srep20092Test
Ware, J J, Chen, X, Vink, J M, Loukola, A, Minica, C C, Pool, R, Milaneschi, Y, Mangino, M, Menni, C, Chen, J, Peterson, R E, Auro, K, Lyytikäinen, L P, Wedenoja, J, Stiby, A I, Hemani, G, Willemsen, G, Hottenga, J J, Korhonen, T, Heliövaara, M, Perola, M, Rose, R J, Paternoster, L, Timpson, N, Wassenaar, C A, Zhu, A Z X, Davey Smith, G, Raitakari, O T, Lehtimäki, T, Kähönen, M, Koskinen, S, Spector, T D, Penninx, B W J H, Salomaa, V, Boomsma, D I, Tyndale, R F, Kaprio, J & Munafò, M 2016, ' Genome-Wide Meta-Analysis of Cotinine Levels in Cigarette Smokers Identifies Locus at 4q13.2 ', Scientific Reports, vol. 6, no. 20092, 20092 . https://doi.org/10.1038/srep20092Test
Scientific Reports, 6(20092):20092. Nature Publishing Group
Ware, J J, Chen, X, Vink, J, Loukola, A, Minica, C, Pool, R, Milaneschi, Y, Mangino, M, Menni, C, Chen, J, Peterson, R E, Auro, K, Lyytikäinen, L-P, Wedenoja, J, Stiby, A I, Hemani, G, Willemsen, G, Hottenga, J J, Korhonen, T, Heliövaara, M, Perola, M, Rose, R J, Paternoster, L, Timpson, N, Wassenaar, C A, Zhu, A Z X, Davey Smith, G, Raitakari, O T, Lehtimäki, T, Kähönen, M, Koskinen, S, Spector, T, Penninx, B W J H, Salomaa, V, Boomsma, D I, Tyndale, R F, Kaprio, J & Munafò, M R 2016, ' Genome-Wide Meta-Analysis of Cotinine Levels in Cigarette Smokers Identifies Locus at 4q13.2 ', Scientific Reports, vol. 6, pp. 20092 . https://doi.org/10.1038/srep20092Test
Ware, J J, Chen, X, Vink, J M, Loukola, A, Minica, C, Pool, R, Milaneschi, Y, Mangino, M, Menni, C, Chen, J, Peterson, R E, Auro, K, Lyytikäinen, L-P, Wedenoja, J, Stiby, A I, Hemani, G, Willemsen, G, Hottenga, J J, Korhonen, T, Heliövaara, M, Perola, M, Rose, R J, Paternoster, L, Timpson, N J, Wassenaar, C A, Zhu, A Z X, Davey Smith, G, T Raitakari, O, Lehtimäki, T, Kähönen, M, Koskinen, S, Spector, T, Penninx, B W J H, Salomaa, V, Boomsma, D I, Tyndale, R F, Kaprio, J & Munafò, M R 2016, ' Genome-Wide Meta-Analysis of Cotinine Levels in Cigarette Smokers Identifies Locus at 4q13.2 ', Scientific Reports, vol. 6, 20092 . https://doi.org/10.1038/srep20092Test
Scientific Reports, 6. Nature Publishing Group

مصطلحات موضوعية: 0301 basic medicine, Male, Netherlands Twin Register (NTR), Linkage disequilibrium, Genome-wide association study, Twin Study, Brain and Behaviour, NICOTINE GLUCURONIDATION, METABOLITES, Linkage Disequilibrium, Nicotine, chemistry.chemical_compound, 0302 clinical medicine, Medicine, URINE, Glucuronosyltransferase, CYP2A6, Cotinine, Genetics, Multidisciplinary, PLASMA, Research Support, Non-U.S. Gov't, SERUM COTININE, Tobacco and Alcohol, Smoking, ASSOCIATION, UGT2B10, 3142 Public health care science, environmental and occupational health, 3. Good health, CARCINOGEN EXPOSURE, Biomarker (medicine), Female, Chromosomes, Human, Pair 4, medicine.drug, Locus (genetics), Article, 03 medical and health sciences, Research Support, N.I.H., Extramural, SDG 3 - Good Health and Well-being, Journal Article, Humans, SMOKING-BEHAVIOR, Genetic association, business.industry, ta3121, 030104 developmental biology, chemistry, Genetic Loci, business, 030217 neurology & neurosurgery, Meta-Analysis, Genome-Wide Association Study

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e87a027dd62b50a34d861fb06837352Test
http://hdl.handle.net/10138/160992Test

المؤلفون: Berg, Jeannette Zinggeler

مصطلحات موضوعية: Cytochrome P450, Glucuronidation, Nicotine, NNK, Tobacco, UGT2B10, Biochemistry, Molecular Bio, and Biophysics

العلاقة: http://purl.umn.edu/57438Test

الإتاحة: http://purl.umn.edu/57438Test