المؤلفون: Yang, Z., Liang, S.Q., Yang, H., Xu, D., Bruggmann, R., Gao, Y., Deng, H., Berezowska, S., Hall, SRR, Marti, T.M., Kocher, G.J., Zhou, Q., Schmid, R.A., Peng, R.W.

المصدر: Cancer research, vol. 81, no. 11, pp. 3121-3133

مصطلحات موضوعية: Aged, Animals, Apoptosis, Benzamides/pharmacology, CRISPR-Cas Systems, Cell Cycle, Cell Cycle Proteins/antagonists & inhibitors, Cell Cycle Proteins/genetics, Cell Proliferation, Combined Modality Therapy, Gene Amplification, Gene Expression Regulation, Neoplastic, Humans, Lung Neoplasms/genetics, Lung Neoplasms/metabolism, Lung Neoplasms/pathology, Lung Neoplasms/therapy, Male, Mice, Piperazines/pharmacology, Protein Kinase Inhibitors/pharmacology, Protein Serine-Threonine Kinases/antagonists & inhibitors, Protein Serine-Threonine Kinases/genetics, Proto-Oncogene Proteins/antagonists & inhibitors, Proto-Oncogene Proteins/genetics, Pyrazoles/pharmacology, Receptor, Fibroblast Growth Factor, Type 1/antagonists & inhibitors

وصف الملف: application/pdf

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/33685992; info:eu-repo/semantics/altIdentifier/eissn/1538-7445; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_6D844130F3DD5; https://serval.unil.ch/notice/serval:BIB_6D844130F3DDTest; urn:issn:0008-5472; https://serval.unil.ch/resource/serval:BIB_6D844130F3DD.P001/REF.pdfTest; http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_6D844130F3DD5Test

الإتاحة: https://doi.org/10.1158/0008-5472.CAN-20-2276Test
https://serval.unil.ch/notice/serval:BIB_6D844130F3DDTest
https://serval.unil.ch/resource/serval:BIB_6D844130F3DD.P001/REF.pdfTest
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_6D844130F3DD5Test

المؤلفون: Butterworth, Sam, Garzon Sanz, Miguel

المصدر: Butterworth , S & Garzon Sanz , M 2020 , ' Discovery of highly selective inhibitors of calmodulin-dependent kinases that restore insulin sensitivity in the diet-induced obese in vivo mouse model ' , Journal of Medicinal Chemistry , vol. 63 , no. 13 , pp. 6784-6801 . https://doi.org/10.1021/acs.jmedchem.9b01803Test

مصطلحات موضوعية: Animals, Calcium-Calmodulin-Dependent Protein Kinase Type 1/antagonists & inhibitors, Diet/adverse effects, Disease Models, Animal, Drug Discovery, Insulin Resistance, Male, Mice, Inbred C57BL, Models, Molecular, Obesity/chemically induced, Protein Conformation, Protein Kinase Inhibitors/pharmacology

وصف الملف: application/pdf

الإتاحة: https://doi.org/10.1021/acs.jmedchem.9b01803Test
https://research.manchester.ac.uk/en/publications/5393c0fd-adae-46fe-9570-7a44744a73a9Test
https://pure.manchester.ac.uk/ws/files/170189811/acs.jmedchem.9b01803.pdfTest
http://www.scopus.com/inward/record.url?scp=85086365189&partnerID=8YFLogxKTest

المؤلفون: Faes, S., Santoro, T., Troquier, L., De Souza Silva, O., Dormond, O.

المصدر: Biochemical and biophysical research communications, vol. 513, no. 3, pp. 546-552

مصطلحات موضوعية: Antineoplastic Agents/pharmacology, Cell Line, Tumor, Cell Proliferation, HT29 Cells, Heterocyclic Compounds, 3-Ring/pharmacology, Humans, Neoplasms/enzymology, Neoplasms/pathology, Phosphoinositide-3 Kinase Inhibitors/pharmacology, Protein Kinase Inhibitors/pharmacology, Proto-Oncogene Proteins c-akt/antagonists & inhibitors, Proto-Oncogene Proteins c-akt/metabolism, Receptor, IGF Type 1/antagonists & inhibitors, TOR Serine-Threonine Kinases/antagonists & inhibitors, Cancer, PI3K, Targeted therapies, Washout, mTOR

وصف الملف: application/pdf

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/30981504; info:eu-repo/semantics/altIdentifier/eissn/1090-2104; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_EE9065608CC64; https://serval.unil.ch/notice/serval:BIB_EE9065608CC6Test; urn:issn:0006-291X; https://serval.unil.ch/resource/serval:BIB_EE9065608CC6.P001/REF.pdfTest; http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_EE9065608CC64Test

الإتاحة: https://doi.org/10.1016/j.bbrc.2019.04.044Test
https://serval.unil.ch/notice/serval:BIB_EE9065608CC6Test
https://serval.unil.ch/resource/serval:BIB_EE9065608CC6.P001/REF.pdfTest
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_EE9065608CC64Test

المساهمون: College of Medicine, Dept. of Internal Medicine, Su Hwan Lee, Ju Hye Shin, Joo Han Song, Ah Young Leem, Moo Suk Park, Young Sam Kim, Joon Chang, Kyung Soo Chung, Kim, Young Sam, Park, Moo Suk, Song, Joo Han, Leem, Ah Young, Chang, Joon, Jung, Kyung Soo

مصطلحات موضوعية: Animals, CD/metabolism Antigens, Apoptosis/drug effects, Bronchoalveolar Lavage Fluid/chemistry/cytology/immunology, Cadherins/metabolism, Lipopolysaccharides, Lung/metabolism, Lung Injury/chemically induced/*prevention & control, Macrophages/metabolism, Mice, Necrosis/*etiology, IGF Type 1/antagonists & inhibitors/*pharmacology/physiology Receptor, Receptor-Interacting Protein Serine-Threonine Kinases/metabolism, Adult, IGF-1 receptor, Lipopolysaccharide, Lung injury, Necroptosis, Respiratory distress syndrome

العلاقة: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS; J00281; OAK-2018-01564; https://ir.ymlib.yonsei.ac.kr/handle/22282913/162243Test; https://www.sciencedirect.com/science/article/pii/S0006291X18305606Test; T201801182; BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.498(4) : 877-883, 2018

الإتاحة: https://doi.org/10.1016/j.bbrc.2018.03.074Test
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162243Test
https://www.sciencedirect.com/science/article/pii/S0006291X18305606Test

المؤلفون: Shun-Qing Liang, Haibin Deng, Ren-Wang Peng, Gregor J. Kocher, Sabina Berezowska, Qinghua Zhou, Zhang Yang, Rémy Bruggmann, Sean Hall, Yanyun Gao, Duo Xu, Thomas M. Marti, Ralph A. Schmid, Haitang Yang

المصدر: Cancer research, vol. 81, no. 11, pp. 3121-3133

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, animal structures, Aged, Animals, Apoptosis, Benzamides/pharmacology, CRISPR-Cas Systems, Cell Cycle, Cell Cycle Proteins/antagonists & inhibitors, Cell Cycle Proteins/genetics, Cell Proliferation, Combined Modality Therapy, Gene Amplification, Gene Expression Regulation, Neoplastic, Humans, Lung Neoplasms/genetics, Lung Neoplasms/metabolism, Lung Neoplasms/pathology, Lung Neoplasms/therapy, Male, Mice, Piperazines/pharmacology, Protein Kinase Inhibitors/pharmacology, Protein Serine-Threonine Kinases/antagonists & inhibitors, Protein Serine-Threonine Kinases/genetics, Proto-Oncogene Proteins/antagonists & inhibitors, Proto-Oncogene Proteins/genetics, Pyrazoles/pharmacology, Receptor, Fibroblast Growth Factor, Type 1/antagonists & inhibitors, Receptor, Fibroblast Growth Factor, Type 1/genetics, Tumor Cells, Cultured, Xenograft Model Antitumor Assays, Cas9, DNA damage, business.industry, Drug resistance, medicine.disease, PLK1, 3. Good health, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Oncology, 030220 oncology & carcinogenesis, embryonic structures, Cancer cell, Cancer research, medicine, CRISPR, Kinome, biological phenomena, cell phenomena, and immunity, Lung cancer, business

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3974a8b4da8571f690f7572bb8db80fTest
https://doi.org/10.1158/0008-5472.can-20-2276Test

المساهمون: College of Medicine, Dept. of Dermatology, Sang Eun Lee, Eun Young Lee, Sang Jin Kang, Seung Hun Lee, Lee, Sang Eun, Lee, Seung Hun

مصطلحات موضوعية: 11-beta-Hydroxysteroid Dehydrogenase Type 1/antagonists & inhibitors, 11-beta-Hydroxysteroid Dehydrogenase Type 1/genetics, Blotting, Western, Cell Proliferation/drug effects, Cells, Cultured, Fibroblasts/metabolism, Glucocorticoids/pharmacology, Humans, Hydrocortisone, Keratinocytes/metabolism, Signal Transduction, Vascular Endothelial Growth Factor A, 11棺-hydroxysteroid dehydrogenase type 1, dermal papilla cells, glucocorticoids

العلاقة: YONSEI MEDICAL JOURNAL; J02813; OAK-2017-05860; https://ir.ymlib.yonsei.ac.kr/handle/22282913/161114Test; T201704082; YONSEI MEDICAL JOURNAL, Vol.58(6) : 1204-1210, 2017

الإتاحة: https://doi.org/10.3349/ymj.2017.58.6.1204Test
https://ir.ymlib.yonsei.ac.kr/handle/22282913/161114Test

المؤلفون: Olga De Souza Silva, Olivier Dormond, Tania Santoro, Seraina Faes, Laetitia Troquier

المصدر: Biochemical and biophysical research communications, vol. 513, no. 3, pp. 546-552

مصطلحات موضوعية: 0301 basic medicine, Drug, media_common.quotation_subject, Biophysics, Antineoplastic Agents, Biochemistry, Receptor, IGF Type 1, 03 medical and health sciences, 0302 clinical medicine, Cell Line, Tumor, Neoplasms, medicine, Humans, Protein Kinase Inhibitors, Molecular Biology, Protein kinase B, PI3K/AKT/mTOR pathway, Cell Proliferation, Phosphoinositide-3 Kinase Inhibitors, media_common, Kinase, business.industry, TOR Serine-Threonine Kinases, Cancer, Cell Biology, medicine.disease, Discontinuation, 030104 developmental biology, 030220 oncology & carcinogenesis, Cancer cell, Cancer research, Phosphorylation, Antineoplastic Agents/pharmacology, HT29 Cells, Heterocyclic Compounds, 3-Ring/pharmacology, Neoplasms/enzymology, Neoplasms/pathology, Phosphoinositide-3 Kinase Inhibitors/pharmacology, Protein Kinase Inhibitors/pharmacology, Proto-Oncogene Proteins c-akt/antagonists & inhibitors, Proto-Oncogene Proteins c-akt/metabolism, Receptor, IGF Type 1/antagonists & inhibitors, TOR Serine-Threonine Kinases/antagonists & inhibitors, PI3K, Targeted therapies, Washout, mTOR, business, Heterocyclic Compounds, 3-Ring, Proto-Oncogene Proteins c-akt

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d50127f306a84e9b0f9602438657ddcbTest
https://doi.org/10.1016/j.bbrc.2019.04.044Test

المؤلفون: Gautier, Emmanuel L, Westerterp, Marit, Bhagwat, Neha, Cremers, Serge, Shih, Alan, Abdel-Wahab, Omar, Lütjohann, Dieter, Randolph, Gwendalyn J, Levine, Ross L, Tall, Alan R, Yvan-Charvet, Laurent

المصدر: Gautier , E L , Westerterp , M , Bhagwat , N , Cremers , S , Shih , A , Abdel-Wahab , O , Lütjohann , D , Randolph , G J , Levine , R L , Tall , A R & Yvan-Charvet , L 2013 , ' HDL and Glut1 inhibition reverse a hypermetabolic state in mouse models of myeloproliferative disorders ' , The Journal of Experimental Medicine , vol. 210 , no. 2 , pp. 339-353 . https://doi.org/10.1084/jem.20121357Test

مصطلحات موضوعية: ATP Binding Cassette Transporter 1, ATP Binding Cassette Transporter, Subfamily G, Member 1, ATP-Binding Cassette Transporters/deficiency, Adipose Tissue/metabolism, Animals, Apolipoprotein A-I/genetics, Bone Marrow Transplantation, Disease Models, Animal, Glucose/metabolism, Glucose Transporter Type 1/antagonists & inhibitors, Glycolysis, Humans, Insulin Resistance, Interleukin-3/metabolism, Leukocytes/metabolism, Lipoproteins/deficiency, Lipoproteins, HDL/metabolism, Mice, Inbred C57BL, Inbred DBA, Knockout, Transgenic, Myeloproliferative Disorders/genetics, Oxidative Phosphorylation, RNA, Small Interfering/genetics

وصف الملف: application/pdf

العلاقة: https://research.rug.nl/en/publications/1ced3809-4071-4048-92b4-25fbdb5df4ddTest

الإتاحة: https://doi.org/10.1084/jem.20121357Test
https://hdl.handle.net/11370/1ced3809-4071-4048-92b4-25fbdb5df4ddTest
https://research.rug.nl/en/publications/1ced3809-4071-4048-92b4-25fbdb5df4ddTest
https://pure.rug.nl/ws/files/76632355/339.full_1_.pdfTest

المؤلفون: Fedor Berditchevski, Lubna Hashmi, Stevenson Brett W, Graziella Greco, Juliet Morgan, Alessio Atzori, Sundaresan Rajesh, Anna M. Grabowska, Divneet Kaur, Ana Varela, Alejandro Cabanillas, Huy V. Nguyen, Marc Lenoir, Sharon C. Cheetham, Greg P. Iacobini, Colin Kenyon, Christopher J. Weston, Christophe Fromont, Clare L. Box, Miguel Garzon, Brendan Leighton, D. Heulyn Jones, Jitendra Kumar, Fiona J. Sorrell, Steven P. Vickers, Sam Butterworth, C. John Harris, Paige Grant, Clara Redondo, Peter Fischer, Michael Overduin, Andreas Krämer, Vera Novitskaya, Stefan Knapp

المصدر: Butterworth, S & Garzon Sanz, M 2020, ' Discovery of highly selective inhibitors of calmodulin-dependent kinases that restore insulin sensitivity in the diet-induced obese in vivo mouse model ', Journal of Medicinal Chemistry, vol. 63, no. 13, pp. 6784-6801 . https://doi.org/10.1021/acs.jmedchem.9b01803Test
Journal of medicinal chemistry 63(13), 6784-6801 (2020). doi:10.1021/acs.jmedchem.9b01803

مصطلحات موضوعية: Gene isoform, Male, Models, Molecular, Calmodulin, Protein Conformation, CAMK1D, Pharmacology, 01 natural sciences, 03 medical and health sciences, Mice, Insulin resistance, In vivo, Diet/adverse effects, Drug Discovery, medicine, Animals, ddc:610, 030304 developmental biology, 0303 health sciences, biology, Drug discovery, Chemistry, Kinase, medicine.disease, 3. Good health, 0104 chemical sciences, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, Disease Models, Animal, Calcium-Calmodulin-Dependent Protein Kinase Type 1/antagonists & inhibitors, Protein Kinase Inhibitors/pharmacology, biology.protein, Molecular Medicine, Obesity/chemically induced, Insulin Resistance, Diet-induced obese

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5530ea1a6282165c274343b752573f14Test
https://doi.org/10.1021/acs.jmedchem.9b01803Test

المساهمون: Seung Hyun Oh, Ju-Hee Kang, Jong Kyu Woo, Ok-Hee Lee, Edward S. Kim, Ho-Young Lee, Lee, Ok Hee

المصدر: T201205749.pdf

مصطلحات موضوعية: Animals, Carcinoma, Squamous Cell/metabolism, Squamous Cell/pathology, Cell Line, Tumor, Cell Movement/drug effects, Farnesyltranstransferase/antagonists & inhibitors, Female, Head and Neck Neoplasms/metabolism, Head and Neck Neoplasms/pathology, Humans, Insulin-Like Growth Factor Binding Protein 3/genetics, Insulin-Like Growth Factor Binding Protein 3/metabolism, Matrix Metalloproteinase 2/metabolism, Mice, Nude, Neoplasm Invasiveness, Neoplasm Metastasis, Piperidines/pharmacology, Proto-Oncogene Proteins c-akt/genetics, Proto-Oncogene Proteins c-akt/metabolism, Pyridines/pharmacology, RNA Interference, RNA, Small Interfering, Receptor, IGF Type 1/antagonists & inhibitors, IGF Type 1/genetics, IGF Type 1/metabolism

العلاقة: INTERNATIONAL JOURNAL OF CANCER; J01092; OAK-2012-03004; https://ir.ymlib.yonsei.ac.kr/handle/22282913/90444Test; T201205749; INTERNATIONAL JOURNAL OF CANCER, Vol.131(3) : 537-547, 2012

الإتاحة: https://ir.ymlib.yonsei.ac.kr/handle/22282913/90444Test