المؤلفون: Fredin Haslum, Johan, Lardeau, Charles Hugues, Karlsson, Johan, Turkki, Riku, Leuchowius, Karl Johan, Smith, Kevin, 1975, Müllers, Erik

المصدر: Nature Communications. 15(1)

وصف الملف: print

الوصول الحر: https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-346401Test
https://doi.org/10.1038/s41467-024-47171-1Test

المؤلفون: Cross-Zamirski, Jan Oscar, Williams, Guy, Mouchet, Elizabeth, Schönlieb, Carola-Bibiane, Turkki, Riku, Wang, Yinhai

مصطلحات موضوعية: Computer Science - Computer Vision and Pattern Recognition

الوصول الحر: http://arxiv.org/abs/2209.07819Test

المؤلفون: Pellinen, Teijo, Sandeman, Kevin, Blom, Sami, Turkki, Riku, Hemmes, Annabrita, Välimäki, Katja, Eineluoto, Juho, Kenttämies, Anu, Nordling, Stig, Kallioniemi, Olli, Rannikko, Antti, Mirtti, Tuomas

المساهمون: Suomen molekyylilääketieteen instituutti, Precision Systems Medicine, Helsinki Institute of Life Science HiLIFE, HUSLAB, Patologian osasto, Research Program in Systems Oncology, HUS Vatsakeskus, Urologian yksikkö, HUS Kuvantaminen, Medicum, Kirurgian osasto, Clinicum, Digital Precision Cancer Medicine (iCAN)

مصطلحات موضوعية: 3122 Syöpätaudit

وصف الملف: application/pdf

العلاقة: Pellinen , T , Sandeman , K , Blom , S , Turkki , R , Hemmes , A , Välimäki , K , Eineluoto , J , Kenttämies , A , Nordling , S , Kallioniemi , O , Rannikko , A & Mirtti , T 2022 , ' Stromal FAP Expression is Associated with MRI Visibility and Patient Survival in Prostate Cancer ' , Cancer research communications , Vuosikerta. 2 , Nro 3 , Sivut 172-181 . https://doi.org/10.1158/2767-9764.CRC-21-0183Test; ORCID: /0000-0003-0455-9891/work/151786534; ORCID: /0000-0002-4261-3484/work/151794003; ORCID: /0000-0002-1878-8911/work/151794023; ORCID: /0000-0002-8690-6983/work/151794069; ORCID: /0009-0005-5051-9331/work/157594303; http://hdl.handle.net/10138/570144Test; 87843d72-e9b0-4e5d-b22c-d888d89c27df; 001033648100001

الإتاحة: http://hdl.handle.net/10138/570144Test

المؤلفون: Turkki, Riku, Byckhov, Dmitrii, Lundin, Mikael, Isola, Jorma, Nordling, Stig, Kovanen, Panu E., Verrill, Clare, von Smitten, Karl, Joensuu, Heikki, Lundin, Johan, Linder, Nina

المصدر: Breast Cancer Research and Treatment. 177(1):41-52

مصطلحات موضوعية: Breast cancer, Machine learning, Deep learning, Outcome prediction

وصف الملف: electronic

الوصول الحر: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-390386Test
https://doi.org/10.1007/s10549-019-05281-1Test
https://uu.diva-portal.org/smash/get/diva2:1341575/FULLTEXT01.pdfTest

المؤلفون: Bruck, Oscar, Lee, Moon Hee, Turkki, Riku, Uski, Ilona, Penttilä, Patrick, Paavolainen, Lassi, Kovanen, Panu, Järvinen, Petrus, Bono, Petri, Pellinen, Teijo, Mustjoki, Satu, Kreutzman, Anna

المساهمون: TRIMM - Translational Immunology Research Program, Research Programs Unit, Digital Precision Cancer Medicine (iCAN), HUS Comprehensive Cancer Center, Department of Oncology, Hematologian yksikkö, Institute for Molecular Medicine Finland, Helsinki Institute of Life Science HiLIFE, Urologian yksikkö, HUS Abdominal Center, HUSLAB, Department of Pathology, Medicum, University of Helsinki, Clinicum, Department of Surgery, Heikki Joensuu / Principal Investigator, Precision Systems Medicine, Department of Clinical Chemistry and Hematology, Bioimage Profiling

مصطلحات موضوعية: UP-REGULATION, EXPRESSION, BLOCKADE, 3111 Biomedicine

وصف الملف: application/pdf

العلاقة: We are grateful to the members of the Hematology Research Unit Helsinki for discussions and technical help. We thank the Helsinki Biobank and the Digital and Molecular Pathology Unit supported by University of Helsinki and Biocenter Finland for digital microscopy services. Supported in part by the Doctoral Programme in Biomedicine (DPBM) in the University of Helsinki, and personal grants from the Finnish Medical Association (Laaketieteen saatio), the Medical Society of Finland (Finska Lakaresallskapet), Foundation for Kidney Diseases (Munuaissaatio), Finnish Cancer Foundation, Paulo Foundation, Perklens Foundation, Juhani Aho's foundation, Orion Research Foundation, and research grants from the Cancer Foundation Finland, Sigrid Juselius Foundation, Academy of Finland, Signe and Ane Gyllenberg Foundation, Relander Foundation, State funding for university-level health research in Finland, and Helsinki Institute of Life Sciences Fellow grant.; Bruck , O , Lee , M H , Turkki , R , Uski , I , Penttilä , P , Paavolainen , L , Kovanen , P , Järvinen , P , Bono , P , Pellinen , T , Mustjoki , S & Kreutzman , A 2021 , ' Spatial immunoprofiling of the intratumoral and peritumoral tissue of renal cell carcinoma patients ' , Modern Pathology , vol. 34 , no. 12 , pp. 2229-2241 . https://doi.org/10.1038/s41379-021-00864-0Test; ORCID: /0000-0002-8690-6983/work/108463524; ORCID: /0000-0002-3778-0237/work/108466253; ORCID: /0000-0003-1508-2718/work/108466539; ORCID: /0000-0002-0816-8241/work/108466652; ORCID: /0000-0002-7842-9419/work/137864711; 37adfe20-72b2-448b-81e6-8151b45525e9; http://hdl.handle.net/10138/340487Test; 000669171200001

الإتاحة: http://hdl.handle.net/10138/340487Test

المؤلفون: Trapotsi, Maria-Anna, Mouchet, Elizabeth, Williams, Guy, Monteverde, Tiziana, Juhani, Karolina, Turkki, Riku, Miljković, Filip, Martinsson, Anton, Mervin, Lewis, Pryde, Kenneth R, Müllers, Erik, Barrett, Ian, Engkvist, Ola, Bender, Andreas, Moreau, Kevin

المصدر: essn: 1554-8937 ; nlmid: 101282906

مصطلحات موضوعية: Humans, High-Throughput Screening Assays, Proteasome Endopeptidase Complex, Proteolysis, Ubiquitin-Protein Ligases

وصف الملف: application/pdf

العلاقة: https://www.repository.cam.ac.uk/handle/1810/339915Test

الإتاحة: https://doi.org/10.17863/CAM.87338Test
https://www.repository.cam.ac.uk/handle/1810/339915Test

المؤلفون: Cross-Zamirski, Jan, Mouchet, Elizabeth, Williams, Guy, Schönlieb, Carola-Bibiane, Turkki, Riku, Wang, Yinhai

وصف الملف: application/pdf

العلاقة: https://www.repository.cam.ac.uk/handle/1810/340995Test

الإتاحة: https://doi.org/10.17863/CAM.88432Test
https://www.repository.cam.ac.uk/handle/1810/340995Test

المؤلفون: Cross-Zamirski, Jan Oscar, Mouchet, Elizabeth, Williams, Guy, Schönlieb, Carola-Bibiane, Turkki, Riku, Wang, Yinhai

المساهمون: BBSRC DTP, AstraZeneca, AstraZeneca, Sweden

المصدر: Scientific Reports ; volume 12, issue 1 ; ISSN 2045-2322

مصطلحات موضوعية: Multidisciplinary

الإتاحة: https://doi.org/10.1038/s41598-022-12914-xTest
https://www.nature.com/articles/s41598-022-12914-x.pdfTest
https://www.nature.com/articles/s41598-022-12914-xTest

المؤلفون: Mendiola, Marta, Pellinen, Teijo, Ramon-Patino, Jorge L., Berjon, Alberto, Bruck, Oscar, Heredia-Soto, Victoria, Turkki, Riku, Escudero, Javier, Hemmes, Annabrita, Garcia de la Calle, Luis E., Crespo, Roberto, Gallego, Alejandro, Hernandez, Alicia, Feliu, Jaime, Redondo, Andres

المصدر: Modern Pathology ; volume 35, issue 2, page 256-265 ; ISSN 0893-3952

مصطلحات موضوعية: Pathology and Forensic Medicine

الإتاحة: https://doi.org/10.1038/s41379-021-00930-7Test
https://www.nature.com/articles/s41379-021-00930-7.pdfTest
https://www.nature.com/articles/s41379-021-00930-7Test
https://api.elsevier.com/content/article/PII:S0893395222003374?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0893395222003374?httpAccept=text/plainTest

المؤلفون: Närhi, Katja, Nagaraj, Ashwini S., Parri, Elina, Turkki, Riku, van Duijn, Petra W., Hemmes, Annabrita, Lahtela, Jenni, Uotinen, Virva, Mäyränpää, Mikko I., Salmenkivi, Kaisa, Räsänen, Jari, Linder, Nina, Trapman, Jan, Rannikko, Antti, Kallioniemi, Olli, Af Hällström, Taija M., Lundin, Johan, Sommergruber, Wolfgang, Anders, Simon, Verschuren, Emmy W.

المساهمون: Institute for Molecular Medicine Finland, Helsinki Institute of Life Science HiLIFE, University of Helsinki, Research Group Verschuren Emmy, HUSLAB, Department of Pathology, Medicum, Clinicum, III kirurgian klinikka, Department of Surgery, Urologian yksikkö, Olli-Pekka Kallioniemi / Principal Investigator, Johan Edvard Lundin / Principal Investigator, HUS Heart and Lung Center, HUS Abdominal Center, Precision Systems Medicine, Lung Cancer Model Systems

مصطلحات موضوعية: non-small-cell lung cancer, prostate cancer, oncogenic signalling, precision-cut slices, targeted therapy, spatial heterogeneity, SQUAMOUS-CELL CARCINOMA, MUTANT KRAS, MOUSE LUNG, CANCER, ADENOCARCINOMA, LKB1, RAS, INACTIVATION, ORIGIN, CULTURES, 3126 Surgery, anesthesiology, intensive care, radiology, 3122 Cancers, 3111 Biomedicine

وصف الملف: application/pdf

العلاقة: This study received financial support from Innovative Medicines Initiative Joint Undertaking grant agreement no. 115188, the resources of which are composed of a financial contribution from the European Union's Seventh Framework Programme (FP7/2007-2013) and EFPIA companies' in-kind contribution (EWV, JT, OK, JLu); a TEKES new generation biobanking grant 40294/11 (to TAfH, OK, and AR); from the Deutsche Forschungsgemeinschaft (DFG) via SFB 1036 (SA); University of Helsinki Doctoral Programme in Biomedicine scholarships (AN and JLa); and the Sigrid Juselius and Orion-Farmos Foundations (EWV). We sincerely thank PREDECT consortium (www.predect.eu) members Heiko van der Kuip and Simon Barry for leading the tissue slice platform, its members for guidance, and John Hickman for coordination and endorsement of the slice technology. We thank Anton Berns for sharing the progenitor cell-directed adenoviruses, the FIMM WebMicroscope team for scanning histological slides, and the Laboratory Animal Centre for husbandry support. We acknowledge statistics support from Swapnil Potdar, and excellent technical support from Siv Knaappila, Arja Tapio, Reija Randen-Brady, Meri Kaustio, and Caroline Pereira. Jennifer Devlin is thanked for critical reading of the manuscript. We dedicate this study in loving memory of colleague and friend Heiko van der Kuip.; Närhi , K , Nagaraj , A S , Parri , E , Turkki , R , van Duijn , P W , Hemmes , A , Lahtela , J , Uotinen , V , Mäyränpää , M I , Salmenkivi , K , Räsänen , J , Linder , N , Trapman , J , Rannikko , A , Kallioniemi , O , Af Hällström , T M , Lundin , J , Sommergruber , W , Anders , S & Verschuren , E W 2018 , ' Spatial aspects of oncogenic signalling determine the response to combination therapy in slice explants from Kras-driven lung tumours ' , Journal of Pathology , vol. 245 , no. 1 , pp. 101-113 . https://doi.org/10.1002/path.5059Test; ORCID: /0000-0002-4261-3484/work/44473385; ORCID: /0000-0002-8690-6983/work/44473545; ORCID: /0000-0002-0877-9640/work/44473365; ORCID: /0000-0001-5771-9129/work/44473258; ORCID: /0000-0002-9144-5421/work/53517189; ORCID: /0000-0003-3930-0513/work/56158114; ORCID: /0009-0005-5051-9331/work/157594292; http://hdl.handle.net/10138/333759Test; 1b1d18e4-9bff-4d2a-b9d6-4bacb8f36b1f; 85044622035; 000430113500011

الإتاحة: http://hdl.handle.net/10138/333759Test