المؤلفون: Miller, Duncan C., Reuillon, Tristan, Molyneux, Lauren, Blackburn, Timothy J., Cook, Simon, Edwards, Noel, Endicott, Jane A., Golding, Bernard T., Griffin, Roger J., Hardcastle, Ian R., Heptinstall, Amy B., Lochhead, Pamela, Martin, Mathew P., Martin, Nick, Myers, Stephanie M., Newell, David R., Noble, Richard, Rigoreau, Laurent J.M., Thomas, Huw, Tucker, Julie Ann, Wang, Lan-Zhen, Waring, Michael J., Wong, Ai-Ching, Wedge, Stephen, Noble, Martin, Cano, Celine

وصف الملف: text

العلاقة: https://eprints.whiterose.ac.uk/185363/3/acs.jmedchem.1c01756.pdfTest; Miller, Duncan C., Reuillon, Tristan, Molyneux, Lauren et al. (23 more authors) (2022) Parallel Optimisation of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Chemical Tool. JOURNAL OF MEDICINAL CHEMISTRY. pp. 6513-6540. ISSN 0022-2623

الإتاحة: https://doi.org/10.1021/acs.jmedchem.1c01756Test
https://eprints.whiterose.ac.uk/185363Test/
https://eprints.whiterose.ac.uk/185363/3/acs.jmedchem.1c01756.pdfTest

المؤلفون: Tucker, Julie Ann, Martin, Mathew P.

وصف الملف: text

العلاقة: https://eprints.whiterose.ac.uk/176270/1/ijms_22_07560.pdfTest; Tucker, Julie Ann orcid.org/0000-0002-6119-676X and Martin, Mathew P. (2021) Recent Advances in Kinase Drug Discovery Part I: the Editors’ Take. International Journal of Molecular Sciences. pp. 1-6. ISSN 1422-0067

الإتاحة: https://doi.org/10.3390/ijms22147560Test
https://eprints.whiterose.ac.uk/176270Test/
https://eprints.whiterose.ac.uk/176270/1/ijms_22_07560.pdfTest

المؤلفون: Cook, Simon, Tucker, Julie Ann, Lochhead, Pamela

وصف الملف: text

العلاقة: https://eprints.whiterose.ac.uk/165318/8/bst_2019_0338c.pdfTest; Cook, Simon, Tucker, Julie Ann orcid.org/0000-0002-6119-676X and Lochhead, Pamela (2020) Small molecule ERK5 kinase inhibitors paradoxically activate ERK5 signalling: be careful what you wish for. Biochemical Society transactions. ISSN 1470-8752

الإتاحة: https://doi.org/10.1042/BST20190338Test
https://eprints.whiterose.ac.uk/165318Test/
https://eprints.whiterose.ac.uk/165318/8/bst_2019_0338c.pdfTest

المؤلفون: Lochhead, Pamela, Tucker, Julie Ann, Tatum, Natalie, Wang, Jinhua, Oxley, David, Kidger, Andrew, Johnson, Victoria, Cassidy, Megan, Gray, Nathanael, Noble, M. E. M., Cook, Simon

وصف الملف: text

العلاقة: https://eprints.whiterose.ac.uk/158535/1/s41467_020_15031_3.pdfTest; Lochhead, Pamela, Tucker, Julie Ann orcid.org/0000-0002-6119-676X , Tatum, Natalie et al. (8 more authors) (2020) Paradoxical activation of the protein kinase-transcription factor ERK5 by ERK5 kinase inhibitors. Nature Communications. 1383. ISSN 2041-1723

الإتاحة: https://doi.org/10.1038/s41467-020-15031-3Test
https://eprints.whiterose.ac.uk/158535Test/
https://eprints.whiterose.ac.uk/158535/1/s41467_020_15031_3.pdfTest

المؤلفون: Tucker, Julie Ann, Myers, Stephanie M., Miller, Duncan C., Molyneux, Lauren, Arasta, Mercedes, Bawn, Ruth H., Blackburn, Timothy J., Cook, Simon J., Edwards, Noel, Endicott, Jane A., Golding, Bernard T., Griffin, Roger J., Hammonds, Tim, Hardcastle, Ian R., Harnor, Suzannah J., Heptinstall, Amy B., Lochhead, Pamela A., Martin, Mathew P., Martin, Nick C., Newell, David R., Owen, Paul J., Pang, Leon C., Reuillon, Tristan, Rigoreau, Laurent J.M., Thomas, Huw D., Wang, Lan-Zhen, Wong, Ai-Ching, Noble, Martin E.M., Wedge, Stephen R., Cano, Celine

وصف الملف: text

العلاقة: https://eprints.whiterose.ac.uk/148098/1/ERK5LeadIDPaper_EurJMedChem_2019_04_29.docxTest; Tucker, Julie Ann orcid.org/0000-0002-6119-676X , Myers, Stephanie M., Miller, Duncan C. et al. (27 more authors) (2019) Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4. European Journal of Medicinal Chemistry. pp. 530-543. ISSN 0223-5234

الإتاحة: https://doi.org/10.1016/j.ejmech.2019.05.057Test
https://eprints.whiterose.ac.uk/148098Test/
https://eprints.whiterose.ac.uk/148098/1/ERK5LeadIDPaper_EurJMedChem_2019_04_29.docxTest

المؤلفون: Al-Khawaldeh, Islam, Alyassiri, Mohammed, Aldred, Greg, Basmadjian, Christine, Bordoni, Cinzia, Harnor, Suzannah J., Heptinstall, Amy B., Hobson, Stephen, Jennings, Claire, Khalifa, Shaimaa, Lebraud, Honorine, Martin, Mathew P., Miller, Duncan C, Shrives, Harry, De Souza, Joao, Stewart, Hannah, Temple, Max J, Thomas, Huw, Totobenazara, Jane, Tucker, Julie Ann, Tudhope, Susan, Wang, Lan-Zhen, Bronowska, Agnieszka, Cano, Celine, Endicott, Jane A., Golding, Bernard, Hardcastle, Ian R., Hickson, Ian, Wedge, Stephen, Willmore, Elaine, Noble, Martin E. M., Waring, Michael J.

وصف الملف: application/vnd.openxmlformats-officedocument.wordprocessingml.document

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::0d0425a07b4fd1c06ab32621f25fa4abTest
https://eprints.whiterose.ac.uk/175696/1/Revised_Manuscript_2_.docxTest

المؤلفون: Wilmes, Stephan, Hafer, Maximillian, Vuorio, Joni, Tucker, Julie Ann, Winkelmann, Hauke, Lochte, Sara, Stanly, Tess Archana, Pulgar Prieto, Katiuska D, Poojari, Chetan, Sharma, Vivek, Richter, Christian P, Kurre, Rainer, Hubbard, Stevan R, Garcia, K Christopher, Moraga, Ignacio, Vattulainen, Ilpo, Hitchcock, Ian Stuart, Piehler, Jacob

وصف الملف: text

العلاقة: https://eprints.whiterose.ac.uk/155270/1/Accpeted_Science_paper_Combined_version.pdfTest; Wilmes, Stephan, Hafer, Maximillian, Vuorio, Joni et al. (15 more authors) (2020) Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations. Science. pp. 643-652. ISSN 0036-8075

الإتاحة: https://doi.org/10.1126/science.aaw3242Test
https://eprints.whiterose.ac.uk/155270Test/
https://eprints.whiterose.ac.uk/155270/1/Accpeted_Science_paper_Combined_version.pdfTest

المؤلفون: Waszkowycz, Bohdan, Smith, Kate M., McGonagle, Alison E., Jordan, Allan M., Acton, Ben, Fairweather, Emma E., Griffiths, Louise A., Hamilton, Niall M., Hamilton, Nicola S., Hitchin, James R., Hutton, Colin P., James, Dominic I., Jones, Clifford D., Jones, Stuart, Mould, Daniel P., Small, Helen F., Stowell, Alexandra I. J., Tucker, Julie Ann, Waddell, Ian D., Ogilvie, Donald J.

وصف الملف: text

العلاقة: https://eprints.whiterose.ac.uk/148099/1/PARG_QD_JMC_revision_R2.docTest; Waszkowycz, Bohdan, Smith, Kate M., McGonagle, Alison E. et al. (17 more authors) (2018) Cell-active Small Molecule Inhibitors of the DNA-damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG) : Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides. JOURNAL OF MEDICINAL CHEMISTRY. pp. 10767-10792. ISSN 0022-2623

الإتاحة: https://doi.org/10.1021/acs.jmedchem.8b01407Test
https://eprints.whiterose.ac.uk/148099Test/
https://eprints.whiterose.ac.uk/148099/1/PARG_QD_JMC_revision_R2.docTest