المؤلفون: Skledar, Darja Gramec, Carino, Adriana, Trontelj, Jurij, Troberg, Johanna, Distrutti, Eleonora, Marchiano, Silvia, Tornasic, Tihomir, Zega, Anamarija, Finel, Moshe, Fiorucci, Stefano, Maisic, Lucija Peterlin

المساهمون: Faculty of Pharmacy, Division of Pharmaceutical Chemistry and Technology, Pharmaceutical Design and Discovery group, Drug Research Program, Moshe Finel / Principal Investigator

مصطلحات موضوعية: Bisphenol AF, Bisphenol AF glucuronide, Glucuronidation, Endocrine activities, Lipid accumulation, IN-VITRO, SEWAGE-SLUDGE, ANALOGS, CELLS, TOXICITY, GAMMA, IDENTIFICATION, PREADIPOCYTES, ANTAGONIST, Biochemistry, cell and molecular biology

وصف الملف: application/pdf

العلاقة: The authors thank OpenEye Scientific Software, Santa Fe, NM, USA, for free academic licenses for the use of their software, and Johanna Mosorin for skillful assistance in recombinant UGT preparations. Financial support of the Slovenian Research Agency (Grant No. P1-0208) and the Sigrid Juseliuksen Saatio, Finland (grant no. 4704583) are acknowledged.; Skledar , D G , Carino , A , Trontelj , J , Troberg , J , Distrutti , E , Marchiano , S , Tornasic , T , Zega , A , Finel , M , Fiorucci , S & Maisic , L P 2019 , ' Endocrine activities and adipogenic effects of bisphenol AF and its main metabolite ' , Chemosphere , vol. 215 , pp. 870-880 . https://doi.org/10.1016/j.chemosphere.2018.10.129Test; ORCID: /0000-0003-3886-4771/work/51564915; http://hdl.handle.net/10138/325049Test; f063b300-8d14-4568-8375-b75ca2da9adc; 85055983814; 000450383400096

الإتاحة: http://hdl.handle.net/10138/325049Test

المؤلفون: Juvonen, Risto O., Heikkinen, Aki T., Kärkkäinen, Olli, Jehangir, Rabia, Huuskonen, Juhani, Troberg, Johanna, Raunio, Hannu, Pentikäinen, Olli T., Finel, Moshe

مصطلحات موضوعية: glucuronidation, dog, intestine, liver, 7-hydroxycoumarin derivative, enzyme kinetics, koira, farmakokinetiikka, koe-eläinmallit, maksa, lääkeaineet, entsyymit, kumariinit, aineenvaihdunta, suolisto

وصف الملف: application/pdf; fulltext

العلاقة: European Journal of Pharmaceutical Sciences; 141; Juvonen, R. O., Heikkinen, A. T., Kärkkäinen, O., Jehangir, R., Huuskonen, J., Troberg, J., Raunio, H., Pentikäinen, O. T., & Finel, M. (2020). In vitro glucuronidation of 7-hydroxycoumarin derivatives in intestine and liver microsomes of Beagle dogs. European Journal of Pharmaceutical Sciences , 141 , Article 105118. https://doi.org/10.1016/j.ejps.2019.105118Test; CONVID_33368498; URN:NBN:fi:jyu-201911054726; http://urn.fi/URN:NBN:fi:jyu-201911054726Test

الإتاحة: http://urn.fi/URN:NBN:fi:jyu-201911054726Test

المؤلفون: Juvonen, Risto O., Rauhamäki, Sanna, Kortet, Sami, Niinivehmas, Sanna, Troberg, Johanna, Petsalo, Aleksanteri, Huuskonen, Juhani, Raunio, Hannu, Finel, Moshe, Pentikäinen, Olli T.

المساهمون: Faculty of Pharmacy, Division of Pharmaceutical Chemistry and Technology, Moshe Finel / Principal Investigator, Pharmaceutical Design and Discovery group, Drug Research Program

مصطلحات موضوعية: 7-hydroxycoumarin derivative, UDP-glucuronosyltransferase, in silico, fluorescence, drug metabolism, DRUG-METABOLISM, FLUORESCENT-PROBE, ORAL BIOAVAILABILITY, CRYSTAL-STRUCTURE, GLUCURONIDATION, ENZYME, XENOBIOTICS, EXPRESSION, AFFINITY, UGT1A10, 317 Pharmacy

وصف الملف: application/pdf

العلاقة: We thank Ms Hannele Jaatinen for excellent expertise in laboratory work. Finnish IT Centre for Science (CSC) is acknowledged for a generous computational grant (O.T.P.: jyy2516 and jyy2585). We thank Johanna Mosorin for her valuable contribution in the preparation of recombinant UGTs. Financial support of the academy of Finland (Grant No. 137589) and the Sigrid Juselius Foundation (Grant No. 4704583) is highly acknowledged.; Juvonen , R O , Rauhamäki , S , Kortet , S , Niinivehmas , S , Troberg , J , Petsalo , A , Huuskonen , J , Raunio , H , Finel , M & Pentikäinen , O T 2018 , ' Molecular Docking-Based Design and Development of a Highly Selective Probe Substrate for UDP-glucuronosyltransferase 1A10 ' , Molecular Pharmaceutics , vol. 15 , no. 3 , pp. 923-933 . https://doi.org/10.1021/acs.molpharmaceut.7b00871Test; ORCID: /0000-0003-3886-4771/work/43467851; 85043298065; bd1c5ed7-a561-400d-bce9-d969ea3381c0; http://hdl.handle.net/10138/301183Test; 000427093600022

الإتاحة: http://hdl.handle.net/10138/301183Test

المؤلفون: Skledar, Darja Gramec, Trontelj, Jurij, Troberg, Johanna, Tomašič, Tihomir, Zega, Anamarija, Finel, Moshe, Mašič, Lucija Peterlin

المساهمون: Divisions of Faculty of Pharmacy, Faculty of Pharmacy, Division of Pharmaceutical Chemistry and Technology, Drug Research Program, Pharmaceutical Design and Discovery group, Moshe Finel / Principal Investigator

مصطلحات موضوعية: ANTAGONIST, BINDING, ESTROGEN, RECEPTOR, 317 Pharmacy

وصف الملف: application/pdf

العلاقة: Skledar , D G , Trontelj , J , Troberg , J , Tomašič , T , Zega , A , Finel , M & Mašič , L P 2019 , ' Data on biosynthesis of BPAF glucuronide, enzyme kinetics of BPAF glucuronidation, and molecular modeling ' , Data in Brief , vol. 22 , pp. 977-986 . https://doi.org/10.1016/j.dib.2018.12.033Test; RIS: urn:94545CA9C581F6027C7252DE6976C546; ORCID: /0000-0003-3886-4771/work/57799882; 85060500571; 5e0a2ace-9bb8-48d7-aa38-589fcda55710; http://hdl.handle.net/10138/302049Test; 000458114600133

الإتاحة: http://hdl.handle.net/10138/302049Test

المؤلفون: Juvonen, Risto O, Heikkinen, Aki T, Kärkkäinen, Olli, Jehangir, Rabia, Huuskonen, Juhani, Troberg, Johanna, Raunio, Hannu, Pentikäinen, Olli T, Finel, Moshe

المساهمون: School of Pharmacy, Activities

مصطلحات موضوعية: glucuronidation, dog, intestine, liver, 7-hydroxycoumarin derivative, enzyme kinetics

العلاقة: European journal of pharmaceutical sciences; http://dx.doi.org/10.1016/j.ejps.2019.105118Test; 105118; 141; https://erepo.uef.fi/handle/123456789/7835Test

الإتاحة: https://doi.org/10.1016/j.ejps.2019.105118Test
https://erepo.uef.fi/handle/123456789/7835Test

المؤلفون: Gramec Skledar, Darja, Trontelj, Jurij, Troberg, Johanna, Tomašič, Tihomir, Zega, Anamarija, Finel, Moshe, Peterlin Mašič, Lucija

المساهمون: Slovenian Research Agency, Sigrid Juselius Foundation

المصدر: Data in Brief ; volume 22, page 977-986 ; ISSN 2352-3409

مصطلحات موضوعية: Multidisciplinary

الإتاحة: https://doi.org/10.1016/j.dib.2018.12.033Test
https://api.elsevier.com/content/article/PII:S2352340918315725?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2352340918315725?httpAccept=text/plainTest

المؤلفون: Juvonen, Risto O., Rauhamäki, Sanna, Kortet, Sami, Niinivehmas, Sanna, Troberg, Johanna, Petsalo, Aleksanteri, Huuskonen, Juhani, Raunio, Hannu, Finel, Moshe, Pentikäinen, Olli

مصطلحات موضوعية: 7-hydroxycoumarin, UDP-glucuronosyltransferase, glucuronidation, in silico, drug metabolism, fluoresenssi

وصف الملف: 923-933; application/pdf

العلاقة: Molecular Pharmaceutics; 15; Juvonen, R. O., Rauhamäki, S., Kortet, S., Niinivehmas, S., Troberg, J., Petsalo, A., Huuskonen, J., Raunio, H., Finel, M., & Pentikäinen, O. (2018). Molecular docking-based design and development of a highly selective probe substrate for UDP-glucuronosyltransferase 1A10. Molecular Pharmaceutics , 15 (3), 923-933. https://doi.org/10.1021/acs.molpharmaceut.7b00871Test; CONVID_27897589; TUTKAID_76789; URN:NBN:fi:jyu-201803051654; http://urn.fi/URN:NBN:fi:jyu-201803051654Test

الإتاحة: http://urn.fi/URN:NBN:fi:jyu-201803051654Test

المؤلفون: Manevski, Nenad, Troberg, Johanna, Svaluto-Moreolo, Paolo, Dziedzic, Klaudyna, Yli-Kauhaluoma, Jari, Finel, Moshe

المساهمون: Faculty of Pharmacy, Division of Pharmaceutical Chemistry and Technology, Centre for Drug Research (-2017), Medicinal Chemistry research group

مصطلحات موضوعية: 317 Pharmacy

وصف الملف: application/pdf

العلاقة: Manevski , N , Troberg , J , Svaluto-Moreolo , P , Dziedzic , K , Yli-Kauhaluoma , J & Finel , M 2013 , ' Albumin Stimulates the Activity of the Human UDP-Glucuronosyltransferases 1A7, 1A8, 1A10, 2A1 and 2B15, but the Effects are Enzyme and Substrate Dependent ' , PLoS One , vol. 8 , no. 1 , pp. e54767 . https://doi.org/10.1371/journal.pone.0054767Test; ORCID: /0000-0003-0370-7653/work/28760623; ORCID: /0000-0003-3886-4771/work/29950385; http://hdl.handle.net/10138/164288Test; ebef86f2-5f10-4776-960f-14c4904a403f; 84872764713; 000314021500122

الإتاحة: http://hdl.handle.net/10138/164288Test

المؤلفون: Lv, Xia, Ge, Guang-Bo, Feng, Lei, Troberg, Johanna, Hu, Liang-Hai, Hou, Jie, Cheng, Hai-Ling, Wang, Ping, Liu, Zhao-Ming, Finel, Moshe, Cui, Jing-Nan, Yang, Ling

المساهمون: National S&T Major Projects of China, National Basic Research Program of China, Natural Sciences Foundation, State Key Laboratory of Fine Chemicals

المصدر: Biosensors and Bioelectronics ; volume 72, page 261-267 ; ISSN 0956-5663

مصطلحات موضوعية: Electrochemistry, Biomedical Engineering, General Medicine, Biophysics, Biotechnology

الإتاحة: https://doi.org/10.1016/j.bios.2015.05.003Test
https://api.elsevier.com/content/article/PII:S0956566315301007?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0956566315301007?httpAccept=text/plainTest

المؤلفون: Manevski, Nenad, Troberg, Johanna, Svaluto-Moreolo, Paolo, Dziedzic, Klaudyna, Yli-Kauhaluoma, Jari, Finel, Moshe

المساهمون: Rodrigues-Lima, Fernando

المصدر: PLoS ONE ; volume 8, issue 1, page e54767 ; ISSN 1932-6203

الإتاحة: https://doi.org/10.1371/journal.pone.0054767Test