دورية أكاديمية
Hematopoietic cell transplantation: five decades of progress.
| العنوان: | Hematopoietic cell transplantation: five decades of progress. |
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| المؤلفون: | Baron, Frédéric, Storb, Rainer, Little, Marie-Terese |
| المصدر: | Archives of Medical Research, 34 (6), 528-44 (2003) |
| بيانات النشر: | Elsevier Science, 2003. |
| سنة النشر: | 2003 |
| مصطلحات موضوعية: | Animals, Graft vs Host Disease, HLA Antigens/immunology/metabolism, Hematologic Diseases/therapy, Hematopoietic Stem Cell Transplantation/history, History, 20th Century, History, 21st Century, Humans, Transplantation Chimera, Transplantation Conditioning, Transplantation Immunology, Transplantation, Homologous/history, Human health sciences, Hematology, Sciences de la santé humaine, Hématologie |
| الوصف: | During the past 50 years, the role of allogeneic hematopoietic cell transplantation (HCT) has changed from a desperate therapeutic maneuver plagued by apparently insurmountable complications to a curative treatment modality for thousands of patients with hematologic diseases. Now, cure rates following human leukocyte antigen (HLA) allogeneic HCT with matched siblings exceed 85% for some otherwise lethal diseases, such as chronic myeloid leukemia, aplastic anemia, or thalassemia. In addition, the recent development of non-myeloablative conditioning and stem cell transplantation has opened the way to include elderly patients with a wide variety of hematologic malignancies. Further progress in adoptive transfer of T cell populations with relative tumor specificity would make the transplant procedure more effective and would extend the use of allogeneic HCT for treatment of non-hematopoietic malignancies. |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501Test article |
| اللغة: | English |
| DOI: | 10.1016/j.arcmed.2003.09.010 |
| الوصول الحر: | https://orbi.uliege.be/handle/2268/151258Test |
| حقوق: | open access http://purl.org/coar/access_right/c_abf2Test info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsorb.151258 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.1016/j.arcmed.2003.09.010 |
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