دورية أكاديمية
Sex differences in the distribution of the steroid receptor coactivator SRC-1 in the song control nuclei of male and female canaries
| العنوان: | Sex differences in the distribution of the steroid receptor coactivator SRC-1 in the song control nuclei of male and female canaries |
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| المؤلفون: | Charlier, Thierry, Balthazart, Jacques, Ball, Gregory F |
| المصدر: | Brain Research, 959 (2), 263-274 (2003-01-10) |
| بيانات النشر: | Elsevier Science Bv |
| سنة النشر: | 2003 |
| المجموعة: | University of Liège: ORBi (Open Repository and Bibliography) |
| مصطلحات موضوعية: | Animals, Vocalization, Animal/physiology, Transcription Factors/analysis/biosynthesis, Sex Characteristics, Male, Histone Acetyltransferases, Female, Canaries/metabolism, Brain/metabolism, steroid receptor coactivator, estrogen receptor, androgen receptor, songbird, sex difference, HVc, area X, canary, Serinus canaria, Life sciences, Anatomy (cytology, histology, embryology.) & physiology, Social & behavioral sciences, psychology, Neurosciences & behavior, Sciences du vivant, Anatomie (cytologie, histologie, embryologie.) & physiologie |
| الوصف: | peer reviewed ; The steroid receptor coactivator SRC-1 modulates ligand-dependent transactivation of several nuclear receptors, including the receptors for sex steroid hormones. The distribution of SRC-1 transcripts was analyzed here by in situ hybridization in coronal sections through the brain of male and female canaries. A broad but heterogeneous distribution of SRC-1 transcripts was observed with high numbers of densely labeled cells being present in many steroid-sensitive areas including the medial preoptic nucleus, several hypothalamic nuclei, five song control nuclei (HVc, the lateral and medial portion of the magnocellular nucleus of the anterior neostriatum, area X and the nucleus uvaeformis) and several catecholaminergic areas (area ventralis of Tsai, substantia nigra, locus coeruleus). The volume of two song control nuclei, HVc and area X were reconstructed based on the boundaries of the cell groups exhibiting a denser SRC-1 expression as compared to the surrounding areas. Sex differences in the expression of SRC-1 were also detected in several song control nuclei. In particular, the volume of HVc based on the high density of SRC-1 expression was significantly larger in males than in females. The effect of steroids on the song control system could be, at least in part, indirect and result from a modulation by steroids of the catecholaminergic inputs to the song control nuclei. The presence of the steroid receptor coactivator SRC-1 in the telencephalic song control nuclei and in the catecholaminergic cell groups that innervate the song system supports the idea that SRC-1 expression could play an active role in the control of singing behavior by modulating estrogen and androgen receptor action at both locations. (C) 2002 Elsevier Science B.V. All rights reserved. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0006-8993 1872-6240 |
| العلاقة: | urn:issn:0006-8993; urn:issn:1872-6240; https://orbi.uliege.be/handle/2268/11721Test; info:hdl:2268/11721; scopus-id:2-s2.0-0037427818; info:pmid:12493614 |
| DOI: | 10.1016/S0006-8993(02)03758-7 |
| الإتاحة: | https://doi.org/10.1016/S0006-8993Test(02)03758-7 https://orbi.uliege.be/handle/2268/11721Test |
| حقوق: | restricted access ; http://purl.org/coar/access_right/c_16ecTest ; info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.4DFC85B2 |
| قاعدة البيانات: | BASE |
| تدمد: | 00068993 18726240 |
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| DOI: | 10.1016/S0006-8993(02)03758-7 |