يعرض 1 - 10 نتائج من 45 نتيجة بحث عن '"Tracy Kleinheinz"', وقت الاستعلام: 0.96s تنقيح النتائج
  1. 1
    دورية أكاديمية
    GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer

    المؤلفون: Jun Liang (251318), Jason R. Zbieg (1892965), Robert A. Blake (8974823), Jae H. Chang (1429789), Stephen Daly (2430460), Antonio G. DiPasquale (1274730), Lori S. Friedman (166879), Thomas Gelzleichter (11113391), Matthew Gill (589302), Jennifer M. Giltnane (11113394), Simon Goodacre (1577413), Jane Guan (166826), Steven J. Hartman (10157036), Ellen Rei Ingalla (8908757), Lorn Kategaya (11113397), James R. Kiefer (1443889), Tracy Kleinheinz (1845637), Sharada S. Labadie (1833826), Tommy Lai (2572615), Jun Li (6494), Jiangpeng Liao (1947631), Zhiguo Liu (594653), Vidhi Mody (8908760), Neville McLean (2128303), Ciara Metcalfe (8908763), Michelle A. Nannini (11113400), Jason Oeh (1845505), Martin G. O’Rourke (11113403), Daniel F. Ortwine (1600621), Yingqing Ran (2100610), Nicholas C. Ray (3064926), Fabien Roussel (3030714), Amy Sambrone (1551289), Deepak Sampath (640340), Leah K. Schutt (11113406), Maia Vinogradova (8908772), John Wai (1503217), Tao Wang (12008), Ingrid E. Wertz (11113409), Jonathan R. White (11113412), Siew Kuen Yeap (1346391), Amy Young (251900), Birong Zhang (1947472), Xiaoping Zheng (566379), Wei Zhou (24328), Yu Zhong (291917), Xiaojing Wang (147040)

    مصطلحات موضوعية: Cell Biology, Genetics, Neuroscience, Pharmacology, Biotechnology, Cancer, Infectious Diseases, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, Exceptional Preclinical Profile, dose, Bioavailable, human, candidate, combination, liability, Phase, Orally, antagonist, Breast Cancer Breast cancer, wild-type ER α tumor model, GDC -9545, estrogen receptor degrader, antiproliferation, SERD, interaction, Estrogen Receptor Antagonist, giredestrant, Fine-tuning, PDX

    العلاقة: https://figshare.com/articles/journal_contribution/GDC-9545_Giredestrant_A_Potent_and_Orally_Bioavailable_Selective_Estrogen_Receptor_Antagonist_and_Degrader_with_an_Exceptional_Preclinical_Profile_for_ER_Breast_Cancer/14959973Test

    الإتاحة: https://doi.org/10.1021/acs.jmedchem.1c00847.s001Test

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  2. 2
    دورية أكاديمية
    Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy

    المؤلفون: Peter S. Dragovich (640339), Thomas H. Pillow (3996851), Robert A. Blake (8974823), Jack D. Sadowsky (1984828), Emel Adaligil (2481943), Pragya Adhikari (8433495), Jinhua Chen (1551307), Nicholas Corr (10157033), Josefa dela Cruz-Chuh (4245010), Geoffrey Del Rosario (3996854), Aaron Fullerton (9160761), Steven J. Hartman (10157036), Fan Jiang (144211), Susan Kaufman (491001), Tracy Kleinheinz (1845637), Katherine R. Kozak (1958674), Liling Liu (296450), Ying Lu (66401), Melinda M. Mulvihill (1319328), Jeremy M. Murray (2044333), Aimee O’Donohue (4245019), Rebecca K. Rowntree (9253992), William S. Sawyer (2951898), Leanna R. Staben (1833829), John Wai (1503217), Jian Wang (5901), BinQing Wei (2128288), Wentao Wei (2135263), Zijin Xu (1551310), Hui Yao (240607), Shang-Fan Yu (3342923), Donglu Zhang (2102533), Hongyan Zhang (618068), Shenhua Zhang (10157039), Yongxin Zhao (311082), Hao Zhou (136535), Xiaoyu Zhu (82055)

    مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Genetics, Pharmacology, Biotechnology, Immunology, Cancer, Mental Health, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, antigen-dependent BRD 4 degradation, Antibody-Mediated Delivery, antiproliferation activities, ubiquitin ligases, Multiple ADCs, chemical literature, Vivo Antitumor Efficacy Heterobifun., antigen-dependent antitumor efficacy, chimeric BRD 4-degrader payloads, BRD 4-degrader antibody conjugates ., Vitro Antiproliferation Activity, tumor models, cell-based experiments, proteolysis-targeting chimeras, PROTAC, BRD 4-targeting chimeric degrader e., mouse xenograft assessments, BRD 4-binding fragment

    العلاقة: https://figshare.com/articles/journal_contribution/Antibody-Mediated_Delivery_of_Chimeric_BRD4_Degraders_Part_2_Improvement_of_In_Vitro_Antiproliferation_Activity_and_In_Vivo_Antitumor_Efficacy/14049506Test

    الإتاحة: https://doi.org/10.1021/acs.jmedchem.0c01846.s004Test

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  3. 3
    دورية أكاديمية
    Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 1: Exploration of Antibody Linker, Payload Loading, and Payload Molecular Properties

    المؤلفون: Peter S. Dragovich (640339), Thomas H. Pillow (3996851), Robert A. Blake (8974823), Jack D. Sadowsky (1984828), Emel Adaligil (2481943), Pragya Adhikari (8433495), Sunil Bhakta (2951277), Nicole Blaquiere (2117977), Jinhua Chen (1551307), Josefa dela Cruz-Chuh (4245010), Karen E. Gascoigne (3160572), Steven J. Hartman (10157036), Mingtao He (1868638), Susan Kaufman (491001), Tracy Kleinheinz (1845637), Katherine R. Kozak (1958674), Liang Liu (50022), Liling Liu (296450), Qi Liu (33068), Ying Lu (66401), Fanwei Meng (7440827), Melinda M. Mulvihill (1319328), Aimee O’Donohue (4245019), Rebecca K. Rowntree (9253992), Leanna R. Staben (1833829), Steven T. Staben (1845742), John Wai (1503217), Jian Wang (5901), BinQing Wei (2128288), Catherine Wilson (165841), Jianfeng Xin (10157041), Zijin Xu (1551310), Hui Yao (240607), Donglu Zhang (2102533), Hongyan Zhang (618068), Hao Zhou (136535), Xiaoyu Zhu (82055)

    مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Pharmacology, Biotechnology, Immunology, Developmental Biology, Cancer, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, entity, Antibody-Mediated Delivery, target proteins, effect intracellular degradation, impact, delivery options, exhibits antigen-dependent antiprol., ubiquitin ligase-mediated ubiquitin., antigen-dependent delivery, vivo pharmacokinetic properties, PC 3-S prostate cancer cells, chimeric entities, Payload Loading, LNCaP prostate cancer cells, novel agents, proteolysis-targeting chimeras, Antibody Linker, intracellular BRD 4 levels

    العلاقة: https://figshare.com/articles/journal_contribution/Antibody-Mediated_Delivery_of_Chimeric_BRD4_Degraders_Part_1_Exploration_of_Antibody_Linker_Payload_Loading_and_Payload_Molecular_Properties/14049508Test

    الإتاحة: https://doi.org/10.1021/acs.jmedchem.0c01845.s001Test

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  4. 4
    Targeted degradation via direct 26S proteasome recruitment

    المؤلفون: Charlene Bashore, Sumit Prakash, Matthew C. Johnson, Ryan J. Conrad, Ivy A. Kekessie, Suzie J. Scales, Noriko Ishisoko, Tracy Kleinheinz, Peter S. Liu, Nataliya Popovych, Aaron T. Wecksler, Lijuan Zhou, Christine Tam, Inna Zilberleyb, Rajini Srinivasan, Robert A. Blake, Aimin Song, Steven T. Staben, Yingnan Zhang, David Arnott, Wayne J. Fairbrother, Scott A. Foster, Ingrid E. Wertz, Claudio Ciferri, Erin C. Dueber

    المصدر: Nature Chemical Biology. 19:55-63

    مصطلحات موضوعية: Ligases, Proteasome Endopeptidase Complex, Ubiquitin-Protein Ligases, Cryoelectron Microscopy, Proteolysis, Nuclear Proteins, Cell Biology, Molecular Biology, Transcription Factors

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cffe718a8e978d9932a3400ef0703faTest
    https://doi.org/10.1038/s41589-022-01218-wTest


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  5. 5
    Overcoming Preclinical Safety Obstacles to Discover (S)-N-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor

    المؤلفون: Christopher McBride, Lynnie Trzoss, Davide Povero, Milos Lazic, Geza Ambrus-Aikelin, Angelina Santini, Rama Pranadinata, Gretchen Bain, Ryan Stansfield, Jeffrey A. Stafford, James Veal, Ryan Takahashi, Justin Ly, Shu Chen, Liling Liu, Marika Nespi, Robert Blake, Arna Katewa, Tracy Kleinheinz, Swathi Sujatha-Bhaskar, Nandhini Ramamoorthi, Jessica Sims, Brent McKenzie, Mark Chen, Mark Ultsch, Matthew Johnson, Jeremy Murray, Claudio Ciferri, Steven T. Staben, Michael J. Townsend, Craig E. Stivala

    المصدر: Journal of Medicinal Chemistry. 65:14721-14739

    مصطلحات موضوعية: Drug Discovery, Molecular Medicine

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::44ab527cf94dae143f3c4497446ed964Test
    https://doi.org/10.1021/acs.jmedchem.2c01250Test


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  6. 6
    Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 1: Exploration of Antibody Linker, Payload Loading, and Payload Molecular Properties

    المؤلفون: Peter S. Dragovich, Mingtao He, Leanna Staben, Hongyan Zhang, Melinda M. Mulvihill, Catherine Wilson, Hao Zhou, Tracy Kleinheinz, Binqing Wei, Jianfeng Xin, Nicole Blaquiere, Fanwei Meng, John S. Wai, Susan Kaufman, Liang Liu, Rebecca K. Rowntree, Steven T. Staben, Jing Wang, Katherine R. Kozak, Josefa dela Cruz-Chuh, Zijin Xu, Steven J. Hartman, Robert A. Blake, Xiaoyu Zhu, Sunil Bhakta, Donglu Zhang, Hui Yao, Aimee O'Donohue, Jack Sadowsky, Qi Liu, Pragya Adhikari, Liling Liu, Ying Lu, Thomas H. Pillow, Jinhua Chen, Emel Adaligil, Karen E. Gascoigne

    المصدر: Journal of Medicinal Chemistry. 64:2534-2575

    مصطلحات موضوعية: BRD4, Immunoconjugates, medicine.drug_class, Cell Cycle Proteins, Monoclonal antibody, 01 natural sciences, 03 medical and health sciences, Ubiquitin, Antigen, Antigens, Neoplasm, In vivo, Drug Discovery, LNCaP, medicine, Humans, Cell Proliferation, 030304 developmental biology, 0303 health sciences, biology, Chemistry, Antibodies, Monoclonal, Dipeptides, 0104 chemical sciences, Cell biology, 010404 medicinal & biomolecular chemistry, Von Hippel-Lindau Tumor Suppressor Protein, PC-3 Cells, Proteolysis, biology.protein, Molecular Medicine, Oxidoreductases, Heterocyclic Compounds, 3-Ring, Linker, Intracellular, Transcription Factors

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eaea12dee6f95904b15f4c9e925d0b1Test
    https://doi.org/10.1021/acs.jmedchem.0c01845Test


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  7. 7
    Discovery of GNE-149 as a Full Antagonist and Efficient Degrader of Estrogen Receptor alpha for ER+ Breast Cancer

    المؤلفون: Kuen Yeap, John S. Wai, Maia Vinogradova, Yu Zhong, Lori Friedman, Xiaojing Wang, Daniel Otwine, Jiangpeng Liao, Nick Ray, James R. Kiefer, Vidhi Mody, Jun Li, Fabien Roussel, Deepak Sampath, Simon Charles Goodacre, Jun Liang, Michelle Nannini, Sharada Labadie, Xiaoping Zheng, Ellen Ingalla, Steven J. Hartman, Birong Zhang, Jae H. Chang, Tao Wang, Yingqing Ran, Jason R. Zbieg, Amy Sambrone, Kwong Wah Lai, Amy Young, Ciara Metcalfe, Neville James Mclean, Robert A. Blake, Tracy Kleinheinz

    المصدر: ACS Med Chem Lett

    مصطلحات موضوعية: Fulvestrant, 010405 organic chemistry, Chemistry, Organic Chemistry, Azetidine, Uterus, Antagonist, Estrogen receptor, medicine.disease, 01 natural sciences, Biochemistry, 0104 chemical sciences, Bioavailability, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, Breast cancer, medicine.anatomical_structure, Drug Discovery, medicine, Cancer research, Estrogen receptor alpha, medicine.drug

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe42f6062f9f361a3f700a527fd2a8dcTest
    https://doi.org/10.1021/acsmedchemlett.0c00224Test


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  8. 8
    GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer

    المؤلفون: Martin O'Rourke, Nicholas Charles Ray, Thomas Gelzleichter, Leah Schutt, Ellen Ingalla, Neville James Mclean, Xiaojing Wang, Stephen Daly, Yingqing Ran, Jiangpeng Liao, Tommy Lai, Yu Zhong, Jun Liang, Sharada Labadie, Lori Friedman, Amy Sambrone, Jun Li, Robert A. Blake, Tao Wang, Liu Zhiguo, Birong Zhang, Steven J. Hartman, Jae H. Chang, Wei Zhou, Jane Guan, Vidhi Mody, Jonathan White, Fabien Roussel, Antonio G. DiPasquale, Jason R. Zbieg, Daniel F. Ortwine, Amy Young, James R. Kiefer, Maia Vinogradova, Simon Charles Goodacre, Deepak Sampath, Tracy Kleinheinz, Xiaoping Zheng, Jennifer M. Giltnane, Lorn Kategaya, Ingrid E. Wertz, Matthew Gill, Ciara Metcalfe, Siew Kuen Yeap, John S. Wai, Jason Oeh, Michelle Nannini

    المصدر: Journal of medicinal chemistry. 64(16)

    مصطلحات موضوعية: Phases of clinical research, Estrogen receptor, Antineoplastic Agents, Breast Neoplasms, Mice, Structure-Activity Relationship, Breast cancer, Dogs, In vivo, Drug Discovery, medicine, Animals, Humans, Dosing, Molecular Structure, Chemistry, Antagonist, Estrogen Receptor alpha, medicine.disease, Xenograft Model Antitumor Assays, In vitro, Rats, Macaca fascicularis, Cell culture, Cancer research, MCF-7 Cells, Molecular Medicine, Female, Estrogen Receptor Antagonists, Carbolines

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee86fe3f8068fbb2ff9647a59eadb710Test
    https://pubmed.ncbi.nlm.nih.gov/34251202Test


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  9. 9
    Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy

    المؤلفون: Steven J. Hartman, Ying Lu, Wentao Wei, Hao Zhou, Geoffrey Del Rosario, Robert A. Blake, Xiaoyu Zhu, Nicholas Corr, Aaron Fullerton, Shang-Fan Yu, Peter S. Dragovich, Jing Wang, Rebecca K. Rowntree, Donglu Zhang, Hui Yao, Emel Adaligil, Fan Jiang, Hongyan Zhang, Jack Sadowsky, John S. Wai, Jinhua Chen, Thomas H. Pillow, Susan Kaufman, Zijin Xu, Katherine R. Kozak, Jeremy Murray, Shenhua Zhang, Leanna Staben, Josefa dela Cruz-Chuh, Pragya Adhikari, Aimee O'Donohue, Tracy Kleinheinz, Liling Liu, Melinda M. Mulvihill, William S. Sawyer, Yongxin Zhao, Binqing Wei

    المصدر: Journal of medicinal chemistry. 64(5)

    مصطلحات موضوعية: BRD4, Immunoconjugates, Antineoplastic Agents, Cell Cycle Proteins, Mice, SCID, 01 natural sciences, 03 medical and health sciences, Mouse xenograft, Ubiquitin, In vivo, Antigens, Neoplasm, Cell Line, Tumor, Neoplasms, Drug Discovery, Animals, Humans, 030304 developmental biology, Cell Proliferation, 0303 health sciences, biology, Chemistry, Antibodies, Monoclonal, Dipeptides, Xenograft Model Antitumor Assays, In vitro, 0104 chemical sciences, Cell biology, 010404 medicinal & biomolecular chemistry, Proteasome, Von Hippel-Lindau Tumor Suppressor Protein, Proteolysis, biology.protein, Molecular Medicine, Female, Antibody, Oxidoreductases, Heterocyclic Compounds, 3-Ring, Conjugate, Transcription Factors

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::519ca8bb4de4ed4b24ce14fe281e518eTest
    https://pubmed.ncbi.nlm.nih.gov/33596073Test


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  10. 10
    Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα)

    المؤلفون: Mingtao He, Chun Sing Li, Yongxin Zhao, Deepak Sampath, Leanna Staben, Ingrid E. Wertz, Hao Zhou, Rebecca K. Rowntree, Ellen Ingalla, Xinxin Wang, Richard Zang, Ying Lu, Qi Liu, Jiawei Lu, Gail Lewis Phillips, Binqing Wei, Fanwei Meng, Nicole Blaquiere, Yun-Xing Cheng, Steven T. Staben, Keyang Xu, Jinping Han, Tommy Lai, Kaishan Peng, Kunpeng Wan, Peter S. Dragovich, Lingyao Meng, Tracy Kleinheinz, Jinhua Chen, Amrita V. Kamath, John S. Wai, Carl Ng, Pragya Adhikari, Steven J. Hartman, Jianfeng Xin, Jintang He, Douglas D. Leipold, Thomas H. Pillow, Donglu Zhang, Hui Yao, Jack Sadowsky, Robert A. Blake, Willem den Besten

    المصدر: Bioorganicmedicinal chemistry letters. 30(4)

    مصطلحات موضوعية: Immunoconjugates, medicine.drug_class, Receptor, ErbB-2, Clinical Biochemistry, Pharmaceutical Science, Estrogen receptor, Antineoplastic Agents, Monoclonal antibody, 01 natural sciences, Biochemistry, In vivo, Drug Discovery, medicine, Humans, Molecular Biology, Drug Carriers, 010405 organic chemistry, Chemistry, Organic Chemistry, Estrogen Receptor alpha, Antibodies, Monoclonal, Fusion protein, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Drug Design, Drug delivery, Proteolysis, MCF-7 Cells, Molecular Medicine, Estrogen receptor alpha, Linker, Intracellular

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b430d3962bed89cedef999868cf940fTest
    https://pubmed.ncbi.nlm.nih.gov/31902710Test


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