دورية أكاديمية
Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis
| العنوان: | Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis |
|---|---|
| المؤلفون: | Bridel, C. (Claire), Van Wieringen, W.N. (Wessel N.), Zetterberg, H. (Henrik), Tijms, B.M. (Betty M.), Teunissen, C.E. (Charlotte), Álvarez-Cermeño, J.C. (José C), Andreasson, U. (Ulf), Axelsson, M. (Markus), Bäckström, D.C. (David C.), Bartos, A. (Ales), Bjerke, M. (Maria), Blennow, K. (Kaj), Boxer, A.L. (Adam), Brundin, L. (Lou), Burman, J. (Joachim), Christensen, T. (Tove), Fialová, L. (Lenká), Forsgren, L. (Lars), Frederiksen, H., Gisslén, M. (Magnus), Gray, E. (Elizabeth), Gunnarsson, M. (Martin), Hall, S. (Sara), Hansson, O. (Oskar), Herbert, M.K. (Megan K.), Jakobsson, J. (Joel), Jessen-Krut, J. (Jan), Janelidze, S. (Shorena), Johannsson, G., Jonsson, M. (Michael), Kappos, L. (Ludwig), Khademi, M. (Mohsen), Khalil, M. (Michael), Kuhle, J. (Jens), Landén, M. (Mikael), Leinonen, V. (Ville), Logroscino, G. (Giancarlo), Lu, C.-H. (Ching-Hua), Lycke, J. (Jan), Magdalinou, N. (Nadia), Malaspina, A. (Andrea), Mattsson, N. (Niklas), Meeter, L.H.H. (Lieke), Mehta, S.R. (Sanjay R.), Modvig, S. (Signe), Olsson, T., Paterson, R.W. (Ross W.), Pérez-Santiago, J. (Josué), Piehl, F. (Fredrik), Pijnenburg, Y.A.L. (Yolande), Pyykkö, O.T. (Okko T.), Ragnarsson, O. (Oskar), Rojas, J.C. (Julio C.), Romme Christensen, J. (Jeppe), Sandberg, L. (Linda), Scherling, C.S. (Carole S.), Schott, J.M. (Jonathan M.), Sellebjerg, F. (Finn), Simone, I.L. (Isabella L.), Skillbäck, T. (Tobias), Stilund, M. (Morten), Sundström, P. (Peter), Svenningsson, A. (Anders), Tortelli, R. (Rosanna), Tortorella, C. (Carla), Trentini, A. (Alessandro), Troiano, M. (Maria), Turner, M.R. (Martin R.), Swieten, J.C. (John) van, Vågberg, M. (Mattias), Verbeek, M.M. (Marcel), Villar, L.M. (Luisa María), Visser, P. (Pim), Wallin, A. (Anders), Weiss, A. (Andreas), Wikkelsø, C. (Carsten), Wild, E.J. (Edward J.) |
| المصدر: | JAMA Neurology |
| سنة النشر: | 2019 |
| المجموعة: | RePub - Publications from Erasmus University, Rotterdam |
| الوصف: | Importance: Neurofilament light protein (NfL) is elevated in cerebrospinal fluid (CSF) of a number of neurological conditions compared with healthy controls (HC) and is a candidate biomarker for neuroaxonal damage. The influence of age and sex is largely unknown, and levels across neurological disorders have not been compared systematically to date. Objectives: To assess the associations of age, sex, and diagnosis with NfL in CSF (cNfL) and to evaluate its potential in discriminating clinically similar conditions. Data Sources: PubMed was searched for studies published between January 1, 2006, and January 1, 2016, reporting cNfL levels (using the search terms neurofilament light and cerebrospinal fluid) in neurological or psychiatric conditions and/or in HC. Study Selection: Studies reporting NfL levels measured in lumbar CSF using a commercially available immunoassay, as well as age and sex. Data Extraction and Synthesis: Individual-level data were requested from study authors. Generalized linear mixed-effects models were used to estimate the fixed effects of age, sex, and diagnosis on log-transformed NfL levels, with cohort of origin modeled as a random intercept. Main Outcome and Measure: The cNfL levels adjusted for age and sex across diagnoses. Results: Data were collected for 10059 individuals (mean [SD] age, 59.7 [18.8] years; 54.1% female). Thirty-five diagnoses were identified, including inflammatory diseases of the central nervous system (n = 2795), dementias and predementia stages (n = 4284), parkinsonian disorders (n = 984), and HC (n = 1332). The cNfL was elevated compared with HC in a majority of neurological conditions studied. Highest levels were observed in cognitively impaired HIV-positive individuals (iHIV), amyotrophic lateral sclerosis, frontotemporal dementia (FTD), and Huntington disease. In 33.3% of diagnoses, including HC, multiple sclerosis, Alzheimer disease (AD), and Parkinson disease (PD), cNfL was higher in men than women. The cNfL increased with age in HC and a majority of ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | http://repub.eur.nl/pub/117374Test; urn:hdl:1765/117374 |
| DOI: | 10.1001/jamaneurol.2019.1534 |
| الإتاحة: | https://doi.org/10.1001/jamaneurol.2019.1534Test http://repub.eur.nl/pub/117374Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.B2B6568B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1001/jamaneurol.2019.1534 |
|---|