دورية أكاديمية
The neural control of micturition ... : from animal models to circuitry ...
| العنوان: | The neural control of micturition ... : from animal models to circuitry ... |
|---|---|
| المؤلفون: | Tish, Margaret Michelle |
| بيانات النشر: | University of Iowa |
| سنة النشر: | 2025 |
| المجموعة: | DataCite Metadata Store (German National Library of Science and Technology) |
| مصطلحات موضوعية: | Barrington's nucleus, mouse model, normal pressure hydrocephalus, public abstract, Incontinence |
| الوصف: | Urinary urge incontinence is a debilitating condition, effecting millions, without a known cure. Urge incontinence can occur after strokes or other lesions to the frontal cortex or hypothalamus and is also a stereotypical symptom in patients with normal pressure hydrocephalus. In NPH, it is believed that the expanding ventricles damage the surrounding white matter, leading to symptomology. Despite the need for better treatments for those with urge incontinence, who often end up in diapers or nursing homes, our knowledge of the neural circuits responsible for maintaining continence is lacking. Here, we present a detailed investigation of micturition in mice and uncover an inhibitory disynaptic pathway from the frontal cortex to the brainstem that is important for inhibiting urination. We first developed a novel, non-invasive assay to measure micturition in awake mice, using thermal imaging to record voids. We then developed a mouse model of incontinence by inducing hydrocephalus in mice. In addition to ... |
| نوع الوثيقة: | text doctoral or postdoctoral thesis |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.25820/etd.006898 |
| الإتاحة: | https://doi.org/10.25820/etd.006898Test https://iro.uiowa.edu/esploro/outputs/doctoral/9984454435402771Test |
| حقوق: | Copyright 2023 Margaret Michelle Tish ; Embargo |
| رقم الانضمام: | edsbas.515A80D |
| قاعدة البيانات: | BASE |
| DOI: | 10.25820/etd.006898 |
|---|