ICES (International Carboplatin Emesis Survey) for the evaluation of the emetogenicity of continuous cycles of carboplatin-based chemotherapy with focus on nausea: A MASCC emesis study group, prospective, observational, real-world multi-centric study
| العنوان: | ICES (International Carboplatin Emesis Survey) for the evaluation of the emetogenicity of continuous cycles of carboplatin-based chemotherapy with focus on nausea: A MASCC emesis study group, prospective, observational, real-world multi-centric study |
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| المؤلفون: | Alexandre Chan, Chia Jie Tan, Tina V Mhazo, Ana Zilic, Snezana Bosnjak, Martin Chasen, Margreet de Necker, Ravi Bhargava, Bernardo Leon Rapoport, Yaxiong Zhang, Liezl Heyman, Teresa Smit, Adnan Abdul Jabbar |
| المصدر: | Journal of Clinical Oncology. 39:e24086-e24086 |
| بيانات النشر: | American Society of Clinical Oncology (ASCO), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Oncology, Cancer Research, medicine.medical_specialty, Chemotherapy, Nausea, business.industry, medicine.medical_treatment, Cancer, medicine.disease, Chemotherapy regimen, Carboplatin, chemistry.chemical_compound, chemistry, Internal medicine, medicine, Observational study, medicine.symptom, business, Chemotherapy-induced nausea and vomiting |
| الوصف: | e24086 Background: Chemotherapy induced nausea and vomiting (CINV) following carboplatin containing chemotherapy regimen remains a considerable problem for cancer patients (pts) despite standard antiemetic prophylaxis. This study was undertaken to prospectively evaluate the incidence of CINV in pts undergoing carboplatin-based chemotherapy receiving guidelines consistent CINV prophylaxis (GCCP). All sites did not prescribe NK1-RA as it is not included in all institutional guidelines. Methods: The study enrolled 207 pts undergoing carboplatin-based chemotherapy, the final analysis evaluated cycle 1 - 6 with a total of 183 evaluable pts from 6 countries. Pt diaries were used to collect data from day 1-10 beginning with cycle 1. Nausea was reported by the pts using a visual analog scale (VAS) with the end-point being no nausea. Vomiting episodes were recorded in the pts’ diaries. Demographic, occurrence and severity of emesis, numbers of emetic episodes and time to the onset of emesis, were summarized using descriptive statistics. Results: There were 129 females and 54 males. The overall incidence of acute and delayed nausea for was 17% and 25% respectively. The incidence of nausea of entire population was significantly higher than vomiting (58% vs. 14%; Chi2 22.271 p |
| تدمد: | 1527-7755 0732-183X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::72821e8673cb30e893c9acf47f1b285eTest https://doi.org/10.1200/jco.2021.39.15_suppl.e24086Test |
| رقم الانضمام: | edsair.doi...........72821e8673cb30e893c9acf47f1b285e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15277755 0732183X |
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