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1دورية أكاديمية
المؤلفون: Bharath Srinivasan, Juan Daniel Flórez Weidinger, Xiang Zhai, Guillaume Lemercier, Timothy Ikeda, Mark Brewer, Bairu Zhang, Stephan Heyse, Jonathan Wingfield, Stephan Steigele
المصدر: SLAS Discovery, Vol 27, Iss 8, Pp 460-470 (2022)
مصطلحات موضوعية: Mechanistic screening, Slow-onset inhibition, Irreversible inhibition, Mechanism-of-action, Data analysis, Drug screening, Medicine (General), R5-920, Biotechnology, TP248.13-248.65
وصف الملف: electronic resource
العلاقة: http://www.sciencedirect.com/science/article/pii/S2472555222136956Test; https://doaj.org/toc/2472-5552Test
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المؤلفون: Huimin Wang, Tony Johnson, Sameer Kawatkar, Peng Wang, Lakshmaiah Gingipalli, Scott D. Edmondson, Jon Read, Scott Boyd, Timothy Ikeda, Andrew Pike, Qibin Su, Olivier Lorthioir, Lianghe Wang, Hannah Dry, Hannah Pollard, Barlaam Bernard Christophe, Haiyun Wang, Scott Boiko
المصدر: Bioorganic & Medicinal Chemistry Letters. 30:127523
مصطلحات موضوعية: Pyrimidine, Clinical Biochemistry, hERG, Pharmaceutical Science, Syk, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Drug Discovery, Animals, Humans, Syk Kinase, Potency, Rats, Wistar, Protein Kinase Inhibitors, Molecular Biology, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, Kinase, Organic Chemistry, Rats, Pyrazolylpyrimidine, Pyrimidines, Microsomes, Liver, biology.protein, Pyrazoles, Molecular Medicine, Selectivity
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b64b2339e860fa1c384ebed0af403608Test
https://doi.org/10.1016/j.bmcl.2020.127523Test -
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المؤلفون: James E. Dowling, Scott G. Lamont, Quanshan Wen, Scott Boiko, Peng Wang, Sameer Kawatkar, Scott D. Edmondson, Haiyun Wang, Ujjal Sarkar, Zhiyuan Yan, Barlaam Bernard Christophe, Andrew Pike, Joe Patel, Jon Read, Iain Simpson, Paul D. Kemmitt, Hannah Pollard, Hannah Dry, Timothy Ikeda, Qibin Su, David W. Watson
المصدر: Bioorganic & Medicinal Chemistry Letters. 30:127393
مصطلحات موضوعية: Models, Molecular, Protein Conformation, Clinical Biochemistry, Pharmaceutical Science, Syk, 01 natural sciences, Biochemistry, Autoimmune Diseases, Cell Line, Substrate Specificity, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Humans, Syk Kinase, Potency, Amino Acid Sequence, Protein Kinase Inhibitors, Molecular Biology, Cell Proliferation, chemistry.chemical_classification, Aza Compounds, 010405 organic chemistry, Kinase, Organic Chemistry, Assay, hemic and immune systems, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Enzyme, chemistry, Drug Design, Molecular Medicine, Benzimidazoles, Lead compound, Protein Binding
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1114c3d707cb69b964dd0155b8dfbd45Test
https://doi.org/10.1016/j.bmcl.2020.127393Test