المؤلفون: Charles N. J. Ravarani, Tilman Flock, Sreenivas Chavali, Madhanagopal Anandapadamanaban, M. Madan Babu, Santhanam Balaji

المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/04a4a2d60faa49f28d7ee8556002ba1aTest

المؤلفون: Daniel Mayer, Fred F. Damberger, Mamidi Samarasimhareddy, Miki Feldmueller, Ziva Vuckovic, Tilman Flock, Brian Bauer, Eshita Mutt, Franziska Zosel, Frédéric H. T. Allain, Jörg Standfuss, Gebhard F. X. Schertler, Xavier Deupi, Martha E. Sommer, Mattan Hurevich, Assaf Friedler, Dmitry B. Veprintsev

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/3fb017c511b74ac5b642a4f342d8976bTest

المؤلفون: Ching-Ju Tsai, Jacopo Marino, Ricardo Adaixo, Filip Pamula, Jonas Muehle, Shoji Maeda, Tilman Flock, Nicholas MI Taylor, Inayatulla Mohammed, Hugues Matile, Roger JP Dawson, Xavier Deupi, Henning Stahlberg, Gebhard Schertler

المصدر: eLife, Vol 8 (2019)

مصطلحات موضوعية: G protein-coupled receptors, G proteins, cryo-EM, Gβ subunit, cellular signaling, Bos taurus, Medicine, Science, Biology (General), QH301-705.5

وصف الملف: electronic resource

العلاقة: https://elifesciences.org/articles/46041Test; https://doaj.org/toc/2050-084XTest

الوصول الحر: https://doaj.org/article/e771e8ad582e45b493b49c84fa5cd9a3Test

المؤلفون: Bianca Plouffe (2517475), Angeliki Karamitri (435673), Tilman Flock (11999862), Jonathan M. Gallion (11999865), Shane Houston (11999868), Carole A. Daly (11999871), Amélie Bonnefond (11371193), Jean-Luc Guillaume (245573), Christian Le Gouill (11371187), Phillipe Froguel (11999874), Olivier Lichtarge (22747), Xavier Deupi (206453), Ralf Jockers (245630), Michel Bouvier (76074)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Neuroscience, Evolutionary Biology, Cancer, Mental Health, Infectious Diseases, Virology, negative matrix factorization, molecular features controlling, arrestin 2 recruitment, combined functional clustering, mutations differently impact, unique signaling features, z , i1 , 2 , gpcr functional selectivity, engage distinct subsets, functional selectivity, mtnr1b <, specific mutations, distinct domains, signaling signatures, signaling pathways, using non, structural modeling

العلاقة: https://figshare.com/articles/journal_contribution/Structural_Elements_Directing_G_Proteins_and_Arrestin_Interactions_with_the_Human_Melatonin_Type_2_Receptor_Revealed_by_Natural_Variants/19067580Test

الإتاحة: https://doi.org/10.1021/acsptsci.1c00239.s001Test

المؤلفون: Bianca Plouffe, Angeliki Karamitri, Tilman Flock, Jonathan M. Gallion, Shane Houston, Carole A. Daly, Amélie Bonnefond, Jean-Luc Guillaume, Christian Le Gouill, Phillipe Froguel, Olivier Lichtarge, Xavier Deupi, Ralf Jockers, Michel Bouvier

المصدر: Plouffe, B, Karamitri, A, Flock, T, Gallion, J M, Houston, S, Daly, C A, Bonnefond, A, Guillaume, J-L, Le Gouill, C, Froguel, P, Lichtarge, O, Deupi, X, Jockers, R & Bouvier, M 2022, ' Structural elements directing G proteins and β-arrestin interactions with the human melatonin type 2 receptor revealed by natural variants ', ACS Pharmacology & Translational Science, vol. 5, no. 2, pp. 89-101 . https://doi.org/10.1021/acsptsci.1c00239Test

مصطلحات موضوعية: Pharmacology, Pharmacology (medical)

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a10e88db95d723db444f3c797d249364Test
https://doi.org/10.1021/acsptsci.1c00239Test

المؤلفون: Sreenivas Chavali, Madhanagopal Anandapadamanaban, Charles N. J. Ravarani, Tilman Flock, M. Madan Babu, S. Balaji

المساهمون: Chavali, Sreenivas [0000-0001-8307-1645], Anandapadamanaban, Madhanagopal [0000-0002-4237-0048], Babu, M Madan [0000-0003-0556-6196], Balaji, Santhanam [0000-0001-8523-4145], Apollo - University of Cambridge Repository

المصدر: Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Transcription, Genetic, genetic processes, General Physics and Astronomy, Plasma protein binding, environment and public health, chemistry.chemical_compound, 0302 clinical medicine, Transcription (biology), Three-domain system, lcsh:Science, Peptide sequence, Multidisciplinary, Eukaryota, TATA Box, Viruses, Algorithms, Protein Binding, Science, Protein domain, Computational biology, macromolecular substances, Biology, General Biochemistry, Genetics and Molecular Biology, Article, Evolution, Molecular, 03 medical and health sciences, Protein Domains, Molecular evolution, Animals, Humans, Amino Acid Sequence, Binding Sites, Bacteria, Sequence Homology, Amino Acid, Binding protein, General Chemistry, Protein sequence analyses, TATA-Box Binding Protein, Archaea, enzymes and coenzymes (carbohydrates), 030104 developmental biology, chemistry, health occupations, lcsh:Q, 030217 neurology & neurosurgery, DNA

وصف الملف: application/pdf; application/zip; text/xml

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::553cb7faf349fffd07bf42cd5666b2c1Test
http://europepmc.org/articles/PMC7221094Test

المؤلفون: M. Madan Babu, S. Balaji, Mithu Baidya, Tilman Flock, Raphael Peer, Ashish Srivastava, Andrija Sente, Arthur M. Lesk, Arun K. Shukla

المصدر: Nature Structural & Molecular Biology. 25:538-545

مصطلحات موضوعية: inorganic chemicals, 0301 basic medicine, genetic structures, Protein Conformation, media_common.quotation_subject, environment and public health, Article, Receptors, G-Protein-Coupled, 03 medical and health sciences, Protein structure, Structural Biology, Arrestin, Humans, Phosphorylation, Structural motif, Internalization, Molecular Biology, G protein-coupled receptor, media_common, Chemistry, C-terminus, eye diseases, Cell biology, 030104 developmental biology, sense organs, Signal transduction, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d64eff1c4e3ea398e05b74d6e52dc4f9Test
https://doi.org/10.1038/s41594-018-0071-3Test

المؤلفون: Xavier Deupi, Eshita Mutt, Elliot Gerrard, Robert J. Lucas, Elena Lesca, Akihisa Terakita, Tilman Flock, Mitsumasa Koyanagi, Takashi Nagata, Gebhard F. X. Schertler

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 115 (24)
Gerrard, E, Mutt, E, Nagata, T, Koyanagi, M, Flock, T, Lesca, E, Schertler, G F X, Terakita, A, Deupi, X & Lucas, R J 2018, ' Convergent evolution of tertiary structure in rhodopsin visual proteins from vertebrates and box jellyfish ', Proceedings of the National Academy of Sciences, vol. 115, no. 24, pp. 6201-6206 . https://doi.org/10.1073/pnas.1721333115Test

مصطلحات موضوعية: inorganic chemicals, 0301 basic medicine, vision, Rhodopsin, Opsin, genetic structures, counterion, Molecular Dynamics Simulation, Evolution, Molecular, opsin, 03 medical and health sciences, 0302 clinical medicine, Box jellyfish, evolution, 箱クラゲ, 収斂進化, Animals, Humans, Photopigment, Phylogeny, Vision, Ocular, chemistry.chemical_classification, Multidisciplinary, biology, G-protein–coupled receptors, 対イオン, Counterion, アンドンクラゲ, biology.organism_classification, Recombinant Proteins, eye diseases, Protein tertiary structure, 光受容タンパク質, Transmembrane domain, HEK293 Cells, 030104 developmental biology, chemistry, Evolutionary biology, Retinaldehyde, Cubozoa, biology.protein, sense organs, 030217 neurology & neurosurgery

وصف الملف: application/application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b25074857c4dfbf85220572dda507c13Test
https://doi.org/10.1073/pnas.1721333115Test

المؤلفون: Melis Kayikci, Charles N. J. Ravarani, Tilman Flock, James Scott-Brown, AJ Venkatakrishnan, M. Madan Babu

المصدر: Nature structural & molecular biology

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Rhodopsin, 030103 biophysics, Computer science, Non covalent, Protein Data Bank (RCSB PDB), Computational biology, Crystallography, X-Ray, Ligands, Protein Structure, Secondary, Article, 03 medical and health sciences, Protein structure, Structural Biology, Protein Interaction Mapping, Humans, Databases, Protein, Molecular Biology, Protein secondary structure, Polymorphism, Genetic, Computational Biology, Proteins, Hydrogen Bonding, DNA, Visualization, 030104 developmental biology, Mutation, Allosteric Site, Biomarkers, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7dceafd24f903ab3192c3497ca98483Test
https://doi.org/10.1038/s41594-017-0019-zTest

المؤلفون: Inayatulla Mohammed, Xavier Deupi, Jacopo Marino, Jonas Mühle, Roger J. P. Dawson, Ching-Ju Tsai, Hugues Matile, Filip Pamula, Gebhard F. X. Schertler, Ricardo Adaixo, Tilman Flock, Shoji Maeda, Henning Stahlberg, Nicholas M.I. Taylor

المصدر: eLife, 8
eLife, Vol 8 (2019)
eLife
Tsai, C-J, Marino, J, Adaixo, R, Pamula, F, Muehle, J, Maeda, S, Flock, T, Taylor, N MI, Mohammed, I, Matile, H, Dawson, R J, Deupi, X, Stahlberg, H & Schertler, G 2019, ' Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the gβ subunit ', eLife, vol. 8, e46041 . https://doi.org/10.7554/eLife.46041Test

مصطلحات موضوعية: Rhodopsin, Mouse, G protein, QH301-705.5, Protein subunit, Structural Biology and Molecular Biophysics, Science, Gi alpha subunit, 03 medical and health sciences, 0302 clinical medicine, G protein-coupled receptors, Biochemistry and Chemical Biology, Heterotrimeric G protein, GTP-Binding Protein gamma Subunits, Animals, Biology (General), Integral membrane protein, 030304 developmental biology, G protein-coupled receptor, 0303 health sciences, G protein-coupled receptor kinase, biology, Chemistry, Cryoelectron Microscopy, GTP-Binding Protein beta Subunits, Gβ subunit, GTP-Binding Protein alpha Subunits, Bos taurus, 3. Good health, Cell biology, Multiprotein Complexes, biology.protein, cryo-EM, Medicine, Cattle, Other, cellular signaling, 030217 neurology & neurosurgery, Protein Binding, Research Article, Human, G proteins

وصف الملف: application/application/pdf; application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6a927567aac87f5a5e193a4bf6589bdTest
https://hdl.handle.net/20.500.11850/355900Test