Spectrophotometric determination of clozapine in pharmaceuticals
| العنوان: | Spectrophotometric determination of clozapine in pharmaceuticals |
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| المؤلفون: | A. Satyanarayana, Chilukuri S. P. Sastry, Thuta Vijaya Rekha |
| المصدر: | Mikrochimica Acta. 128:201-205 |
| بيانات النشر: | Springer Science and Business Media LLC, 1998. |
| سنة النشر: | 1998 |
| مصطلحات موضوعية: | chemistry.chemical_classification, Chromatography, medicine.diagnostic_test, Hydrochloride, Hydrazone, Dosage form, Analytical Chemistry, chemistry.chemical_compound, chemistry, Chloranilic acid, Sodium hypochlorite, Spectrophotometry, medicine, Oxidative coupling of methane, Quantitative analysis (chemistry) |
| الوصف: | New Spectrophotometric methods for the assay of clozapine (CZP) in pure and dosage forms are described. Method A is based on the oxidative coupling reaction of CZP with 3-methyl-2-benzothiazolinone hydrazone hydrochloride (MBTH) in the presence of ceric ammonium sulphate to form a coloured species (λmax 570 nm). Method B is also based on the oxidative coupling reaction of CZP withP-,N,N-dimethylpheny-lenediamine dihydrochloride (DMPD) in the presence of sodium hypochlorite to form a coloured species (λmax 690 nm). Method C is based on the formation of coloured charge-transfer complex between CZP and chloranilic acid (λmax 540 nm). Regression analysis of Beer-Lambert plots showed good correlation in the concentration ranges 2–25, 10–120 and 15–300 μg/ml for methods A, B and C, respectively. The validity of the proposed methods was tested by analysing pharmaceutical dosage forms containing CZP and the relative standard deviation values were within 1.0%. |
| تدمد: | 1436-5073 0026-3672 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::c03bfdba9ac39ab620b28e024e626ba0Test https://doi.org/10.1007/bf01243050Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........c03bfdba9ac39ab620b28e024e626ba0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14365073 00263672 |
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