المؤلفون: Ji Jiang, James Neels, David A. Gordon, Ruth R. Wexler, Alice Ye A. Chen, Michael Basso, Jon J. Hangeland, Leonard P. Adam, Heather Finlay, Paul G. Sleph, Lynn M. Abell, Richard Yang, Thomas Harrity, R. Michael Lawrence, David S. Taylor, Lauren Haque, Christine Huang, Xiaohong Yin, Todd J. Friends, Joelle M. Onorato

المصدر: ACS Medicinal Chemistry Letters. 9:673-678

مصطلحات موضوعية: 0301 basic medicine, Endothelial lipase, Lipoprotein lipase, Chemistry, Organic Chemistry, Substrate (chemistry), Plasma protein binding, 030204 cardiovascular system & hematology, Biochemistry, Molecular biology, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, In vivo, Drug Discovery, Lipase inhibitors, Hepatic lipase, IC50

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f785fa1a2ceebdbf57f8010e5dea4a83Test
https://doi.org/10.1021/acsmedchemlett.8b00138Test

المؤلفون: Paul E. Morin, Haixia Wang, Lawrence J. Kennedy, Stephen P. O'connor, James J. Li, Akbar Nayeem, Vidhyashankar Ramamurthy, Steven Sheriff, Nathan Morgan, Steven J. Walker, Xiang-Yang Ye, Frederick Moulin, Brad D. Maxwell, Thomas Harrity, Jeffrey A. Robl, Stephanie Y. Chen, Timothy W. Harper, Rachel Zebo, Jun Li, Zhenqiu Hong, Shung Wu, Mengmeng Wang, Randolph P. Ponticiello, David A. Gordon, Rajasree Golla, Ramakrishna Seethala, Daniel M. Camac, Joseph R. Taylor, David S. Yoon

مصطلحات موضوعية: 0301 basic medicine, biology, Chemistry, Organic Chemistry, Adipose tissue, Dehydrogenase, Pharmacology, Biochemistry, Bioavailability, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Pharmacokinetics, 11β-hydroxysteroid dehydrogenase type 1, 030220 oncology & carcinogenesis, Pharmacodynamics, Drug Discovery, biology.protein, IC50, Ex vivo

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::537bf023154f9aff48423a9bc7df61b2Test
https://europepmc.org/articles/PMC6295842Test/

المؤلفون: Carrie Xu, George C. Morton, Vinayak Hosagrahara, Shung Wu, Denis E. Ryono, Jonathan Lippy, Narayanan Hariharan, Kenneth T. Locke, Xiang-Xang Ye, Wei Wang, Liqun Gu, Yi-Xin Li, Fucheng Qu, Peter T. W. Cheng, Sean S. Chen, Kevin O’Malley, Michael Cap, Robert Zahler, Tao Wang, Lori Kunselman, Charles Z. Ding, Cuixia Chu, Rebecca A. Smirk, Neil Flynn, Pratik Devasthale, Hao Zhang, Nathan Morgan, Atsu Apedo, Thomas Harrity, Lisa Zhang, Dennis Farrelly, Arthur M. Doweyko, Zhi Lai, Tim Herpin, Pathanjali Kadiyala

المصدر: Bioorganic & Medicinal Chemistry Letters. 25:1196-1205

مصطلحات موضوعية: Blood Glucose, Pyrrolidines, Stereochemistry, Clinical Biochemistry, Mice, Obese, Pharmaceutical Science, Peroxisome proliferator-activated receptor, Ligands, Biochemistry, Pyrrolidine, Fasting glucose, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Animals, Hypoglycemic Agents, PPAR alpha, Molecular Biology, Triglycerides, Biological evaluation, chemistry.chemical_classification, Triglyceride, Organic Chemistry, Stereoisomerism, PPAR gamma, Diabetes Mellitus, Type 2, chemistry, Drug Design, Molecular Medicine, Female

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef9c9221e9206ed0e57f44f10281d7abTest
https://doi.org/10.1016/j.bmcl.2015.01.066Test

المؤلفون: Steven J. Walker, Vidyhashankar Ramamurthy, Jun Li, Shung Wu, David K. Leahy, John D. Dimarco, Brad D. Maxwell, Daniel M. Camac, Joseph R. Taylor, Akbar Nayeem, Zhiwei Guo, James J. Li, Xiang-Yang Ye, Frederick Moulin, Paul E. Morin, Stepen P O’Connor, Haixia Wang, Jeffrey A. Robl, Rachel Zebo, Mark S. Kirby, Thomas Harrity, Joel C. Barrish, Timothy W. Harper, Lawrence L Kennedy, Rajasree Golla, Atsu Apedo, Bogdan Sleczka, Yi-Xin Li, David S. Yoon, Bin He, Steven Sheriff, Ramakrishna Seethala, Nathan Morgan, Mengmeng Wang, Randolph P. Ponticiello, Raymond P. Scaringe, Stephanie Y. Chen, Jianqing Li, Zhenqiu Hong, Ronald L. Hanson, David A. Gordon

المصدر: Journal of medicinal chemistry. 60(12)

مصطلحات موضوعية: 0301 basic medicine, Male, Hypothalamo-Hypophyseal System, Administration, Oral, Biological Availability, Mice, Obese, Dehydrogenase, Adamantane, Pharmacology, Crystallography, X-Ray, 03 medical and health sciences, chemistry.chemical_compound, Inhibitory Concentration 50, Structure-Activity Relationship, Dogs, Pharmacokinetics, 11β-hydroxysteroid dehydrogenase type 1, Drug Discovery, 11-beta-Hydroxysteroid Dehydrogenase Type 1, Animals, Humans, Enzyme Inhibitors, IC50, ED50, ADME, chemistry.chemical_classification, biology, Chemistry, Actins, Rats, Macaca fascicularis, 030104 developmental biology, Enzyme, biology.protein, Molecular Medicine, Azetidines, Female, Acetamide, Half-Life

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d86602b708c78e42f5648acb482b306bTest
https://pubmed.ncbi.nlm.nih.gov/28537398Test

المؤلفون: Ramakrishna Seethala, Steven J. Walker, Jun Li, Stephen P. O'connor, Lawrence J. Kennedy, Steven Sheriff, Rachel Zebo, Daniel M. Camac, Paul E. Morin, Jeffrey A. Robl, Joseph R. Taylor, James J. Li, Haixia Wang, Thomas Harrity, David A. Gordon, Akbar Nayeem, Timothy W. Harper, Zhenqiu Hong, Mengmeng Wang, Randolph P. Ponticiello, Rajasree Golla, Nathan Morgan

المصدر: ACS Medicinal Chemistry Letters. 5:803-808

مصطلحات موضوعية: chemistry.chemical_classification, Pregnane X receptor, Stereochemistry, Organic Chemistry, Pregnane, Biology, Biochemistry, chemistry.chemical_compound, Transactivation, Enzyme, chemistry, 11β-hydroxysteroid dehydrogenase type 1, Drug Discovery, Pyridine, biology.protein, Receptor, Alkyl

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f50571624276edc8a5db39e2719422cTest
https://doi.org/10.1021/ml500144hTest

المؤلفون: Yaqun Zhang, Dianlin Xie, Kevin Kish, Aiying Wang, Stephen P. O'connor, Wei Meng, Herbert E. Klei, Huji Turdi, Lawrence G. Hamann, Robert Zahler, Jovita Marcinkeviciene, Robert Paul Brigance, Thomas Harrity, James K. Tamura, Aberra Fura, Carolyn A. Weigelt, Chao Hannguang J, Mark S. Kirby

المصدر: Journal of Medicinal Chemistry. 53:5620-5628

مصطلحات موضوعية: Male, Models, Molecular, ERG1 Potassium Channel, Pyrimidine, Stereochemistry, Dipeptidyl Peptidase 4, hERG, Mice, Obese, Crystallography, X-Ray, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Catalytic Domain, Amide, Drug Discovery, Hydrolase, Animals, Humans, Hypoglycemic Agents, Imidazole, Dipeptidyl peptidase-4, Dipeptidyl-Peptidase IV Inhibitors, biology, Aryl, Imidazoles, Active site, Stereoisomerism, Ether-A-Go-Go Potassium Channels, Rats, Pyrimidines, Diabetes Mellitus, Type 2, chemistry, biology.protein, Molecular Medicine, Sodium Channel Blockers

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ca7c24a1f6700c83b6ed4ef874c797Test
https://doi.org/10.1021/jm100634aTest

المؤلفون: Doree F. Sitkoff, Ming Chang, Carolyn A Cuff, Bang-Chi Chen, Cort S. Madsen, Xiaohong Yin, Saleem Ahmad, Evan B. Janovitz, Richard A. Reeves, Thomas Harrity, Lawrence J. Kennedy, Carol S. Ryan, Hossain Monshizadegan, Van Nguyen-Tran, Tong Li, Robert Zahler, Michael A. Blanar, Khehyong Ngu, Philip D. Stein, Rongan Zhang, Sharon N. Bisaha, Christine Huang, Joel C. Barrish, Eileen Bird, Debra Search, Celia D’Arienzo, Mary Giancarli, Robert Setters, Rulin Zhao, Jeffrey A. Robl, Xing Chen, Shaobin Zhuang

المصدر: Journal of Medicinal Chemistry. 51:2722-2733

مصطلحات موضوعية: Models, Molecular, Guinea Pigs, Administration, Oral, Biological Availability, In Vitro Techniques, Reductase, Crystallography, X-Ray, Chemical synthesis, Rats, Sprague-Dawley, Structure-Activity Relationship, Dogs, Oral administration, In vivo, Drug Discovery, Animals, Humans, Structure–activity relationship, chemistry.chemical_classification, Muscle Cells, biology, Chemistry, Stereoisomerism, Haplorhini, Triazoles, Hydroxymethylglutaryl-CoA reductase, Rats, Cholesterol, Pyrimidines, Enzyme, Liver, Biochemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Female, Hydroxymethylglutaryl CoA Reductases, Chemical and Drug Induced Liver Injury, Hydroxymethylglutaryl-CoA Reductase Inhibitors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b90d3adf6a8d7ca839916f3bce8ae5a0Test
https://doi.org/10.1021/jm800001nTest

المؤلفون: Lori Kunselman, Narayanan Hariharan, Pathanjali Kadiyala, Kenneth T. Locke, Denis E. Ryono, Thomas Harrity, Wei Wang, Arthur M. Doweyko, Randy Ponticiello, Liqun Gu, Pratik Devasthale, Lisa Zhang, Dennis Farrelly, Rachel Zebo, Michael Cap, Robert Zahler, Jodi K. Muckelbauer, Chiehying Chang, Cuixia Chu, Peter T. W. Cheng, Kevin O’Malley, Nathan Morgan, Litao Zhang, Jonathan Lippy, Vinayak Hosagrahara

المصدر: Bioorganic & Medicinal Chemistry Letters. 18:1939-1944

مصطلحات موضوعية: Agonist, ERG1 Potassium Channel, Protein Conformation, Stereochemistry, medicine.drug_class, Clinical Biochemistry, Administration, Oral, Biological Availability, Pharmaceutical Science, Peroxisome proliferator-activated receptor, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Diabetes Mellitus, Experimental, Mice, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Drug Discovery, medicine, Animals, Cytochrome P-450 Enzyme Inhibitors, PPAR alpha, Receptor, Molecular Biology, Triglycerides, Dyslipidemias, chemistry.chemical_classification, Molecular Structure, Chemistry, Organic Chemistry, Stereoisomerism, Ether-A-Go-Go Potassium Channels, Mice, Mutant Strains, In vitro, PPAR gamma, Glucose, Nuclear receptor, Lactam, Azetidines, Molecular Medicine, Copper

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8bfbf6fa4536695047baca135da5c60Test
https://doi.org/10.1016/j.bmcl.2008.01.126Test

المؤلفون: Bang-Chi Chen, Neil Flynn, R. Michael Lawrence, Rulin Zhao, Ching-Hsuen Chu, James J. Li, Vito G. Sasseville, Scott A. Biller, Luping Chen, Randy Ponticiello, Haixia Wang, Dora M. Schnur, Dong Cheng, Jamil Haris, Jeffrey A. Robl, Kristen Pike, Joseph A. Tino, Mary T. Obermeier, Thomas Harrity, Timothy F. Herpin, Ramesh Padmanabha

المصدر: Bioorganic & Medicinal Chemistry Letters. 17:3208-3211

مصطلحات موضوعية: Blood Glucose, ATP citrate lyase, Clinical Biochemistry, Pharmaceutical Science, ATP Citrate (pro-S)-Lyase, Biochemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Animals, Structure–activity relationship, Enzyme Inhibitors, Molecular Biology, Cells, Cultured, Triglycerides, chemistry.chemical_classification, Sulfonamides, biology, Triglyceride, Cholesterol, Body Weight, Organic Chemistry, Benzene, Lyase, Rats, Enzyme, Adipose Tissue, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Anti-Obesity Agents

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::863f1596275d02b6a6a0c62e58561a4dTest
https://doi.org/10.1016/j.bmcl.2007.03.017Test

المؤلفون: Narayanan Hariharan, Kasim A. Mookhtiar, Liqun Gu, Jimmy Ren, Chen Sean, Ramakrishna Seethala, Michael Cap, Lori Kunselman, Min Zhou, Peter T. W. Cheng, William Fenderson, Chunning Shao, Cuixia Chu, Scott A. Biller, Hao Zhang, Fucheng Qu, Pratik Devasthale, Dennis Farrelly, Jeon Yoon T, Randolph P. Ponticiello, John R. Wetterau, Wei Wang, Wen-Pin Yang, Thomas Harrity, Aaron Tieman, Denis E. Ryono, Richard E. Gregg

المصدر: Diabetes. 55:240-248

مصطلحات موضوعية: chemistry.chemical_classification, medicine.medical_specialty, Adiponectin, Endocrinology, Diabetes and Metabolism, Insulin, medicine.medical_treatment, Fatty liver, Peroxisome proliferator-activated receptor, White adipose tissue, Biology, medicine.disease, Muraglitazar, Endocrinology, chemistry, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Rosiglitazone, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::e4d94ba455d51e1e5f39b4a1484a6b08Test
https://doi.org/10.2337/diabetes.55.01.06.db05-0648Test