المؤلفون: Tamara Casteels, Yufeng Zhang, Thomas Frogne, Caterina Sturtzel, Charles-Hugues Lardeau, Ilke Sen, Xiaocheng Liu, Shangyu Hong, Florian M. Pauler, Thomas Penz, Marlene Brandstetter, Charlotte Barbieux, Ekaterine Berishvili, Thomas Heuser, Christoph Bock, Christian G. Riedel, Dirk Meyer, Martin Distel, Jacob Hecksher-Sørensen, Jin Li, Stefan Kubicek

المصدر: Molecular Metabolism, Vol 54, Iss , Pp 101329- (2021)

مصطلحات موضوعية: Diabetes, Beta-cell dedifferentiation, FoxO1 inhibitor, Loperamide, Internal medicine, RC31-1245

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2212877821001769Test; https://doaj.org/toc/2212-8778Test

الوصول الحر: https://doaj.org/article/a0e438a3cef045b6a78157d78619e54dTest

المؤلفون: Violeta Georgieva Tsonkova, Fredrik Wolfhagen Sand, Xenia Asbæk Wolf, Lars Groth Grunnet, Anna Kirstine Ringgaard, Camilla Ingvorsen, Louise Winkel, Mark Kalisz, Kevin Dalgaard, Christine Bruun, Johannes Josef Fels, Charlotte Helgstrand, Sven Hastrup, Fredrik Kryh Öberg, Erik Vernet, Michael Paolo Bastner Sandrini, Allan Christian Shaw, Carsten Jessen, Mads Grønborg, Jacob Hald, Hanni Willenbrock, Dennis Madsen, Rasmus Wernersson, Lena Hansson, Jan Nygaard Jensen, Annette Plesner, Tomas Alanentalo, Maja Borup Kjær Petersen, Anne Grapin-Botton, Christian Honoré, Jonas Ahnfelt-Rønne, Jacob Hecksher-Sørensen, Philippe Ravassard, Ole D. Madsen, Claude Rescan, Thomas Frogne

المصدر: Molecular Metabolism, Vol 8, Iss , Pp 144-157 (2018)

مصطلحات موضوعية: Internal medicine, RC31-1245

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2212877817308451Test; https://doaj.org/toc/2212-8778Test

الوصول الحر: https://doaj.org/article/87dc16429b2843beab1b7a3a86b28d77Test

المؤلفون: Thomas Frogne, Kathrine Beck Sylvestersen, Stefan Kubicek, Michael Lund Nielsen, Jacob Hecksher-Sørensen

المصدر: PLoS ONE, Vol 7, Iss 4, p e35233 (2012)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

العلاقة: http://europepmc.org/articles/PMC3324462?pdf=renderTest; https://doaj.org/toc/1932-6203Test

الوصول الحر: https://doaj.org/article/749381c5541343f3a69203eb7abae1d4Test

المؤلفون: Caterina Sturtzel, Florian M. Pauler, Jin Li, Thomas Penz, Jacob Hecksher-Sørensen, Thomas Frogne, Ekaterine Berishvili, Yufeng Zhang, Christian G. Riedel, Martin Distel, Shangyu Hong, Christoph Bock, Dirk Meyer, Ilke Sen, Thomas Heuser, Xiaocheng Liu, Stefan Kubicek, Marlene Brandstetter, Charlotte Barbieux, Tamara Casteels, Charles-Hugues Lardeau

المصدر: Molecular metabolism, Vol. 54 (2021) P. 101329
Molecular Metabolism
Molecular Metabolism, Vol 54, Iss, Pp 101329-(2021)

مصطلحات موضوعية: Adult, Male, Cell type, Cellular Dedifferentiation, Beta-cell dedifferentiation, medicine.medical_treatment, FOXO1, Biology, Loperamide, Mice, Insulin-Secreting Cells, medicine, Animals, Humans, Insulin, Progenitor cell, FoxO1 inhibitor, Internal medicine, Molecular Biology, Transcription factor, Zebrafish, Cells, Cultured, ddc:617, Forkhead Box Protein O1, Diabetes, Cell Biology, Cell Dedifferentiation, Middle Aged, Glucagon, biology.organism_classification, RC31-1245, Cell biology, Female, Original Article, Beta cell

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6979005f2039a97781a78d413edaa0e0Test
https://archive-ouverte.unige.ch/unige:155411Test

المؤلفون: Emilie Bricout-Neveu, Thomas Frogne, Raphael Scharfmann, Philippe Ravassard, Claude Rescan, Mads Grønborg, Ole D. Madsen, Marc Diedisheim, Olivier Albagli, Signe Ingvarsen, Jeannette S. Kirkegaard

المساهمون: HAL UPMC, Gestionnaire, Novo Nordisk A/S, University of Copenhagen = Københavns Universitet (UCPH), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Endocells, University of Copenhagen = Københavns Universitet (KU), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), University of Copenhagen ( KU ), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute ( ICM ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) -CHU Pitié-Salpêtrière [APHP], Institut Cochin ( UM3 (UMR 8104 / U1016) ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS )

المصدر: Journal of Clinical Investigation
Journal of Clinical Investigation, 2016, 126 (3), pp.1109-1113. ⟨10.1172/JCI83573⟩
Journal of Clinical Investigation, American Society for Clinical Investigation, 2016, 126 (3), pp.1109-1113. ⟨10.1172/JCI83573⟩
Journal of Clinical Investigation, American Society for Clinical Investigation, 2016, 126 (3), pp.1109-1113. 〈10.1172/JCI83573〉

مصطلحات موضوعية: 0301 basic medicine, Virus Integration, Xenotropic murine leukemia virus-related virus, Xenotransplantation, medicine.medical_treatment, Gene Expression, Endogenous retrovirus, Genome, Viral, Mice, SCID, Biology, Virus Replication, [ SDV.MP.VIR ] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Cell Line, Mice, 03 medical and health sciences, Retrovirus, Viral Envelope Proteins, Insulin-Secreting Cells, Murine leukemia virus, medicine, Animals, Humans, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Brief Report, HEK 293 cells, General Medicine, biology.organism_classification, Virology, Rats, 030104 developmental biology, Viral replication, Cell culture, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Heterografts

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa09b6f5794614b1960642c6501cb8ebTest
https://doi.org/10.1172/jci83573Test

المؤلفون: Rasmus Wernersson, Fredrik Wolfhagen Sand, Charlotte Helgstrand, Kevin Dalgaard, Jacob Hald, Anne Grapin-Botton, Sven Hastrup, Thomas Frogne, Jonas Ahnfelt-Rønne, Ole D. Madsen, Lena Hansson, Erik Vernet, Mark Kalisz, Dennis Madsen, Tomas Alanentalo, Mads Grønborg, Maja Borup Kjær Petersen, Fredrik Kryh Öberg, Michael Paolo Bastner Sandrini, Annette Plesner, Claude Rescan, Christian Honoré, Philippe Ravassard, Carsten Jessen, Louise Winkel, Camilla Ingvorsen, Xenia Asbæk Wolf, Hanni Willenbrock, Jan N. Jensen, Anna Kirstine Ringgaard, Christine Bruun, Violeta Georgieva Tsonkova, Jacob Hecksher-Sørensen, Johannes Josef Fels, Lars Groth Grunnet, Allan Christian Shaw

المساهمون: University of Copenhagen = Københavns Universitet (KU), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)

المصدر: Molecular metabolism
Molecular metabolism, Elsevier, 2018, 8, pp.144-157. ⟨10.1016/j.molmet.2017.12.007⟩
Molecular Metabolism
Molecular Metabolism, Vol 8, Iss, Pp 144-157 (2018)
Tsonkova, V G, Sand, F W, Wolf, X A, Grunnet, L G, Ringgaard, A K, Ingvorsen, C, Winkel, L, Kalisz, M, Dalgaard, K, Bruun, C, Fels, J J, Helgstrand, C, Hastrup, S, Öberg, F K, Vernet, E, Sandrini, M P B, Shaw, A C, Jessen, C, Grønborg, M, Hald, J, Willenbrock, H, Madsen, D, Wernersson, R, Hansson, L, Jensen, J N, Plesner, A, Alanentalo, T, Petersen, M B K, Grapin-Botton, A, Honoré, C, Ahnfelt-Rønne, J, Hecksher-Sørensen, J, Ravassard, P, Madsen, O D, Rescan, C & Frogne, T 2018, ' The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates ', Molecular Metabolism, vol. 8, pp. 144-157 . https://doi.org/10.1016/j.molmet.2017.12.007Test

مصطلحات موضوعية: 0301 basic medicine, [SDV.BIO]Life Sciences [q-bio]/Biotechnology, SI, Stimulation index, medicine.medical_treatment, EndoC-βH1, Proliferation, Cell Culture Techniques, Drug Evaluation, Preclinical, Mice, SCID, CytMix, Cytokine mixture, Mice, 0302 clinical medicine, Insulin-Secreting Cells, Insulin Secretion, Cells, Cultured, Chemistry, Bxv1, B10 xenotropic virus 1, EdU, 5-ethynyl-2′-deoxyuridine, 3. Good health, Cell biology, Cytokine, Original Article, Beta cell, Glucose stimulated insulin secretion, medicine.drug, lcsh:Internal medicine, Somatostatin signaling, Incretin, GSIS, Glucose stimulated insulin secretion, 030209 endocrinology & metabolism, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Cell Line, Diabetes Mellitus, Experimental, 03 medical and health sciences, GLP1R, GLP1 receptor, PACAP, Pituitary Adenylate Cyclase-Activating Polypeptides, medicine, Animals, Humans, Hypoglycemic Agents, Pseudoislets, lcsh:RC31-1245, sXBP1, spliced XBP1, Molecular Biology, IPGTT, Intraperitoneal glucose tolerance test, Insulin, SST, Somatostatin, BB, Bombesin, STZ, Streptozotocin, Cell Biology, Streptozotocin, SSTR, Somatostatin receptor, SEM, Standard error of the mean, 030104 developmental biology, Cell culture, Apoptosis, Unfolded protein response, Ex4, Exendin-4

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cb3e641ee305f9db5f81e09f4ed88e7Test
https://hal.sorbonne-universite.fr/hal-02018209/documentTest

المؤلفون: Sara Sdelci, Tibor Harkany, Keiryn L. Bennett, Kilian Huber, Patrick Collombat, Christian Honoré, Florian M. Pauler, Matthias Farlik, Ekaterine Berishvili, Monica Courtney, Igor Baburin, Stefan Kubicek, Nicole Schmitner, Jin Li, Steffen Hering, Peter Májek, Jacob Hecksher-Sørensen, Thierry Sulpice, Martin Distel, Robin A. Kimmel, Charles-Hugues Lardeau, Manuela Gridling, Johanna Klughammer, Camilla Ingvorsen, Alexey Stukalov, Christoph Bock, Andhira Vieira, François Briand, Giulio Superti-Furga, Roman A. Romanov, Thomas Frogne, Dirk Meyer, Caterina Sturtzel, Thomas Penz, Fabio Avolio, Katja Parapatics, Jacques Colinge, Andreas Spittler, Charlotte Barbieux, Tamara Casteels

المساهمون: Harbin Engineering University (HRBEU), Research Center for Molecular Medicine of the Austrian Academy of Sciences [Vienna, Austria] (CeMM ), Austrian Academy of Sciences (OeAW), CeMM Research Center for Molecular Medicine [Vienna, Austria], Novo Nordisk A/S , Danemark, Novo Nordisk, Institut de Biologie Valrose (IBV), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Institute for Research on Cancer and Aging, Nice (IRCAN), INSERM, U1081, CNRS UMR 7284, Nice, Innsbruck Medical University [Austria] (IMU), Leopold Franzens Universität Innsbruck - University of Innsbruck, Medizinische Universität Wien = Medical University of Vienna, Karolinska Institutet [Stockholm], Tumor Immunology [Vienna, Austria] (Children’s Cancer Research Institute), St. Anna Kinderkrebsforschung e.V. [Vienna, Austria], CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria, Physiological Chemistry, Biocenter, Am Hubland, Julius-Maximilians-Universität Würzburg [Wurtzbourg, Allemagne] (JMU), IBM PSSC Montpellier - Innovation Lab., IBM PSSC Montpellier, Physiogenex, University of Geneva [Switzerland], Geneva University Hospital (HUG), Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Children’s Cancer Research Institute [Vienna, Austria], University of Vienna [Vienna], Cancer Center Karolinska [Karolinska Institutet] (CCK), Directors's Laboratory, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark [Lyngby] (DTU)

المصدر: Cell
Cell, Elsevier, 2017, 168 (1-2), pp.86-100.e15. ⟨10.1016/j.cell.2016.11.010⟩
Cell, Vol. 168, No 1-2 (2017) pp. 86-100.e15

مصطلحات موضوعية: 0301 basic medicine, insulin secretion, Artemisinins/administration & dosage/pharmacology, β cell, Carrier Proteins/metabolism, Diabetes Mellitus/drug therapy, Mice, Single-cell analysis, Insulin-Secreting Cells, GABA-receptor signaling, Insulin, artemisinins, gamma-Aminobutyric Acid/metabolism, Cells, Cultured, Zebrafish, gamma-Aminobutyric Acid, pancreatic endocrine transdifferentiation, ddc:617, biology, diabetes, Protein Stability, Receptors, GABA-A/metabolism, Transdifferentiation, Diabetes Mellitus, Type 1/drug therapy/pathology, 3. Good health, Cell biology, medicine.anatomical_structure, Biochemistry, ARX translocation, Artemether, MESH: Animals, Disease models, animal, Insulin/Genetics, Signal transduction, Artemisinins/Pharmacology, Single-Cell Analysis, Signal Transduction, Cell type, regenerative medicine, chemical biology, [SDV.CAN]Life Sciences [q-bio]/Cancer, Cell Transdifferentiation/drug effects, Article, General Biochemistry, Genetics and Molecular Biology, Diabetes Mellitus, Experimental, Islets of Langerhans, 03 medical and health sciences, Genetic model, Protein Stability/drug effects, Diabetes Mellitus, medicine, Homeodomain Proteins/metabolism, Regeneration, Animals, Humans, Transcription Factors/metabolism, Transcription factor, Homeodomain Proteins, Insulin/genetics/metabolism, Gephyrin, Biochemistry, Genetics and Molecular Biology(all), Gene Expression Profiling, Pancreatic islets, Membrane Proteins, Islets of Langerhans/drug effects, Receptors, GABA-A, gephyrin, Rats, Disease Models, Animal, Diabetes Mellitus, Type 1, 030104 developmental biology, Cell Transdifferentiation, biology.protein, Membrane Proteins/metabolism, Carrier Proteins, Transcription Factors

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eebb27a89e331313da6daa3b1b61b868Test
https://hal.umontpellier.fr/hal-02284911Test

المؤلفون: Ida C Norrie, Ib J Christiansen, Katrine Sonne-Hansen, Thomas Frogne, Tove Kirkegaard, Rikke V. Benjaminsen, Kristina B. Emdal, Anne E. Lykkesfeldt

المصدر: Breast Cancer Research and Treatment. 121:601-613

مصطلحات موضوعية: Cancer Research, Morpholines, Estrogen receptor, Breast Neoplasms, Pharmacology, chemistry.chemical_compound, ErbB, Cell Line, Tumor, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, skin and connective tissue diseases, Fulvestrant, Protein kinase B, Estradiol, Estrogen Receptor alpha, Oncogene Proteins v-erbB, Antiestrogen, Oncology, chemistry, Drug Resistance, Neoplasm, Cancer research, Female, Growth inhibition, Signal transduction, Estrogen receptor alpha, Signal Transduction, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::776b7e93f3ecb4b1fe2972abd2ad9dcdTest
https://doi.org/10.1007/s10549-009-0506-yTest

المؤلفون: Tove Kirkegaard, Anne E. Lykkesfeldt, Thomas Frogne, Katrine L Henriksen, Katrine Sonne-Hansen

المصدر: Acta Oncologica. 47:795-801

مصطلحات موضوعية: Oncology, medicine.medical_specialty, Aromatase Inhibitors, business.industry, Endocrine therapy, Estrogen receptor, Breast Neoplasms, Hematology, General Medicine, medicine.disease, Response to treatment, Breast cancer, Estrogen Receptor Modulators, Hormone receptor, Internal medicine, Progesterone receptor, Biomarkers, Tumor, Humans, Medicine, Endocrine system, Female, Radiology, Nuclear Medicine and imaging, business, Prolonged treatment

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56822c1e43b330287adf9758140714f8Test
https://doi.org/10.1080/02841860802026993Test

المؤلفون: Thomas Frogne, Olaf-Georg Issinger, Iduna Fichtner, Christina Westmose Yde, Jan Stenvang, Anne E. Lykkesfeldt

المصدر: Yde, C W, Frogne, T, Lykkesfeldt, A E, Fichtner, I, Issinger, O-G & Stenvang, J 2007, ' Induction of cell death in antiestrogen resistant human breast cancer cells by the protein kinase CK2 inhibitor DMAT ', Cancer Letters, vol. 256, no. 2, pp. 229-237 . https://doi.org/10.1016/j.canlet.2007.06.010Test

مصطلحات موضوعية: Cancer Research, Programmed cell death, Time Factors, genetic structures, Polyunsaturated Alkamides, Antineoplastic Agents, Apoptosis, Breast Neoplasms, Biology, Transfection, Breast cancer, Estrogen Receptor Modulators, Cell Line, Tumor, medicine, Humans, Casein Kinase II, skin and connective tissue diseases, Fulvestrant, Cell Proliferation, Dose-Response Relationship, Drug, Estradiol, Antiestrogen, medicine.disease, eye diseases, Tamoxifen, Proto-Oncogene Proteins c-bcl-2, Oncology, Drug Resistance, Neoplasm, Cell culture, Caspases, Cancer cell, Cancer research, Benzimidazoles, Female, sense organs, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91af526143166028e3f6e55bf5afab3eTest
https://doi.org/10.1016/j.canlet.2007.06.010Test