التفاصيل البيبلوغرافية
| العنوان: |
Table_1_Butyrate and hexanoate-enriched triglycerides increase postprandrial systemic butyrate and hexanoate in men with overweight/obesity: A double-blind placebo-controlled randomized crossover trial.DOCX |
| المؤلفون: |
Thirza van Deuren (14325717), Lotte Smolders (14325720), Anita Hartog (3558266), Freek G. Bouwman (230180), Jens J. Holst (8921173), Koen Venema (260576), Ellen E. Blaak (10510529), Emanuel E. Canfora (10984797) |
| سنة النشر: |
2023 |
| مصطلحات موضوعية: |
Clinical and Sports Nutrition, Dietetics and Nutrigenomics, Nutritional Physiology, Public Nutrition Intervention, Nutrition and Dietetics not elsewhere classified, Food Chemistry and Molecular Gastronomy (excl. Wine), Food Nutritional Balance, Animal Nutrition, Crop and Pasture Nutrition, butyrate, hexanoate, obesity, metabolic health, short chain fatty acids |
| الوصف: |
Background Short chain fatty acids (SCFA) are increasingly recognized for their potential ability to alleviate obesity-associated chronic low-grade inflammation and disturbed energy homeostasis. Evidence suggests that an increase in circulating SCFA might be necessary to induce beneficial alterations in energy metabolism. Objective To compare the bioaccessibility of two different SCFA-enriched triglycerides: Akovita SCT (butyrate and hexanoate esterified with long chain fatty acids) and tributyrin/caproin (solely butyrate and hexanoate) and investigate whether the SCFA from orally administrated Akovita SCT reach the circulation and affect postprandial metabolism in men with overweight/obesity. Methods The site, speed, and amount of SCFA release from Akovita SCT and tributyrin/caproin were assessed in a validated In vitro Model of the stomach and small intestine (TIM-1). Subsequently, a double-blind placebo-controlled randomized crossover study was conducted at Maastricht University with fourteen men with overweight/obesity (BMI 25–35 kg/m 2 ) of which twelve men finished all testdays and were included for analysis. The participants received a liquid high fat mixed meal test containing either a low (650 mg), medium (1,325 mg), or high dose (2,000 mg) of Akovita SCT or a placebo (sunflower oil) in randomized order. Blood was sampled at baseline and after ingestion for 6 h for the primary outcome plasma butyrate and hexanoate concentration. Secondary outcomes included hydrogen breath, appetite, gastrointestinal complaints, circulating glucagon-like peptide 1, free fatty acids, glucose, triglycerides, insulin, and cytokines concentrations. Results In TIM-1, tributyrin/caproin was rapidly cleaved in the gastric compartment whereas the release of SCFA from Akovita SCT occurred predominantly in the small intestine. In vivo, all doses were well-tolerated. The medium dose increased (P < 0.05) and the high dose tended to increase (P < 0.10) postprandial circulating butyrate and both doses increased circulating ... |
| نوع الوثيقة: |
dataset |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/dataset/Table_1_Butyrate_and_hexanoate-enriched_triglycerides_increase_postprandrial_systemic_butyrate_and_hexanoate_in_men_with_overweight_obesity_A_double-blind_placebo-controlled_randomized_crossover_trial_DOCX/21812844Test |
| DOI: |
10.3389/fnut.2022.1066950.s001 |
| الإتاحة: |
https://doi.org/10.3389/fnut.2022.1066950.s001Test |
| حقوق: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.115B1A42 |
| قاعدة البيانات: |
BASE |
