دورية أكاديمية
Expression of cytotoxic mediators (perforin, granzyme B, FAS, and FAS-l) in renal allograft biopsies
| العنوان: | Expression of cytotoxic mediators (perforin, granzyme B, FAS, and FAS-l) in renal allograft biopsies |
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| المؤلفون: | Therezinha Gauri Leitão, Luís Eduardo Becker, Ivone Braga de Oliveira, Flávia Ramos de Siqueira, Maria Regina Teixeira Araújo, João Egídio Romão Junior, Hugo Abensur, Irene de Lourdes Noronha |
| المصدر: | Einstein (São Paulo), Vol 4, Iss 4, Pp 277-283 (2006) |
| بيانات النشر: | Instituto Israelita de Ensino e Pesquisa Albert Einstein, 2006. |
| سنة النشر: | 2006 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | Kidney transplantation/immunology, Kidney/pathology, Immunohistochemistry, Antigens, CD95, Graft rejection, Medicine |
| الوصف: | Objectives: To analyze the in situ expression of perforin, granzymeB, FAS-L and FAS in renal allograft biopsies by means ofimmunohistochemistry and correlate these findings with the degreeof histologic rejection and allograft outcome. Methods: Ninety-sixallograft biopsies were divided into three groups: acute rejection (n= 56), chronic rejection (n = 31), and cases with stable renal function(no rejection; n = 9). The expression of perforin, granzyme B, FAS-L,and FAS was evaluated by immunohistochemistry. Results: Asignificantly higher expression of perforin and granzyme B wasobserved in acute rejection biopsies (4.83 ± 0.65 and 30.05 ± 7.93cells/mm2) compared to chronic rejection biopsies (0.71 ± 0.13 and11.4 ± 3.84 cells/mm2; p < 0.001, and p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Portuguese |
| تدمد: | 1679-4508 |
| العلاقة: | http://www.einstein.br/revista/arquivos/PDF/Einstein_vol4_n4_2006_p277.pdfTest; https://doaj.org/toc/1679-4508Test |
| الوصول الحر: | https://doaj.org/article/b91fd6496c894b0880ca954e94ce2047Test |
| رقم الانضمام: | edsdoj.b91fd6496c894b0880ca954e94ce2047 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 16794508 |
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