المؤلفون: Anagha Krishna, Thaddeus S. Stappenbeck, Xiaohua Jin, Ron Bose, Elisa M. Murray, Takahiro E. Ohara, Xiaoqing Cheng

المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 1105-1120 (2021)

مصطلحات موضوعية: 0301 basic medicine, Genetically modified mouse, Colorectal cancer, Receptor, ErbB-2, Transgene, Crypt, Adenomatous Polyposis Coli Protein, Mice, Transgenic, RC799-869, Biology, Stem cell marker, 03 medical and health sciences, Mice, 0302 clinical medicine, Tg, transgenic, Gene expression, medicine, Animals, Intestinal Mucosa, TALEN, transcription activator-like effector nucleases, HER, human epidermal growth factor receptor, Original Research, Gene Editing, Colorectal Cancer, Mucin-2, Hyperplasia, Hepatology, Gastroenterology, Intermediate Cells, APC, adenomatous polyposis coli, Diseases of the digestive system. Gastroenterology, medicine.disease, Molecular biology, Intestinal epithelium, Epithelium, mRNA, messenger RNA, qRT-PCR, quantitative reverse-transcription polymerase chain reaction, EGFR, epidermal growth factor receptor, 030104 developmental biology, medicine.anatomical_structure, Editorial, Matrix Metalloproteinase 7, Mutation, CRC, colorectal cancer, 030211 gastroenterology & hepatology, Intestinal Organoids, MAPK, mitogen-activated protein kinase

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d6ffa0c444bfacb709541dc4fc8a4d5Test
http://europepmc.org/articles/PMC8350008Test

المؤلفون: Norbert Frey, Lucie Carrier, Franziska Dierck, Frauke Senger, Gabriele Brunke, Christian Kuhn, Nesrin Schmiedel, Ashraf Yusuf Rangrez, Derk Frank, Susanne Hille, Rainer Will, Samuel Sossalla, Maja Menke, Thomas Eschenhagen, Renate Lüllmann-Rauch, Inga Schmidt, Pia Bünger, Claudia Mack

المصدر: JACC: Basic to Translational Science

مصطلحات موضوعية: 0301 basic medicine, Cardiac function curve, Genetically modified mouse, autophagy, NRCM, neonatal rat cardiomyocytes, mRNA, messenger ribonucleic acid, heart failure, 030204 cardiovascular system & hematology, 03 medical and health sciences, Cellular degradation, RFP, red fluorescent protein, 0302 clinical medicine, In vivo, TG, transgenic, BFA, bafilomycin A1, medicine, FYCO1, GFP, green fluorescent protein, Pressure overload, KO, knockout, business.industry, Autophagy, microRNA, micro–ribonucleic acid, medicine.disease, WT, wild-type, Cell biology, Glucose deprivation, 030104 developmental biology, Heart failure, CSA, cell surface area, Preclinical Research, TAC, transverse aortic constriction, Cardiology and Cardiovascular Medicine, business, MHC, myosin heavy chain

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b8e5357537596081286716a9a13fac0Test
http://europepmc.org/articles/PMC8093479Test

المؤلفون: Tram Anh Tran, Qing-Jun Zhang, Lei Wang, Christopher Gonzales, Luc Girard, Herman May, Thomas Gillette, Zhi-Ping Liu, Elisabeth D. Martinez

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: Cardiomyopathy, Dilated, Jumonji Domain-Containing Histone Demethylases, Jumonji enzymes, IgG, immunoglobulin G, HDAC, histone deacetylase, Biochemistry, CnA, calcineurin A, Histones, Small Molecule Libraries, MEF2, myocyte enhancer factor 2, Mice, cDNA, complementary DNA, transcriptional reprogramming, GSEA, gene set enrichment analysis, Tg, transgenic, GO, Gene Ontology, TSA, trichostatin A, Animals, Humans, GEO, Gene Expression Omnibus, Enzyme Inhibitors, calcineurin, Molecular Biology, KO, knock-out, H3K9me3, trimethylation of histone 3 lysine 9, Histone Demethylases, TAC, transaortic constriction, Lysine, UTSW, UT Southwestern, HRP, horseradish peroxidase, mTORC1, mammalian target of rapamycin complex 1, Cell Biology, NFAT, nuclear factor of activated T-cell, H3K4me3, trimethylation of histone 3 lysine 4, JIB-04, LVAD, left ventricular assist device, cardiomyopathy, small-molecule inhibitor, EMT, epithelial-to-mesenchymal transition, MHC, myosin heavy chain, Research Article, KDM, histone lysine demethylase

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::112f854788555475bb177a80293d9bd2Test
https://pubmed.ncbi.nlm.nih.gov/34933013Test

المؤلفون: Romil Saxena, Wenjie Cai, Yang Zhang, Menghao Huang, Xiaolin Zhong, Kushan Chowdhury, Robert F. Schwabe, Suthat Liangpunsakul, Hyeong-Geug Kim, X. Charlie Dong

المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 2, Pp 341-364 (2020)
Cellular and Molecular Gastroenterology and Hepatology

مصطلحات موضوعية: Liver Cirrhosis, 0301 basic medicine, Steatosis, Nonalcoholic Steatohepatitis, Pathogenesis, PCR, polymerase chain reaction, 0302 clinical medicine, SMAD3, SMAD family member 3, Fibrosis, Sirtuin 6, Sirtuins, Original Research, GFP, green fluorescent protein, WD, Western diet, Fatty liver, Gastroenterology, SIRT6, sirtuin 6, HSC, hepatic stellate cell, mRNA, messenger RNA, ChIP, chromatin immunoprecipitation, Sirtuin, shRNA, short hairpin RNA, TGFB, transforming growth factor β, 030211 gastroenterology & hepatology, Lrat, lecithin retinol acyltransferase, medicine.symptom, NASH, nonalcoholic steatohepatitis, SIRT6, Deacetylation, PBS, phosphate-buffered saline, Inflammation, Biology, 03 medical and health sciences, ALT, alanine aminotransferase, Tg, transgenic, Hepatic Stellate Cells, medicine, Humans, lcsh:RC799-869, KO, knockout, Hepatology, medicine.disease, WT, wild-type, digestive system diseases, 030104 developmental biology, Cancer research, biology.protein, Hepatic stellate cell, DMEM, Dulbecco’s modified Eagle medium, lcsh:Diseases of the digestive system. Gastroenterology, NAFLD, nonalcoholic fatty liver disease, HA, hemagglutinin, Transforming growth factor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e993c50fadc362faaa1fba27859fd85Test
http://www.sciencedirect.com/science/article/pii/S2352345X20300497Test

المؤلفون: Tomohide Kurahashi, Satoshi Ogura, Takahiro Kodama, Yoshihiro Kamada, I-Ching Wang, Ryotaro Sakamori, Yuichiro Doki, Eiichi Morii, Kunimaro Furuta, Mayumi Egawa, Masaki Mori, Yuichi Yoshida, Hidetoshi Eguchi, Tomohide Tatsumi, Tetsuo Takehara, Shinichi Kiso, Hayato Hikita, Vladimir V. Kalinichenko

المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 3, Pp 425-446 (2020)
Cellular and Molecular Gastroenterology and Hepatology

مصطلحات موضوعية: bp, base pair, 0301 basic medicine, Chemokine, Tet, tetracycline, Mice, 0302 clinical medicine, GalNAc, N-acetylgalactosamine, TG, transgenic, CCl4, carbon tetrachloride, HFHC, high-fat/high-cholesterol, Original Research, Liver injury, biology, Liver Neoplasms, Gastroenterology, CCL2, chemokine (C-C motif) ligand 2, medicine.anatomical_structure, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, Hepatocyte, Hepatocellular carcinoma, AS, antisense, 030211 gastroenterology & hepatology, FoxM1, Forkhead Box M1 transcription factor, medicine.symptom, CCL2, Transgene, DOX, doxycycline, PBS, phosphate-buffered saline, Inflammation, 03 medical and health sciences, RT-PCR, reverse transcription polymerase chain reaction, ALT, alanine aminotransferase, medicine, Animals, lcsh:RC799-869, Hepatology, business.industry, medicine.disease, WT, wild-type, Fibrosis, 030104 developmental biology, S, sense, FoxM1, Hepatocytes, Cancer research, FOXM1, biology.protein, lcsh:Diseases of the digestive system. Gastroenterology, NPC, nonparenchymal cell, HCC, hepatocellular carcinoma, business, TUNEL, terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick end labeling, Liver Inflammation, Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1403d8cda7ea7dc20a251ac03e8852adTest
https://doi.org/10.1016/j.jcmgh.2019.10.008Test

المؤلفون: Hae Li Ko, Kyung Won Kang, Manki Song, Sang-Myeong Lee, Hye-Lim Park, Jae-Ouk Kim, Hye-Jung Kim, Jae-Hwan Nam, Eui-Cheol Shin, Hye Won Kwak, Seung Rok Ryu, Hyo Jung Park, Dae Gwin Jeong, Rhoon-Ho Kim, Min Ho Cha, Hun Kim

المصدر: Vaccine

مصطلحات موضوعية: CD4-Positive T-Lymphocytes, ELISPOT, enzyme-linked immunospot, dLN, draining lymph node, T-Lymphocytes, medicine.medical_treatment, Tfh, follicular helper T, CoV, coronavirus, CD8-Positive T-Lymphocytes, Antibodies, Viral, Mice, 0302 clinical medicine, IRES, 030212 general & internal medicine, Th1/Th2, Alum, Cells, Cultured, Adjuvant, Mice, Inbred BALB C, TNF, tumor necrosis factor, RIG-I, Chemotaxis, ELISA, enzyme-linked immunosorbent assay, Flow Cytometry, CrPV, Th2, T helper 2, NAbs, neutralizing antibodies, IGR, intergenic region, Infectious Diseases, Dicistroviridae, Molecular Medicine, Female, RIG, retinoic acid-inducible gene, DCs, dendritic cells, TLR, Toll-like receptor, PRNT, plaque-reduction neutralization test, HPV, 030231 tropical medicine, Enzyme-Linked Immunosorbent Assay, HPV, human papillomavirus, Internal Ribosome Entry Sites, Biology, CrPV, Cricket paralysis virus, Article, 03 medical and health sciences, Th2 Cells, Immune system, Adjuvants, Immunologic, MERS, Immunity, Tg, transgenic, medicine, Animals, Humans, IFN, interferon, ssRNAs, single-stranded RNAs, IRESs, internal ribosome entry sites, General Veterinary, General Immunology and Microbiology, fungi, MERS, Middle East respiratory syndrome, Public Health, Environmental and Occupational Health, RNA, TLR7, Th1 Cells, Vaccine efficacy, WT, wild-type, Virology, Immunity, Innate, IL, interleukin, Mice, Inbred C57BL, PFUs, plaque-forming units, APCs, Antigen presenting cells, hPBMCs, human peripheral blood mononuclear cells, VLP, virus-like particle, Myd88, myeloid differentiation primary response 88, Leukocytes, Mononuclear, Vaccine, Leukocyte chemotaxis

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56bee6776ec07d79debcbc88725f48c1Test
https://doi.org/10.1016/j.vaccine.2019.07.070Test

المؤلفون: Aaron J. Donner, Rosanne M. Crooke, Adam E. Mullick, Richard G. Lee, Mingxia Liu, Thomas A. Bell

المصدر: Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100101-(2021)

مصطلحات موضوعية: Endothelial lipase, antisense oligonucleotide, EL, endothelial lipase, Biochemistry, chemistry.chemical_compound, Mice, Endocrinology, ANGPTL3, cardiovascular disease, RCT, reverse cholesterol transport, Hyperlipidemia, hyperlipidemia, LOF, loss-of-function, chemistry.chemical_classification, Mice, Knockout, WD, Western diet, Reverse cholesterol transport, tg, transgenic, lipids (amino acids, peptides, and proteins), ASCVD, atherosclerotic cardiovascular disease, coronary artery disease, Research Article, medicine.medical_specialty, HDL, Transgene, ASO, antisense oligonucleotide, QD415-436, ANGPTL3, angiopoietin-like protein 3, TPC, total plasma cholesterol, lipids, Internal medicine, medicine, Animals, Humans, Loss function, Angiopoietin-Like Protein 3, LSC, liquid scintillation counting, 3H-CHE, 3H-cholesteryl hexadecyl ether, FCR, fractional catabolic rate, Cholesterol, Cholesterol, HDL, cholesterol, Biological Transport, Cell Biology, FHBL2, familial combined hypobetalipoproteinemia, Oligonucleotides, Antisense, medicine.disease, reverse cholesterol transport, Mice, Inbred C57BL, Enzyme, chemistry, atherosclerosis

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a3dd6baedbaa871b44ae87791eadae9Test
http://europepmc.org/articles/PMC8417398Test

المؤلفون: Tirthadipa Pradhan-Sundd

المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 1199-1201 (2021)

مصطلحات موضوعية: Male, Arteriosclerosis, SREBP, sterol regulatory element-binding protein, CREB3L3, FGF21, fibroblast growth factor 21, Bioinformatics, CREB3L3, cAMP responsive element-binding protein 3 like 3, Mice, Enterohepatic Circulation, Cyclic AMP Response Element-Binding Protein, Insig, insulin-induced gene, Original Research, GFP, green fluorescent protein, Mice, Knockout, Sterol Regulatory Element Binding Proteins, TBA, total bile acid, WD, Western diet, TG, triglyceride, Chemistry, Gastroenterology, Editorial, Hyperlipidemia, LPL, lipoprotein lipase, Female, lipids (amino acids, peptides, and proteins), Sterol Regulatory Element Binding Protein 1, HDL, high-density lipoprotein, Hyperlipidemias, SREBP, ER, endoplasmic reticulum, Competition (economics), Tg, transgenic, FFA, free fatty acid, medicine, Animals, Humans, lcsh:RC799-869, KO, knockout, PPARα, peroxisome proliferator-activated receptor alpha, Hepatology, PLA, proximity ligation assay, S1P, site-1 protease, Lipogenesis, SREBF, sterol regulatory element-binding factor, VLDL, very-low-density lipoprotein, Atherosclerosis, Lipid Metabolism, medicine.disease, Sterol regulatory element-binding protein, Mice, Inbred C57BL, TC, total cholesterol, Gene Expression Regulation, Receptors, LDL, Apo, apolipoprotein, HPLC, high-performance liquid chromatography, HSV, herpes simplex virus, lcsh:Diseases of the digestive system. Gastroenterology, LXR, liver X receptor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b659cdeaf5713387b2f5a214c940ddfTest
https://doi.org/10.1016/j.jcmgh.2021.01.002Test

المؤلفون: Seema Singh, Fang Niu, Annadurai Thangaraj, Prakash P. Pillai, Shilpa Buch, Palsamy Periyasamy, Ernest T. Chivero, Minglei Guo, Ashutosh Tripathi

المصدر: Redox Biology, Vol 40, Iss, Pp 101843-(2021)
Redox Biol
Redox Biology

مصطلحات موضوعية: 0301 basic medicine, Clinical Biochemistry, TIMP3, tissue inhibitor of metalloproteinase-3, HIV Infections, medicine.disease_cause, Biochemistry, Mice, 0302 clinical medicine, Neuroinflammation, Sirtuin 3, Microglial activation, lcsh:QH301-705.5, lcsh:R5-920, Microglia, medicine.anatomical_structure, TAT, Trans-activator of transcription, tat Gene Products, Human Immunodeficiency Virus, Mitochondria stress, SA β-gal, senescence-associated beta-galactosidase, Corrigendum, lcsh:Medicine (General), Viral load, Research Paper, Senescence, SIRT3, HIVE, HIV infected patients with encephalopathy, HIV TAT, PBS, phosphate-buffered saline, Biology, Proinflammatory cytokine, PI, propidium iodide, 03 medical and health sciences, ROS, reactive oxygen species, Downregulation and upregulation, FBS, fetal bovine serum, Tg, transgenic, Gpx, glutathione peroxidase, medicine, Animals, 3′-UTR, 3′-untranslated regions, miRNA, SIRT3, Sirtuin-3, Organic Chemistry, cART, combined antiretroviral treatment, mPMs, mouse primary microglial cells, SOD2, superoxide dismutase-2, SASPs, senescence-associated secretory phenotypes, WT, wild-type, Rats, Oxidative Stress, 030104 developmental biology, lcsh:Biology (General), HAND, HIV-associated neurocognitive disorders, Cancer research, MMPs, matrix metalloproteinases, CAT, catalase, 030217 neurology & neurosurgery, Oxidative stress

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e66406faaf5105dd93747b37dca68a72Test
http://www.sciencedirect.com/science/article/pii/S221323172031048XTest

المؤلفون: George Gardner, Evangelia G. Kranias, Guo-Chang Fan, Guan-Sheng Liu, Jiang Qian, Yutian Li, Nathan Robbins, Kobra Haghighi, Jack Rubinstein, Burns C. Blaxall, Min Jiang, Joshua G. Travers

المصدر: JACC: Basic to Translational Science

مصطلحات موضوعية: inorganic chemicals, 0301 basic medicine, WT, wild type, STAT3, signal transducer and activator of transcription 3, heart failure, I/R, ischemia/reperfusion, 030204 cardiovascular system & hematology, environment and public health, TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling, fibroblast, Ccl2, C-C motif chemokine ligand 2, 03 medical and health sciences, Paracrine signalling, PRECLINICAL RESEARCH, 0302 clinical medicine, Downregulation and upregulation, In vivo, TG, transgenic, Col1a1, collagen 1A1, medicine, Hsp, heat shock protein, Col3A1, collagen 3A1, Fibroblast, Postn, periostin, TGF, transforming growth factor, remodeling, Hsp20, IL-6, TNF, tumor necrosis factor, business.industry, fungi, medicine.disease, 3. Good health, Cell biology, Blockade, ECM, extra-cellular matrix, IL, interleukin, enzymes and coenzymes (carbohydrates), 030104 developmental biology, medicine.anatomical_structure, Ccl3, C-C motif chemokine ligand 3, Heart failure, bacteria, Phosphorylation, SMA, smooth muscle actin, Cardiology and Cardiovascular Medicine, business, Ex vivo

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26181058fcf099bc40c4dd72e341bce2Test
http://europepmc.org/articles/PMC6488766Test