Increased cortisol metabolism in women with pregnancy-related hypertension
| العنوان: | Increased cortisol metabolism in women with pregnancy-related hypertension |
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| المؤلفون: | Anna Siemiątkowska, Agata Szpera-Goździewicz, Franciszek K. Główka, Grzegorz H Breborowicz, Katarzyna Kosicka, Mariola Krzyścin |
| المصدر: | Endocrine |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Gestational hypertension, medicine.medical_specialty, Hydrocortisone, Tetrahydrometabolites, Endocrinology, Diabetes and Metabolism, Urinary system, 030209 endocrinology & metabolism, Kidney, Cortisol, Preeclampsia, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Pre-Eclampsia, Limit of Detection, Pregnancy, 11-beta-Hydroxysteroid Dehydrogenase Type 2, Internal medicine, 11-beta-Hydroxysteroid Dehydrogenase Type 1, medicine, Humans, 5β-reductase, 030219 obstetrics & reproductive medicine, business.industry, Hypertension, Pregnancy-Induced, 11β-hydroxysteroid dehydrogenase, medicine.disease, Cortisone, medicine.anatomical_structure, Hypertension, Female, Original Article, business, hormones, hormone substitutes, and hormone antagonists, Glucocorticoid, medicine.drug |
| الوصف: | Purpose The diminished function of 11β-hydroxysteroid dehydrogenase 2 (11β-HSD2) was found in placentae from preeclamptic pregnancies. Here, we examine the overall maternal glucocorticoid balance in pregnancy-related hypertension. We aim to answer the question if the functions of primary enzymes involved in cortisol metabolism: 11β-HSD1 and 11β-HSD2 and 5-reductases (both 5α- and 5β) are altered in the course of hypertensive pregnancy. Methods We determined plasma and urinary cortisol and cortisone as well as their urinary tetrahydro- and allo-tetrahydrometabolites, both in free and conjugated forms in samples obtained from 181 Polish women in the third trimester of pregnancy. We compared steroid profiles in women with preeclampsia (PE), gestational hypertension (GH), chronic hypertension (CH) and in normotensives (controls). Results We found significant differences in glucocorticoid balance in pregnancy-related hypertension. Plasma cortisol to cortisone was significantly lower in PE than in controls (3.00 vs. 4.79; p |
| تدمد: | 1559-0100 1355-008X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eb0f5eea1630bd8cd84823a57b5f4d6Test https://doi.org/10.1007/s12020-018-1586-4Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0eb0f5eea1630bd8cd84823a57b5f4d6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15590100 1355008X |
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