التفاصيل البيبلوغرافية
| العنوان: |
Tg.AC Genetically Altered Mouse: Assay Working Group Overview of Available Data |
| المؤلفون: |
Eastin, William C., Mennear, John H., Tennant, Ray W., Stoll, Ray E., Branstetter, Dan G., Bucher, John R., Mccullough, Bruce, Binder, Robert L., Spalding, Judson W., Mahler, Joel F. |
| المصدر: |
Toxicologic Pathology ; volume 29, issue 1_suppl, page 60-80 ; ISSN 0192-6233 1533-1601 |
| بيانات النشر: |
SAGE Publications |
| سنة النشر: |
2001 |
| مصطلحات موضوعية: |
Cell Biology, Toxicology, Molecular Biology, Pathology and Forensic Medicine |
| الوصف: |
In a Government/Industry/Academic partnership to evaluate alternative approaches to carcinogenicity testing, 21 pharmaceutical agents representing a variety of chemical and pharmacological classes and possessing known human and or rodent carcinogenic potential were selected for study in several rodent models. The studies from this partnership project, coordinated by the International Life Sciences Institute, provide additional data to better understand the models' limitations and sensitivity in identifying carcinogens. The results of these alternative model studies were reviewed by members of Assay Working Groups (AWG) composed of scientists fromgovernmentand industry with expertise in toxicology, genetics, statistics, and pathology. The Tg.AC genetically manipulated mouse was one of the models selected for this project based on previous studies indicating that Tg.AC mice seem to respond to topical application of either mutagenic or nonmutagenic carcinogens with papilloma formation at the site of application. This communication describes the results and AWG interpretations of studies conducted on 14 chemicals administered by the topical and oral (gavage and/or diet) routes to Tg.AC genetically manipulated mice. Cyclosporin A, an immunosuppresant human carcinogen, ethinyl estradiol and diethylstilbestrol (human hormone carcinogens) and clofi brate, an hepatocarcinogenicperoxisome proliferator in rodents, were considered clearly positive in the topical studies. In the oral studies, ethinyl estradiol and diethylstilbestrol were negative, cyclosporin was considered equivocal, and results were not available for the clofibrate study. Of the 3 genotoxic human carcinogens (phenacetin, melphalan, and cyclophosphamide), phenacetin was negative by both the topical and oral routes. Melphalan and cyclophosphamide are, respectively, direct and indirect DNA alkylating agents and topical administration of both caused equivocal responses. With the exception of clofi brate, Tg.AC mice did not exhibit tumor responses to the rodent ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1080/019262301753178483 |
| الإتاحة: |
https://doi.org/10.1080/019262301753178483Test |
| حقوق: |
http://journals.sagepub.com/page/policies/text-and-data-mining-licenseTest |
| رقم الانضمام: |
edsbas.62EB3780 |
| قاعدة البيانات: |
BASE |
