التفاصيل البيبلوغرافية
| العنوان: |
Multicomponent intervention to prevent mobility disability in frail older adults:randomised controlled trial (SPRINTT project) |
| المؤلفون: |
Bernabei, R. (Roberto), Landi, F. (Francesco), Calvani, R. (Riccardo), Cesari, M. (Matteo), Del Signore, S. (Susanna), Anker, S. D. (Stefan D.), Bejuit, R. (Raphael), Bordes, P. (Philippe), Cherubini, A. (Antonio), Cruz-Jentoft, A. J. (Alfonso J.), Di Bari, M. (Mauro), Friede, T. (Tim), Ayestaran, C. G. (Carmen Gorostiaga), Goyeau, H. (Harmonie), Jonsson, P. V. (Palmi, V), Kashiwa, M. (Makoto), Lattanzio, F. (Fabrizia), Maggio, M. (Marcello), Mariotti, L. (Luca), Miller, R. R. (Ram R.), Rodriguez-Manas, L. (Leocadio), Roller-Wirnsberger, R. (Regina), Ryznarova, I. (Ingrid), Scholpp, J. (Joachim), Schols, A. M. (Annemie M. W. J.), Sieber, C. C. (Cornel C.), Sinclair, A. J. (Alan J.), Skalska, A. (Anna), Strandberg, T. (Timo), Tchalla, A. (Achille), Topinkova, E. (Eva), Tosato, M. (Matteo), Vellas, B. (Bruno), von Haehling, S. (Stephan), Pahor, M. (Marco), Roubenoff, R. (Ronenn), Marzetti, E. (Emanuele) |
| بيانات النشر: |
BMJ |
| سنة النشر: |
2022 |
| المجموعة: |
Jultika - University of Oulu repository / Oulun yliopiston julkaisuarkisto |
| الوصف: |
Objective: To determine whether a multicomponent intervention based on physical activity with technological support and nutritional counselling prevents mobility disability in older adults with physical frailty and sarcopenia. Design: Evaluator blinded, randomised controlled trial. Setting: 16 clinical sites across 11 European countries, January 2016 to 31 October 2019. Participants: 1519 community dwelling men and women aged 70 years or older with physical frailty and sarcopenia, operationalised as the co-occurrence of low functional status, defined as a short physical performance battery (SPPB) score of 3 to 9, low appendicular lean mass, and ability to independently walk 400 m. 760 participants were randomised to a multicomponent intervention and 759 received education on healthy ageing (controls). Interventions: The multicomponent intervention comprised moderate intensity physical activity twice weekly at a centre and up to four times weekly at home. Actimetry data were used to tailor the intervention. Participants also received personalised nutritional counselling. Control participants received education on healthy ageing once a month. Interventions and follow-up lasted for up to 36 months. Main outcome measures: The primary outcome was mobility disability (inability to independently walk 400 m in <15 minutes). Persistent mobility disability (inability to walk 400 m on two consecutive occasions) and changes from baseline to 24 and 36 months in physical performance, muscle strength, and appendicular lean mass were analysed as pre-planned secondary outcomes. Primary comparisons were conducted in participants with baseline SPPB scores of 3–7 (n=1205). Those with SPPB scores of 8 or 9 (n=314) were analysed separately for exploratory purposes. Results: Mean age of the 1519 participants (1088 women) was 78.9 (standard deviation 5.8) years. The average follow-up was 26.4 (SD 9.5) months. Among participants with SPPB scores of 3–7, mobility disability occurred in 283/605 (46.8%) assigned to the ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| الإتاحة: |
http://urn.fi/urn:nbn:fi-fe2022110964969Test |
| حقوق: |
info:eu-repo/semantics/openAccess ; © 2022 BMJ Publishing Group Ltd. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0Test/. ; https://creativecommons.org/licenses/by-nc/4.0Test/ |
| رقم الانضمام: |
edsbas.4458BD0A |
| قاعدة البيانات: |
BASE |
