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1دورية أكاديمية
المؤلفون: Ji Zeng, Shuying Fang, Jinquan Guo, Min Dong, Guo‐Bao Tian, Liang Tao
المصدر: mLife, Vol 3, Iss 1, Pp 14-20 (2024)
مصطلحات موضوعية: C. difficile, sporulation, TcdA, TcdB, toxin production, Microbiology, QR1-502
وصف الملف: electronic resource
العلاقة: https://doaj.org/toc/2770-100XTest
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2دورية أكاديمية
المؤلفون: D. Annie Doyle, Paul L. DeAngelis, Jimmy D. Ballard
المصدر: mSphere, Vol 9, Iss 4 (2024)
مصطلحات موضوعية: Clostridioides difficile, TcdB, calcium, chondroitin sulfate, Microbiology, QR1-502
وصف الملف: electronic resource
العلاقة: https://doaj.org/toc/2379-5042Test
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3دورية أكاديمية
المؤلفون: Ashleigh S. Paparella, Isabella Brew, Huynh A. Hong, William Ferriera, Simon Cutting, Farah Lamiable-Oulaidi, Michael Popadynec, Peter C. Tyler, Vern L. Schramm
مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Ecology, Immunology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, two murine models, glucocation transition state, multiple toxin variants, length toxin variants, important therapeutic targets, induced cell rounding, tcdb use udp, preventing recurring c, multiple tcdb variants, isofagomine inhibits tcda, sequence variants, isofagomine inhibits, important barrier, induced morbidity, tcdb across, protects tcdb, isofagomine treatment, isofagomine supports, isofagomine protects, isofagomine inhibition, threatening diarrhea
الإتاحة: https://doi.org/10.1021/acsinfecdis.3c00507.s001Test
https://figshare.com/articles/journal_contribution/Isofagomine_Inhibits_Multiple_TcdB_Variants_and_Protects_Mice_from_Clostridioides_difficile-Induced_Mortality/25196713Test -
4دورية أكاديمية
المؤلفون: Md Zahidul Alam, Rajat Madan
المصدر: Toxins, Vol 16, Iss 6, p 241 (2024)
مصطلحات موضوعية: Clostridioides difficile infection, C. difficile transferase (CDT), toxin A (TcdA) and toxin B (TcdB), GTPase proteins, pathogenicity locus (PaLoc), Medicine
وصف الملف: electronic resource
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5دورية أكاديمية
المصدر: International Journal of Molecular Sciences, Vol 25, Iss 9, p 5005 (2024)
مصطلحات موضوعية: VIC superfamily, pLIC family, TCDB, homology, bioinformatics, Biology (General), QH301-705.5, Chemistry, QD1-999
وصف الملف: electronic resource
العلاقة: https://www.mdpi.com/1422-0067/25/9/5005Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test
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6دورية أكاديمية
المؤلفون: Yuhang Shen, Shan Lin, Peijun You, Yu Chen, Yun Luo, Xiaojun Song, Yunbo Chen, Dazhi Jin
المصدر: Frontiers in Microbiology, Vol 15 (2024)
مصطلحات موضوعية: Clostridioides difficile, infection, colonization, real-time cell analysis, TcdB, Microbiology, QR1-502
وصف الملف: electronic resource
العلاقة: https://www.frontiersin.org/articles/10.3389/fmicb.2024.1348892/fullTest; https://doaj.org/toc/1664-302XTest
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7دورية أكاديمية
المؤلفون: Aminzadeh, Aria, Hilgers, Luuk, Paul Platenburg, Peter, Riou, Mickaël, Perrot, Noémie, Rossignol, Christelle, Cauty, Axel, Barc, Céline, Jørgensen, René
المصدر: Aminzadeh , A , Hilgers , L , Paul Platenburg , P , Riou , M , Perrot , N , Rossignol , C , Cauty , A , Barc , C & Jørgensen , R 2024 , ' Immunogenicity and safety in rabbits of a Clostridioides difficile vaccine combining novel toxoids and a novel adjuvant ' , Vaccine , vol. 42 , no. 7 , pp. 1582-1592 . https://doi.org/10.1016/j.vaccine.2024.01.076Test
مصطلحات موضوعية: Alum, Carbohydrate fatty acid monosulphate esters, CDI, Clostridioides difficile, Clostridium difficile, CMS, CMS adjuvant, Rabbits, TcdA, TcdB, Toxins, Vaccine
وصف الملف: application/pdf
الإتاحة: https://doi.org/10.1016/j.vaccine.2024.01.076Test
https://forskning.ruc.dk/da/publications/15579d70-71b1-455f-8ea0-83c6c01ab9afTest
https://hdl.handle.net/1800/15579d70-71b1-455f-8ea0-83c6c01ab9afTest
https://rucforsk.ruc.dk/ws/files/100468173/1-s2.0-S0264410X24001014-main.pdfTest -
8دورية أكاديمية
المؤلفون: K. E. Popruga, V. V. Makarov, К. Э. Попруга, В. В. Макаров
المصدر: Journal Infectology; Том 15, № 4 (2023); 35-41 ; Журнал инфектологии; Том 15, № 4 (2023); 35-41 ; 2072-6732 ; 10.22625/2072-6732-2023-15-4
مصطلحات موضوعية: наноантитела, TcdA, TcdB, immunotherapy, monoclonal antibodies, bezlotoxumab, nanobodies, иммунотерапия, моноклональные антитела, безлотоксумаб
وصف الملف: application/pdf
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Incidence and Outcomes Associated With Clostridium difficile Infections // JAMA Netw. Open. 2020. Vol. 3, № 1. P. e1917597.; Hall A.J. et al. The Roles of Clostridium difficile and Norovirus Among Gastroenteritis-Associated Deaths in the United States, 1999–2007 // Clin. Infect. Dis. 2012. Vol. 55, № 2. P. 216–223.; Dubberke E.R., Olsen M.A. Burden of Clostridium difficile on the Healthcare System // Clin. Infect. Dis. 2012. Vol. 55, № suppl_2. P. S88–S92.; Филь Т.С. Стратификация факторов риска развития антибиотикоассоциированной диареи: автореф. дис. . канд. наук 2017.; Nikolaeva I. V. et al. Clostridioides (Clostridium) difficile infection. Review of current clinical guidelines // Pract. Med. 2020. Vol. 18, № 6. P. 106–112.; Hensgens M.P.M. et al. Time interval of increased risk for Clostridium difficile infection after exposure to antibiotics // J. Antimicrob. Chemother. 2012. Vol. 67, № 3. P. 742–748.; Theriot C.M., Young V.B. Interactions Between the Gastrointestinal Microbiome and Clostridium difficile // Annu. Rev. Microbiol. 2015. Vol. 69, № 1. P. 445–461.; Theriot C.M. et al. Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infection // Nat. Commun. 2014. Vol. 5, № 1. P. 3114.; Owens, Jr. R.C. et al. Antimicrobial-Associated Risk Factors for Clostridium difficile Infection // Clin. Infect. Dis. 2008. Vol. 46, № s1. P. S19–S31.; Surawicz C.M. et al. Guidelines for Diagnosis, Treatment, and Prevention of Clostridium difficile Infections // Am. J. Gastroenterol. 2013. Vol. 108, № 4. P. 478–498.; Debast S.B., Bauer M.P., Kuijper E.J. European Society of Clinical Microbiology and Infectious Diseases: Update of the Treatment Guidance Document for Clostridium difficile Infection // Clin. Microbiol. Infect. 2014. Vol. 20. P. 1–26.; McFarland L. V. et al. Recurrent Clostridium Difficile Disease: Epidemiology and Clinical Characteristics // Infect. Control Hosp. Epidemiol. 1999. Vol. 20, № 01. P. 43–50.; Ghantoji S.S. et al. Economic healthcare costs of Clostridium difficile infection: a systematic review // J. Hosp. Infect. 2010. Vol. 74, № 4. P. 309–318.; Kuehne S.A. et al. The role of toxin A and toxin B in Clostridium difficile infection // Nature. 2010. Vol. 467, № 7316. P. 711–713.; Aktories K. Bacterial protein toxins that modify host regulatory GTPases // Nat. Rev. Microbiol. 2011. Vol. 9, № 7. P. 487–498.; Pruitt R.N. et al. Structural organization of the functional domains of Clostridium difficile toxins A and B // Proc. Natl. Acad. Sci. 2010. Vol. 107, № 30. P. 13467–13472.; Kordus S.L., Thomas A.K., Lacy D.B. Clostridioides difficile toxins: mechanisms of action and antitoxin therapeutics // Nat. Rev. Microbiol. 2022. Vol. 20, № 5. P. 285–298.; Chen P. et al. Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection // Nat. Commun. 2021. Vol. 12, № 1. P. 3748.; Kyne L. et al. Asymptomatic Carriage of Clostridium difficile and Serum Levels of IgG Antibody against Toxin A // N. Engl. J. Med. 2000. Vol. 342, № 6. P. 390–397.; Kyne L. et al. Association between antibody response to toxin A and protection against recurrent Clostridium difficile diarrhoea // Lancet. 2001. Vol. 357, № 9251. P. 189–193.; Leav B.A. et al. Serum anti-toxin B antibody correlates with protection from recurrent Clostridium difficile infection (CDI) // Vaccine. 2010. Vol. 28, № 4. P. 965–969.; Raeisi H. et al. Application of recombinant antibodies for treatment of Clostridioides difficile infection: Current status and future perspective // Front. Immunol. 2022. Vol. 13.; Wilcox M.H. et al. Bezlotoxumab for Prevention of Recurrent Clostridium difficile Infection // N. Engl. J. Med. 2017. Vol. 376, № 4. P. 305–317.; Rupnik M. Heterogeneity of large clostridial toxins: importance of Clostridium difficile toxinotypes // FEMS Microbiol. Rev. 2008. Vol. 32, № 3. P. 541–555.; Shen E. et al. Subtyping analysis reveals new variants and accelerated evolution of Clostridioides difficile toxin B // Commun. Biol. 2020. Vol. 3, № 1. P. 347.; Hernandez L.D. et al. Broad Coverage of Genetically Diverse Strains of Clostridium difficile by Actoxumab and Bezlotoxumab Predicted by In Vitro Neutralization and Epitope Modeling // Antimicrob. Agents Chemother. 2015. Vol. 59, № 2. P. 1052–1060.; Orrell K.E., Melnyk R.A. Large Clostridial Toxins: Mechanisms and Roles in Disease // Microbiol. Mol. Biol. Rev. 2021. Vol. 85, № 3.; Lyras D. et al. Toxin B is essential for virulence of Clostridium difficile // Nature. 2009. Vol. 458, № 7242. P. 1176–1179.; Drudy D., Fanning S., Kyne L. Toxin A-negative, toxin B-positive Clostridium difficile // Int. J. Infect. Dis. 2007. Vol. 11, № 1. 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Camelid single-domain antibody-fragment engineering for (pre)clinical in vivo molecular imaging applications: adjusting the bullet to its target // Expert Opin. Biol. Ther. 2013. Vol. 13, № 8. P. 1149–1160.; Arbabi-Ghahroudi M., Tanha J., MacKenzie R. Prokaryotic expression of antibodies // Cancer Metastasis Rev. 2005. Vol. 24, № 4. P. 501–519.; Dmitriev O.Y., Lutsenko S., Muyldermans S. Nanobodies as Probes for Protein Dynamics in Vitro and in Cells // J. Biol. Chem. 2016. Vol. 291, № 8. P. 3767–3775.; Ackaert C. et al. Immunogenicity Risk Profile of Nanobodies // Front. Immunol. 2021. Vol. 12.; Unger M. et al. Selection of Nanobodies that Block the Enzymatic and Cytotoxic Activities of the Binary Clostridium Difficile Toxin CDT // Sci. Rep. 2015. Vol. 5, № 1. P. 7850.; Greco A. et al. Carbohydrate recognition by Clostridium difficile toxin A // Nat. Struct. Mol. Biol. 2006. Vol. 13, № 5. P. 460–461.; Hussack G. et al. 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الإتاحة: https://doi.org/10.22625/2072-6732-2023-15-4-35-41Test
https://doi.org/10.22625/2072-6732-2023-15-4Test
https://journal.niidi.ru/jofin/article/view/1565Test -
9دورية أكاديمية
المؤلفون: Diane Sapa, Anaïs Brosse, Héloïse Coullon, Gauthier Péan de Ponfilly, Thomas Candela, Alban Le Monnier
المصدر: Toxins, Vol 16, Iss 1, p 38 (2024)
مصطلحات موضوعية: Clostridioides difficile, toxin, recombinant protein, cytotoxic activity, TcdA, TcdB, Medicine
العلاقة: https://www.mdpi.com/2072-6651/16/1/38Test; https://doaj.org/toc/2072-6651Test; https://doaj.org/article/3f1bd010598a43268634dfcc1d0e47a9Test
الإتاحة: https://doi.org/10.3390/toxins16010038Test
https://doaj.org/article/3f1bd010598a43268634dfcc1d0e47a9Test -
10دورية أكاديمية
المؤلفون: Chen, Baohua, Perry, Kay, Jin, Rongsheng
مصطلحات موضوعية: Medical Microbiology, Biomedical and Clinical Sciences, Digestive Diseases, Infectious Diseases, Prevention, Immunization, Vaccine Related, Emerging Infectious Diseases, Infection, Animals, Bacterial Toxins, Clostridioides difficile, Single-Domain Antibodies, Epitopes, C, difficile infection, TcdA, TcdB, large clostridial glucosylating toxin, VHH, antibody, antitoxin, C. difficile infection, Immunology, Biochemistry and cell biology, Genetics
وصف الملف: application/pdf
الوصول الحر: https://escholarship.org/uc/item/6st547wgTest