دورية أكاديمية
The impact of ischemia-reperfusion injuries on skin resident murine dendritic cells
| العنوان: | The impact of ischemia-reperfusion injuries on skin resident murine dendritic cells |
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| المؤلفون: | Goh, CC, Evrard, M, Chong, SZ, Tan, Y, Tan, LDL, Teng, KWW, Weninger, W, Becker, DL, Tey, HL, Newell, EW, Liu, B, Ng, LG |
| بيانات النشر: | WILEY |
| سنة النشر: | 2018 |
| المجموعة: | The University of Melbourne: Digital Repository |
| الوصف: | Pressure ulcers are a chronic problem for patients or the elderly who require extended periods of bed rest. The formation of ulcers is due to repeated cycles of ischemia-reperfusion (IR), which initiates an inflammatory response. Advanced ulcers disrupt the skin barrier, resulting in further complications. To date, the immunological aspect of skin IR has been understudied, partly due to the complexity of the skin immune cells. Through a combination of mass cytometry, confocal imaging and intravital multiphoton imaging, this study establishes a workflow for multidimensionality single cell analysis of skin myeloid cell responses in the context of IR injury with high spatiotemporal resolution. The data generated has provided us with previously uncharacterized insights into the distinct cellular behavior of resident dendritic cells (DCs) and recruited neutrophils post IR. Of interest, we observed a drop in DDC numbers in the IR region, which was subsequently replenished 48h post IR. More importantly, in these cells, we observe an attenuated response to repeated injuries, which may have implications in the subsequent wound healing process. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0014-2980 1521-4141 |
| العلاقة: | Goh, C. C., Evrard, M., Chong, S. Z., Tan, Y., Tan, L. D. L., Teng, K. W. W., Weninger, W., Becker, D. L., Tey, H. L., Newell, E. W., Liu, B. & Ng, L. G. (2018). The impact of ischemia-reperfusion injuries on skin resident murine dendritic cells. EUROPEAN JOURNAL OF IMMUNOLOGY, 48 (6), pp.1014-1019. https://doi.org/10.1002/eji.201747347Test.; http://hdl.handle.net/11343/283735Test |
| الإتاحة: | https://doi.org/10.1002/eji.201747347Test http://hdl.handle.net/11343/283735Test |
| رقم الانضمام: | edsbas.12AD52AF |
| قاعدة البيانات: | BASE |
| تدمد: | 00142980 15214141 |
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