المؤلفون: Lu Feng, Kai Zhang, Bo Liu, Tingting Jiang, Liang Ouyang, Guan Wang, Jiamei Li, Shiou Zhu, Junping Pei

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 3015-3034 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: Target, ONRs, orphan nuclear receptors, Parkinson's disease, Small-molecule compound, MPP+, 1-methyl-4-phenylpyridinium, Autolysosome, GAPDH, glyceraldehyde 3-phosphate dehydrogenase, GBA, glucocerebrosidase β acid, Review, MPTP, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine, Disease, mTORC1, mTOR, the mammalian target of rapamycin, PD, Parkinson's disease, 0302 clinical medicine, CL, clearance rate, DAT, dopamine transporter, HDAC6, histone deacetylase 6, PD therapy, A2A, adenosine 2A, MYCBP2, MYC-binding protein 2, TFEB, transcription factor EB, AUTAC, autophagy targeting chimera, General Pharmacology, Toxicology and Pharmaceutics, SAS, solvent accessible surface, 0303 health sciences, α-syn, α-synuclein, ALP, autophagy-lysosomal pathway, AADC, aromatic amino acid decarboxylase, DJ-1, Parkinson protein 7, PI3K, phosphatidylinositol 3-kinase, COMT, catechol-O-methyltransferase, LUHMES, lund human mesencephalic, LRRK2, CMA, chaperone-mediated autophagy, KI, knockin, 030220 oncology & carcinogenesis, LRS, leucyl-tRNA synthetase, BBB, blood−brain barrier, SN, substantia nigra, IMPase, inositol monophosphatase, IPPase, inositol polyphosphate 1-phosphatase, HSPA8, heat shock 70 kDa protein 8, MAO-B, monoamine oxidase B, PREP, prolyl oligopeptidase, Parkinson's disease (PD), DR, dopamine receptor, PDE4, phosphodiesterase 4, AMPK, 5ʹAMP-activated protein kinase, 5-HT2C, serotonin 2C, SNCA, α-synuclein gene, TSC2, tuberous sclerosis complex 2, RM1-950, LIMP-2, lysosomal integrated membrane protein-2, CNS, central nervous system, 5-HT2A, Serotonin 2A, ER, endoplasmic reticulum, ATG, autophagy related protein, 03 medical and health sciences, PLC, phospholipase C, ROS, reactive oxygen species, ERRα, estrogen-related receptor alpha, SAR, structure–activity relationship, ULK1, UNC-51-like kinase 1, medicine, Autophagy, NMDA, N-methyl-d-aspartic acid, mAChR, muscarinic acetylcholine receptor, GWAS, genome-wide association study, LAMP2A, lysosome-associated membrane protein 2 A, Lamp2a, type 2A lysosomal-associated membrane protein, 030304 developmental biology, Parkin, parkin RBR E3 ubiquitin−protein ligase, PINK1, PTEN-induced kinase 1, ATTEC, autophagosome-tethering compound, ATP13A2, ATPase cation transporting 13A2, business.industry, ULK1, medicine.disease, LC3, light chain 3, PI3P, phosphatidylinositol 3-phosphate, SYT11, synaptotagmin 11, AUC, the area under the curve, UPS, ubiquitin−proteasome system, TFEB, DA, dopamine, Therapeutics. Pharmacology, business, BAF, bafilomycinA1, HSC70, heat shock cognate 71 kDa protein, Neuroscience, 3-MA, 3-methyladenine, F, oral bioavailability, LRRK2, leucine-rich repeat sequence kinase 2

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d12dab43aca56bfd6a912c2aa71297ffTest
http://www.sciencedirect.com/science/article/pii/S2211383521000642Test

المؤلفون: Yi Ren, Han-Ming Shen

المصدر: Redox Biology
Redox Biology, Vol 25, Iss, Pp-(2019)

مصطلحات موضوعية: AMPK, AICAR, 5-aminoimidazole-4-carboxamide ribonucleotide, MAGE A3/6, melanoma-associated antigen 3/6, OXPHOS, oxidative phosphorylation, DHA, dehydroascorbic acid, PPAR, peroxisome proliferator-activated receptor, ACC, acetyl-CoA carboxylase, AMP-Activated Protein Kinases, Biochemistry, G6PD, glucose-6-phosphate dehydrogenase, NADPH, reduced nicotinamide adenine dinucleotide phosphate, 0302 clinical medicine, ARE, antioxidant response, 6PGD, 6-phosphogluconate dehydrogenase, HIF-1α, hypoxia-inducible factor 1-α, GR, glutathione reductase, PPP, the pentose phosphate pathway, Glycolysis, lcsh:QH301-705.5, Cancer, Glucose metabolism, α-KG, α-ketoglutaric acid, Kinase, FAS, fatty acid synthesis, GSSG, oxidized glutathione, SREBP, sterol regulatory element binding protein, ME, malic enzyme, Cell biology, ECM, extracellular matrix, NRF2, nuclear factor (erythroid-derived 2)-like 2, COX-2, cyclooxygenase-2, CRC, colorectal cancer, KEAP1, Kelch-like ECH-associated protein 1, lcsh:Medicine (General), 3PG, 3-phosphoglyceric acid, R-5P, ribose 5-phosphate, KRAS, Kirsten rat sarcoma, IDH, isocitrate dehydrogenase, GLUT1, glucose transporter 1, Pentose phosphate pathway, 6P-2DG, 6-phospho 2-deoxygluconate, mTORC1, mTOR Complex 1, Article, 03 medical and health sciences, LKB1, liver kinase B1, RAPTOR, regulatory-associated protein of mammalian target of rapamycin, ULK1, UNC-51-like kinase 1, Humans, PGC-1α, peroxisome proliferator-activated receptor γ coactivator 1-α, Protein kinase A, Fatty acid metabolism, HK, hexokinase, NQO1, NADPH dehydrogenase (quinone 1), Metabolic pathway, 030104 developmental biology, Glucose, 6P-G, 6-phosphogluconate, NADP+, nicotinamide adenine dinucleotide phosphate, CRM, calorie restriction mimetic, UCP2, mitochondrial uncoupling protein 2, CAT, catalase, 030217 neurology & neurosurgery, FAO, fatty acid oxidation, MAPK, mitogen-activated protein kinase, 0301 basic medicine, ERK2, extracellular signal-regulated kinase 2, GSH, reduced glutathione, PDAC, pancreatic ductal adenocarcinoma, Clinical Biochemistry, FASN, fatty acid synthase, 5TG, 5-thioglucose, HO-1, heme oxygenase 1, medicine.disease_cause, chemistry.chemical_compound, UBE2O, (E3-independent) E2 ubiquitin-conjugating enzyme, Neoplasms, FADH2, the quinone form flavin adenine dinucleotide, Trx, thioredoxin, BRAF, B-Raf proto-oncogene, 2DG-6P, 2-deoxyglucose 6-phosphate, lcsh:R5-920, GPx, glutathione peroxidase, Chemistry, AMPK, 5′ AMP-activated protein kinase, mTOR, the mechanistic target of rapamycin, Glc, glucose, NOX, NADPH oxidases, NADH, the reduced nicotinamide adenine dinucleotide, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, SGLT2, sodium/glucose cotransporter 2, Oxidation-Reduction, CaMKKβ, calcium/calmodulin-dependent protein kinase kinase β, TCA, tricarboxylic acid cycle, CPT1, carnitine palmitoyltransferase 1, PI3K, phosphoinositide-3-kinase, ETC, electron transport chain, G-6P, glucose 6-phosphate, TSC2, tuberous sclerosis complex 2, ROS, reactive oxygen species, MTP, mitochondrial trifunctional protein, NSCLC, non-small cell lung cancer, SOD, superoxide dismutase, medicine, Animals, 2DG, 2-deoxyglucose, MEF, mouse embryonic fibroblasts, TP, trifunctional protein, KO, knockout, MEK, MAPK Kinase, Organic Chemistry, SCD1, stearoyl-CoA desaturase-1, HNE, 4-hydroxy-2-nonenal, TRIM28, tripartite motif-containing 28, PTEN, phosphatase and tensin homolog, Oxidative Stress, lcsh:Biology (General), NAC, N-acetyl cysteine, Reactive oxygen species, Oxidative stress

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ed3374d5e3861a33fee3afc63c774d4Test
https://pubmed.ncbi.nlm.nih.gov/30853530Test

المؤلفون: Milica Vucetic, Kari E. Fladmark, Antonio Cuadrado, Irina Milisav, Bilge Debelec, Marta Pajares, Samo Ribarič, Irundika H.K. Dias, Huveyda Basaga, Natalia Jiménez-Moreno

المساهمون: Kidney Research UK, European Cooperation in Science and Technology, UAM. Departamento de Bioquímica, Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ), Instituto de Investigaciones Biomédicas 'Alberto Sols' (IIBM), Ege Üniversitesi

المصدر: Digital.CSIC. Repositorio Institucional del CSIC
instname
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Redox Biology
Biblos-e Archivo. Repositorio Institucional de la UAM

مصطلحات موضوعية: GSH, reduced glutathione, Clinical Biochemistry, NOX, nicotinamide adenine dinucleotide phosphate oxidase, Review Article, Aβ, amyloid beta, ASK1, apoptosis signal-regulating kinase 1, Protein oxidation, Biochemistry, HIF-1, hypoxia inducible factor-1, ATG4, autophagy related protein 4, Prion Diseases, Unfolded protein response, 0302 clinical medicine, UPR, unfolded protein response, Ubiquitin, IKKB, inhibitor of nuclear factor kappa-B kinase subunit beta, Trx, thioredoxin, Ub, ubiquitin, 0303 health sciences, biology, GSSG, oxidized glutathione, PI3K, phosphatidylinositol 3-kinase, mTORC1, mammalian target of rapamycin complex 1, Parkinson Disease, Cell biology, CMA, chaperone mediated autophagy, Oxidation-Reduction, Intracellular, Proteasome Endopeptidase Complex, Proteinoxidation, Medicina, Nerve Tissue Proteins, TSC2, tuberous sclerosis complex 2, Protein degradation, PDIs, protein disulfide isomerase, ER, endoplasmic reticulum, 03 medical and health sciences, UPS, ubiquitin proteasome system, NRF1/2, nuclear factor (erythroid-derived 2)-like 1/2, Alzheimer Disease, LC3, microtubule-associated protein light chain 3, Autophagy, Humans, 030304 developmental biology, α-SYN, α-synuclein, ROS, reactive oxygen species (mtROS, mitochondrial ROS), Proteasome, Organic Chemistry, PARP1, poly [ADP-ribose] polymerase 1, PrP, prion protein (PrPc, cellular form, PrPsc, scrapie form), Ubiquitination, ATM, ataxia-telangiectasia mutated, PTEN, phosphatase and tensin homolog, ULK1, unc-51 like autophagy activating kinase 1, Proteostasis, AMPK, AMP activated protein kinase, NFκB, nuclear factor kappa B, PDH, prolyl-4-hydroxylase, Proteolysis, biology.protein, Reactive Oxygen Species, Protein Processing, Post-Translational, 030217 neurology & neurosurgery, BCL-2, B-cell lymphoma 2, JNK1, c-Jun N-terminal kinase

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::704cabd6dd52ab864fe6016a11573eb5Test
https://publications.aston.ac.uk/id/eprint/26853/1/Redox_control_of_protein_degradation.pdfTest

المؤلفون: Ruzica, Bago, Nazma, Malik, Michael J, Munson, Alan R, Prescott, Paul, Davies, Eeva, Sommer, Natalia, Shpiro, Richard, Ward, Darren, Cross, Ian G, Ganley, Dario R, Alessi

المصدر: Biochemical Journal

مصطلحات موضوعية: N-Myc downstream-regulated gene-1 (NDRG1), PRAS40, proline-rich Akt substrate 40 kDa, IGF, insulin-like growth factor, Class I Phosphatidylinositol 3-Kinases, Amino Acid Motifs, PH, pleckstrin homology, Aminopyridines, PDK1, phosphoinositide-dependent kinase 1, Accelerated Publication, SHIP1/2, Src homology 2-domain-containing inositol phosphatase 1/2, Endosomes, mTOR, mammalian target of rapamycin, TSC2, tuberous sclerosis complex 2, Protein Serine-Threonine Kinases, phosphoinositide 3-kinase (PI3K), 4E-BP1, eukaryotic initiation factor 4E-binding protein 1, Cell Line, PX, Phox homology, Phosphatidylinositol Phosphates, NDRG1, N-Myc downstream-regulated gene-1, Humans, Phosphorylation, mTORC, mammalian target of rapamycin complex, Vps34, vacuolar protein sorting 34, IP1, inositol phosphate, VSV-G, vesicular stomatitis virus glycoprotein, Class II Phosphatidylinositol 3-Kinases, Phosphoinositide-3 Kinase Inhibitors, DMEM, Dulbecco's modified Eagle's medium, protein kinase inhibitor, INPP4B, inositol polyphosphate 4-phosphatase type II, ITC, isothermal titration calorimetry, fungi, Inositol Polyphosphate 5-Phosphatases, mammalian target of rapamycin (mTOR), HRP, horseradish peroxidase, Class III Phosphatidylinositol 3-Kinases, Phosphoric Monoester Hydrolases, Protein Structure, Tertiary, signal transduction inhibitor, Pyrimidines, Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases, PtdIns, phosphatidylinositol, SGK3, serum- and glucocorticoid-regulated kinase-3, EEA1, early endosome antigen 1, Hydrophobic and Hydrophilic Interactions, PI3K, phosphoinositide 3-kinase, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::e482468dace2fe9575967a237a98adb3Test
https://pubmed.ncbi.nlm.nih.gov/25177796Test

المؤلفون: Mark Kidd, Irvin M. Modlin, Ignat Drozdov, Lisa Bodei

المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 1, Iss 2, Pp 131-153 (2015)

مصطلحات موضوعية: ISG, immature secretory vesicles, Proliferation, Review, CgA, chromogranin A, Metastasis, Transcriptome, GEP-NEN, gastroenteropancreatic neuroendocrine neoplasms, CGH, comparative genomic hybridization, TGF, transforming growth factor, D cell, somatostatin, biology, PI3K, phosphoinositide-3 kinase, Gastroenterology, Chromogranin A, MSI, microsatellite instability, cAMP, adenosine 3′,5′-cyclic monophosphate, EC, enterochromaffin, Blood, TSC2, tuberous sclerosis complex 2 (tuberin), VMAT, vesicular monoamine transporters, Protein kinase B signaling, MEN-1/MEN1, multiple endocrine neoplasia type 1, Ki-67, miR/miRNA, micro-RNA, Somatostatin, X/A-like cells, ghrelin, Gastroenteropancreatic Neuroendocrine Neoplasms, NEN, neuroendocrine neoplasms, mTOR, mammalian target of rapamycin, Computational biology, ERK, extracellular-signal-regulated kinase, PET, positron emission tomography, 5-HT, serotonin, 5-hydroxytryptamine, SD-208, 2-(5-chloro-2-fluorophenyl)-4-[(4-pyridyl)amino]p-teridine, MTA, metastasis associated-1, PI3, phosphoinositide-3, PKC, protein kinase C, medicine, PTEN, lcsh:RC799-869, LOH, loss of heterozygosity, Grading (tumors), SNV, single-nucleotide variant, PTEN, phosphatase and tensin homolog deleted on chromosome 10, Hepatology, IGF-I, insulin-like growth factor-I, TGN, trans-Golgi network, medicine.disease, Carcinoid, EGFR, epidermal growth factor receptor, GPCR, G-protein coupled receptor, NFκB, nuclear factor κB, SSA, somatostatin analog, ECL, enterochromaffin-like, Akt, protein kinase B, Cancer research, biology.protein, CREB, cAMP response element-binding protein, lcsh:Diseases of the digestive system. Gastroenterology, PKA, protein kinase A, BRAF, gene encoding serine/threonine-protein kinase B-Raf, TSC2, G cell, gastrin, SST, somatostatin, DAG, diacylglycerol, GABA, γ-aminobutyric acid, MAPK, mitogen-activated protein kinase, Comparative genomic hybridization

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd7b790520f931d0bd7ff0b95d6e026eTest