نتائج البحث

المساهمون: Cibles thérapeutiques, formulation et expertise pré-clinique du médicament (CITHEFOR), Université de Lorraine (UL), Biotechnologie et signalisation cellulaire (BSC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Lorrain de Chimie Moléculaire (L2CM), Institut de Chimie - CNRS Chimie (INC-CNRS)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), ANR-20-SFRI-0012,STRAT'US,Façonner les talents en formation et en recherche à l'Université de Strasbourg(2020)

المصدر: ISSN: 1661-6596.

مصطلحات موضوعية: RAS, Angiotensin II, Ang-(1–7), AT1 receptor, TRV023, TRV027, beta-arrestin, biased agonism, cerebrovascular disease, [CHIM.ORGA]Chemical Sciences/Organic chemistry, [CHIM.THER]Chemical Sciences/Medicinal Chemistry

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/34201646; hal-03287839; https://hal.univ-lorraine.fr/hal-03287839Test; https://hal.univ-lorraine.fr/hal-03287839/documentTest; https://hal.univ-lorraine.fr/hal-03287839/file/2021%20IntJMolSci.pdfTest; PUBMED: 34201646; PUBMEDCENTRAL: PMC8269339

الإتاحة: https://doi.org/10.3390/ijms22136738Test
https://hal.univ-lorraine.fr/hal-03287839Test
https://hal.univ-lorraine.fr/hal-03287839/documentTest
https://hal.univ-lorraine.fr/hal-03287839/file/2021%20IntJMolSci.pdfTest

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4

دورية أكاديمية

Targeting the Angiotensin II Type 1 Receptor in Cerebrovascular Diseases: Biased Signaling Raises New Hopes

المؤلفون: Céline Delaitre, Michel Boisbrun, Sandra Lecat, François Dupuis

المصدر: International Journal of Molecular Sciences; Volume 22; Issue 13; Pages: 6738

مصطلحات موضوعية: AT 1 receptor, Angiotensin II, cerebrovascular disease, biased agonism, beta-arrestin, RAS, TRV023, TRV027, Ang-(1–7)

جغرافية الموضوع: agris

وصف الملف: application/pdf

العلاقة: Molecular Pathology, Diagnostics, and Therapeutics; https://dx.doi.org/10.3390/ijms22136738Test

الإتاحة: https://doi.org/10.3390/ijms22136738Test

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5

دورية أكاديمية

Biased ligand of the angiotensin II type 1 receptor in patients with acute heart failure:A randomized, double-blind, placebo-controlled, phase IIB, dose ranging trial (BLAST-AHF)

المؤلفون: Pang, Peter S., Butler, Javed, Collins, Sean P., Cotter, Gad, Davison, Beth A., Ezekowitz, Justin A., Filippatos, Gerasimos, Levy, Phillip D., Metra, Marco, Ponikowski, Piotr, Teerlink, John R., Voors, Adriaan A., Bharucha, David, Goin, Kathleen, Soergel, David G., Felker, G. Michael

المصدر: Pang , P S , Butler , J , Collins , S P , Cotter , G , Davison , B A , Ezekowitz , J A , Filippatos , G , Levy , P D , Metra , M , Ponikowski , P , Teerlink , J R , Voors , A A , Bharucha , D , Goin , K , Soergel , D G & Felker , G M 2017 , ' Biased ligand of the angiotensin II type 1 receptor in patients with acute heart failure : A randomized, double-blind, placebo-controlled, phase IIB, dose ranging ....

مصطلحات موضوعية: Acute heart failure, Biased ligand, Angiotensin-II, Clinical trials, THERAPEUTICS, GUIDELINES, MANAGEMENT, MORTALITY, EFFICACY, TRV027

وصف الملف: application/pdf

العلاقة: https://research.rug.nl/en/publications/d8759692-17dc-4daa-9c7b-9bcc650e71d1Test

الإتاحة: https://doi.org/10.1093/eurheartj/ehx196Test
https://hdl.handle.net/11370/d8759692-17dc-4daa-9c7b-9bcc650e71d1Test
https://research.rug.nl/en/publications/d8759692-17dc-4daa-9c7b-9bcc650e71d1Test
https://pure.rug.nl/ws/files/49090604/ehx196.pdfTest

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6

β-Arrestin-Biased AT1 Agonist TRV027 Causes a Neonatal-Specific Sustained Positive Inotropic Effect Without Increasing Heart Rate

المؤلفون: Hiroyuki Kawagishi, Mitsuhiko Yamada, Cheng-Kun Du, Tsutomu Nakada, Toshihide Kashihara, Sachio Morimoto, Elena E. Wolf, Shin Kadota, Takuro Numaga-Tomita, Yuji Shiba

المصدر: JACC: Basic to Translational Science

مصطلحات موضوعية: 0301 basic medicine, Inotrope, Agonist, PHF, pediatric heart failure, hiPSC-CM, human induced pluripotent stem cell–derived cardiac myocyte, medicine.drug_class, BBA, β-arrestin–biased angiotensin type 1 receptor agonist, 030204 cardiovascular system & hematology, Pharmacology, 03 medical and health sciences, chemistry.chemical_compound, ECG, electrocardiography, 0302 clinical medicine, ROS, reactive oxygen species, beta-arrestin-biased AT1 angiotensin receptor agonist, Renin–angiotensin system, Heart rate, medicine, OCR, oxygen consumption rate, Aldosterone, Angiotensin II receptor type 1, UCG, ultrasound cardiogram, business.industry, pediatric heart failure, AngII, angiotensin II, medicine.disease, human induced pluripotent stem cell-derived cardiac myocytes, inotropic vasodilator, Angiotensin II, human induced pluripotent stem cell–derived cardiac myocytes, congenital dilated cardiomyopathy, 030104 developmental biology, mNVCM, mouse neonatal ventricular cardiac myocyte, chemistry, β-arrestin–biased AT1 angiotensin receptor agonist, Heart failure, AT1R, angiotensin type 1 receptor, GPCR, G protein–coupled receptor, Preclinical Research, neonate, Cardiology and Cardiovascular Medicine, business, Editorial Comment, LTCC, CaV1.2 L-type Ca2+ channel, TRV027

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1f2d81ed3d68f51843a352e270a974bTest
https://soar-ir.repo.nii.ac.jp/records/2001244Test

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دورية أكاديمية

Heart Failure Therapeutics on the Basis of a Biased Ligand of the Angiotensin-2 Type 1 Receptor Rationale and Design of the BLAST-AHF Study (Biased Ligand of the Angiotensin Receptor Study in Acute Heart Failure)

المؤلفون: Felker, G. Michael, Butler, Javed, Collins, Sean P., Cotter, Gad, Davison, Beth A., Ezekowitz, Justin A., Filippatos, Gerasimos, Levy, Phillip D., Metra, Marco, Ponikowski, Piotr, Soergel, David G., Teerlink, John R., Violin, Jonathan D., Voors, Adriaan A., Pang, Peter S.

المصدر: Felker , G M , Butler , J , Collins , S P , Cotter , G , Davison , B A , Ezekowitz , J A , Filippatos , G , Levy , P D , Metra , M , Ponikowski , P , Soergel , D G , Teerlink , J R , Violin , J D , Voors , A A & Pang , P S 2015 , ' Heart Failure Therapeutics on the Basis of a Biased Ligand of the Angiotensin-2 Type 1 Receptor Rationale and Design of the BLAST-AHF Study (Biased Ligand of the ....

مصطلحات موضوعية: BLAST-AHF, NT-proBNP, TRV027, LEFT-VENTRICULAR DYSFUNCTION, ACUTE MYOCARDIAL-INFARCTION, MULTIPLE END-POINTS, CLINICAL-TRIALS, INTRAVENOUS ENALAPRILAT, CARDIAC MYOCYTES, BETA-ARRESTINS, I RECEPTOR, PHASE-II, ASSOCIATION