المؤلفون: Mercedes Lopez-Santalla, Juan A. Bueren, Marina I. Garin

المصدر: EBioMedicine, Vol 69, Iss, Pp 103427-(2021)
EBioMedicine

مصطلحات موضوعية: Oncology, ID, intradermal, RANTES, regulated upon activation normal T cells expressed and presumably secreted, AS, arthritis score, RA, rheumatoid arthritis, PPAR, peroxisome proliferator-activated receptor, Etanercept, TNF-α, tumour necrosis factor α, Bzb, bortezomib, iLNs, inguinal lymph nodes, CXCR3, chemokine receptor 3-alternative, BMZ, betamethasone, Medicine, CIA, collagen-induced arthritis, PP, peyer's patch, GIP, gastric inhibitory polypeptide, D, days, EVs, extracellular vesicles, Mtx, methotrexate, mAIA, antigen-induced arthritis in mouse, MTC, Masson´s trichrome, 030220 oncology & carcinogenesis, Rheumatoid arthritis, CTLA4, cytotoxic T lymphocyte antigen, iNOS, inducible nitric oxide synthase, KC, keratinocyte chemo-attractant, OCPs, osteoclast precursors, MCP-1, monocyte chemotactic protein 1, PTPN22, protein tyrosine-phosphatase 22, medicine.medical_specialty, rAIA, adjuvant-induced arthritis in rats, MensMSCs, MSCs from menstrual fluid, BM-MSCs, MSCs from bone marrow, MIP-2, macrophage inflammatory protein 2, 03 medical and health sciences, R5-920, IP10, IFN-γ-induced protein 10, IM, intramuscular, NRP-1, neuropilin-1, S, syngeneic, ESR, erythrocyte sedimentation rate, MPs, microparticles, PBMCs, peripheral blood mononuclear cells, AD, adipose tissue, MVs, microvesicles, P, placenta, sCIA, collagen-induced arthritis in sheep, Bregs, regulatory B cells, X, xenogeneic, Improvements in MSC-based therapy, AD-MSCs, MSCs from adipose tissue, 030104 developmental biology, TF, tissue factor, Protocols, Gilz, glucocorticoid-induced leucine zipper, DM, dexamethasone, STAT3, signal transducer and activator of transcription 3, ANA, Anti-nuclear antibodies, SAA, serum amyloid-A, ERDF, European Regional Development Fund, µCT, micro computed tomography imaging, Arthritis, Rheumatoid, T-AOC, total antioxidant capacity, rCIA, collagen-induced arthritis in rats, ISCT, international society for cellular therapy, NF-κB, nuclear factor-kappa B, RORγT, retinoic acid-related orphan receptor, TCR, T cell receptor, OVAIA, ovalbumin-induced arthritis, UC, umbilical cord, CAIA, collagen-antibody induced arthritis, Flk, tyrosine kinase receptor for vascular endothelial growth factor, IDO, indoleamine 2,3-dioxygenase, MMP, matrix metalloproteinase, Tr1, IL-10-expressing T cells, SM, synovial membrane, medicine.anatomical_structure, IAA, indoleacetic acid, MPCs, mesenchymal precursor cells, SNP, sodium nitroprusside, medicine.drug, NA, not available, IL-1RA, IL-1 receptor antagonist, CD, cluster of differentiation, DMARDs, antirheumatic drugs, TBO, toluidine blue O, =, similar to or equal, SM-MSCs, MSCs from synovial membrane, Mesenchymal Stem Cell Transplantation, PB, peripheral blood, G, gingiva tissue, IFA, incomplete Freund´s adjuvant, OVA, ovalbumin, MSCs, mesenchymal stem/ stromal cells, SO, safranin, TRAF, tumour necrosis factor receptor-associated factor, Animals, SP, spleen, ILA, indole-3-lactic acid, mBSA, methylated bovine serum albumin, business.industry, F, female, SF, synovial fluid, Th, T helper cells, TLR, toll-like receptors, BM, bone marrow, Bone marrow, Synovial membrane, MRI, magnetic resonance imaging, WT, wild type, Medicine (General), IHC, immunohistochemical analysis, Review, miR, microRNA, TRACP, tartrate-resistant acid phosphatase, AAV, adeno-associated virus, 0302 clinical medicine, GSH, glutathione, SVF, stromal vascular fraction, H/E, haematoxylin/eosin staining, GITR, glucocorticoid-induced tumour necrosis factor receptor, pLNs, popliteal lymph nodes, FOXP3, General Medicine, IFI, indirect immunofluorescence, Tregs, regulatory T cells, M, male, RF, rheumatoid factor, RNA, ribonucleic acid, TNFR, tumour necrosis factor receptor, <, worse than, IP, intraperitoneal, NuMa, nuclear mitotic apparatus, COMP, cartilage oligomeric matrix protein, GSH-Px, glutathione peroxidase, >, better than, LP, lamina propria, LPS, lipopolysaccharide, IN, intranodal, AT, antithrombin, General Biochemistry, Genetics and Molecular Biology, CM, conditioned medium, Consec., consecutive, RAGE, receptor for advanced glycation products, ETN, etanercept, Humans, dLNs, draining lymph nodes, MDA, malondialdehyde, IFN-γ, interferon gamma, ALP, alkaline phosphatase, HSCs, hematopoietic stem cells, Mesenchymal stem cell, Mesenchymal Stem Cells, medicine.disease, EMA, European medicine agency, IL, interleukin, CFA, Freund's complete adjuvant, DAB, 3,3´-diaminobenzidine, OPG, osteoprotegerin, HMGB-1, high-mobility group box-1, CRP, C reactive protein, Tol-DCs, tolerogenic dendritic cells, 0301 basic medicine, CII, collagen II, SF-MSCs, MSCs from synovial fluid, MPO, myeloperoxidease, A, allogeneic, LDL, low density lipoprotein, APCP, α, β methylene selective A2A adenosine receptor competitive antagonist (CD73 inhibitor), Translational Research, Biomedical, SSEA, severe spontaneous erosive arthritis, mLNs, mesenteric lymph nodes, PGIA, proteoglycan-induced arthritis, Exos, small vesicles/Exosomes, FOXP3, forkhead box P3, RANKL, receptor activator of nuclear factor κB ligand, TGF-β, transforming growth factor β, Stromal vascular fraction, NSAIDs, non-steroidal anti-inflammatory drugs, VEGF, vascular endothelial growth factor, Animal models, AhR, aryl hydrocarbon receptor, DCs, dendritic cells, IV, intravenous, Stromal cell, IA, intra-articular, SIRT1, sirtuin 1, O-MSCs, MSCs from nasal tissue, PA, peri-articular, Tfh, follicular T helper cells, AxLNs, axillar lymph nodes, NK, natural killer cells, T-MSCs, MSCs from tonsil tissue, SOD, superoxide dismutase, Internal medicine, MHC, major histocompatibility complex, GLP-1, glucagon-like peptide 1, G-MSCs, MSCs from gingiva tissue, Mesenchymal stem/stromal cells, PG, proteoglycan, HLA-II, human leukocyte antigen-II, PLGA, poly-lactic-co-glycolic acid, HDL, high density lipoprotein, Ig, immunoglobulin, SC, subcutaneous, P-MSCs, MSCs from placenta tissue, POM-1, sodium polyoxotungstate (CD39 inhibitor), UC-MSCs, MSCs from umbilical cord, business, sIL6R, soluble IL-6 receptor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e59ac03e508af98279e7efcb573e18b9Test
https://doi.org/10.1016/j.ebiom.2021.103427Test

المؤلفون: Bulatov, Emil, Ciulli, Alessio

المصدر: Biochemical Journal

مصطلحات موضوعية: Models, Molecular, Skp2, S-phase kinase-associated protein 2, Fbxl, F-box/leucine-rich motif-containing protein, SCF, Skp1–Cdc53–F-box Cdc4, DDB, damage-specific DNA-binding protein, DCAF, DDB1–Cul4A-associated factor, EloBC, ElonginB–ElonginC complex, Review Article, SV5, simian virus 5, Nrf2, nuclear factor-erythroid 2-related factor 2, Vpr, viral protein R, JA-Ile, jasmonoyl-isoleucine, CRL, Cullin–RING E3 ubiquitin ligase, HERC2, HECT domain- and RLD (regulator of chromosome condensation 1 protein-like domain) domain-containing E3 ubiquitin protein ligase 2, BCR, BTB–Cul3–Rbx1, Drug Discovery, NAE, NEDD8-activating enzyme, KLHL, Kelch-like protein, Ub, ubiquitin, IκB, inhibitor of NF-κB, Vif, virion infectivity factor, Molecular Structure, ITC, isothermal titration calorimetry, CPH, conserved within Cul7, PARC and HERC2, Cpd, compound, Aux, auxin, Cullin Proteins, structure-based design, CTD, C-terminal domain, Protac, proteolysis-targeting chimaeric molecule, Cul, Cullin, Fbw/Fbxw, F-box/WD repeat-containing protein, STAT, signal transducer and activator of transcription, GHR, growth hormone receptor, UBL, ubiquitin-like protein, FP, fluorescence polarization, NF-κB, nuclear factor κB, Cks1, cyclin-dependent protein kinase regulatory subunit 1, Rbx1, RING-box protein 1, Proteasome Inhibitors, SH2, Src homology 2, assembly, SPOP, speckle-type POZ protein, UPS, ubiquitin–proteasome system, PARC, p53-associated parkin-like cytoplasmic protein, β-TrCP, β-transducin repeat-containing protein, PPI, protein–protein interaction, small molecule, JAZ1, jasmonate/ZIM (zinc finger expressed in inflorescence) domain protein 1, Fbxo, F-box/other domain-containing protein, mTOR, mammalian target of rapamycin, NEDD, neural-precursor-cell-expressed developmentally down-regulated, ubiquitination, APC/C, anaphase-promoting complex/cyclosome, MEL26, maternal effect lethal 26, RING, really interesting new gene, CAND1, Cullin-associated NEDD8-dissociated protein 1, Cdc, cell division cycle, ubiquitin, Ubc12, ubiquitin-conjugating enzyme 12, COI1, coronatine-insensitive protein 1, CSA, Cockayne syndrome A, Humans, structure, NTD, N-terminal domain, CRBN, cereblon, Protein Structure, Quaternary, SMER3, small-molecule enhancer of rapamycin 3, CSN, COP9 (constitutive photomorphogenesis 9) signalosome complex, CBFβ, core binding factor β, IAA, indole-3-acetic acid, SOCS, suppressor of cytokine signalling, BTB, bric-a-brac/tramtrack/broad complex, MATH, meprin and TRAF (tumour necrosis factor receptor-associated factor) homology, Keap1, Kelch-like enoyl-CoA hydratase-associated protein 1, Protein Structure, Tertiary, VHL, von Hippel–Lindau, Protein Subunits, ASB, ankyrin repeat and SOCS-box, BP, β-propeller, HECT, homologous with E6-associated protein C-terminus, Drug Design, HIF-1α, hypoxia-inducible factor 1α, VPRBP, Vpr-binding protein, TIR1, transport inhibitor response 1, POZ, pox virus and zinc finger

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::5b07715f4217b08830d90ae742dc138fTest
http://europepmc.org/articles/PMC4403949Test

المؤلفون: Julia Janzen, Elke Mühlberger, Steven C. Ley, Nicholas A. Morrice, Steven Howell, Thorsten Gantke, Sabrina Boussouf

المصدر: Biochemical Journal

مصطلحات موضوعية: MBP, myelin basic protein, viruses, TBK1, TANK [TRAF (tumour-necrosis-factor-receptor-associated factor)-associated NF-κB activator]-binding kinase 1, TNF, tumour necrosis factor, Biochemistry, Hsp, heat-shock protein, law.invention, chemistry.chemical_compound, Plasmid, law, GST, glutathione transferase, Viral Regulatory and Accessory Proteins, IKK, IκB kinase, IκB, inhibitor of NF-κB, HA, haemagglutinin, TCEP, tris-(2-carboxyethyl)phosphine, nuclear factor κB 1 (NF-κB1), tumour progression locus 2 (TPL-2), Transfection, Ebolavirus, MAP Kinase Kinase Kinases, Recombinant Proteins, BMDM, bone-marrow-derived macrophage, Up-Regulation, virus protein 35 (VP35), VP35, virus protein 35, Recombinant DNA, NF-κB, nuclear factor κB, ABIN-2, A20-binding inhibitor of nuclear factor κB 2, Accelerated Publication, MKK, MAPK kinase, Biology, ERK, extracellular-signal-regulated kinase, DM, decyl β-D-maltopyranoside, HEK, human embryonic kidney, Proto-Oncogene Proteins, Humans, double-stranded-RNA-dependent protein kinase (PKR), TPL-2, tumour progression locus 2, Protein kinase A, PKR, double-stranded RNA-dependent protein kinase, Molecular Biology, Adaptor Proteins, Signal Transducing, A20-binding inhibitor of nuclear factor κB 2 (ABIN-2), HEK 293 cells, NF-kappa B p50 Subunit, Cell Biology, Protein kinase R, Molecular biology, Embryonic stem cell, HEK293 Cells, chemistry, DTT, dithiothreitol, Multiprotein Complexes, cancer Osaka thyroid (COT), MAPK, mitogen-activated protein kinase, DNA

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c74292a5250f885ef51695960eb11d1Test
https://doi.org/10.1042/bj20121873Test

المؤلفون: Axel Knebel, Lorna Plater, Christoph H. Emmerich, Sam Strickson, Natalia Shpiro, Philip Cohen, David G. Campbell, Maria Stella Ritorto

المصدر: Biochemical Journal

مصطلحات موضوعية: Lipopolysaccharides, Ubiquitin-conjugating enzyme, Biochemistry, DMEM, Dulbecco’s modified Eagle’s medium, Mice, linear ubiquitin assembly complex (LUBAC), K63-pUb, Lys63-linked polyubiquitin, NF-KappaB Inhibitor alpha, Ubiquitin, MS/MS, tandem MS, nuclear factor κB (NF-κB), pUb, polyubiquitin, TRAF, tumour-necrosis-factor-receptor-associated factor, Sulfones, RBR, RING-between-RING, TAB, TAK1-binding protein, IKK, IκB kinase, IκB, inhibitor of NF-κB, GFP, green fluorescent protein, HOIP, haem-oxidized IRP2 ligase-1-interacting protein, NEMO, NF-κB essential modifier, K48-pUb, Lys48-linked polyubiquitin, biology, LUBAC, linear ubiquitin assembly complex, Kinase, NEDD8, neural-precursor-cell-expressed developmentally down-regulated 8, Ubiquitin ligase, HRMS, high-resolution mass spectra, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, TBK1, tumour-necrosis-factor-receptor-associated factor-associated NF-κB activator-binding kinase 1, JNK, c-Jun N-terminal kinase, LPS, lipopolysaccharide, Phosphorylation, I-kappa B Proteins, ubiquitin conjugating 13 (Ubc13), NF-κB, nuclear factor κB, DLBCL, diffuse large B-cell lymphoma, PAMP, pathogen-associated molecular pattern, Signal Transduction, Research Article, Proteasome Endopeptidase Complex, Molecular Sequence Data, lymphoma, MALDI–TOF, matrix-assisted laser-desorption ionization–time-of-flight, ERK, extracellular-signal-regulated kinase, HEK, human embryonic kidney, Ubc, ubiquitin conjugating, Cell Line, Tumor, Nitriles, MyD88, myeloid differentiation factor 88, Animals, Humans, Amino Acid Sequence, Molecular Biology, HIF1α, hypoxia-inducible factor 1α, IL-1R, IL-1 receptor, HTLV-1, human T-cell lymphotropic virus 1, Macrophages, HEK 293 cells, Ubiquitination, NF-kappa B p50 Subunit, Receptors, Interleukin-1, myeloid differentiation factor 88 (MyD88), TAK1, transforming growth factor β-activated kinase 1, Cell Biology, Hypoxia-Inducible Factor 1, alpha Subunit, Molecular biology, IL, interleukin, UBE, ubiquitin-activating enzyme, IκBα, proteasome, Gene Expression Regulation, Proteasome, IRAK, IL-receptor-associated kinase, Myeloid Differentiation Factor 88, Ubiquitin-Conjugating Enzymes, biology.protein, MAPK, mitogen-activated protein kinase, Interleukin-1, DAPI, 4′,6-diamidino-2-phenylindole

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3af6008194e741619655a2e05fd75147Test
https://doi.org/10.1042/bj20121651Test

المؤلفون: Claudia Broder, Christoph Becker-Pauly

المصدر: Biochemical Journal

مصطلحات موضوعية: Proteomics, metalloprotease, medicine.medical_treatment, ADAM10, BMP-1, bone morphogenetic protein-1, Review Article, IR, ischaemia/reperfusion, Biochemistry, Amyloid precursor protein, TRAF, tumour-necrosis-factor-receptor-associated factor, DSS, dextran sodium sulfate, ERK1/2, extracellular-signal-regulated kinase 1/2, Metalloproteinase, IBD, inflammatory bowel disease, Neurodegeneration, VEGF-A, vascular endothelial growth factor A, neurodegeneration, Metalloendopeptidases, Neurodegenerative Diseases, SNP, single nucleotide polymorphism, MBP, mannan-binding protein, TAILS, terminal amine isotopic labelling of substrates, ECM, extracellular matrix, MMP, matrix metalloproteinase, ADAM, a disintegrin and metalloprotease domain, BACE1, β-site APP-cleaving enzyme 1, EGFR, EGF receptor, TGFα, transforming growth factor α, MAM, meprin A5 protein tyrosine phosphatase μ, Proteases, Aβ, amyloid β, Biology, AKI, acute kidney injury, AD, Alzheimer’s disease, meprin, APP, amyloid precursor protein, medicine, Disintegrin, CD, Crohn’s disease, cancer, Animals, Humans, Molecular Biology, CF, cystic fibrosis, EGF, epidermal growth factor, Inflammation, KLK, kallikrein-related peptidase, Protease, Amyloid beta-Peptides, AIEC, adherent-invasive Escherichia coli, fibrosis, Cell Biology, medicine.disease, IL, interleukin, UC, ulcerative colitis, biology.protein

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e2d41d55625e37295b557f9de89670eTest
http://europepmc.org/articles/PMC3573791Test

المؤلفون: Feng Ruan, Qiang Zheng, Jinfu Wang

المصدر: Bioscience Reports, Vol 32, Iss 6 (2012)
Bioscience Reports

مصطلحات موضوعية: Anabolism, Common disease, Osteoporosis, lcsh:Life, lcsh:QR1-502, MKP-1, MAPK phosphatase-1, Osteoclasts, Review Article, BMSC, bone-marrow-derived mesenchymal stem cell, Disease, Bioinformatics, Biochemistry, lcsh:Microbiology, FPP, farnesyl pyrophosphate, TGFβ, transforming growth factor β, TRAF, tumour-necrosis-factor-receptor-associated factor, OVX, ovariectomized, HMG-CoA, 3-hydroxy-3-methylglutaryl-CoA, mesenchymal stem cell (MSC), apoptosis, Osteoblast, medicine.anatomical_structure, DN, dominant negative, TNFR, tumour necrosis factor receptor, NF-κB, nuclear factor κB, Signal transduction, PI3K, phosphoinositide 3-kinase, Signal Transduction, Bone mass, medicine.medical_specialty, ER, oestrogen receptor, BMD, bone mineral density, Biophysics, DGBP, digeranyl bisphosphonate, CVD, cardiovascular disease, ERK, extracellular-signal-regulated kinase, GGPP, geranylgeranyl pyrophosphate, Bone and Bones, S4, osteogenesis, statins, RANKL, RANK ligand, ZGA, zaragozic acid, Internal medicine, Elderly population, medicine, Animals, Humans, Molecular Biology, osteoclastogenesis, GGPPs, GGPP synthase, GR, glucocorticoid receptor, Osteoblasts, ALP, alkaline phosphatase, business.industry, Cell Biology, medicine.disease, BMP-2, bone morphogenetic protein-2, osteoporosis, lcsh:QH501-531, Endocrinology, OPG, osteoprotegerin, RANK, receptor activator of NF-κB, Hydroxymethylglutaryl-CoA Reductase Inhibitors, business, MAPK, mitogen-activated protein kinase

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a317cd2e7a94a10ef8ff1ec46d7e637dTest
https://doi.org/10.1042/bsr20110118Test

المؤلفون: Canning, Peter, Bullock, Alex N.

المصدر: Biochemical Society Transactions

مصطلحات موضوعية: SPOP, speckle-type POZ protein, antioxidant response, drug design, BTB, broad complex/tramtrack/bric-à-brac, MATH, meprin and TRAF (tumour-necrosis-factor-receptor-associated factor) homology, Nrf2, nuclear factor erythroid 2-related factor 2, S5, Protein Structure, Secondary, Rbx, RING box protein, RING, really interesting new gene, cancer, Humans, ARE, antioxidant-response element, Molecular Targeted Therapy, ubiquitylation, Protein Structure, Quaternary, Biochemical Society Focused Meeting, degradation, Kelch-Like ECH-Associated Protein 1, KLHL, Kelch-like, BACK, BTB and C-terminal Kelch, Intracellular Signaling Peptides and Proteins, Ubiquitination, cell signalling, Cullin Proteins, Protein Structure, Tertiary, CRL, Cullin–RING ligase, HECT, homologous with E6-associated protein C-terminus, Multiprotein Complexes, KEAP1, Kelch-like ECH-associated protein 1, POZ, pox virus and zinc finger

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::839c55b704708e46a63bc6a374e7ab21Test
https://ora.ox.ac.uk/objects/uuid:92171bca-21d7-40fe-9f4e-b174e8406f7dTest

المؤلفون: Goh, Eddy T. H., Arthur, J. Simon C., Cheung, Peter C. F., Akira, Shizuo, Toth, Rachel, Cohen, Philip

المصدر: Goh , E T H , Arthur , J S C , Cheung , P C F , Akira , S , Toth , R & Cohen , P 2012 , ' Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system ' , Biochemical Journal , vol. 441 , pp. 339-346 . https://doi.org/10.1042/BJ20111415Test

مصطلحات موضوعية: interleukin-1-receptor-associated kinase (IRAK), inhibitor of nuclear factor kappa B kinase (IKK), TANK [TRAF (tumour-necrosis-factor-receptor-associated factor)-associated nuclear factor kappa B activator]-binding kinase 1 (TBK1), tumour necrosis factor alpha (TNF alpha), Toll-like receptor (TLR), FHA DOMAIN, IRAK1, POLYUBIQUITINATION, PHOSPHORYLATION, BINDING, FAMILY, ROLES, TAK1

العلاقة: https://discovery.dundee.ac.uk/en/publications/c98c2b36-fc53-42a0-a71f-e53e1b1d23d3Test

الإتاحة: https://doi.org/10.1042/BJ20111415Test
https://discovery.dundee.ac.uk/en/publications/c98c2b36-fc53-42a0-a71f-e53e1b1d23d3Test