المؤلفون: Yu, Mengdi, Zhang, Hongxia, Wang, Brian, Zhang, Yinuo, Zheng, Xiaoying, Shao, Bei, Zhuge, Qichuan, Jin, Kunlin

المصدر: Cells

مصطلحات موضوعية: metabolism, ampk, sirt1, aging, health span, intervention, mTOR, senescence, signaling, AMP-Activated Protein Kinases / metabolism, Age Factors, Animals, Biomarkers / metabolism, Cognition / drug effects, Cognitive Aging, Enzyme Activation, Enzyme Activators / therapeutic use, Functional Status, Healthy Aging / drug effects, Healthy Aging / metabolism, Healthy Aging / psychology, Humans, Mental Health, Molecular Targeted Therapy, Protein Kinase Inhibitors / therapeutic use, Signal Transduction / drug effects, Sirtuin 1 / metabolism, TOR Serine-Threonine Kinases / antagonists & inhibitors, TOR Serine-Threonine Kinases / metabolism

وصف الملف: application/pdf

العلاقة: https://doi.org/10.3390/cells10030660Test; Yu, M., Zhang, H., Wang, B., Zhang, Y., Zheng, X., Shao, B., Zhuge, Q., & Jin, K. (2021). Key Signaling Pathways in Aging and Potential Interventions for Healthy Aging. Cells, 10(3), 660. https://doi.org/10.3390/cells10030660Test; https://hdl.handle.net/20.500.12503/31700Test; 10

الإتاحة: https://doi.org/20.500.12503/31700Test
https://doi.org/10.3390/cells10030660Test
https://hdl.handle.net/20.500.12503/31700Test

المساهمون: Hyunho Yoon, Chih-Min Tang, Sudeep Banerjee, Mayra Yebra, Sangkyu Noh, Adam M Burgoyne, Jorge De la Torre, Martina De Siena, Mengyuan Liu, Lillian R Klug, Yoon Young Choi, Mojgan Hosseini, Antonio L Delgado, Zhiyong Wang, Randall P French, Andrew Lowy, Ronald P DeMatteo, Michael C Heinrich, Alfredo A Molinolo, J Silvio Gutkind, Olivier Harismendy, Jason K Sicklick, Choi, Yoon Young

مصطلحات موضوعية: Cancer-Associated Fibroblasts / drug effects, Cancer-Associated Fibroblasts / pathology, Cell Line, Tumor, Epithelial-Mesenchymal Transition / genetics, Gastrointestinal Stromal Tumors / drug therapy, Gastrointestinal Stromal Tumors / genetics, Gastrointestinal Stromal Tumors / pathology, Humans, Lymphokines / genetics, Neoplasm Metastasis, Paracrine Communication / drug effects, Phosphatidylinositol 3-Kinases / drug effects, Platelet-Derived Growth Factor / genetics, Protein Kinase Inhibitors / pharmacology, Receptor, Platelet-Derived Growth Factor alpha / genetics, Signal Transduction / drug effects, Snail Family Transcription Factors / genetics, TOR Serine-Threonine Kinases / antagonists & inhibitors, TOR Serine-Threonine Kinases / genetics, Tumor Microenvironment / drug effects

العلاقة: ONCOGENE; J02413; OAK-2022-05212; https://ir.ymlib.yonsei.ac.kr/handle/22282913/191025Test; T9992022432; ONCOGENE, Vol.40(11) : 1957-1973, 2021-03

الإتاحة: https://doi.org/10.1038/s41388-021-01685-wTest
https://ir.ymlib.yonsei.ac.kr/handle/22282913/191025Test

المساهمون: Hyung Joon Kim, Mi Kyung Gong, Cheol Yong Yoon, Jaeku Kang, Mijin Yun, Nam Hoon Cho, Sun Young Rha, Young Deuk Choi, Rha, Sun Young

مصطلحات موضوعية: Antineoplastic Agents / therapeutic use, Antineoplastic Combined Chemotherapy Protocols, Apoptosis / drug effects, Benzoquinones / pharmacology, Benzoquinones / therapeutic use, Cell Cycle Checkpoints / drug effects, Cell Line, Tumor, Cisplatin / pharmacology, Cisplatin / therapeutic use, DNA Damage / drug effects, Drug Resistance, Neoplasm, Humans, Imidazoles, Lactams, Macrocyclic / pharmacology, Macrocyclic / therapeutic use, Phosphatidylinositol 3-Kinases / metabolism, Phosphoinositide-3 Kinase Inhibitors, Protein Kinase Inhibitors / pharmacology, Protein Kinase Inhibitors / therapeutic use, Quinolines, TOR Serine-Threonine Kinases / antagonists & inhibitors, TOR Serine-Threonine Kinases / metabolism, Urinary Bladder Neoplasms / drug therapy, 17-DMAG, Bladder cancer, Cisplatin, NVP-BEZ235

العلاقة: YONSEI MEDICAL JOURNAL; J02813; OAK-2020-04946; https://ir.ymlib.yonsei.ac.kr/handle/22282913/179512Test; T202002852; YONSEI MEDICAL JOURNAL, Vol.61(7) : 587-596, 2020-07; 67105

الإتاحة: https://doi.org/10.3349/ymj.2020.61.7.587Test
https://ir.ymlib.yonsei.ac.kr/handle/22282913/179512Test

المساهمون: Sun Woo Um, Min Jee Kim, Joong Woo Leem, Sun Joon Bai, Bae Hwan Lee, Bai, Sun Joon

مصطلحات موضوعية: Analgesics/pharmacology, Analgesics/therapeutic use, Animals, Electric Stimulation, Gyrus Cinguli/drug effects, Gyrus Cinguli/pathology, Hyperalgesia/complications, Hyperalgesia/pathology, Male, Microinjections, Nerve Tissue/injuries, Nerve Tissue/pathology, Neuralgia/drug therapy, Rats, Sprague-Dawley, Signal Transduction/drug effects, Sirolimus/pharmacology, Sirolimus/therapeutic use, Synapses/drug effects, Synapses/metabolism, TOR Serine-Threonine Kinases/antagonists & inhibitors, TOR Serine-Threonine Kinases/metabolism, Anterior cingulate cortex, Neuropathic pain, Rapamycin, Synaptic plasticity, mTOR

العلاقة: MOLECULAR NEUROBIOLOGY; J03461; OAK-2019-05791; https://ir.ymlib.yonsei.ac.kr/handle/22282913/173327Test; T201904501; MOLECULAR NEUROBIOLOGY, Vol.56(4) : 2482-2494, 2019; 64227

الإتاحة: https://doi.org/10.1007/s12035-018-1245-zTest
https://ir.ymlib.yonsei.ac.kr/handle/22282913/173327Test

المؤلفون: Faes, S., Santoro, T., Troquier, L., De Souza Silva, O., Dormond, O.

المصدر: Biochemical and biophysical research communications, vol. 513, no. 3, pp. 546-552

مصطلحات موضوعية: Antineoplastic Agents/pharmacology, Cell Line, Tumor, Cell Proliferation, HT29 Cells, Heterocyclic Compounds, 3-Ring/pharmacology, Humans, Neoplasms/enzymology, Neoplasms/pathology, Phosphoinositide-3 Kinase Inhibitors/pharmacology, Protein Kinase Inhibitors/pharmacology, Proto-Oncogene Proteins c-akt/antagonists & inhibitors, Proto-Oncogene Proteins c-akt/metabolism, Receptor, IGF Type 1/antagonists & inhibitors, TOR Serine-Threonine Kinases/antagonists & inhibitors, Cancer, PI3K, Targeted therapies, Washout, mTOR

وصف الملف: application/pdf

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/30981504; info:eu-repo/semantics/altIdentifier/eissn/1090-2104; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_EE9065608CC64; https://serval.unil.ch/notice/serval:BIB_EE9065608CC6Test; urn:issn:0006-291X; https://serval.unil.ch/resource/serval:BIB_EE9065608CC6.P001/REF.pdfTest; http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_EE9065608CC64Test

الإتاحة: https://doi.org/10.1016/j.bbrc.2019.04.044Test
https://serval.unil.ch/notice/serval:BIB_EE9065608CC6Test
https://serval.unil.ch/resource/serval:BIB_EE9065608CC6.P001/REF.pdfTest
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_EE9065608CC64Test

المؤلفون: El Zaoui, Ikram, Bucher, Maya, Rimoldi, Donata, Nicolas, Michael, Kaya, Gurkan, Pescini Gobert, Rosanna, Bedoni, Nicola, Schalenbourg, Ann, Sakina, Ezziat, Zografos, Leonidas, Leyvraz, Serge, Riggi, Nicolo, Rivolta, Carlo, Moulin, Alexandre P

المصدر: ISSN: 0146-0404 ; Investigative Ophthalmology & Visual Science, vol. 60, no. 7 (2019) p. 2764-2772.

مصطلحات موضوعية: info:eu-repo/classification/ddc/616, Adult, Aged, 80 and over, Antineoplastic Agents/therapeutic use, Benzimidazoles/therapeutic use, Blotting, Western, Conjunctival Neoplasms/drug therapy/enzymology/pathology, Female, Fluorescent Antibody Technique, Indirect, Humans, Imidazoles/therapeutic use, Indazoles/therapeutic use, Male, Melanoma/drug therapy/enzymology/pathology, Middle Aged, Mitogen-Activated Protein Kinases/antagonists & inhibitors, Molecular Targeted Therapy, Phosphatidylinositol 3-Kinases/drug effects, Protein Kinase Inhibitors/therapeutic use, Proto-Oncogene Proteins B-raf/genetics, Pyridones/therapeutic use, Pyrimidinones/therapeutic use, Quinolines/therapeutic use, Sulfonamides/therapeutic use, TOR Serine-Threonine Kinases/antagonists & inhibitors, Tumor Cells, Cultured

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/31247083; https://archive-ouverte.unige.ch/unige:134887Test; unige:134887

الإتاحة: https://doi.org/10.1167/iovs.18-26508Test
https://archive-ouverte.unige.ch/unige:134887Test

المؤلفون: Zabala-Letona, A., Arruabarrena-Aristorena, A., Martín-Martín, N., Fernandez-Ruiz, S., Sutherland, J.D., Clasquin, M., Tomas-Cortazar, J., Jimenez, J., Torres, I., Quang, P., Ximenez-Embun, P., Bago, R., Ugalde-Olano, A., Loizaga-Iriarte, A., Lacasa-Viscasillas, I., Unda, M., Torrano, V., Cabrera, D., van Liempd, S.M., Cendon, Y., Castro, E., Murray, S., Revandkar, A., Alimonti, A., Zhang, Y., Barnett, A., Lein, G., Pirman, D., Cortazar, A.R., Arreal, L., Prudkin, L., Astobiza, I., Valcarcel-Jimenez, L., Zuñiga-García, P., Fernandez-Dominguez, I., Piva, M., Caro-Maldonado, A., Sánchez-Mosquera, P., Castillo-Martín, M., Serra, V., Beraza, N., Gentilella, A., Thomas, G., Azkargorta, M., Elortza, F., Farràs, R., Olmos, D., Efeyan, A., Anguita, J., Muñoz, J., Falcón-Pérez, J.M., Barrio, R., Macarulla, T., Mato, J.M., Martinez-Chantar, M.L., Cordon-Cardo, C., Aransay, A.M., Marks, K., Baselga, J., Tabernero, J., Nuciforo, P., Manning, B.D., Marjon, K., Carracedo, A.

المصدر: Nature, vol. 547, no. 7661, pp. 109-113

مصطلحات موضوعية: Adenosylmethionine Decarboxylase/immunology, Adenosylmethionine Decarboxylase/metabolism, Animals, Cell Proliferation, Enzyme Activation, Everolimus/therapeutic use, Humans, Male, Metabolomics, Mice, Multiprotein Complexes/antagonists & inhibitors, Multiprotein Complexes/metabolism, PTEN Phosphohydrolase/metabolism, Phosphatidylinositol 3-Kinases/metabolism, Polyamines/metabolism, Prostatic Neoplasms/drug therapy, Prostatic Neoplasms/metabolism, Prostatic Neoplasms/pathology, Protein Stability, S-Adenosylmethionine/analogs & derivatives, S-Adenosylmethionine/metabolism, TOR Serine-Threonine Kinases/antagonists & inhibitors, TOR Serine-Threonine Kinases/metabolism

وصف الملف: application/pdf

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/28658205; info:eu-repo/semantics/altIdentifier/eissn/1476-4687; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_A2A21769118A7; https://serval.unil.ch/notice/serval:BIB_A2A21769118ATest; urn:issn:0028-0836; https://serval.unil.ch/resource/serval:BIB_A2A21769118A.P001/REF.pdfTest; http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_A2A21769118A7Test

الإتاحة: https://doi.org/10.1038/nature22964Test
https://serval.unil.ch/notice/serval:BIB_A2A21769118ATest
https://serval.unil.ch/resource/serval:BIB_A2A21769118A.P001/REF.pdfTest
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_A2A21769118A7Test

المساهمون: College of Medicine, Dept. of Life Science, Sun Min Lim, Hyung Soon Park, Sangwoo Kim, Sora Kim, Siraj M. Ali, Joel R. Greenbowe, In Seok Yang, Nak-Jung Kwon, Jae Lyun Lee, Min-Hee Ryu, Jin-Hee Ahn, Jeeyun Lee, Min Goo Lee, Hyo Song Kim, Hyunki Kim, Hye Ryun Kim, Yong Wha Moon, Hyun Cheol Chung, Joo-Hang Kim, Yoon-Koo Kang, Byoung Chul Cho, Kim, Sang Woo, Kim, Hyun Ki, Kim, Hye Ryun, Kim, Hyo Song, Park, Hyung Soon, Lee, Min Goo, Lim, Sun Min, Chung, Hyun Cheol, Cho, Byoung Chul, Kim, So Ra

مصطلحات موضوعية: Adenocarcinoma/drug therapy, Adult, Aged, 80 and over, Antineoplastic Agents/therapeutic use, Carcinoma, Renal Cell/drug therapy, Class I Phosphatidylinositol 3-Kinases, Class Ib Phosphatidylinositol 3-Kinase/genetics, Drug Resistance, Neoplasm/genetics, Everolimus/therapeutic use, Female, Head and Neck Neoplasms/drug therapy, High-Throughput Nucleotide Sequencing, Humans, Kidney Neoplasms/drug therapy, Lacrimal Apparatus/pathology, Male, Middle Aged, Mutation/genetics, Neurofibromin 1/genetics, Phosphatidylinositol 3-Kinases/genetics, Polymorphism, Single Nucleotide/genetics, Sarcoma/drug therapy, Stomach Neoplasms/drug therapy, TOR Serine-Threonine Kinases/antagonists & inhibitors, TOR Serine-Threonine Kinases/genetics, Thyroid Neoplasms/drug therapy

وصف الملف: application/pdf

العلاقة: ONCOTARGET; J02421; OAK-2016-06233; https://ir.ymlib.yonsei.ac.kr/handle/22282913/152318Test; T201604204; ONCOTARGET , Vol.7(9) : 10547-10556, 2016; 48053

الإتاحة: https://doi.org/10.18632/oncotarget.7234Test
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152318Test

المساهمون: College of Medicine, Dept. of Internal Medicine, S. J. Kim, D.-Y. Shin, J. S. Kim, D. H. Yoon, W. S. Lee, H. Lee, Y. R. Do, H. J. Kang, H. S. Eom, Y. H. Ko, S. H. Lee, H. Y. Yoo, M. Hong, C. Suh, W. S. Kim, Kim, Jin Seok

مصطلحات موضوعية: Adult, Aged, Antineoplastic Combined Chemotherapy Protocols/administration & dosage, Antineoplastic Combined Chemotherapy Protocols/adverse effects, Cyclophosphamide/administration & dosage, Cyclophosphamide/adverse effects, Disease-Free Survival, Doxorubicin/administration & dosage, Doxorubicin/adverse effects, Drug Administration Schedule, Everolimus/administration & dosage, Everolimus/adverse effects, Female, Humans, Lymphoma, T-Cell, Peripheral/drug therapy, Peripheral/pathology, Male, Middle Aged, Neoplasm Staging, PTEN Phosphohydrolase/biosynthesis, PTEN Phosphohydrolase/genetics, Prednisone/administration & dosage, Prednisone/adverse effects, TOR Serine-Threonine Kinases/antagonists & inhibitors, TOR Serine-Threonine Kinases/genetics, Treatment Outcome, Vincristine/administration & dosage, Vincristine/adverse effects

العلاقة: ANNALS OF ONCOLOGY; J00171; OAK-2016-07707; https://ir.ymlib.yonsei.ac.kr/handle/22282913/152779Test; T201605305; ANNALS OF ONCOLOGY, Vol.27(4) : 712-718, 2016

الإتاحة: https://doi.org/10.1093/annonc/mdv624Test
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152779Test

المساهمون: College of Medicine, Dept. of Surgery, B.S. Kim, Y. Cho, H. Lee, D.J. Joo, K.H. Huh, M.S. Kim, Y.S. Kim, Kim, Myoung Soo, Kim, Beom Seok, Kim, Yu Seun, Joo, Dong Jin, Huh, Kyu Ha

مصطلحات موضوعية: Acute Kidney Injury/chemically induced, Animals, Calcineurin Inhibitors/pharmacokinetics, Calcineurin Inhibitors/toxicity, Cells, Cultured, Cyclosporine/pharmacology, Cyclosporine/toxicity, Drug Combinations, Immunosuppressive Agents/pharmacology, Immunosuppressive Agents/toxicity, Kidney/metabolism, Mice, Podocytes/drug effects, Podocytes/metabolism, Proteins/drug effects, Proteins/metabolism, Proteinuria/metabolism, Proteomics/methods, Sirolimus/pharmacology, Sirolimus/toxicity, TOR Serine-Threonine Kinases/antagonists & inhibitors

وصف الملف: 1297~1301

العلاقة: TRANSPLANTATION PROCEEDINGS; J02755; OAK-2016-02745; https://ir.ymlib.yonsei.ac.kr/handle/22282913/146978Test; http://www.sciencedirect.com/science/article/pii/S0041134516001901Test; T201601905; TRANSPLANTATION PROCEEDINGS, Vol.48(4) : 1297-1301, 2016

الإتاحة: https://doi.org/10.1016/j.transproceed.2016.01.022Test
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146978Test
http://www.sciencedirect.com/science/article/pii/S0041134516001901Test