نتائج البحث - "TJ, tight junction"

1

Evolution of blood–brain barrier in brain diseases and related systemic nanoscale brain-targeting drug delivery strategies

المؤلفون: Liang Han, Chen Jiang

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 8, Pp 2306-2325 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: PSMA, prostate-specific membrane antigen, Gd, gadolinium, BACE1, β-secretase 1, MMP9, metalloproteinase-9, PLGA, poly(lactic-co-glycolic acid), Disease, Review, Aβ, amyloid beta, ICAM-1, intercellular adhesion molecule-1, KCa, calcium-dependent potassium channels, PD, Parkinson's disease, LDL, low density lipoprotein, PEG, polyethyleneglycol, Epilepsy, 0302 clinical medicine, P-gp, P-glycoprotein, Medicine, LRP1, LDLR-related protein 1, General Pharmacology, Toxicology and Pharmaceutics, BBB, blood–brain barrier, siRNA, short interfering RNA, 0303 health sciences, ZO1, zona occludens 1, LAT1, L-type amino acid transporter 1, LDLR, LDL receptor, RBC, red blood cell, AMT, alpha-methyl-l-tryptophan, DTPA-Gd, Gd-diethyltriaminepentaacetic acid, RAGE, receptor for advanced glycosylation end products, VEGF, vascular endothelial growth factor, Drug delivery systems, KATP, ATP-sensitive potassium channels, medicine.anatomical_structure, TJ, tight junction, 030220 oncology & carcinogenesis, Drug delivery, cardiovascular system, AD, Alzheimer's disease, Brain diseases, RMT, receptor-mediated transcytosis, Traumatic brain injury, Brain tumor, BDNF, brain derived neurotrophic factor, Brain-targeting, TfR, transferrin receptor, RM1-950, Blood–brain barrier, TBI, traumatic brain injury, MFSD2A, major facilitator superfamily domain-containing protein 2a, 03 medical and health sciences, ROS, reactive oxygen species, EPR, enhanced permeability and retention, NPs, nanoparticles, 030304 developmental biology, CMT, carrier-mediated transportation, PEG-PLGA, polyethyleneglycol-poly(lactic-co-glycolic acid), business.industry, LFA-1, lymphocyte function associated antigen-1, GLUT1, glucose transporter-1, medicine.disease, tPA, tissue plasminogen activator, Brain targeting, BTB, blood–brain tumor barrier, nervous system, Nanoparticles, Nasal administration, Therapeutics. Pharmacology, business, Neuroscience, MRI, magnetic resonance imaging

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a05eff9f72ac70fe48cb5ed9a111b5bTest
http://www.sciencedirect.com/science/article/pii/S2211383520308522Test

2

A Novel Microphysiological Colon Platform to Decipher Mechanisms Driving Human Intestinal Permeability

المؤلفون: Rohit A. Panchakshari, Athanasia Apostolou, Cosmas Giallourakis, Galeb Abu-Ali, Antara Banerjee, Tengku Ibrahim Maulana, Raymond Luc, Gauri Kulkarni, Carolina Lucchesi, Jordan Kerns, Katia Karalis, Alexandra Dimitriou, Maria D. Paraskevopoulou, Magdalena Kasendra, Elias S. Manolakos, Lorna Ewart, Geraldine A. Hamilton, Bertram Bleck, Dimitris V. Manatakis

المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 5, Pp 1719-1741 (2021)

مصطلحات موضوعية: EdU, 5-ethynyl-2’-deoxyuridine, Cell Culture Techniques, RC799-869, Wnt, wingless-related integration site, IEC, intestinal epithelial cell, Interleukin 22, ZO-1, zonula occludens-1, IL, interleukin 6, Organ-on-Chip, Leaky Gut, Lab-On-A-Chip Devices, Intestinal Mucosa, Receptor, Original Research, DKK1, Dickkopf-related protein 1, IBD, inflammatory bowel disease, cHIMEC, colonic human intestinal microvascular endothelial cell, Gastroenterology, Diseases of the digestive system. Gastroenterology, Intestinal epithelium, NHS, N-hydroxysuccinimide, Cell biology, ECM, extracellular matrix, Organoids, STAT, signal transducer and activator of transcription, TNFα, tumor necrosis factor α, medicine.anatomical_structure, TJ, tight junction, Cellular Microenvironment, PDMS, polydimethylsiloxane, qPCR, quantitative polymerase chain reaction, Endothelium, Colon, PBS, phosphate-buffered saline, Biology, Permeability, In vivo, medicine, Organoid, Humans, DGE, differential gene expression, IFNγ, interferon-γ, GO, gene ontology, Intestinal permeability, Hepatology, Mechanism (biology), Gene Expression Profiling, Interleukins, RNA-seq, RNA sequencing, Computational Biology, medicine.disease, IL22BP, interleukin 22 binding protein, Papp, apparent permeability, Gene Expression Regulation, Transcriptome, Biomarkers

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c73f86b030301637ffe301dbedd59d97Test
http://europepmc.org/articles/PMC8551844Test

3

Control of Intestinal Epithelial Permeability by Lysophosphatidic Acid Receptor 5

المؤلفون: Mo Wang, C. Chris Yun, Yiran Han, Lei Dong, Peijian He

المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 1073-1092 (2021)

مصطلحات موضوعية: 0301 basic medicine, Male, Lipopolysaccharide, RC799-869, RT-PCR, reverse transcriptase polymerase chain reaction, IEC, intestinal epithelial cell, Cell membrane, chemistry.chemical_compound, Transactivation, Mice, 0302 clinical medicine, LPA5, FD-4, fluorescein isothiocyanate-labeled 4 kDa dextran, Lysophosphatidic acid, Intestinal Mucosa, Receptors, Lysophosphatidic Acid, Receptor, Original Research, ATX, autotaxin, IBD, inflammatory bowel disease, Dextran Sulfate, Gastroenterology, Diseases of the digestive system. Gastroenterology, GI, gastrointestinal, Colitis, Cell biology, LPA, medicine.anatomical_structure, TJ, tight junction, shRNA, short hairpin RNA, LPS, lipopolysaccharide, 030211 gastroenterology & hepatology, Signal transduction, JAMs, junctional adhesion molecules, Rac1, LPA, lysophosphatidic acid, LPA5, LPA receptor 5, Barrier, PBS, phosphate-buffered saline, RAC1, ROCK, RhoA-associated kinase, Permeability, TER, transepithelial electrical resistance, Cell Line, GEF, guanine nucleotide exchange factor, 03 medical and health sciences, Stat, signal transducers and activators of transcription, DSS, dextran sulfate sodium, medicine, Animals, Humans, IF, immunofluorescence, GPCR, G protein-coupled receptor, Intestinal permeability, Hepatology, Stat3, NHE3, Na+/H+ exchanger 3, medicine.disease, AJ, adherens junction, EGFR, epidermal growth factor receptor, Disease Models, Animal, 030104 developmental biology, chemistry, Caco-2 Cells, Lysophospholipids, SD, standard deviation

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76070d2010df41333ad81cb10e8a8f40Test
http://europepmc.org/articles/PMC8350072Test

4

Regulation of Intestinal Epithelial Barrier and Immune Function by Activated T Cells

المؤلفون: Kien Huu Nguyen, Alan D. Levine, Nga Thanh Le, Claire Mazahery

المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 55-76 (2021)

مصطلحات موضوعية: 0301 basic medicine, Intravital Microscopy, PD-L1, programmed death ligand 1, T-Lymphocytes, Cell Communication, Lymphocyte Activation, Cell morphology, TNF-α, tumor necrosis factor-α, IEC, intestinal epithelial cell, 0302 clinical medicine, Cell Movement, ZO, zonula occludens, FD4, fluorescein isothiocyanate–labeled 4-kilodalton dextran, IFN-γ, interferon-γ, Intestinal Mucosa, Receptor, 3-D, 3-dimensional, Original Research, IBD, inflammatory bowel disease, Tight junction, Chemistry, Gastroenterology, CLDN, claudin, Intestinal epithelium, Healthy Volunteers, mRNA, messenger RNA, Cell biology, TJ, tight junction, medicine.anatomical_structure, Cytokines, 030211 gastroenterology & hepatology, Programmed cell death, Primary Cell Culture, B2M, β2-microglobulin, PBS, phosphate-buffered saline, Permeability, Tight Junctions, TER, transepithelial electrical resistance, 03 medical and health sciences, Immune system, Occludin, TGF-β, transforming growth factor-β, medicine, Humans, MHC, major histocompatibility complex, lcsh:RC799-869, Leak Pathway, Pore Pathway, Hepatology, HBSS, Hank’s balanced salt solution, 2-D, 2-dimensional, Epithelial Cells, PD-1, programmed death 1, Coculture Techniques, Epithelium, Claudin, IL, interleukin, Paracellular Permeability, 030104 developmental biology, lcsh:Diseases of the digestive system. Gastroenterology, Caco-2 Cells, Flux (metabolism), BBe, brush border expressing clone

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::450cac7e7a2afdff8746af24c48114abTest
https://doi.org/10.1016/j.jcmgh.2020.07.004Test

5

Muc2 Mucin and Nonmucin Microbiota Confer Distinct Innate Host Defense in Disease Susceptibility and Colonic Injury

المؤلفون: Aralia Leon-Coria, Manish Kumar, Matthew Workentine, France Moreau, Michael Surette, Kris Chadee

المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 77-98 (2021)

مصطلحات موضوعية: Male, 0301 basic medicine, Antibiotics, Pathogenesis, Mice, 0302 clinical medicine, LPL, lamina propria lymphocyte, DSS, dextran sodium sulfate, Intestinal Mucosa, Original Research, Disease Resistance, TGF-β, transforming growth factor β, Mice, Knockout, IBD, inflammatory bowel disease, FMT, fecal microbiota transplantation, Microbiota, Dextran Sulfate, Gastroenterology, ILC, innate lymphoid cell, respiratory system, Colitis, mRNA, messenger RNA, Anti-Bacterial Agents, 3. Good health, TJ, tight junction, Female, 030211 gastroenterology & hepatology, DAI, disease activity index, FITC, fluorescein isothiocyanate, medicine.symptom, PICRUSt, phylogenetic investigation of communities by reconstruction of unobserved states, Colon, medicine.drug_class, Inflammation, Biology, digestive system, CDNA, complementary DNA, Microbiology, 03 medical and health sciences, Chimera (genetics), Immune system, medicine, Animals, Humans, lcsh:RC799-869, Immunity, Mucosal, Mucin-2, Host Microbial Interactions, Hepatology, medicine.disease, WT, wild-type, Mucus, digestive system diseases, IL, interleukin, Gastrointestinal Microbiome, Disease Models, Animal, 030104 developmental biology, Muc2, Dysbiosis, lcsh:Diseases of the digestive system. Gastroenterology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23ef6f03e7145e2cd814002bfa26033aTest
https://doi.org/10.1016/j.jcmgh.2020.07.003Test

6

Loss of Claudin-3 Impairs Hepatic Metabolism, Biliary Barrier Function, and Cell Proliferation in the Murine Liver

المؤلفون: Adolfo Odriozola, Mariana Castro Dias, Daniel Candinas, Tural Yarahmadov, Fadi Jebbawi, Mikio Furuse, Benoît Zuber, Alex Odermatt, Cristina Gómez Castellà, Urban Deutsch, Adrian Keogh, Riccardo Tombolini, Deborah Stroka, Britta Engelhardt, Daniel Sánchez-Taltavull, Felix Alexander Baier

المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 2, Pp 745-767 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Baier, Felix Alexander; Sánchez-Taltavull, Daniel; Yarahmadov, Tural; Castellà, Cristina Gómez; Jebbawi, Fadi; Keogh, Adrian; Tombolini, Riccardo; Odriozola, Adolfo; Castro Dias, Mariana; Deutsch, Urban; Furuse, Mikio; Engelhardt, Britta; Zuber, Benoît; Odermatt, Alex; Candinas, Daniel; Keogh-Stroka, Deborah M. (2021). Loss of claudin-3 impairs hepatic metabolism, biliary barrier function and cell proliferation in the murine liver. Cellular and molecular gastroenterology and hepatology, 12(2), pp. 745-767. Elsevier 10.1016/j.jcmgh.2021.04.003 <http://dx.doi.org/10.1016/j.jcmgh.2021.04.003Test>

مصطلحات موضوعية: 0301 basic medicine, Aging, Muricholic acid, RC799-869, Single-Cell RNA Sequencing, chemistry.chemical_compound, 0302 clinical medicine, Claudin-3, UMI, unique molecular identifiers, Original Research, Mice, Knockout, scRNA-seq, single-cell RNA sequencing, CA, cholic acid, Bile acid, Tight junction, Tight Junction, Chemistry, Liver cell, Gastroenterology, Diseases of the digestive system. Gastroenterology, mRNA, messenger RNA, Liver regeneration, 3. Good health, Cell biology, TJ, tight junction, medicine.anatomical_structure, Liver, PHx, partial hepatectomy, Hepatocyte, qPCR, quantitative polymerase chain reaction, 030211 gastroenterology & hepatology, Bile Acid, ALT, alanine-aminotransferase, medicine.drug_class, TCA, taurocholic acid, PBS, phosphate-buffered saline, Taurochenodeoxycholic acid, 610 Medicine & health, Tight Junctions, 03 medical and health sciences, medicine, Animals, Hepatectomy, Claudin, Cell Proliferation, ALP, alkaline phosphatase, Hepatology, Gene Expression Profiling, pHH3, phosphohistone H3, Lipid Metabolism, Liver Regeneration, Mice, Inbred C57BL, 030104 developmental biology, Gene Expression Regulation, Hepatocytes, AST, aspartate-aminotransferase, 570 Life sciences, biology, Bile Ducts, Gene Deletion, DAPI, 4′,6-diamidino-2-phenylindole