دورية أكاديمية
Is COVID-19 infection more severe in kidney transplant recipients?
| العنوان: | Is COVID-19 infection more severe in kidney transplant recipients? |
|---|---|
| المؤلفون: | CAILLARD, S., CHAVAROT, N., FRANCOIS, H., MATIGNON, M., GREZE, C., KAMAR, N., GATAULT, P., THAUNAT, O., LEGRIS, T., FRIMAT, L., WESTEEL, P.F., GOUTAUDIER, V., JDIDOU, M., SNANOUDJ, R., COLOSIO, C., SICARD, A., BERTRAND, D., MOUSSON, C., BAMOULID, J., MASSET, C., THIERRY, A., COUZI, Lionel, CHEMOUNY, J.M., DUVEAU, A., MOAL, V., BLANCHO, G., GRIMBERT, P., DURRBACH, A., MOULIN, B., ANGLICHEAU, D., RUCH, Y., KAEUFFER, C., BENOTMANE, I., SOLIS, M., LEMEUR, Y., HAZZAN, M., DANION, F., THE FRENCH SOT COVID, Registry |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Cardiovascular disease, Clinical research / practice, Glomerular filtration rate (GFR), Immunosuppressive regimens, Infection and infectious agents - viral, Infectious disease, Kidney failure / injury, Kidney transplantation / nephrology, Sciences du Vivant [q-bio]/Immunologie |
| الوصف: | There are no studies which have compared the risk of severe COVID-19 and related mortality between transplant recipients and nontransplant patients. We enrolled two groups of patients hospitalized for COVID-19, that is, kidney transplant recipients (KTR) from the French Registry of Solid Organ Transplant (n = 306) and a single-center cohort of nontransplant patients (n = 795). An analysis was performed among subgroups matched for age and risk factors for severe COVID-19 or mortality. Severe COVID-19 was defined as admission (or transfer) to an intensive care unit, need for mechanical ventilation, or death. Transplant recipients were younger and had more comorbidities compared to nontransplant patients. They presented with higher creatinine levels and developed more episodes of acute kidney injury. After matching, the 30-day cumulative incidence of severe COVID-19 did not differ between KTR and nontransplant patients; however, 30-day COVID-19-related mortality was significantly higher in KTR (17.9% vs 11.4%, respectively, p = .038). Age >60 years, cardiovascular disease, dyspnea, fever, lymphopenia, and C-reactive protein (CRP) were associated with severe COVID-19 in univariate analysis, whereas transplant status and serum creatinine levels were not. Age >60 years, hypertension, cardiovascular disease, diabetes, CRP >60 mg/L, lymphopenia, kidney transplant status (HR = 1.55), and creatinine level >115 µmol/L (HR = 2.32) were associated with COVID-19-related mortality in univariate analysis. In multivariable analysis, cardiovascular disease, dyspnea, and fever were associated with severe disease, whereas age >60 years, cardiovascular disease, dyspnea, fever, and creatinine level>115 µmol/L retained their independent associations with mortality. KTR had a higher COVID-19-related mortality compared to nontransplant hospitalized patients. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1600-6143 |
| العلاقة: | https://oskar-bordeaux.fr/handle/20.500.12278/140004Test |
| DOI: | 10.1111/ajt.16424 |
| الإتاحة: | https://doi.org/20.500.12278/140004Test https://doi.org/10.1111/ajt.16424Test https://oskar-bordeaux.fr/handle/20.500.12278/140004Test https://hdl.handle.net/20.500.12278/140004Test |
| حقوق: | open ; Pas de Licence CC |
| رقم الانضمام: | edsbas.F0276374 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16006143 |
|---|---|
| DOI: | 10.1111/ajt.16424 |