نتائج البحث - "TGF-β, Transforming Growth Factor-Β"

المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 1, Pp 95-112 (2022)

مصطلحات موضوعية: Liver Cirrhosis, Wt, wild-type, Cirrhosis, WST, water-soluble tetrazolium, P70-S6 Kinase 1, RC799-869, Chronic liver disease, PDGF, platelet-derived growth factor, Chronic Liver Disease, α-SMA, α-smooth muscle actin, Mice, Fibrosis, TGF-β, transforming growth factor-β, medicine, Hepatic Stellate Cells, Animals, Humans, p70S6K, p70 ribosomal protein S6 kinase, Transforming Growth Factor-β, Original Research, Cell Proliferation, Hepatology, business.industry, Platelet-Derived Growth Factor BB, phHSC, primary human hepatic stellate cell, Gastroenterology, GFAP, glial fibrillary acidic protein, Ribosomal Protein S6 Kinases, 70-kDa, Diseases of the digestive system. Gastroenterology, medicine.disease, Hepatic stellate cell activation, HSC, hepatic stellate cell, pmHSC, murine hepatic stellate cell, siRNA, small interfering RNA, Ribosomal protein s6, CLD, chronic liver disease, Hepatic stellate cell, Cancer research, Liver cancer, business, NASH, nonalcoholic steatohepatitis, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e045ef39f1e3824b43c456c1e617007Test
http://europepmc.org/articles/PMC8593664Test

6

Involvement of INF-γ functional single nucleotide polymorphism +874 T/A (rs2430561) in breast cancer risk

المؤلفون: Hanan E. Al-Rashidi, Dalia T Hussein, Sherif Refaat, Enas Ahmed, Fatma M. El-Tantawy, Sahar Hamed

المصدر: Saudi Journal of Biological Sciences
Saudi Journal of Biological Sciences, Vol 28, Iss 11, Pp 6289-6296 (2021)

مصطلحات موضوعية: 0106 biological sciences, 0301 basic medicine, ARMS-PCR, amplification refractory mutation system, polymerase chain reaction method, ER, estrogen receptor, BC, Breast cancer, medicine.disease_cause, 01 natural sciences, Gastroenterology, TNF-α, tumor necrosis factor-α, Breast cancer, Polymorphism (computer science), Genotype, HER2, human epidermal growth factor receptor 2, Biology (General), INF-γ, CI, 95% confidence intervals, PPI, poor prognostic index, C, controls, PAM50, Prediction Analysis of Microarray 50, Original Article, ICB, inflamed cells of breast, General Agricultural and Biological Sciences, INF-γ, Interferon-γ, TNBC, Triple Negative BC, medicine.medical_specialty, IRB, Institutional Review Board, QH301-705.5, Genotypes, CD, cluster of differentiation, Single-nucleotide polymorphism, NPI, the mandatory prognostic index, NK, natural killer cells, 03 medical and health sciences, Internal medicine, TGF-β, transforming growth factor-β, medicine, Allele, Polymorphism, GPI, good prognostic index, business.industry, Cancer, PR, progesterone receptor, medicine.disease, IL, interleukin, OR, odds ratio, 030104 developmental biology, SNPs, single nucleotide polymorphism, ISGs, INF-stimulated genes, MPI, moderate prognostic index, Gene polymorphism, Risk factor, Carcinogenesis, business, Th1, T helper1, 010606 plant biology & botany

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb25f5926719ed18f82fc75955e0093dTest
http://europepmc.org/articles/PMC8568710Test

7

The application of nanoparticles in cancer immunotherapy: Targeting tumor microenvironment

المؤلفون: Xianqun Fan, Jipeng Li, Muyue Yang, Ping Gu

المصدر: Bioactive Materials
Bioactive Materials, Vol 6, Iss 7, Pp 1973-1987 (2021)

مصطلحات موضوعية: MDSCs, myeloid-derived suppressor cells, medicine.medical_treatment, PLGA, poly(lactic-co-glycolic acid), Cancer immunotherapy, BTK, Bruton's tyrosine kinase, 02 engineering and technology, CAFs, cancer associated fibroblasts, CCL, chemoattractant chemokines ligand, DSF/Cu, disulfiram/copper, melittin-NP, melittin-lipid nanoparticle, IFN-γ, interferon-γ, TNF-α, tumor necrosis factor alpha, ANG2, angiopoietin-2, Hypoxia, lcsh:QH301-705.5, cDCs, conventional dendritic cells, TME, tumor microenvironment, DMXAA, 5,6-dimethylxanthenone-4-acetic acid, HB-GFs, heparin-binding growth factors, M2NP, M2-like TAM dual-targeting nanoparticle, ECM, extracellular matrix, IFP, interstitial fluid pressure, HIF, hypoxia-inducible factor, Tumor microenvironment, PDT, photodynamic therapy, Tregs, regulatory T cells, tdLNs, tumor-draining lymph nodes, 0210 nano-technology, Ab, antibodies, BBB, blood-brain barrier, DMMA, 2,3-dimethylmaleic anhydrid, SA, sialic acid, FDA, the Food and Drug Administration, PS, photosensitizer, Biomedical Engineering, Ag, antigen, Article, PD-1, programmed cell death protein 1, Biomaterials, TAMs, tumor-associated macrophages, lcsh:TA401-492, FAP, fibroblast activation protein, EPR, enhanced permeability and retention, NPs, nanoparticles, MPs, microparticles, NO, nitric oxide, Tumor therapy, scFv, single-chain variable fragment, medicine.disease, IL, interleukin, Radiation therapy, siRNA, small interfering RNA, Nanoparticles, TDPA, tumor-derived protein antigens, lcsh:Materials of engineering and construction. Mechanics of materials, HSA, human serum albumin, RLX, relaxin-2, Bcl-2, B-cell lymphoma 2, PSCs, pancreatic stellate cells, VDA, vasculature disrupting agent, Photodynamic therapy, CaCO3, calcium carbonate, Metastasis, AuNCs, gold nanocages, CTLA4, cytotoxic lymphocyte antigen 4, HPMA, N-(2-hydroxypropyl) methacrylamide, HA, hyaluronic acid, TIM-3, T cell immunoglobulin domain and mucin domain-3, TGF-β, transforming growth factor β, UPS-NP, ultra-pH-sensitive nanoparticle, IBR, Ibrutinib, MCMC, mannosylated carboxymethyl chitosan, α-SMA, alpha-smooth muscle actin, 021001 nanoscience & nanotechnology, VEGF, vascular endothelial growth factor, TAAs, tumor-associated antigens, LPS, lipopolysaccharide, APCs, antigen-presenting cells, Delivery system, DCs, dendritic cells, NF-κB, nuclear factor κB, PHDs, prolyl hydroxylases, EMT, epithelial-mesenchymal transition, TLR, Toll-like receptor, Biotechnology, PFC, perfluorocarbon, 0206 medical engineering, CAP, cleavable amphiphilic peptide, SPARC, secreted protein acidic and rich in cysteine, TfR, transferrin receptor, CTL, cytotoxic T lymphocytes, ODN, oligodeoxynucleotides, nMOFs, nanoscale metal-organic frameworks, ROS, reactive oxygen species, AuNPs, gold nanoparticles, medicine, EPG, egg phosphatidylglycerol, CAR-T, Chimeric antigen receptor-modified T-cell therapy, Chemotherapy, business.industry, AC-NPs, antigen-capturing nanoparticles, TIE2, tyrosine kinase with immunoglobulin and epidermal growth factor homology domain 2, 020601 biomedical engineering, EGFR, epidermal growth factor receptor, LMWH, low molecular weight heparin, PTX, paclitaxel, lcsh:Biology (General), Cancer research, MnO2, manganese dioxide, NK, nature killer, sense organs, business, RBC, red-blood-cell

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9e3a12774af1e45fb188f205ad9bdcTest
https://doi.org/10.1016/j.bioactmat.2020.12.010Test

8

The Ca2+-activated chloride channel ANO1/TMEM16A: An emerging therapeutic target for epithelium-originated diseases?

المؤلفون: Kewei Wang, Zongtao Liu, Yani Liu

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1412-1433 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: PASMC, pulmonary artery smooth muscle cells, PIP2, phosphatidylinositol 4,5-bisphosphate, ASM, airway smooth muscle, Drug target, ANO1, Review, HNSCC, head and neck squamous cell carcinoma, HTS, high-throughput screening, CaCCs, Ca2+ activated chloride channels, 0302 clinical medicine, ENaC, epithelial sodium channels, IPAH, idiopathic pulmonary arterial hypertension, General Pharmacology, Toxicology and Pharmaceutics, BBB, blood–brain barrier, VGCC, voltage gated calcium channel, VRAC, volume regulated anion channel, Cancer, 0303 health sciences, biology, Smooth muscle contraction, ICC, interstitial cells of Cajal, GI, gastrointestinal, Phenotype, DRG, dorsal root ganglion, VSMC, vascular smooth muscle cells, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Chloride channel, ANO1, anoctamin-1, ESCC, esophageal squamous cell carcinoma, NF-κB, nuclear factor κB, PAH, pulmonary arterial hypertension, Signal transduction, CAMK, Ca2+/calmodulin-dependent protein kinase, Anoctamin-1, CaCCinh-A01, FRT, fisher rat thyroid, PKD, polycystic kidney disease, RM1-950, Cystic fibrosis, ER, endoplasmic reticulum, GIST, gastrointestinal stromal tumor, 03 medical and health sciences, Channelopathy, TGF-β, transforming growth factor-β, medicine, CFTR, cystic fibrosis transmembrane conductance regulator, T16Ainh-A01, 030304 developmental biology, CF, cystic fibrosis, TMEM16A, Ang II, angiotensin II, business.industry, PAR2, protease activated receptor 2, medicine.disease, YFP, yellow fluorescent protein, Epithelium, EGFR, epidermal growth factor receptor, Ca2+-activated Cl– channels (CaCCs), GPCR, G-protein coupled receptor, biology.protein, Therapeutics. Pharmacology, business, Neuroscience, MAPK, mitogen-activated protein kinase

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b93ad5ed1da50ffcb970b7aa59df7feTest
https://doi.org/10.1016/j.apsb.2020.12.003Test

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The role of ALDH2 in tumorigenesis and tumor progression: Targeting ALDH2 as a potential cancer treatment

المؤلفون: Liwu Fu, Hong Zhang

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1400-1411 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: FANCD2, Fanconi anemia protein, DFS, disease-free survival, HNC, head and neck cancer, Cancer therapy, Review, medicine.disease_cause, SCC, squamous cell carcinoma, Metastasis, εPKC, epsilon protein kinase C, 0302 clinical medicine, NAD, nicotinamide adenine dinucleotide, Polymorphism (computer science), PdG, N2-propano-2′-deoxyguanosine, EC, esophageal cancer, General Pharmacology, Toxicology and Pharmaceutics, FA, Fanconi anemia, Cancer, TGF-β, transforming growth factor β, 0303 health sciences, Progression, GCA, gastric cancer, NRF2, nuclear factor erythroid 2 (NF-E2)-related factor 2, ccRCC, clear-cell renal cell carcinomas, NHEJ, non-homologous end-joining, PC, pancreatic cancer, 030220 oncology & carcinogenesis, CRC, colorectal cancer, NeG, 1,N2-etheno-dGuo, PBMC, peripheral blood mononuclear cell, ALD, alcoholic liver disease, CSCs, cancer stem cells, OvCa, ovarian cancer, COUP-TF, chicken ovalbumin upstream promoter-transcription factor, BCa, bladder cancer, NF-κB, nuclear factor-κB, Single-nucleotide polymorphism, Acetaldehyde, RM1-950, 4-HNE, 4-hydroxy-2-nonenal, OS, overall survival, 03 medical and health sciences, NSCLC, non-small-cell lung, medicine, SNP, MN, micronuclei, Polymorphism, ALDH2, 030304 developmental biology, LCSCs, liver cancer stem cells, MDA, malondialdehyde, business.industry, ALDH2, aldehyde dehydrogenase 2, MDR, multi-drug resistance, OPC, oropharyngeal cancer, HDACs, histone deacetylases, medicine.disease, AMPK, AMP-activated protein kinase, VHL, von Hippel-Lindau, Tumor progression, REV1, Y-family DNA polymerase, NER, nucleotide excision repair pathway, NRRE, nuclear receptor response element, Tumorigenesis, Cancer research, NCEs, normochromic erythrocytes, Therapeutics. Pharmacology, HR, homologous recombination, HCC, hepatocellular carcinoma, business, Carcinogenesis, HNF-4, hepatocyte nuclear factor 4

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dd88ae6dedbdf2435fcfad1324d1900Test
https://doi.org/10.1016/j.apsb.2021.02.008Test

10

Hedgehog signaling in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment

المؤلفون: Xian Zeng, Dianwen Ju, Jiajun Fan, Yichen Wang, Jinghui Zhang, Jingyun Luan, Kai Yin, Mingming Nie

المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 609-620 (2021)

مصطلحات موضوعية: BCL-2, B cell lymphoma 2, G protein coupled receptor kinase 2, HH, Carcinogenesis, Hedgehog, HIF-1α, MDSCs, myeloid-derived suppressor cells, STAT3, signal transducer and activator of transcription 3, FOLFOX, oxaliplatin, Review, medicine.disease_cause, SMO, Smoothened, Immune tolerance, 0302 clinical medicine, βArr2, β-arrestin2, ATO, arsenic trioxide, hypoxia-inducible factor 1α, IFN-γ: interferon-γ, Medicine, General Pharmacology, Toxicology and Pharmaceutics, TGF-β, transforming growth factor β, 0303 health sciences, glioma-associated oncogene homologue, GRK2, Cancer stem cells, 5-Fu, 5-fluorouracil, TME, tumor microenvironment, IHH, Indian Hedgehog, VEGF, vascular endothelial growth factor, SHH, Sonic Hedgehog, Hedgehog signaling pathway, PD-L1, programmed cell death ligand-1, Tumor microenvironment, 030220 oncology & carcinogenesis, BMI-1, B cell-specific moloney murine leukemia virus insertion region-1, SUFU, Suppressor of Fused, Signal transduction, DHH, Desert Hedgehog, NK, natural killer, CSCs, cancer stem cells, and leucovorin, GLI, NOX4, NADPH Oxidase 4, ALK5, TGF-β receptor I kinase, PTCH, Patched, SNF5, sucrose non-fermenting 5, Gastrointestinal cancer, 03 medical and health sciences, ROS, reactive oxygen species, Immune system, Cancer stem cell, BCC, basal cell carcinoma, 030304 developmental biology, EGF, epidermal growth factor, IL-10/6, interleukin 10/6, ITCH, itchy E3 ubiquitin ligase, ch5E1, chimeric monoclonal antibody 5E1, business.industry, lcsh:RM1-950, WNT, Wingless/Integrated, PD-1, programmed cell death-1, SMAD3, mothers against decapentaplegic homolog 3, medicine.disease, lcsh:Therapeutics. Pharmacology, Drug resistance, Cancer research, PKA, protein kinase A, TAMs, tumor-related macrophages, sense organs, business, Hedgehog, CAFs, cancer-associated fibroblasts

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9591fe5f71a6d93ff75c586983adcbTest
https://doi.org/10.1016/j.apsb.2020.10.022Test

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