المؤلفون: Jian-Guang Luo, Tianyu Zhu, Chen Chen, Yi Zhang, Hao Zhang, Dong-Rong Zhu, Xiao-Qin Liu, Ling-Yi Kong, Chao Han, Sifang Wu

المصدر: Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 246-261 (2022)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: PHGDH, phosphoglycerate dehydrogenase, PSAT, phosphoserine aminotransferase, Allosteric regulation, CuAAC, copper-catalyzed alkyne–azide cycloaddition, Regulatory site, ABPP, affinity-based protein profiling, RM1-950, Proteomics, RMSD, root mean square deviation, Serine, CETSA, cellular thermal shift assay, 03 medical and health sciences, 3-PHP, 3-phosphohydroxypyruvate, ROS, reactive oxygen species, 0302 clinical medicine, DARTS, drug affinity responsive target stability, TCEP, tris(2-carboxyethyl) phosphine, GSH, glutathione, TBTA, tris[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl]amine, Phosphoglycerate dehydrogenase, General Pharmacology, Toxicology and Pharmaceutics, Covalent inhibitor, Withanolides, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Chemical proteomics, NADPH, nicotinamide adenine dinucleotide phosphate, Serine synthesis pathway, MD, molecular dynamics, Small molecule, 3-PG, 3-phosphoglycerate, Colon cancer, RMSF, root mean square fluctuations, Enzyme, chemistry, Biochemistry, Oxidative stress, SBD, substrate-binding domain, 030220 oncology & carcinogenesis, Original Article, BLI, biolayer interferometry assay, Therapeutics. Pharmacology, SSP, serine synthesis pathway, Withangulatin A, Cysteine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3543b6d3266f2b136393cdedb4c3da23Test
http://www.sciencedirect.com/science/article/pii/S2211383521002203Test

المؤلفون: James Kelly

المصدر: Biochemistry and Biophysics Reports, Vol 28, Iss, Pp 101186-(2021)
Biochemistry and Biophysics Reports

مصطلحات موضوعية: Hepatocyte growth factor, IPF, Idiopathic pulmonary fibrosis, Fc fusion, QH301-705.5, Biophysics, Long half-life, QD415-436, TCEP, (tris(2-carboxyethyl)phosphine), Hepatocyte growth factor mimetic, Biochemistry, FcRN, neonatal Fc receptor, Branching morphogenesis, HGF, hepatocyte growth factor, Hepatocyte division, Biology (General), Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f60cc61edc9f126e654a333fac4ecdb6Test
http://www.sciencedirect.com/science/article/pii/S2405580821002806Test

المؤلفون: Nurit Livnat-Levanon, Nir Ben-Tal, Elena Vigonsky, Amy C. Rosenzweig, Rose C. Hadley, Jessica Rose, Oded Lewinson, Gal Masrati, Daniel Zhitnitsky

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: crystal structure, Operon, Protein Data Bank (RCSB PDB), lac operon, HMM, Hidden Markov model, Biochemistry, NDH-2, NADH dehydrogenase II, chemistry.chemical_compound, Structure-Activity Relationship, JGI, Joint Genome Institute, PDB, Protein Data Bank, Metalloprotein, Escherichia coli, pfam10709, Protein family 10709, Molecular Biology, Chelating Agents, chemistry.chemical_classification, Escherichia coli Proteins, DUF2511, Domain of Unknown Function 2511, metalloprotein, Cue, Cu efflux, TCEP, Tris(2-carboxyethyl)phosphine, Cell Biology, Periplasmic space, bioinformatics, Cus, Cu sensing, E. coli, ICP–MS, inductively coupled plasma MS, MSA, multiple sequence alignment, SEC–MALS, size-exclusion chromatography with multiangle light scattering, chemistry, Membrane protein, DOE, Department of Energy, Periplasmic Binding Proteins, copper transport, metal homeostasis, AZY, yobA–yebZ–yebY, Cop/Pco, copper resistance or plasmid-borne copper resistance, Copper, Isopropyl β-D-1-thiogalactopyranoside, Cysteine, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ba8ff10957a16317cb12cd0ca39a6a7Test
http://europepmc.org/articles/PMC8689200Test

المؤلفون: Katlin B. Massirer, Lewis E. Pennicott, Fiona Scott, Jonathan M. Elkins, Simon E. Ward, Tristan Reuillon, A.M. Fala

المصدر: Bioorganic & Medicinal Chemistry Letters

مصطلحات موضوعية: Models, Molecular, HATU, hexafluorophosphate azabenzotriazole tetramethyl uronium, PARP, poly(ADP-ribose) polymerase, Chemical tool, Clinical Biochemistry, Pharmaceutical Science, IC50, half maximal inhibitory concentration, Chemical probe, PRK, protein kinase C-related kinase, DMSO, dimethyl sulfoxide, Crystallography, X-Ray, PRO2, glutamate 5-kinase Pro2, EGTA, egtazic acid, Benzimidazole, 01 natural sciences, Biochemistry, GST, glutathione S-transferase, CDI, 1,1′-carbonyldiimidazole, AGC, protein kinase A/G/C families, DNA, deoxyribonucleic acid, Neoplasms, CLK, CDC2-like kinase, DMF, N,N-dimethyl-formamide, Drug Discovery, PDB, protein databank, Kinome, Ki, inhibitor constant, Protein Kinase C, Cancer, ChEMBL, European Molecular Biology Laboratory Chemical database, Molecular Structure, Kinase, Chemistry, PRK2, KD, dissociation constant, PAK2, p21 activated kinase 2, DCM, dichloromethane, SFM, scanning force microscopy, Agc kinase, Molecular Medicine, THF, tetrahydrofuran, EtOH, ethanol, SDS, sodium dodecyl sulfate, ATP, adenosine triphosphate, TCEP, tris(2-carboxyethyl)phosphine, Antineoplastic Agents, Kinases, Heart failure, STK, serine/threonine kinase, Article, Structure-Activity Relationship, Protein kinase N2, Drug Development, TR-FRET, time resolved fluorescence resonance energy transfer, AcOH, acetic acid, PKC, protein kinase C, DIPEA, N,N-diisopropylethylamine, medicine, Humans, NMR, nuclear magnetic resonance, Protein kinase A, Protein Kinase Inhibitors, Molecular Biology, PAGE, polyacrylamide gel electrophoresis, ComputingMethodologies_COMPUTERGRAPHICS, PKN2, Inflammation, Dose-Response Relationship, Drug, EDTA, ethylenediaminetetraacetic acid, 010405 organic chemistry, Organic Chemistry, HEPES, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid, AGC kinase, medicine.disease, SAR, structure activity relationship, 0104 chemical sciences, Abl, Abelson murine leukemia viral oncogene, 010404 medicinal & biomolecular chemistry, CV, column volumes, Benzimidazoles, MeOH, methanol, PKN, protein kinase N

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee1561d0a57fd94895c128a26cfe5805Test
https://doi.org/10.1016/j.bmcl.2020.127040Test

المؤلفون: Amit Singh, Ballachanda N. Devaiah, Dinah S. Singer, Jocelyn D. Weissman, Ross C. Larue, Peter Schuck

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: ET, extra terminal domain, BD1 and BD2, bromodomains 1 and 2, Amino Acid Motifs, RNA polymerase II, Biochemistry, Mice, DDM, n-dodecyl β-D-maltoside, CTM, C-terminal motif, BET, bromodomain and extra terminal, P-TEFb, biology, Chemistry, Nuclear Proteins, TAF7, BID, basic residue-rich interaction domain, Cell biology, A and B, conserved BET motifs, BRD4, RNA Polymerase II, Casein kinase 2, PTEFb, positive transcription elongation factor b, Research Article, SEED, Ser/Glu/Asp-rich region, SEC, size-exclusion chromatography, extended dimer, kinase, CTD, RNA polymerase II carboxy terminal domain, Protein Domains, TCEP, Tris(2-carboxyethyl) phosphine hydrochloride, BRD4, bromodomain protein 4, Animals, Kinase activity, Protein Structure, Quaternary, Km, Michaelis–Menten constant, Molecular Biology, Vmax, maximal rate, TATA-Binding Protein Associated Factors, AUC, analytical ultracentrifugation, Cell Biology, CTD, NPS and CPS, N and C-terminal phosphorylation sites respectively, Bromodomain, CK2, casein kinase 2, Protein kinase domain, biology.protein, MLVIN, murine leukemia virus integrase, Cyclin-dependent kinase 9, Transcription Factor TFIID, Protein Multimerization, Protein Kinases, Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acb6e26f25e292e91d4313135fd65decTest
https://pubmed.ncbi.nlm.nih.gov/34688663Test

المؤلفون: Shaun Spisak, Steven E. Rokita, Bing Xu, Jennifer M. Kavran, Zuodong Sun

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: Models, Molecular, Protein Folding, TCEP, tris(2-carboxyethyl)phosphine, Flavin mononucleotide, DmIYD, IYD from Drosophila melanogaster, nitroreductase, Biochemistry, Iodide Peroxidase, Substrate Specificity, chemistry.chemical_compound, Nitroreductase, Structure-Activity Relationship, FMN binding, Bacterial Proteins, Protein Domains, flavoprotein, halotyrosine, Humans, music, Molecular Biology, Thermophilic organism, Dehalogenase, superfamily, NTR, nitroreductase superfamily, music.instrument, biology, Thermophile, dehalogenase, Cell Biology, biology.organism_classification, IYD, iodotyrosine deiodinase, FMN, flavin mononucleotide, Thermotoga neapolitana, chemistry, TnIYD, IYD from T. neapolitana, reductase, Iodotyrosine deiodinase, SSN, sequence similarity network, HhIYD, IYD from Haliscomenobacter hydrossis, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be79555d175b00f23fd0c65fac08e16cTest
https://pubmed.ncbi.nlm.nih.gov/34748729Test

المؤلفون: Ramberger, Evelyn, Suarez-Artiles, Lorena, Perez-Hernandez, Daniel, Haji, Mohamed, Popp, Oliver, Reimer, Ulf, Leutz, Achim, Dittmar, Gunnar, Mertins, Philipp

المصدر: Molecular & Cellular Proteomics : MCP

مصطلحات موضوعية: Proteomics, FDR, false discovery rate, point mutations, Amino Acid Motifs, PTMs, post-translational modifications, PPIs, protein–protein interactions, IDRs, intrinsically disordered regions, SLiMs, short linear motifs, post-translational modifications, Humans, Point Mutation, AGC, automated gain control, Protein Interaction Domains and Motifs, TCEP, Tris(2-carboxyethyl)phosphine hydrochloride, ABC, ammonium bicarbonate, MBR, match between run, Technological Innovation and Resources, LFQ, label-free quantification, short linear motifs, CAA, chloroacetamide, MoRFs, molecular recognition features, EGFR, epidermal growth factor receptor, peptide interaction screen, CRs, conserved regions, PRISMA, protein interaction screen on a peptide matrix, IT, injection time, Peptides, Protein Processing, Post-Translational, SH2, Src homology 2, HeLa Cells, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::731cf962626f951b3ea4e766deee12d5Test
http://europepmc.org/articles/PMC8453223Test

المؤلفون: Thomas Nebl, Joel P. Mackay, Jason Low, William J. McKinstry, Jan Shaw, Bin Ren, George O. Lovrecz, Lenka Bittova, Lindsay G. Sparrow, Ronald J. Hill, Marek Jindra, Louis Lu, Tram Phan

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: Receptor complex, MFBS1, MET–FISC binding site 1, NCBI, National Center for Biotechnology Information, Ligand Binding Protein, JH, juvenile hormone, Biochemistry, EcR, ecdysone receptor, AHR, aryl hydrocarbon receptor, IMAC, immobilized metal affinity chromatography, Aedes, protein purification, Protein purification, Sf9 Cells, AaTAI, Aedes aegypti taiman, Protein phosphorylation, MET, methoprene-tolerant, SFM, serum-free media, SEC–MALLS, size-exclusion chromatography in combination with multiangle laser-light scattering, Phosphorylation, HEK293, human embryonic kidney 293 cell line, FA, formic acid, Tribolium, Ha, Helicoverpa armigera, TAI, Taiman, ESI, electrospray ionization, JHRE, juvenile hormone response element, Chemistry, Kr-h1, Krüppel-homolog 1, GCE, germ cell–expressed, JHR, juvenile hormone receptor, ET, early trypsin, Ligand (biochemistry), ligand-binding protein, Juvenile Hormones, bHLH–PAS, basic helix–loop–helix/Per–Arnt–Sim, Insect Proteins, HSP, heat shock protein, λPP, lambda protein phosphatase, Tc, Tribolium castaneum, Research Article, FDR, false discovery rate, Protein subunit, nuclear translocation, Receptors, Cell Surface, Spodoptera, FBS, fetal bovine serum, Animals, TcTAI, Tribolium castaneum taiman, Molecular Biology, PAS domain, juvenile hormone, Cell Biology, hormone receptor, USP, ultraspiracle, basic helix–loop–helix/transcription factor, protein phosphorylation, TCEP, Tris (2-carboxyethyl) phosphine, AaMET, Aedes aegypti methoprene-tolerant, NLS, nuclear localization signal, Juvenile hormone, ARNT, aryl hydrocarbon receptor nuclear translocator, insect, BSA, bovine serum albumin, methoprene, TSAP, thermosensitive alkaline phosphatase, Ecdysone receptor, Protein Processing, Post-Translational, Sf9, Spodoptera frugiperda 9 cell line

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::505faf7d5cd39986321b4414f709b2d0Test
https://pubmed.ncbi.nlm.nih.gov/34758356Test

المؤلفون: Orsola di Martino, Margaret A. Ferris, Haixia Niu, Gayla Hadwiger, John S. Welch

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: Transcriptional Activation, Nerve growth factor IB, MWCO, molecular weight cutoff, medicine.medical_treatment, NR4A1, Biochemistry, Cell Line, TFA, trifluoroacetic acid, Transactivation, Upstream activating sequence, Mice, MeCN, acetonitrile, Granulocyte Colony-Stimulating Factor, Transcriptional regulation, medicine, Nuclear Receptor Subfamily 4, Group A, Member 1, Animals, Humans, nuclear receptor, mass spectrometry (MS), Molecular Biology, Janus Kinases, FA, formic acid, Chemistry, Kinase, phosphorylation, TOR Serine-Threonine Kinases, IL-3, Nur77 mutants, nano-LC-MS, capillary liquid chromatography interfaced to a mass spectrometer, Cell Biology, G-SCF, Hematopoietic Stem Cells, MS1, mass spectra of peptide precursors, Cell biology, TCEP, Tris (2-carboxyethyl) phosphine, Cytokine, Nuclear receptor, DTT, dithiothreitol, HCD, high-energy collision-induced dissociation, Interleukin-3, Signal transduction, transcription regulation, MS2, fragmentation mass spectrum of peptide from precursor ion, signal transduction, Research Article, proximity labeling

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c99aa4be44c900232e7687a01220fd4Test
https://pubmed.ncbi.nlm.nih.gov/34571009Test

المؤلفون: Kupper, Michaël B., Herzog, Konrad, Bennink, Sandra, Schlömer, Philipp, Bogaerts, Pierre, Glupczynski, Youri, Fischer, Rainer, Bebrone, Carine, Hoffmann, Kurt

المصدر: FEBS Journal, 282 (12), 2352-2360 (2015-04-13)

مصطلحات موضوعية: active site, antibiotic resistance, crystallographic structures, Enterobacter cloacae, metallo-b-lactamase Abbreviations DLS, dynamic light scattering, MBL, metallo-b-lactamase, PDB, Protein Data Bank, TCEP, Tris(2-carboxyethyl)phosphine, Cell Biology, Molecular Biology, Biochemistry, Life sciences, Biochemistry, biophysics & molecular biology, Sciences du vivant, Biochimie, biophysique & biologie moléculaire

العلاقة: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Ffebs.13283Test; urn:issn:1742-464X; urn:issn:1742-4658

الوصول الحر: https://orbi.uliege.be/handle/2268/301320Test