التفاصيل البيبلوغرافية
| العنوان: |
A non-targeted LC–MS metabolic profiling of pregnancy:longitudinal evidence from healthy and pre-eclamptic pregnancies |
| المؤلفون: |
Jääskeläinen, T. (Tiina), Kärkkäinen, O. (Olli), Jokkala, J. (Jenna), Klåvus, A. (Anton), Heinonen, S. (Seppo), Auriola, S. (Seppo), Lehtonen, M. (Marko), T. F. (The FINNPEC Core Investigator Group), Hanhineva, K. (Kati), Laivuori, H. (Hannele) |
| بيانات النشر: |
Springer Nature |
| سنة النشر: |
2021 |
| المجموعة: |
Jultika - University of Oulu repository / Oulun yliopiston julkaisuarkisto |
| مصطلحات موضوعية: |
LC–MS, Metabolomics, Preeclampsia, Pregnancy |
| الوصف: |
Introduction: Maternal metabolism changes substantially during pregnancy. However, few studies have used metabolomics technologies to characterize changes across gestation. Objectives and methods: We applied liquid chromatography–mass spectrometry (LC–MS) based non-targeted metabolomics to determine whether the metabolic profile of serum differs throughout the pregnancy between pre-eclamptic and healthy women in the FINNPEC (Finnish Genetics of Preeclampsia Consortium) Study. Serum samples were available from early and late pregnancy. Results: Progression of pregnancy had large-scale effects to the serum metabolite profile. Altogether 50 identified metabolites increased and 49 metabolites decreased when samples of early pregnancy were compared to samples of late pregnancy. The metabolic signatures of pregnancy were largely shared in pre-eclamptic and healthy women, only urea, monoacylglyceride 18:1 and glycerophosphocholine were identified to be increased in the pre-eclamptic women when compared to healthy controls. Conclusions: Our study highlights the need of large-scale longitudinal metabolomic studies in non-complicated pregnancies before more detailed understanding of metabolism in adverse outcomes could be provided. Our findings are one of the first steps for a broader metabolic understanding of the physiological changes caused by pregnancy per se. ; Collaborators for The FINNPEC Core Investigator Group Eero Kajantie (Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland; Children’s Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland; PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland). Juha Kere (Department of Biosciences and Nutrition, and Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden; Molecular Neurology Research Program, University of Helsinki, Helsinki, Finland; Folkhälsan Institute of Genetics, Helsinki, Finland), Katja Kivinen (Institute for Molecular ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| الإتاحة: |
http://urn.fi/urn:nbn:fi-fe2021092046654Test |
| حقوق: |
info:eu-repo/semantics/openAccess ; © The Author(s) 2021. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0Test/. ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.5568BAB6 |
| قاعدة البيانات: |
BASE |
