التفاصيل البيبلوغرافية
| العنوان: |
Ca 2+ Waves in PC12 Neurites: A Bidirectional, Receptor-oriented Form of Ca 2+ Signaling |
| المؤلفون: |
Paola Lorenzon, Daniele Zacchetti, T Franca Codazzi, Guido Fumagalli, Jacopo Meldolesi, Fabio Grohovaz*t |
| المساهمون: |
The Pennsylvania State University CiteSeerX Archives |
| المصدر: |
ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/ff/ba/J_Cell_Biol_1995_May_1_129(3)_797-804.tar.gz |
| المجموعة: |
CiteSeerX |
| الوصف: |
Spatial and temporal aspects of Ca 2+ signaling were investigated in PC12 cells differentiated with nerve growth factor, the well known nerve cell model. Activation of receptors coupled to polyphosphoinositide hydrolysis gave rise in a high proportion of the cells to Ca:+ waves propagating non decrementally and at constant speed (2-4 #m/s at 18°C and,,d0-fold faster at 37°C) along the neurites. These waves relied entirely on the release of Ca 2 ÷ from intracellular stores since they could be generated even when the cells were incubated in Ca2+-free medium. In contrast, when the cells were depolarized with high K + in Ca 2÷containing medium, increases of cytosolic Ca 2 ÷ occurred in the neurites but failed to evolve into waves. Depending on the receptor agonist employed (bradykinin |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/zip |
| اللغة: |
English |
| العلاقة: |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.273.6862Test |
| حقوق: |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: |
edsbas.3D7E6B75 |
| قاعدة البيانات: |
BASE |
