دورية أكاديمية
Emerging cerebrospinal fluid biomarkers in autosomal dominant Alzheimer's disease.
| العنوان: | Emerging cerebrospinal fluid biomarkers in autosomal dominant Alzheimer's disease. |
|---|---|
| المؤلفون: | Schindler, Suzanne E, Li, Yan, Hassenstab, Jason J, Benzinger, Tammie L S, Cruchaga, Carlos, Jucker, Mathias, Levin, Johannes, Chhatwal, Jasmeer P, Noble, James M, Ringman, John M, Graff-Radford, Neill R, Holtzman, David M, Todd, Kaitlin W, Ladenson, Jack H, Morris, John C, Bateman, Randall J, Xiong, Chengjie, Fagan, Anne M, Network, Dominantly Inherited Alzheimer, Herries, Elizabeth M, Henson, Rachel L, Gray, Julia D, Wang, Guoqiao, Graham, Danielle L, Shaw, Leslie M, Trojanowski, John Q |
| المصدر: | Alzheimer's and dementia 15(5), 655-665 (2019). doi:10.1016/j.jalz.2018.12.019 |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | info:eu-repo/classification/ddc/610, Aged, Alzheimer Disease: cerebrospinal fluid, Alzheimer Disease: genetics, Amyloid beta-Peptides: cerebrospinal fluid, Biomarkers: cerebrospinal fluid, Chitinase-3-Like Protein 1: cerebrospinal fluid, Disease Progression, Female, Humans, Inflammation, Male, Middle Aged, Mutation: genetics, Neurocalcin: cerebrospinal fluid, Neurogranin: cerebrospinal fluid, Positron-Emission Tomography, Synaptosomal-Associated Protein 25: cerebrospinal fluid |
| جغرافية الموضوع: | DE |
| الوصف: | Four less well-studied but promising 'emerging' cerebrospinal fluid (CSF) biomarkers are elevated in late-onset Alzheimer disease (AD): neurogranin, synaptosomal-associated protein-25 (SNAP-25), visinin-like protein 1 (VILIP-1), and chitinase-3-like protein 1 (YKL-40).CSF neurogranin, SNAP-25, VILIP-1, and YKL-40 were measured in families carrying autosomal-dominant AD mutations.The four emerging CSF biomarkers were significantly elevated in the mutation carriers (n = 235) versus noncarriers (n = 145). CSF SNAP-25, VILIP-1, and YKL-40 were altered very early in the AD time course, approximately 15-19 years before estimated symptom onset. All CSF biomarkers predicted important AD-related outcomes including performance on a cognitive composite, brain amyloid burden as measured by amyloid positron emission tomography, and the estimated years from symptom onset.Early abnormalities in CSF tTau, pTau, SNAP-25, VILIP-1, and YKL-40 suggest that synaptic damage, neuronal injury, and neuroinflammation begin shortly after the commencement of brain amyloid accumulation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/issn/1552-5279; info:eu-repo/semantics/altIdentifier/issn/1552-5260; info:eu-repo/semantics/altIdentifier/pmid/pmid:30846386; https://pub.dzne.de/record/140676Test; https://pub.dzne.de/search?p=id:%22DZNE-2020-06998%22Test |
| الإتاحة: | https://doi.org/10.1016/j.jalz.2018.12.019Test https://pub.dzne.de/record/140676Test https://pub.dzne.de/search?p=id:%22DZNE-2020-06998%22Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.5DEFE0F2 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |