Synapsin I and Synapsin II regulate neurogenesis in the dentate gyrus of adult mice
| العنوان: | Synapsin I and Synapsin II regulate neurogenesis in the dentate gyrus of adult mice |
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| المؤلفون: | Barbieri, Contestabile, Ciardo, M.G., Forte, Marte, Baldelli, Benfenati, Onofri |
| المصدر: | Oncotarget 9 (2018): 18760–18774. doi:10.18632/oncotarget.24655 info:cnr-pdr/source/autori:Barbieri, R. and Contestabile, A. and Ciardo, M.G. and Forte, N. and Marte, A. and Baldelli, P. and Benfenati, F. and Onofri, F./titolo:Synapsin I and Synapsin II regulate neurogenesis in the dentate gyrus of adult mice/doi:10.18632%2Foncotarget.24655/rivista:Oncotarget/anno:2018/pagina_da:18760/pagina_a:18774/intervallo_pagine:18760–18774/volume:9 Oncotarget |
| بيانات النشر: | Impact Journals, LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, nervous system development, animal diseases, synapsin I, animal cell, Hippocampal formation, juvenile animal, Adult neurogenesis, Adult neurogenesis, Brain-derived neurotrophic factor, Dentate gyrus, Epilepsy, Synapsins, Oncology, neural stem cell, 0302 clinical medicine, Neurotrophic factors, cognitive defect, heterocyclic compounds, long term potentiation, adult, Neurogenesis, Long-term potentiation, Synapsin, protein function, Oncology, brain derived neurotrophic factor, Research Paper, medicine.medical_specialty, Synapsin I, phenotype, regulatory mechanism, animal experiment, Biology, cell survival, Article, Brain-derived neurotrophic factor, animal tissue, 03 medical and health sciences, male, Internal medicine, medicine, controlled study, Dentate gyrus, gene, protein expression, mouse, synapsin II, nonhuman, Epilepsy, gene deletion, nerve cell plasticity, Synapsins, nervous system diseases, cell differentiation, cell proliferation, 030104 developmental biology, Endocrinology, nervous system, health occupations, Syn I gene, 030217 neurology & neurosurgery, Syn II gene |
| الوصف: | Adult neurogenesis is emerging as an important player in brain functions and homeostasis, while impaired or altered adult neurogenesis has been associated with a number of neuropsychiatric diseases, such as depression and epilepsy. Here we investigated the possibility that synapsins (Syns) I and II, beyond their known functions in developing and mature neurons, also play a role in adult neurogenesis. We performed a systematic evaluation of the distinct stages of neurogenesis in the hippocampal dentate gyrus of Syn I and Syn II knockout (KO) mice, before (2-monthsold) and after (6-months-old) the appearance of the epileptic phenotype. We found that Syns I and II play an important role in the regulation of adult neurogenesis. In juvenile mice, Syn II deletion was associated with a specific decrease in the proliferation of neuronal progenitors, whereas Syn I deletion impaired the survival of newborn neurons. These defects were reverted after the appearance of the epileptic phenotype, with Syn I KO and Syn II KO mice exhibiting significant increases in survival and proliferation, respectively. Interestingly, long-term potentiation dependent on newborn neurons was present in both juvenile Syn mutants while, at later ages, it was only preserved in Syn II KO mice that also displayed an increased expression of brain-derived neurotrophic factor. This study suggests that Syns I and II play a role in adult neurogenesis and the defects in neurogenesis associated with Syn deletion may contribute to the alterations of cognitive functions observed in Syn-deficient mice. © Barbieri et al. |
| تدمد: | 1949-2553 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d58c297801c62a30d637ca3328a0f90Test https://doi.org/10.18632/oncotarget.24655Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6d58c297801c62a30d637ca3328a0f90 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19492553 |
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