المؤلفون: 23andMe Research Team, Estonian Biobank Research Team, Budu-Aggrey, Ashley, Kilanowski, Anna, Fadista, Joao, Järvelin, Marjo-Riitta

المساهمون: Institute for Molecular Medicine Finland

مصطلحات موضوعية: Susceptibility loci, Gene-expression, Gwas, Filaggrin, Transcriptome, Regression, Children, Variants, Pathways, Reveals, 3111 Biomedicine

وصف الملف: application/pdf

العلاقة: For this work, A.B.-A., S.J.B. and L.P. were funded by the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No. 821511 (BIOMAP). The J.U. receives support from the European Union's Horizon 2020 research and innovation programme and EFPIA. This publication reflects only the author's view and the J.U. is not responsible for any use that may be made of the information it contains. A.B.A., M.K.S., J.L.M., and L.P. and work in a research unit funded by the UK Medical Research Council (MC_UU_00011/1 and MC_UU_00011/4). LP received funding from the British Skin Foundation (8010 Innovative Project) and the Academy of Medical Sciences Springboard Award, which is supported by the Wellcome Trust, The Government Department for Business, Energy and Industrial Strategy, the Global Challenges Research Fund and the British Heart Foundation [SBF003\1094]. S.J.B. holds a Wellcome Trust Senior Research Fellowship in Clinical Science [220875/Z/20/Z]. S.H. is supported by a Vera Davie Study and Research Sabbatical Bursary, NRF Thuthuka Grant (117721), NRF Competitive Support for Unrated Researcher (138072), MRC South Africa under a Self-initiated grant. M.S. has received funding fromthe European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (Grant Agreement No. 949906). Thanks to Sergi Sayols (developer of rrvgo), who provided additional code to alter the scatter plot produced by rrvgo to only display parent terms, and to Gibran Hemani (University of Bristol) who provided valuable guidance on the comparison of effects between ancestries. This publication is the work of the authors and LP will serve as guarantor for the contents of this paper. This work was carried out using the computational facilities of the Advanced Computing Research Centre, University of Bristol-http://www.bristolTest. ac.uk/acrc/. Individual cohort acknowledgements are in the Supplementary Methods.; 23andMe Research Team , Estonian Biobank Research Team , Budu-Aggrey , A , Kilanowski , A , Fadista , J & Järvelin , M-R 2023 , ' European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation ' , Nature Communications , vol. 14 , no. 1 , 6172 . https://doi.org/10.1038/s41467-023-41180-2Test; 85173731134; 105743f6-f316-48ed-b121-6bc2887047b0; http://hdl.handle.net/10138/571354Test; 001097145300032

الإتاحة: http://hdl.handle.net/10138/571354Test

المؤلفون: FinnGen, Tervi, Anniina, Junna, Nella, Broberg, Martin, Jones, Samuel E., Strausz, Satu, Kreivi, Hanna-Riikka, Heckman, Caroline A., Ollila, Hanna M.

المساهمون: Helsinki Institute of Life Science HiLIFE, Joint Activities, Institute for Molecular Medicine Finland, University of Helsinki, Genomic Discoveries and Clinical Translation, HUS Heart and Lung Center, Department of Medicine, Helsinki University Hospital Area, Keuhkosairauksien yksikkö

مصطلحات موضوعية: LD SCORE REGRESSION, PULMONARY TUBERCULOSIS, SUSCEPTIBILITY LOCI, ASSOCIATION, ALLELES, VARIANTS, DISEASES, 3111 Biomedicine, 1182 Biochemistry, cell and molecular biology, 1184 Genetics, developmental biology, physiology

وصف الملف: application/pdf

العلاقة: Business Finland (HUS 4685/31/2016 and UH4386/31/2016); AbbVie Inc.; AstraZeneca UK Ltd.; BiogenMA Inc.; Bristol Myers Squibb; Genentech Inc.; Merck Sharp Dohme Corp; Pfizer Inc.; Glaxo-SmithKline Intellectual Property Development Ltd; Sanofi US Services Inc.; Maze Therapeuticslnc.; Janssen Biotech Inc; Novartis Pharma AG and Boehringer Ingelheim. Following biobanks are acknowledged for delivering biobank samples to FinnGen: Auria Biobank (wwv.T.auria.fi/biopankki), THL Biobank (,,www.thl.fi/biobank), Helsinki Biobank (www.helsinginbiopankki.fi), Biobank Borealis of Northern Finland (https:www.ppshp.fil Tutkimus-ja-opetus/Biopankki/Pages/Biobank-Borealis-bi efly in En Tx), Finnish Clinical Biobank Tampere (wwwLays. S/Research/and/dev,eloprnent)Einnish/Clinical/Biobanki re), Biobank of Eastern Finland (ww ila suornenbiopankki. filen), Central Finland Biobank (www.ksshp.filfi-FI/Potilaallel Bio_.ankki), Finnish Red Cross Blood Service Biobank (\ARARAr. veripalvelufilverenluovutus/biopankkitoiminta) and Terveystalo Biobank (www.terveystalo.comlfi/YrybistietoalTerveysLalo Riopankki/Biopankki/). All Finnish biobanks are members of BBMRI.fi infrastructure (www.bbrnrifi), and FINBB Biobank Cooperative (https://finbbfiTest/) is the coordinator of the BBMRIERIC operations in Finland covering all Finnish biobanks.; FinnGen , Tervi , A , Junna , N , Broberg , M , Jones , S E , Strausz , S , Kreivi , H-R , Heckman , C A & Ollila , H M 2023 , ' Large registry-based analysis of genetic predisposition to tuberculosis identifies genetic risk factors at HLA ' , Human Molecular Genetics , vol. 32 , no. 1 , pp. 161–171 . https://doi.org/10.1093/hmg/ddac212Test; ORCID: /0000-0002-5302-6429/work/127508093; ORCID: /0000-0002-5953-5523/work/127508101; ORCID: /0000-0002-5419-9479/work/127508398; ORCID: /0000-0003-0153-922X/work/127509926; ORCID: /0000-0002-9857-2132/work/127510036; c005c1d5-3d0b-482f-9b96-ed14e06fba81; http://hdl.handle.net/10138/569554Test; 000866202200001

الإتاحة: http://hdl.handle.net/10138/569554Test

المؤلفون: David Ellinghaus

المصدر: Cambridge Prisms: Precision Medicine, Vol 1 (2023)

مصطلحات موضوعية: COVID-19 host genetics, COVID-19 susceptibility loci, ABO gene, ABO blood group susceptibility, SARS-CoV-2 transmission models, ABO-compatibility-dependence model, Internal medicine, RC31-1245, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

العلاقة: https://www.cambridge.org/core/product/identifier/S2752614322000126/type/journal_articleTest; https://doaj.org/toc/2752-6143Test

الوصول الحر: https://doaj.org/article/6e27fdca9e1c4a269fd002fec1d21c3dTest

المؤلفون: Ming-Chen Tsai, Chia-Lin Tsai, Chih-Sung Liang, Yu-Kai Lin, Guan-Yu Lin, Chia-Kuang Tsai, Po-Kuan Yeh, Yi Liu, Kuo-Sheng Hung, Fu-Chi Yang

المصدر: Frontiers in Psychiatry, Vol 13 (2023)

مصطلحات موضوعية: migraine, depression, single nucleotide polymorphism (SNP), genetic variant, Han Chinese, susceptibility loci, Psychiatry, RC435-571

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1067503/fullTest; https://doaj.org/toc/1664-0640Test

الوصول الحر: https://doaj.org/article/27261b8f82b946798480ce0c6bf5f210Test

المؤلفون: International Consortium for Cluster Headache Genetics, Winsvold, Bendik, Harder, Aster V. E. A., Ran, Caroline, Häppolä, Paavo, Pirinen, Matti, Hautakangas, Heidi, Wilbrink, Leopoldine A.

المساهمون: Complex Disease Genetics, Institute for Molecular Medicine Finland, Genomics of Neurological and Neuropsychiatric Disorders, Helsinki Institute of Life Science HiLIFE, Centre of Excellence in Complex Disease Genetics, Statistical and population genetics, Department of Mathematics and Statistics, Department of Public Health

مصطلحات موضوعية: Susceptibility loci, Wide association, 3112 Neurosciences, 3124 Neurology and psychiatry

وصف الملف: application/pdf

العلاقة: International Consortium for Cluster Headache Genetics , Winsvold , B , Harder , A V E A , Ran , C , Häppolä , P , Pirinen , M , Hautakangas , H & Wilbrink , L A 2023 , ' Cluster Headache Genomewide Association Study and Meta-Analysis Identifies Eight Loci and Implicates Smoking as Causal Risk Factor ' , Annals of Neurology , vol. 94 , no. 4 , pp. 713-726 . https://doi.org/10.1002/ana.26743Test; ORCID: /0000-0002-1664-1350/work/145925135; 92c3c63e-7bf0-4f14-9f28-c43488f7b64b; http://hdl.handle.net/10138/566752Test; 001049965200001

الإتاحة: http://hdl.handle.net/10138/566752Test

المؤلفون: Azzolini, Francesca, Berentsen, Geir D., Skaug, Hans J., Hjelmborg, Jacob V. B., Kaprio, Jaakko A.

المساهمون: Institute for Molecular Medicine Finland, University of Helsinki

مصطلحات موضوعية: OBESITY-SUSCEPTIBILITY LOCI, BODY-MASS INDEX, POOLED ANALYSIS, AGE, WEIGHT, BIRTH, OVERWEIGHT, ADULTHOOD, GROWTH, General medicine, internal medicine and other clinical medicine, 3143 Nutrition

وصف الملف: application/pdf

العلاقة: Azzolini , F , Berentsen , G D , Skaug , H J , Hjelmborg , J V B & Kaprio , J A 2022 , ' The heritability of BMI varies across the range of BMI-a heritability curve analysis in a twin cohort ' , International Journal of Obesity , vol. 46 , pp. 1786–1791 . https://doi.org/10.1038/s41366-022-01172-6Test; ORCID: /0000-0002-3716-2455/work/130598145; http://hdl.handle.net/10138/355857Test; 381e4a22-56b4-4471-aed3-a0ac17df609e; 000825042900002

الإتاحة: http://hdl.handle.net/10138/355857Test

المؤلفون: Estonian Biobank Research Team, FinnGen, Koel, Mariann, Vosa, Urmo, Joeloo, Maarja, Läll, Kristi, Gualdo, Natalia P., Laivuori, Hannele, Lemmelä, Susanna, Daly, Mark, Palta, Priit, Mägi, Reedik, Laisk, Triin

المساهمون: Genomics of Neurological and Neuropsychiatric Disorders, Institute for Molecular Medicine Finland, Department of Medical and Clinical Genetics, Helsinki Institute of Life Science HiLIFE, HUS Helsinki and Uusimaa Hospital District, Centre of Excellence in Complex Disease Genetics

مصطلحات موضوعية: Genome-wide association, Antigen class-ii, Susceptibility loci, Lichen-sclerosus, Expression, Diseases, Heritability, Regression, Accuracy, Women, 1182 Biochemistry, cell and molecular biology

وصف الملف: application/pdf

العلاقة: Estonian Biobank Research Team , FinnGen , Koel , M , Vosa , U , Joeloo , M , Läll , K , Gualdo , N P , Laivuori , H , Lemmelä , S , Daly , M , Palta , P , Mägi , R & Laisk , T 2023 , ' GWAS meta-analyses clarify the genetics of cervical phenotypes and inform risk stratification for cervical cancer ' , Human Molecular Genetics , vol. 32 , no. 12 , pp. 2103-2116 . https://doi.org/10.1093/hmg/ddad043Test; ORCID: /0000-0001-9320-7008/work/137441357; 561fa122-6b01-4677-8e10-991f20689043; http://hdl.handle.net/10138/359608Test; 000966602600001

الإتاحة: http://hdl.handle.net/10138/359608Test

المؤلفون: Hebbar, Prashantha, Abubaker, Jehad Ahmed, Abu-Farha, Mohamed, Alsmadi, Osama, Elkum, Naser, Alkayal, Fadi, John, Sumi Elsa, Channanath, Arshad, Iqbal, Rasheeba, Pitkaniemi, Janne, Tuomilehto, Jaakko, Sladek, Robert, Al-Mulla, Fahd, Thanaraj, Thangavel Alphonse

المساهمون: Faculty of Medicine, University of Helsinki, Clinicum, Department of Public Health

مصطلحات موضوعية: 1184 Genetics, developmental biology, physiology, 3142 Public health care science, environmental and occupational health, SUSCEPTIBILITY LOCI, VARIANT ASSOCIATION, DISEASE, OBESITY, METAANALYSIS, IMPUTATION, EFFICIENT, COMMON, TRANSFERABILITY, HYPERTENSION

وصف الملف: application/pdf

العلاقة: Hebbar , P , Abubaker , J A , Abu-Farha , M , Alsmadi , O , Elkum , N , Alkayal , F , John , S E , Channanath , A , Iqbal , R , Pitkaniemi , J , Tuomilehto , J , Sladek , R , Al-Mulla , F & Thanaraj , T A 2021 , ' Genome-wide landscape establishes novel association signals for metabolic traits in the Arab population ' , Human Genetics , vol. 140 , pp. 505–528 . https://doi.org/10.1007/s00439-020-02222-7Test; RIS: urn:9F8F6F4CC8394CA7F1E83B8AA3A07904; RIS: Hebbar2020; 12224e77-fb34-4516-be3e-e3c46ba5a9e0; http://hdl.handle.net/10138/353204Test; 000567730100001

الإتاحة: http://hdl.handle.net/10138/353204Test

المؤلفون: OPAL Study Grp, AOCS Grp, DeVries, Amber A., Dennis, Joe, Tyrer, Jonathan P.

المساهمون: Helsinki University Hospital Area, Clinicum, Department of Pathology, HUSLAB

مصطلحات موضوعية: GENOME-WIDE ASSOCIATION, SUSCEPTIBILITY LOCI, GERMLINE MUTATIONS, BRCA2 MUTATIONS, COMMON VARIANTS, BREAST, GENES, IDENTIFICATION, REARRANGEMENTS, DELETIONS, 3122 Cancers

وصف الملف: application/pdf

العلاقة: OPAL Study Grp , AOCS Grp , DeVries , A A , Dennis , J & Tyrer , J P 2022 , ' Copy Number Variants Are Ovarian Cancer Risk Alleles at Known and Novel Risk Loci ' , Journal of the National Cancer Institute , vol. 114 , no. 11 , pp. 1533–1544 . https://doi.org/10.1093/jnci/djac160Test; a9cc8dd3-2068-44c5-9cf1-59a2db98cbf9; http://hdl.handle.net/10138/353572Test; 000865391400001

الإتاحة: http://hdl.handle.net/10138/353572Test

المؤلفون: Jung, Seulgi, Park, Dohoon, Lee, Ho-Su, Kim, Yongjae, Baek, Jiwon, Hwang, Sung Wook, Park, Sang Hyoung, Yang, Suk-Kyun, Ye, Byong Duk, Han, Buhm, Sun, Yonghu, Liu, Hong, Zhang, Furen, Liu, Jianjun, Song, Kyuyoung

المساهمون: Han, Buhm

مصطلحات موضوعية: INFLAMMATORY-BOWEL-DISEASE, GENOME-WIDE ASSOCIATION, SUSCEPTIBILITY LOCI, PROTEIN, GENES, RISK, PATHOGENESIS, IMPUTATION, VARIANTS, PATHWAY

العلاقة: Human Molecular Genetics, Vol.31 No.22, pp.3934-3944; https://hdl.handle.net/10371/191457Test; 000805227600001; 2-s2.0-85139946576; 178895

الإتاحة: https://doi.org/10.1093/hmg/ddac101Test
https://hdl.handle.net/10371/191457Test