التفاصيل البيبلوغرافية
| العنوان: |
Interferons induce tyrosine phosphorylation of the eIF2alpha kinase PKR through activation of Jak1 and Tyk2 |
| المؤلفون: |
Qiaozhu Su, Shuo Wang, Dionissios Baltzis, Li-ke Quw, Jennifer F. Raven, Suiyang Liz, Andrew Hoi-tao Wong Y, Antonis E. Koromilas |
| المساهمون: |
The Pennsylvania State University CiteSeerX Archives |
| المصدر: |
http://www.medicine.mcgill.ca/oncology/pubs/Koromilas/Koromilas_2007_01_Interferons-Induce.pdfTest. |
| سنة النشر: |
2007 |
| المجموعة: |
CiteSeerX |
| مصطلحات موضوعية: |
EMBO reports (2007) 8, 265–270. doi, 10.1038/sj.embor.7400891 |
| الوصف: |
The interferon (IFN)-inducible, double-stranded RNA activated protein kinase (PKR) is a dual-specificity kinase, which has an essential role in the regulation of protein synthesis by phosphor-ylating the translation eukaryotic initiation factor 2 (eIF2). Here, we show the tyrosine (Tyr) phosphorylation of PKR in response to type I or type II IFNs. We show that PKR physically interacts with either Jak1 or Tyk2 in unstimulated cells and that these interactions are increased in IFN-treated cells. We also show that PKR acts as a substrate of activated Jaks, and is phosphorylated at Tyr 101 and Tyr 293 both in vitro and in vivo. Moreover, we provide strong evidence that both the induction of eIF2a phosphorylation and inhibition of protein synthesis by IFN are impaired in cells lacking Jak1 or Tyk2, which corresponds to a lack of induction of PKR tyrosine phosphorylation. We conclude that PKR tyrosine phosphorylation provides an important link between IFN signalling and translational control through the regulation of eIF2a phosphorylation. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.526.8121Test; http://www.medicine.mcgill.ca/oncology/pubs/Koromilas/Koromilas_2007_01_Interferons-Induce.pdfTest |
| الإتاحة: |
http://www.medicine.mcgill.ca/oncology/pubs/Koromilas/Koromilas_2007_01_Interferons-Induce.pdfTest |
| حقوق: |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: |
edsbas.2725047A |
| قاعدة البيانات: |
BASE |
