المؤلفون: Parwana, Diksha, Gu, Jing, Chen, Shuang, Bethel, Christopher R, Marshall, Emma, Hujer, Andrea M, Bonomo, Robert A, Haider, Shozeb

المصدر: Angewandte Chemie International Edition , Article e202317315. (2024) (In press).

مصطلحات موضوعية: β-lactam antibiotics, β-lactamase, metadynamics, substrate-assisted catalysis, enhanced sampling

وصف الملف: application/pdf

العلاقة: https://discovery.ucl.ac.uk/id/eprint/10187214/1/The%20Structural%20Role%20of%20N170%20in%20Substrate%20Assisted%20Deacylation.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10187214Test/

الإتاحة: https://discovery.ucl.ac.uk/id/eprint/10187214/1/The%20Structural%20Role%20of%20N170%20in%20Substrate%20Assisted%20Deacylation.pdfTest
https://discovery.ucl.ac.uk/id/eprint/10187214Test/

المؤلفون: Juan Carlos Fontecilla-Camps

المصدر: Biomolecules, Vol 14, Iss 5, p 518 (2024)

مصطلحات موضوعية: RNA polymerase, aminoacyl-tRNA synthetase, ribosome, substrate-assisted catalysis, entropic trap, Microbiology, QR1-502

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2218-273X/14/5/518Test; https://doaj.org/toc/2218-273XTest

الوصول الحر: https://doaj.org/article/7d52346ec8174271bc6f00df43ce67b5Test

المؤلفون: Khan, Abdul Kareem

المساهمون: University/Department: Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut

مرشدي الرسالة: Villà i Freixa, Jordi

المصدر: TDX (Tesis Doctorals en Xarxa)

مصطلحات موضوعية: dinàmica, centre actiu, relacions d'estructura activitat, preorganització, reorganització, estat de transició, estat actiu, estabilitat electrostàtica, interacción proteïna-proteïna, test de ranks de Wilcoxon, P-loop, G1 motif, HVR, metastability, RMSD, substrate assisted catalysis, sequence alignment, beta sheet, helix, Z-test, wilcoxon rank test, protein-protein interactions, electrostatic stability, active state, dynamics, signal transduction, electrostatic stabilization, ras effectors, guanine exchange factor, GTPase-activating proteins, quantum mechanics/molecular, PDLD/S-LRA, X-ray crystallography, solvation energy, free energy perturbation, statistical analysis, GTP hydrolysis, guanosine diphosphate, guanosine triphosphate, computer simulation, thermodynamics, protein conformation, electrostatics, interruptor II, interruptor I, llaç P, motiu G1, HVR (regions altament variables), metaestabilita, catàlisi assistida pel substrat, aliniament de seqüència, fulla beta, hèlix, test Z, transducció del senyal, estabilització electrostàtica, efectors de ras, factor de bescamvi de guanina, proteïnes activadores de l'activitat, mecànica quàntica/mecànica, cristalografia de raigs X, energia de solvatació, perturbació de l'energia lliure, anàlisi estadística, hidròlisi de GTP, difosfat de guanosina, trifosfat de guanosina, simulació computacional, termodinàmica, conformació proteïca, electrostàtica, switch-I, switch-II

وصف الملف: application/pdf

الوصول الحر: http://www.tdx.cat/TDX-0714109-112338Test
http://hdl.handle.net/10803/7161Test

المؤلفون: Sofia A. Shilova, Maria G. Khrenova, Ilya O. Matyuta, Alena Y. Nikolaeva, Tatiana V. Rakitina, Natalia L. Klyachko, Mikhail E. Minyaev, Konstantin M. Boyko, Vladimir O. Popov, Ekaterina Yu. Bezsudnova

المصدر: Molecules; Volume 28; Issue 5; Pages: 2109

مصطلحات موضوعية: transaminase, D-amino acids, substrate-assisted catalysis, enzymes, structure, X-ray analysis

جغرافية الموضوع: agris

وصف الملف: application/pdf

العلاقة: Photochemistry; https://dx.doi.org/10.3390/molecules28052109Test

الإتاحة: https://doi.org/10.3390/molecules28052109Test

المؤلفون: Fontecilla-Camps, Juan-Carlos

المساهمون: Institut de biologie structurale (IBS - UMR 5075), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA)

المصدر: ISSN: 2218-273X ; Biomolecules ; https://hal.science/hal-04569108Test ; Biomolecules, 2024, 14 (5), pp.518. ⟨10.3390/biom14050518⟩.

مصطلحات موضوعية: RNA polymerase, aminoacyl-tRNA synthetase, Ribosome, substrate-assisted catalysis, entropic trap, [SDV]Life Sciences [q-bio]

العلاقة: hal-04569108; https://hal.science/hal-04569108Test

الإتاحة: https://doi.org/10.3390/biom14050518Test
https://hal.science/hal-04569108Test

المساهمون: Kappock, T. [Purdue Univ., West Lafayette, IN (United States). Dept. of Biochemistry]

المصدر: Frontiers in Chemistry; 4

وصف الملف: Medium: ED; Size: 16 p.

الوصول الحر: http://www.osti.gov/scitech/servlets/purl/1345618Test

المؤلفون: Alteen, Matthew G, Oehler, Verena, Nemčovičová, Ivana, Wilson, Iain B H, Vacadlo, David J, Gloster, Tracey Maureen

المصدر: Alteen , M G , Oehler , V , Nemčovičová , I , Wilson , I B H , Vacadlo , D J & Gloster , T M 2016 , ' Mechanism of the human nucleocytoplasmic hexosaminidase D ' , Biochemistry , vol. 55 , no. 19 , pp. 2753-2747 . https://doi.org/10.1021/acs.biochem.5b01285Test

مصطلحات موضوعية: Hexosaminidase, Glycoside hydrolase, Enzyme kinetics, Enzyme mechanism, Enzyme inhibition, Substrate-assisted catalysis

وصف الملف: application/pdf

العلاقة: https://research-portal.st-andrews.ac.uk/en/researchoutput/mechanism-of-the-human-nucleocytoplasmic-hexosaminidase-dTest(5fcde72d-67eb-4e0f-a650-0a5c2a33b1b5).html

الإتاحة: https://doi.org/10.1021/acs.biochem.5b01285Test
https://research-portal.st-andrews.ac.uk/en/researchoutput/mechanism-of-the-human-nucleocytoplasmic-hexosaminidase-dTest(5fcde72d-67eb-4e0f-a650-0a5c2a33b1b5).html
https://research-repository.st-andrews.ac.uk/bitstream/10023/8880/1/Alteen_2016_Mechanism_Biochem_CC.pdfTest

المؤلفون: Daizou Kudou, Dan Sato, Kazuo Furutani, Kenji Inagaki, Mitsuki Fukumoto, Shigeharu Harada, Shunsuke Yunoto, Takashi Tamura, Tomoo Shiba, 佐藤 暖, 原田 繁春, 古谷 和大, 工藤 大蔵, 志波 智生, 湯之戸 俊介, 田村 隆, 福本 充樹, 稲垣 賢二

المصدر: ビタミン / VITAMINS. 2018, 92(3):117

المؤلفون: Ita Gruić-Sovulj, Stephen Cusack, Branimir Bertoša, Andrés Palencia, Igor Zivkovic, Morana Dulic, Nevena Cvetesic

المصدر: Journal of Molecular Biology. 430:1-16

مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Acylation, Aminoacylation, RNA, Transfer, Amino Acyl, Biology, Substrate Specificity, Amino Acyl-tRNA Synthetases, 03 medical and health sciences, chemistry.chemical_compound, Structural Biology, Escherichia coli, Amino Acids, Molecular Biology, chemistry.chemical_classification, Binding Sites, Aminoacyl tRNA synthetase, Hydrolysis, Leucyl-tRNA synthetase, Translation (biology), Amino acid, Kinetics, 030104 developmental biology, chemistry, Biochemistry, Transfer RNA, Leucine-tRNA Ligase, aminoacyl-tRNA synthetases, proofreading, catalytic RNA, substrate-assisted catalysis, norvaline, Leucine, Norvaline

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b42a82356303c26ee33b808d82f76f3bTest
https://doi.org/10.1016/j.jmb.2017.10.024Test

المؤلفون: Markham, George D., Takusagawa, Fusao, DiJuliio, Anthony M., Bock, Charles W.

مصطلحات موضوعية: S-adenosylmethionine, Methionine adenosyltransferase, Enzyme mechanism, Substrate-assisted-catalysis, QM/MM

وصف الملف: application/pdf

العلاقة: Markham, George D., Fusao Takusagawa, Anthony M. Dijulio, and Charles W. Bock. "An Investigation of the Catalytic Mechanism of S-adenosylmethionine Synthetase by QM/MM Calculations." Archives of Biochemistry and Biophysics 492.1-2 (2009): 82-92.; http://hdl.handle.net/1808/22632Test

الإتاحة: https://doi.org/10.1016/j.abb.2009.08.010Test
http://hdl.handle.net/1808/22632Test