دورية أكاديمية
Inhibition of RAC1 activity in cancer associated fibroblasts favours breast tumour development through IL-1β upregulation
| العنوان: | Inhibition of RAC1 activity in cancer associated fibroblasts favours breast tumour development through IL-1β upregulation |
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| المؤلفون: | Martínez López, Angélica, García Casas, Ana, Bragado Domingo, Paloma, Orimo, Akira, Castañeda-Saucedo, Eduardo, Castillo Lluva, Sonia |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2021 |
| المجموعة: | Universidad Complutense de Madrid (UCM): E-Prints Complutense |
| مصطلحات موضوعية: | 577.1, Stromal RAC1, Cancer-associated fibroblasts, Breast cancer, IL-1β, Química, Bioquímica (Química), 23 Química |
| الوصف: | CRUE-CSIC (Acuerdos Transformativos 2021) ; Cancer-associated fibroblasts (CAFs) are highly abundant stromal components in the tumour microenvironment. These cells contribute to tumorigenesis and indeed, they have been proposed as a target for anti-cancer therapies. Similarly, targeting the Rho-GTPase RAC1 has also been suggested as a potential therapeutic target in cancer. Here, we show that targeting RAC1 activity, either pharmacologically or by genetic silencing, increases the pro-tumorigenic activity of CAFs by upregulating IL-1β secretion. Moreover, inhibiting RAC1 activity shifts the CAF subtype to a more aggressive phenotype. Thus, as RAC1 suppresses the secretion of IL-1β by CAFs, reducing RAC1 activity in combination with the depletion of this cytokine should be considered as an interesting therapeutic option for breast cancer in which tumour cells retain intact IL-1β signalling. ; Depto. de Bioquímica y Biología Molecular ; Sección Deptal. de Bioquímica y Biología Molecular (Farmacia) ; Fac. de Ciencias Químicas ; Fac. de Farmacia ; TRUE ; Ministerio de Ciencia e Innovación (MICINN) ; Ministerio de Economía y Competitividad (MINECO)/FEDER ; pub |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0304-3835 |
| العلاقة: | (PID2019-104991RB-I00); (SAF2015-64499-R; RTI2018-094130-B-100).; https://doi.org/10.1016/j.canlet.2021.08.014Test; https://hdl.handle.net/20.500.14352/4678Test |
| DOI: | 10.1016/j.canlet.2021.08.014 |
| الإتاحة: | https://doi.org/20.500.14352/4678Test https://doi.org/10.1016/j.canlet.2021.08.014Test https://hdl.handle.net/20.500.14352/4678Test |
| حقوق: | Atribución-NoComercial-SinDerivadas 3.0 España ; open access ; https://creativecommons.org/licenses/by-nc-nd/3.0/esTest/ |
| رقم الانضمام: | edsbas.E01AE111 |
| قاعدة البيانات: | BASE |
| تدمد: | 03043835 |
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| DOI: | 10.1016/j.canlet.2021.08.014 |