يعرض 1 - 10 نتائج من 52 نتيجة بحث عن '"Stefano Crosignani"', وقت الاستعلام: 0.69s تنقيح النتائج
  1. 1
    Supplementary Tables 1-2 and Figures 1-10 from Inhibition of Tryptophan-Dioxygenase Activity Increases the Antitumor Efficacy of Immune Checkpoint Inhibitors

    المؤلفون: Benoit J. Van den Eynde, Gregory Driessens, Julie Preillon, Vincent Stroobant, Luc Pilotte, Delia Hoffmann, Kim Frederix, Stefano Crosignani, Florence Schramme

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a519215ebea4592f0eae90ce9cd84ebTest
    https://doi.org/10.1158/2326-6066.22543473Test


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  2. 2
    Data from Inhibition of Tryptophan-Dioxygenase Activity Increases the Antitumor Efficacy of Immune Checkpoint Inhibitors

    المؤلفون: Benoit J. Van den Eynde, Gregory Driessens, Julie Preillon, Vincent Stroobant, Luc Pilotte, Delia Hoffmann, Kim Frederix, Stefano Crosignani, Florence Schramme

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68b90e2322021f688dafbac417e912a9Test
    https://doi.org/10.1158/2326-6066.c.6550281Test


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  3. 3
    Table S2 from Characterization of the Selective Indoleamine 2,3-Dioxygenase-1 (IDO1) Catalytic Inhibitor EOS200271/PF-06840003 Supports IDO1 as a Critical Resistance Mechanism to PD-(L)1 Blockade Therapy

    المؤلفون: Manfred Kraus, Joseph Tumang, Xianxian Zheng, Li-Chin Yao, Martin Wythes, Benoit J. Van den Eynde, Konstantinos Tsaparikos, Vince R. Torti, Nicole Streiner, Chad Ray, Virginie Rabolli, Romain Pirson, Nichol Miller, Reece Marillier, Karen Maegley, Wenlin Li, Marie-Claire Letellier, Jie Guo, Valeria R. Fantin, Christopher P. Dillon, Sofie Denies, Deepak Dalvie, Stefano Crosignani, Sandra Cauwenberghs, Danying Cai, Derek Bartlett, Gregory Driessens, Bruno Gomes

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47698983ea67ec47db744f5010daf12aTest
    https://doi.org/10.1158/1535-7163.22505134Test


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  4. 4
    Supplementary Methods from Characterization of the Selective Indoleamine 2,3-Dioxygenase-1 (IDO1) Catalytic Inhibitor EOS200271/PF-06840003 Supports IDO1 as a Critical Resistance Mechanism to PD-(L)1 Blockade Therapy

    المؤلفون: Manfred Kraus, Joseph Tumang, Xianxian Zheng, Li-Chin Yao, Martin Wythes, Benoit J. Van den Eynde, Konstantinos Tsaparikos, Vince R. Torti, Nicole Streiner, Chad Ray, Virginie Rabolli, Romain Pirson, Nichol Miller, Reece Marillier, Karen Maegley, Wenlin Li, Marie-Claire Letellier, Jie Guo, Valeria R. Fantin, Christopher P. Dillon, Sofie Denies, Deepak Dalvie, Stefano Crosignani, Sandra Cauwenberghs, Danying Cai, Derek Bartlett, Gregory Driessens, Bruno Gomes

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f74526ae85eebdbe19c754931a606d3Test
    https://doi.org/10.1158/1535-7163.22505140Test


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  5. 5
    Table S1, Table S3, Figures S1-S8 from Characterization of the Selective Indoleamine 2,3-Dioxygenase-1 (IDO1) Catalytic Inhibitor EOS200271/PF-06840003 Supports IDO1 as a Critical Resistance Mechanism to PD-(L)1 Blockade Therapy

    المؤلفون: Manfred Kraus, Joseph Tumang, Xianxian Zheng, Li-Chin Yao, Martin Wythes, Benoit J. Van den Eynde, Konstantinos Tsaparikos, Vince R. Torti, Nicole Streiner, Chad Ray, Virginie Rabolli, Romain Pirson, Nichol Miller, Reece Marillier, Karen Maegley, Wenlin Li, Marie-Claire Letellier, Jie Guo, Valeria R. Fantin, Christopher P. Dillon, Sofie Denies, Deepak Dalvie, Stefano Crosignani, Sandra Cauwenberghs, Danying Cai, Derek Bartlett, Gregory Driessens, Bruno Gomes

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18a821fe08534fa5982eef4c3eb5ce76Test
    https://doi.org/10.1158/1535-7163.22505137Test


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  6. 6
    Data from Characterization of the Selective Indoleamine 2,3-Dioxygenase-1 (IDO1) Catalytic Inhibitor EOS200271/PF-06840003 Supports IDO1 as a Critical Resistance Mechanism to PD-(L)1 Blockade Therapy

    المؤلفون: Manfred Kraus, Joseph Tumang, Xianxian Zheng, Li-Chin Yao, Martin Wythes, Benoit J. Van den Eynde, Konstantinos Tsaparikos, Vince R. Torti, Nicole Streiner, Chad Ray, Virginie Rabolli, Romain Pirson, Nichol Miller, Reece Marillier, Karen Maegley, Wenlin Li, Marie-Claire Letellier, Jie Guo, Valeria R. Fantin, Christopher P. Dillon, Sofie Denies, Deepak Dalvie, Stefano Crosignani, Sandra Cauwenberghs, Danying Cai, Derek Bartlett, Gregory Driessens, Bruno Gomes

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::3b26f8def31d8e1dfcb01fcbd392ab72Test
    https://doi.org/10.1158/1535-7163.c.6537964.v1Test


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  7. 7
    Structure-Based Optimization and Discovery of M3258, a Specific Inhibitor of the Immunoproteasome Subunit LMP7 (β5i)

    المؤلفون: Felix Rohdich, Stefano Crosignani, Michael Busch, Christina Esdar, Manja Friese-Hamim, Markus Klein, Thomas Fuchss, Oliver Schadt, Djordje Musil, Ugo Zanelli, Michael P. Sanderson, Gina Walter-Bausch, Philip Hewitt, Jeyaprakashnarayanan Seenisamy

    المصدر: Journal of Medicinal Chemistry. 64:10230-10245

    مصطلحات موضوعية: Gene isoform, Proteasome Endopeptidase Complex, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Protein subunit, Protein degradation, medicine.disease, Protein Subunits, Structure-Activity Relationship, Haematopoiesis, Proteasome, Biochemistry, Drug Discovery, medicine, Humans, Molecular Medicine, Potency, Structure based, Proteasome Inhibitors, Multiple myeloma

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1a3d051fc60306aef1b64a7ba1b3e7bTest
    https://doi.org/10.1021/acs.jmedchem.1c00604Test


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  8. 8
    Characterization of the Selective Indoleamine 2,3-Dioxygenase-1 (IDO1) Catalytic Inhibitor EOS200271/PF-06840003 Supports IDO1 as a Critical Resistance Mechanism to PD-(L)1 Blockade Therapy

    المؤلفون: Jie Guo, Li-Chin Yao, Christopher P. Dillon, Wenlin Li, Stefano Crosignani, Karen A. Maegley, Danying Cai, Reece Marillier, Sandra Cauwenberghs, Manfred Kraus, Virginie Rabolli, Valeria Fantin, Benoît Van den Eynde, Deepak Dalvie, Joseph Tumang, Derek W. Bartlett, Martin James Wythes, Vince Torti, Xianxian Zheng, Sofie Denies, Gregory Driessens, Bruno Gomes, Nichol Miller, Konstantinos Tsaparikos, Nicole Streiner, Marie-Claire Letellier, Chad Ray, Romain Pirson

    المصدر: Molecular Cancer Therapeutics. 17:2530-2542

    مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Indoles, T-Lymphocytes, medicine.medical_treatment, Succinimides, Antineoplastic Agents, Antibodies, Monoclonal, Humanized, B7-H1 Antigen, Substrate Specificity, Immune tolerance, Interferon-gamma, 03 medical and health sciences, chemistry.chemical_compound, Lymphocytes, Tumor-Infiltrating, 0302 clinical medicine, Downregulation and upregulation, Cell Line, Tumor, medicine, Animals, Humans, Indoleamine-Pyrrole 2,3,-Dioxygenase, CTLA-4 Antigen, Enzyme Inhibitors, Indoleamine 2,3-dioxygenase, Kynurenine, Cell Proliferation, Mice, Inbred BALB C, Tumor microenvironment, Chemistry, Antibodies, Monoclonal, FOXP3, Stereoisomerism, Immunotherapy, Immune checkpoint, Mice, Inbred C57BL, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Biocatalysis, Cancer research, Female

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4e86621e1bbba77214c450e8001b4c6Test
    https://doi.org/10.1158/1535-7163.mct-17-1104Test


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  9. 9
    Inhibition of tryptophan-dioxygenase activity increases the antitumor efficacy of immune checkpoint inhibitors

    المؤلفون: Luc Pilotte, Delia Hoffmann, Vincent Stroobant, Julie Preillon, Kim Frederix, Stefano Crosignani, Florence Schramme, Gregory Driessens, Benoît Van den Eynde

    المساهمون: UCL - SSS/DDUV - Institut de Duve, UCL - SSS/DDUV/GECE - Génétique cellulaire, UCL - SSS/IREC/MORF - Pôle de Morphologie

    المصدر: Cancer immunology research, Vol. 8, no. 1, p. 32-45 (2020)

    مصطلحات موضوعية: 0301 basic medicine, Cancer Research, medicine.medical_treatment, Programmed Cell Death 1 Receptor, Pharmacology, chemistry.chemical_compound, Mice, 0302 clinical medicine, Antineoplastic Agents, Immunological, IDO1, Cancer immunotherapy, Oral administration, RESISTANCE MECHANISM, CTLA-4 Antigen, Enzyme Inhibitors, Kynurenine, Mice, Knockout, Mice, Inbred BALB C, Dioxygenase activity, INTERSTITIAL FLUID, Tryptophan, Immunosuppression, Drug Synergism, MOUSE MODEL, CANCER, Tryptophan Oxygenase, INDOLEAMINE 2,3-DIOXYGENASE EXPRESSION, Oncology, 030220 oncology & carcinogenesis, Colonic Neoplasms, Life Sciences & Biomedicine, Immunology, DENDRITIC CELLS, Small Molecule Libraries, 03 medical and health sciences, Cell Line, Tumor, medicine, Animals, Humans, SUPPRESSION, T-CELL PROLIFERATION, Science & Technology, INTERFERON-GAMMA, Immunotherapy, Neoplasms, Experimental, Mice, Inbred C57BL, 030104 developmental biology, chemistry, Cell culture

    وصف الملف: Print-Electronic

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36082075ff24fda1d254c695e3510f11Test
    https://ora.ox.ac.uk/objects/uuid:e4f52d6c-351b-4a2f-b6d4-73f56fe26dc1Test


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  10. 10
    Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1 H -indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate

    المؤلفون: Nichol Miller, Marie Cordonnier, Hélène Cannelle, Frederik Deroose, Joseph Tumang, James Soloweij, Bruno Gomes, Stefano Crosignani, Michel Negrerie, Patrick Bingham, Karen A. Maegley, A.E. Stewart, Sandra Cauwenberghs, Martin James Wythes, Pauline Bottemanne, Benoît Van den Eynde, Stephen E. Kaiser, Vince Torti, Manfred Kraus, Brion W. Murray, Jun Li Feng, Deepak Dalvie, Manfred Schneider, Samantha Elizabeth Greasley

    المساهمون: iTeos Therapeutics (iTeos), Pfizer, Asclepia Outsourcing Solutions, Laboratoire d'Optique et Biosciences (LOB), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École polytechnique (X), Université Catholique de Louvain = Catholic University of Louvain (UCL)

    المصدر: Journal of Medicinal Chemistry
    Journal of Medicinal Chemistry, American Chemical Society, 2017, 60 (23), pp.9617-9629. ⟨10.1021/acs.jmedchem.7b00974⟩

    مصطلحات موضوعية: 0301 basic medicine, Male, Indoles, Succinimides, Pharmacology, Crystallography, X-Ray, Pyrrolidine, Immune tolerance, Cell Line, 03 medical and health sciences, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Dogs, Drug Discovery, Structure–activity relationship, Animals, Humans, Indoleamine-Pyrrole 2,3,-Dioxygenase, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Enzyme Inhibitors, Indoleamine 2,3-dioxygenase, ComputingMilieux_MISCELLANEOUS, ADME, chemistry.chemical_classification, Effector, Oxidoreductase inhibitor, 3. Good health, Rats, Molecular Docking Simulation, Macaca fascicularis, 030104 developmental biology, Enzyme, chemistry, Cancer research, Molecular Medicine

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9b3e812bb87fe80822746419021eb31Test
    https://hal-polytechnique.archives-ouvertes.fr/hal-01760561Test


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