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1دورية أكاديمية
المؤلفون: Javier R. Balboa (14309680), Dominik J. Essig (14309683), Sana Ma (14309686), Nichlas Karer (14309689), Louise S. Clemmensen (9941146), Søren W. Pedersen (585022), Andreas C. Joerger (250020), Stefan Knapp (244328), Søren Østergaard (5216057), Kristian Strømgaard (412489)
مصطلحات موضوعية: Biophysics, Biochemistry, Molecular Biology, Neuroscience, Pharmacology, Biotechnology, Developmental Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, unnatural amino acids, terminal peptides derived, provided molecular insights, postsynaptic density protein, optimized cyclic peptides, attractive therapeutic target, alternative starting point, acute ischemic stroke, hairpin peptide arrays, hairpin mimetic peptide, peptide macrocycle inhibitor, pdz protein domains, nnos binds psd, cyclic nnos β, pdz domains, hairpin motif, potent inhibitor, nnos ), n <, formed via, developing psd
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2دورية أكاديمية
المؤلفون: Giuseppe Faudone (8735997), Rezart Zhubi (10961545), Fatih Celik (5228297), Stefan Knapp (244328), Apirat Chaikuad (244322), Jan Heering (1373691), Daniel Merk (1373682)
مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Pharmacology, Biotechnology, Immunology, Chemical Sciences not elsewhere classified, tumor suppressor genes, related nuclear receptors, potent tlx modulators, potent tlx agonist, 10 b, fragment screening hit, rational fragment fusion, fragment screening, fragment fusion, rational basis, fragment linkage, transcriptional repressor, submicromolar potency, promising potential, pharmacophore similarity, pharmacophore modeling, neurodegenerative diseases, master regulator, high selectivity, hence considered
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3دورية أكاديمية
المؤلفون: Vanesa Nozal (9034427), Loreto Martínez-González (2911010), Marta Gomez-Almeria (11896116), Claudia Gonzalo-Consuegra (11896119), Paula Santana (3820921), Apirat Chaikuad (244322), Eva Pérez-Cuevas (11896122), Stefan Knapp (244328), Daniel Lietha (193525), David Ramírez (4053370), Sabrina Petralla (5681105), Barbara Monti (1504795), Carmen Gil (146118), Angeles Martín-Requero (11896125), Valle Palomo (356637), Eva de Lago (4767084), Ana Martinez (1313100)
مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Neuroscience, Pharmacology, Immunology, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, promising therapeutic strategy, motor neuron preservation, future als therapy, valuable lead compound, ttbk1 inhibitors emerge, 29 b, valuable inhibitors, vivo <, tubulin kinase, translational modifications, spinal cord, proposing pyrrolopyrimidine, pathological hallmark, new avenue, m2 anti, inflammatory microglia, familiar patients, effective treatment, cell cultures, biological evaluation, animal models
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4دورية أكاديمية
المؤلفون: Sandra Röhm (8042966), Benedict-Tilman Berger (5391620), Martin Schröder (1300113), Deep Chatterjee (11419350), Sebastian Mathea (2584216), Andreas C. Joerger (250020), Daniel M. Pinkas (2208313), Joshua C. Bufton (5627087), Amelie Tjaden (11419353), Lohitesh Kovooru (11419356), Mark Kudolo (5508644), Christian Pohl (476404), Alex N. Bullock (258156), Susanne Müller (1305876), Stefan Laufer (11558), Stefan Knapp (244328)
مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Immunology, Developmental Biology, Inorganic Chemistry, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, loop folding process, comprehensively characterized ddr, active dual ddr, 7 b, 30 b, tropomyosin receptor kinases, p38 chemical probe, 2 kinase signaling, ddr kinase, p38 probe, various forms, valuable tool, selective inhibitors, pulmonary fibrosis, normal physiology, neuronal toxicity, fibrotic disorders, 302 )
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5دورية أكاديمية
المؤلفون: Nadine Russ (11458084), Martin Schröder (1300113), Benedict-Tilman Berger (5391620), Sebastian Mandel (11458087), Yagmur Aydogan (11458090), Sandy Mauer (11458093), Christian Pohl (476404), David H. Drewry (386307), Apirat Chaikuad (244322), Susanne Müller (1305876), Stefan Knapp (244328)
مصطلحات موضوعية: Biochemistry, Genetics, Neuroscience, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, unusual pocket created, still phosphorylate substrates, potential drug target, including colorectal cancer, functional studies revealed, associated guanylate kinase, canonical dfg motif, linked mental retardation, first chemical probe, thr kinase cask, thr kinase, chemical probe, suggesting cask, roles implicated, parkinson ’, neuronal synapses, neurexin kinases, many diseases, highly potent, gfg motif, general strategy, exploited structure
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6دورية أكاديمية
المؤلفون: Florian Wittlinger (8708742), David E. Heppner (1921762), Ciric To (7554050), Marcel Günther (1474408), Bo Hee Shin (7554056), Jaimin K. Rana (11586202), Anna M. Schmoker (11586205), Tyler S. Beyett (11586208), Lena M. Berger (10925273), Benedict-Tilman Berger (5391620), Nicolas Bauer (11586211), James D. Vasta (5701775), Cesear R. Corona (5701772), Matthew B. Robers (1290444), Stefan Knapp (244328), Pasi A. Jänne (1277622), Michael J. Eck (240706), Stefan A. Laufer (128881)
مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Genetics, Pharmacology, Cancer, Hematology, Infectious Diseases, Virology, Chemical Sciences not elsewhere classified, significantly lower activity, selective lead compound, selective cellular efficacies, fused benzylisoindolinedione scaffold, 9 nm ), 47 nm ), sensitive activating mutations, one ” mutant, egfr kinase domain, generation agent osimertinib, c797s mutant egfr, drug resistance due, overcome drug, resistant mutations, acquired mutations, type egfr, “ two, successive generations, simultaneously occupies, pyridinyl imidazole
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7دورية أكاديمية
المؤلفون: Nicole Bata (11741104), Apirat Chaikuad (244322), Nicole A. Bakas (9651877), Allison S. Limpert (9651880), Lester J. Lambert (1621522), Douglas J. Sheffler (1319997), Lena M. Berger (10925273), Guoxiong Liu (11741107), Cunxiang Yuan (11741110), Li Wang (15202), Yi Peng (306871), Jing Dong (102657), Maria Celeridad (845392), Fabiana Layng (11741113), Stefan Knapp (244328), Nicholas D. P. Cosford (8933033)
مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Cancer, Hematology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, valuable chemical probe, protein kinases 3, possessed favorable pharmacokinetic, hippo signaling pathway, acute myeloid leukemia, potential therapeutic target, point hinge binding, cultured mammalian cells, 6 b, 20 b, stk4 revealed two, regulates cell proliferation, potential therapy, binding pocket, aml cells, stk4 suppress, specifically inhibited, pyrrolopyrimidine derivatives
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8دورية أكاديمية
المؤلفون: Giuseppe Faudone (8735997), Whitney Kilu (6369071), Xiaomin Ni (2509591), Apirat Chaikuad (244322), Sridhar Sreeramulu (1478524), Pascal Heitel (3863806), Harald Schwalbe (24749), Stefan Knapp (244328), Manfred Schubert-Zsilavecz (1373706), Jan Heering (1373691), Daniel Merk (1373682)
مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Neuroscience, Pharmacology, Biotechnology, Developmental Biology, Computational Biology, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, suggesting direct interactions, repressor silencing mediator, promising drug target, limited functional understanding, expressed almost exclusively, intrinsic repressor activity, retinoid x receptor, receptor ’, unprecedented role, tool compounds, sensitive recruitment, residues lining, nuclear receptors, hormone receptors, hence considered, helix 5, essential factor
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9دورية أكاديمية
المؤلفون: Felix F. Lillich (11752500), Sabine Willems (5436311), Xiaomin Ni (2509591), Whitney Kilu (6369071), Carmen Borkowsky (11752503), Mirko Brodsky (5899634), Jan S. Kramer (4677838), Steffen Brunst (7391504), Victor Hernandez-Olmos (2019454), Jan Heering (1373691), Simone Schierle (5436308), Roxane-I. Kestner (11752506), Franziska M. Mayser (11752509), Moritz Helmstädter (10063373), Tamara Göbel (1373688), Lilia Weizel (1373694), Dmitry Namgaladze (758826), Astrid Kaiser (1373712), Dieter Steinhilber (182458), Waltraud Pfeilschifter (149411), Astrid S. Kahnt (1373697), Anna Proschak (6792107), Apirat Chaikuad (244322), Stefan Knapp (244328), Daniel Merk (1373682), Ewgenij Proschak (34926)
مصطلحات موضوعية: Biochemistry, Medicine, Pharmacology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, type ii diabetes, soluble epoxide hydrolase, one representative compound, activated receptor γ, fluid retention associated, complex disease cluster, seh inhibitor using, dual seh inhibitors, synergistically counteracted mets, partial pparγ agonists, problems associated, heart disease, weight gain, vivo <, simultaneous targeting, pparγ leads, peroxisome proliferator, mets ), metabolic syndrome, including obesity, guided approach, full activation, desirable activity, crystal structures, based design
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10دورية أكاديمية
المؤلفون: Stanislav Andreev (11067165), Tatu Pantsar (5733545), Roberta Tesch (535867), Niclas Kahlke (11067168), Ahmed El-Gokha (3643501), Francesco Ansideri (1474417), Lukas Grätz (8855417), Jenny Romasco (11067171), Giulia Sita (6828527), Christian Geibel (11067174), Michael Lämmerhofer (1333284), Andrea Tarozzi (2259433), Stefan Knapp (244328), Stefan A. Laufer (128881), Pierre Koch (560721)
مصطلحات موضوعية: Biophysics, Biochemistry, Molecular Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, hydration site, location, kinome selectivity profile, High-Energy Water, SH-SY 5Y cells, ligand binding, WaterMap analysis, GSK -3 autophosphorylation, molecule binding, inhibitor, water molecule, microsecond timescale, co-crystallized glycogen synthase k., binding site, Potent Pyrimidoindole-Based Glycoge., IC 50 value, 6 nM, dynamics simulations, target engagement