دورية أكاديمية
OCTN2- and ATB0,+-targeted nanoemulsions for improving ocular drug delivery
| العنوان: | OCTN2- and ATB0,+-targeted nanoemulsions for improving ocular drug delivery |
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| المؤلفون: | Bo Tang, Qiuxiang Wang, Guowei Zhang, Aiwen Zhang, Lu Zhu, Rongrong Zhao, Hongwei Gu, Jie Meng, Junfang Zhang, Guihua Fang |
| المصدر: | Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-19 (2024) |
| بيانات النشر: | BMC, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biotechnology LCC:Medical technology |
| مصطلحات موضوعية: | Stearoyl l-carnitine, Nanoemulsions, Novel organic cation/carnitine transporter 2 (OCTN2), Amino acid transporter B (0 +) (ATB0,+), Endotoxin-induced uveitis, Ocular drug bioavailability, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5 |
| الوصف: | Abstract Traditional eye drops are administered via topical instillation. However, frequent dosing is needed due to their relatively rapid precorneal removal and low ocular bioavailability. To address these issues, stearoyl L-carnitine-modified nanoemulsions (SC-NEs) were fabricated. The physicochemical properties of SC-NEs in terms of size, morphology, zeta potential, encapsulation efficiency, and in vitro drug release behavior were characterized. The cellular uptake and mechanisms of SC-NEs were comprehensively studied in human corneal epithelial cells and the stearoyl L-carnitine ratio in SC-NEs was optimized. The optimized SC-NEs could target the novel organic cation/carnitine transporter 2 (OCTN2) and amino acid transporter B (0 +) (ATB0,+) on the corneal epithelium, which led to superior corneal permeation, ocular surface retention ability, ocular bioavailability. Furthermore, SC-NEs showed excellent in vivo anti-inflammatory efficacy in a rabbit model of endotoxin-induced uveitis. The ocular safety test indicated that the SC-NEs were biocompatible. In general, the current study demonstrated that OCTN2 and ATB0,+-targeted nanoemulsions were promising ophthalmologic drug delivery systems that can improve ocular drug bioavailability and boost the therapeutic effects of drugs for eye diseases. Graphical Abstract |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1477-3155 |
| العلاقة: | https://doaj.org/toc/1477-3155Test |
| DOI: | 10.1186/s12951-024-02402-x |
| الوصول الحر: | https://doaj.org/article/4dea0e7eccf142e791bc6ecc25879de1Test |
| رقم الانضمام: | edsdoj.4dea0e7eccf142e791bc6ecc25879de1 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14773155 |
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| DOI: | 10.1186/s12951-024-02402-x |