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المؤلفون: Kathleen Hoyt, Kim Fletcher, Christian Harcken, Steven Richard Brunette, T. Gregg Davis, Delphine Collin, Ryan M. Fryer, Robert Sibley, Thomas Wieckowski, Jörg P Hehn, Dustin Smith, Yin-Chao Tseng, Stanley Kugler, Csengery Johanna, Donald Souza, Liang Shuang, Michael Robert Turner, Mark E. Labadia, Donna Terenzio, Anita L. Wayne, Mark Panzenbeck, Wu Lifen, Robert Hughes
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: 010405 organic chemistry, Organic Chemistry, Retinoic acid, Interleukin, Metabolic stability, Scaffold hopping, 01 natural sciences, Biochemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, chemistry, Nuclear receptor, RAR-related orphan receptor gamma, Drug Discovery, Aqueous solubility, Cancer research, Transcription factor
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e86af9280bb7f85b4a15b0ef59af3fccTest
https://pubmed.ncbi.nlm.nih.gov/33488976Test -
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المؤلفون: Neil Moss, Lee Fader, Jeremy R Richman, Stanley Kugler, Matthew A. Cerny, Jennifer Burke, Raquel Arenas, Derek Cogan, Federico Colombo, Maolin Yu, Kosea Frederick, John Lord, Zhidong Chen, Jean-Huges Parmentier, Balestra Michael, Nicholas F. Brown, Steven M. Weldon, Xin Guo, Daniel R. Goldberg, Michael Zhang, Holly Clifford, Jennifer Schmenk, Kenneth M. Meyers, Daniel Richard Marshall, Keith R Hornberger
المصدر: Bioorganic & Medicinal Chemistry Letters. 28:979-984
مصطلحات موضوعية: 0301 basic medicine, Aldosterone synthase, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, In vivo, Drug Discovery, medicine, Cytochrome P-450 CYP11B2, Humans, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Aldosterone, Dose-Response Relationship, Drug, Molecular Structure, ATP synthase, biology, Organic Chemistry, Isoxazoles, Metabolism, In vitro, 030104 developmental biology, Enzyme, medicine.anatomical_structure, chemistry, 030220 oncology & carcinogenesis, Hepatocyte, biology.protein, Molecular Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44b0efa78c0594d187a77fbd86938a66Test
https://doi.org/10.1016/j.bmcl.2017.12.015Test -
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المؤلفون: Xiang Li, Robert Hughes, Charles Kennedy, Brian Nicholas Cook, Stanley Kugler, Ingo Muegge, Delphine Collin, John Wan, Marie Anderson, Mark E. Labadia, Donna Terenzio, Neil A. Farrow, Siqi Lin, Debra L. Brennan
المصدر: Journal of Biological Chemistry. 292:11618-11630
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Drug Inverse Agonism, Protein Conformation, Stereochemistry, Phenylalanine, Recombinant Fusion Proteins, Molecular Conformation, Ligands, Binding, Competitive, Biochemistry, Protein Refolding, 03 medical and health sciences, Protein structure, Genes, Reporter, Coactivator, Humans, Inverse agonist, Protein Interaction Domains and Motifs, Binding site, Molecular Biology, Cells, Cultured, Orphan receptor, Binding Sites, Protein Stability, Chemistry, Drug discovery, Phenylurea Compounds, Anti-Inflammatory Agents, Non-Steroidal, Interleukin-17, Cell Biology, Nuclear Receptor Subfamily 1, Group F, Member 3, Peptide Fragments, HEK293 Cells, 030104 developmental biology, Nuclear receptor, Protein Structure and Folding, Biophysics, Th17 Cells, Apoproteins
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd028be21b18235969de935bcc1a90d4Test
https://doi.org/10.1074/jbc.m117.789024Test -
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المؤلفون: Mohammed A. Kashem, Stanley Kugler, Lida Soleymanzadeh, Yunlong Zhang, Jeffery B. Madwed, Xin Guo, Kirrane Thomas M, Roger J. Snow, Alan David Swinamer, Jennifer Burke, Margaret M. O’Neill, Stephen J. Boyer
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:738-742
مصطلحات موضوعية: Indoles, Nitrogen, Chemistry, Pharmaceutical, Clinical Biochemistry, Drug Evaluation, Preclinical, Molecular Conformation, Pharmaceutical Science, Crystallography, X-Ray, Ribosomal Protein S6 Kinases, 90-kDa, Biochemistry, Ribosomal s6 kinase, Inhibitory Concentration 50, Structure-Activity Relationship, In vivo, Drug Discovery, Humans, Structure–activity relationship, Potency, Enzyme Inhibitors, Molecular Biology, Cell potency, Indole test, biology, Kinase, Chemistry, Organic Chemistry, Amides, In vitro, Cell biology, Models, Chemical, Drug Design, biology.protein, Molecular Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e3a6710f1742d2d831246aeb83ce910Test
https://doi.org/10.1016/j.bmcl.2011.10.029Test -
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المؤلفون: Zhaoming Xiong, Stephen J. Boyer, Lida Soleymanzadeh, Stanley Kugler, John Westbrook, Yunlong Zhang, Anil Kumar Padyana, Jennifer Burke, Jeffrey B. Madwed, Derek Cogan, Alan David Swinamer, Chris Sarko, Mohammed A. Kashem, Frank M. DiCapua, Kirrane Thomas M, Amy Gao, Roger J. Snow, Xin Guo, Margaret M. O’Neill
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:733-737
مصطلحات موضوعية: Indoles, Nitrogen, Chemistry, Pharmaceutical, High-throughput screening, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Crystallography, X-Ray, Ribosomal Protein S6 Kinases, 90-kDa, Biochemistry, Ribosomal s6 kinase, Inhibitory Concentration 50, Structure-Activity Relationship, Ribosomal Protein S6 Kinases, Drug Discovery, Humans, Inhibitory concentration 50, Structure–activity relationship, Enzyme Inhibitors, Molecular Biology, Indole test, biology, Chemistry, Kinase, Organic Chemistry, Azepines, Amides, Models, Chemical, Drug Design, biology.protein, Molecular Medicine, Pharmacophore
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::280d6ba59ece0c6b1b215b764b652158Test
https://doi.org/10.1016/j.bmcl.2011.10.030Test -
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المؤلفون: Stanley Kugler, John D. Ginn, Xiang Li, Todd Bosanac, Mohammed A. Kashem, Steven Kerr, Anthony S. Prokopowicz, Michael Robert Turner, Frank Wu, Erick R. R. Young, James D. Smith, Eugene R. Hickey, Sabine Schlyer, Charles L. Cywin, Rhonda Chen
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:5153-5156
مصطلحات موضوعية: Models, Molecular, Clinical Biochemistry, Pharmaceutical Science, Blood Pressure, Pharmacology, Biochemistry, Structure-Activity Relationship, In vivo, Oral administration, Rats, Inbred SHR, Drug Discovery, Animals, Structure–activity relationship, ROCK2, Protein Kinase Inhibitors, Molecular Biology, Rho-associated protein kinase, chemistry.chemical_classification, rho-Associated Kinases, biology, Chemistry, Organic Chemistry, Isoquinolines, Rats, Blood pressure, Enzyme, Enzyme inhibitor, biology.protein, Molecular Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c1691612ce33705cab799aaae34b250Test
https://doi.org/10.1016/j.bmcl.2010.07.014Test -
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المؤلفون: Steven Kerr, Charles L. Cywin, Frank H. Büttner, Frank Wu, Mohammed A. Kashem, Scott Jakes, Zofia Paw, Roger J. Snow, Erick R. R. Young, Eugene R. Hickey, Stanley Kugler, Paul Kaplita, Cheng-Kon Shih, Rhonda Chen, Anthony S. Prokopowicz
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:3235-3239
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Blood Pressure, Non-specific serine/threonine protein kinase, Crystallography, X-Ray, Biochemistry, In vivo, Drug Discovery, Animals, Protein Kinase Inhibitors, Molecular Biology, Rho-associated protein kinase, Antihypertensive Agents, rho-Associated Kinases, biology, Drug discovery, Chemistry, Organic Chemistry, Hit to lead, Isoquinolines, Rats, Enzyme inhibitor, biology.protein, Molecular Medicine, Signal transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c2d691a0169d6458e981f329be40c8bTest
https://doi.org/10.1016/j.bmcl.2010.04.070Test -
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المؤلفون: Stanley Kugler, Yunlong Zhang, Melissa Hill-Drzewi, Ingo Muegge, Lana Smith, Delphine Collin, Josh Horan, Xiang Li, Mark E. Labadia, Brian Nicholas Cook
المصدر: Bioorganicmedicinal chemistry letters. 25(9)
مصطلحات موضوعية: Reporter gene, Virtual screening, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Drug discovery, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Nuclear Receptor Subfamily 1, Group F, Member 3, Biochemistry, Combinatorial chemistry, Structure-Activity Relationship, RAR-related orphan receptor gamma, Drug Discovery, Molecular Medicine, Structure–activity relationship, Inverse agonist, Humans, Benzothiazoles, Molecular Biology, IC50, Fluorescence anisotropy
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76908aa9df44092150a8cca25c4a5a4aTest
https://pubmed.ncbi.nlm.nih.gov/25840886Test -
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المؤلفون: Akalushi Muthukumarana, Frank M. DiCapua, Stanley Kugler, Fariba Soleymanzadeh, Glenn A. Reinhart, Rong Rhonda Chen, Margaret M. O’Neill, Jennifer Burke, Ryan M. Fryer, Roger J. Snow, Suzanne Nodop Mazurek, Jeffrey B. Madwed, Kirrane Thomas M, Roger M. Dinallo, Paul C. Harrison, Mohammed A. Kashem, Stephen J. Boyer, James D. Smith, Yunlong Zhang, Kyle E. Harrington, Xin Guo
المصدر: The Journal of pharmacology and experimental therapeutics. 340(3)
مصطلحات موضوعية: Cardiac function curve, Male, Mean arterial pressure, Adrenergic receptor, Stereochemistry, Adrenergic, Blood Pressure, Pharmacology, Ribosomal Protein S6 Kinases, 90-kDa, Ribosomal s6 kinase, Rats, Sprague-Dawley, In vivo, Receptors, Adrenergic, alpha-2, Receptors, Adrenergic, alpha-1, Heart rate, Drug Discovery, Potency, Animals, Protein Kinase Inhibitors, biology, Dose-Response Relationship, Drug, Chemistry, Azepines, Rats, biology.protein, Molecular Medicine, Benzimidazoles
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1053be1edf09cbfc285b06ebeacf7b3cTest
https://pubmed.ncbi.nlm.nih.gov/22128344Test -
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المؤلفون: Steven Kerr, Erick R. R. Young, Eugene R. Hickey, Todd Bosanac, Alan Olague, John D. Ginn, Sabine Schlyer, Stanley Kugler, Xiang Li, Mohammed A. Kashem
المصدر: Bioorganicmedicinal chemistry letters. 20(12)
مصطلحات موضوعية: Pyrrolidines, Molecular model, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Pyrrolidine, chemistry.chemical_compound, Inhibitory Concentration 50, Structure-Activity Relationship, Drug Discovery, Potency, Animals, Molecular Biology, Rho-associated protein kinase, Protein Kinase Inhibitors, Aorta, rho-Associated Kinases, biology, Molecular Structure, Chemistry, Aryl, Organic Chemistry, Isoquinolines, Rats, Enzyme inhibitor, Drug Design, Hypertension, Lactam, biology.protein, Molecular Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f9c2c4f36334933f05f7838dd863ba1Test
https://pubmed.ncbi.nlm.nih.gov/20471253Test