دورية أكاديمية
Re-examining the characteristics of pediatric multiple sclerosis in the era of antibody-associated demyelinating syndromes
| العنوان: | Re-examining the characteristics of pediatric multiple sclerosis in the era of antibody-associated demyelinating syndromes |
|---|---|
| المؤلفون: | Güngör, Olcay, Yılmaz, Sanem, Özgör, Bilge, Dundar, Nihal Olgac, Dursun, Büşra DaÅŸlı, YalnızoÄŸlu, Dilek, Yılmaz, Deniz, AkbaÅŸ, Salih, Ä°pek, Rojan, Güngör, Serdal, BeÅŸen, Åžeyda, Dilber, Cengiz, Kutluk, Gültekin, HaliloÄŸlu, Göknur, Karaca, Nazlı Balcan, Serin, Hepsen Mine, KaradaÄŸ, Meral, Hakkı Akbeyaz, Ä°smail, BektaÅŸ, Ömer, Orgun, Leman Tekin, Keskin, Filiz, Akyüz, Gülcan, Çarman, KürÅŸat Bora, Alıcı, Nurettin, Aksoy, Erhan, Öztürk, Sedef TerzioÄŸlu, Arslan, Mutluay, Deniz, Adnan, Okuyaz, Çetin, Atasoy, Ergin, Bilgin, Neslihan, SarıtaÅŸ, Serdar, Öztoprak, Ãœlkühan, Elitez, Duygu Aykol, Ãœnalp, Aycan, Anlar, Banu, Aykol, Duygu, Yıldız, Edibe Pembegül, Yarar, CoÅŸkun, Kara, Bülent, Acer, Hamit, Yılmaz, Ãœ., Gücüyener, K., Yavuz, M., Öncel, Ä°., Canpolat, M., Saltık, S., Ãœnver, O., Çıtak Kurt, AyÅŸegül NeÅŸe, Tosun, AyÅŸe, Haspolat, Åženay, Ä°ncecik, Faruk, Tan, Hüseyin, Dilek, Tuğçe Damla, TürkdoÄŸan, DilÅŸad, Güleç, Ayten, AyanoÄŸlu, Müge, Kanmaz, Seda, Öztürk, Gülten, Öztürk, Selcan, Yüksel, Deniz, GürkaÅŸ, Esra, KaraoÄŸlu, Pakize, YiÅŸ, Uluç, Polat, Burçin Gönüllü, Okan, Mehmet Sait, Günbey, Ceren, Per, Hüseyin, Gültutan, Pembe, Öztürk, Semra Büyükkorkmaz, Tekgül, Hasan, Kürekçi, Fulya, Kurul, A. Semra Hız, Asadova, Nargis, Alikılıç, Defne, Duman, Özgür, Kömür, Mustafa, Yıldırım, Miraç, Gümüş, Hakan, Polat, Muzaffer, KamaÅŸak, Tülay, KonuÅŸkan, Bahadır, Mert, Gülen Gül, Edizer, Selvinaz, Mıhçı, Filiz, Toker, Rabia Tütüncü, ÅženoÄŸlu, Mine ÇiÄŸdem, Åžahin, Sevim, Gencpinar, Pinar, Yıldırım, Elif, Yüksel, Ersin, Ekici, Arzu, KayılıoÄŸlu, Hülya, Yayici Köken, Özlem, Süt, NurÅŸah Yeniay, Ayça, Senem, Solmaz, Ä°smail, Yetkin, Mehmet Fatih, Atasever, Aslı Kübra, Tekin, Hande Gazeteci, Dokurel, Ä°pek, Özçelik, Aysima, Sarıgeçili, Esra, Aksoy, AyÅŸe, Türköz, AyÅŸe Nur, Koç, Habibe, Cavusoglu, Dilek, Åžahin, Türkan Uygur, Erol, Ä°lknur, Direk, Meltem ÇobanoÄŸulları, Bodur, Muhittin, Teber, Serap, Oktay, Seçil |
| بيانات النشر: | W.B. Saunders Ltd |
| سنة النشر: | 2022 |
| المجموعة: | Pamukkale University Repository / Pamukkale Üniversitesi Açık Erişim Arşivi |
| مصطلحات موضوعية: | Anti-AQP4-IgG, Anti-MOG-IgG, Antibody, Demyelinating, Pediatric multiple sclerosis, autoantibody, immunoglobulin G, myelin oligodendrocyte glycoprotein, acute disseminated encephalomyelitis, diagnostic imaging, female, human, male, multiple sclerosis, myelooptic neuropathy, nuclear magnetic resonance imaging, Autoantibodies, Encephalomyelitis, Acute Disseminated, Humans, Magnetic Resonance Imaging, Myelin-Oligodendrocyte Glycoprotein, Neuromyelitis Optica |
| الوصف: | Background: The discovery of anti-myelin oligodendrocyte glycoprotein (MOG)-IgG and anti-aquaporin 4 (AQP4)-IgG and the observation on certain patients previously diagnosed with multiple sclerosis (MS) actually have an antibody-mediated disease mandated re-evaluation of pediatric MS series. Aim: To describe the characteristics of recent pediatric MS cases by age groups and compare with the cohort established before 2015. Method: Data of pediatric MS patients diagnosed between 2015 and 2021 were collected from 44 pediatric neurology centers across Türkiye. Clinical and paraclinical features were compared between patients with disease onset before 12 years (earlier onset) and ≥12 years (later onset) as well as between our current (2015–2021) and previous (2015) cohorts. Results: A total of 634 children (456 girls) were enrolled, 89 (14%) were of earlier onset. The earlier-onset group had lower female/male ratio, more frequent initial diagnosis of acute disseminated encephalomyelitis (ADEM), more frequent brainstem symptoms, longer interval between the first two attacks, less frequent spinal cord involvement on magnetic resonance imaging (MRI), and lower prevalence of cerebrospinal fluid (CSF)-restricted oligoclonal bands (OCBs). The earlier-onset group was less likely to respond to initial disease-modifying treatments. Compared to our previous cohort, the current series had fewer patients with onset 12 years, initial presentation with ADEM-like features, brainstem or cerebellar symptoms, seizures, and spinal lesions on MRI. The female/male ratio, the frequency of sensorial symptoms, and CSF-restricted OCBs were higher than reported in our previous cohort. Conclusion: Pediatric MS starting before 12 years was less common than reported previously, likely due to exclusion of patients with antibody-mediated diseases. The results underline the importance of antibody testing and indicate pediatric MS may be a more homogeneous disorder and more similar to adult-onset MS than previously thought. © 2022 European ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1090-3798 |
| العلاقة: | European Journal of Paediatric Neurology; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.1016/j.ejpn.2022.08.006Test; https://hdl.handle.net/11499/51246Test; 41; 18; 2-s2.0-85143379946 |
| DOI: | 10.1016/j.ejpn.2022.08.006 |
| الإتاحة: | https://doi.org/10.1016/j.ejpn.2022.08.006Test https://hdl.handle.net/11499/51246Test |
| حقوق: | none |
| رقم الانضمام: | edsbas.28DD1C6A |
| قاعدة البيانات: | BASE |
| تدمد: | 10903798 |
|---|---|
| DOI: | 10.1016/j.ejpn.2022.08.006 |