Detailed stratified GWAS analysis for severe COVID-19 in four European populations

التفاصيل البيبلوغرافية
العنوان:	Detailed stratified GWAS analysis for severe COVID-19 in four European populations
المؤلفون:	Degenhardt, Frauke, Ellinghaus, David, Juzenas, Simonas, Lerga Jaso, Jon, Wendorff, Mareike, Maya-Miles, Douglas, Uellendahl-Werth, Florian, ElAbd, Hesham, RÃ¼hlemann, Malte C, Arora, Jatin, Ã–zer, Onur, Lenning, Ole Bernt, Myhre, Ronny, Vadla, May Sissel, Wacker, Eike M, Wienbrandt, Lars, Blandino Ortiz, Aaron, de Salazar, Adolfo, Garrido Chercoles, Adolfo, Palom, Adriana, Ruiz, AgustÃn, Garcia-Fernandez, Alba-Estela, Blanco-Grau, Albert, Mantovani, Alberto, Zanella, Alberto, Holten, Aleksander Rygh, Mayer, Alena, Bandera, Alessandra, Cherubini, Alessandro, Protti, Alessandro, Aghemo, Alessio, Gerussi, Alessio, Ramirez, Alfredo, Braun, Alice, Nebel, Almut, Barreira-Diaz, Ana, Lleo, Ana, Teles, Ana, Kildal, Anders Benjamin, Biondi, Andrea, Caballero, Andrea, Ganna, Andrea, Gori, Andrea, GlÃ¼ck, Andreas, Lind, Andreas, Tanck, Anja, Hinney, Anke, Carreras Nolla, Anna, Fracanzani, Anna Ludovica, Peschuck, Anna, Cavallero, Annalisa, Dyrhol-Riise, Anne Ma, Ruello, Antonella, JuliÃ Cano, Antonio, Muscatello, Antonio, Pesenti, Antonio, Voza, Antonio, Rando-Segura, Ariadna, Solier, Aurora, Schmidt, Axel, CortÃ©s, Beatriz, Mateos, Beatriz, Nafria-Jimenez, Beatriz, Schaefer, Benedikt, Jensen, BjÃ¶rn, Bellinghausen, Carla, Maj, Carlo, Ferrando, Carlos, de la Horra, Carmen, Quereda, Carmen, Skurk, Carsten, Thibeault, Charlotte, Scollo, Chiara, Herr, Christian, Spinner, Christoph D, Gassner, Christoph, Lange, Christoph, Hu, Cinzia, Paccapelo, Cinzia, Lehmann, Clara, Angelini, Claudio, Cappadona, Claudio, Azuure, Clinton, Bianco, Cristiana, Cea, Cristina, Sancho, Cristina, Hoff, Dag Arne Lihaug, Galimberti, Daniela, Prati, Daniele, Haschka, David, JimÃ©nez JimÃ©nez, David, PestaÃ±a, David, Toapanta, David, MuÃ±iz-Diaz, Eduardo, Azzolini, Elena, Sandoval, Elena, Binatti, Eleonora, Scarpini, Elio, Helbig, Elisa T, Casalone, Elisabetta, Urrechaga, Eloisa, Paraboschi, Elvezia Maria, Pontali, Emanuele, Reverter, Enric, CalderÃ³n, Enrique J, Navas, Enrique, SolligÃ¥rd, Erik, Contro, Ernesto, Arana-Arri, Eunate, Aziz, FÃ¡tima, Garcia, Federico, GarcÃa SÃ¡nchez, FÃ©lix, Ceriotti, Ferruccio, Martinelli-Boneschi, Filippo, Peyvandi, Flora, Kurth, Florian, Blasi, Francesco, Malvestiti, Francesco, Medrano, Francisco J, Mesonero, Francisco, RodrÃguez FrÃas, Francisco, Hanses, Frank, MÃ¼ller, Fredrik, Hemmrich-Stanisak, Georg, Bellani, Giacomo, Grasselli, Giacomo, Pezzoli, Gianni, Costantino, Giorgio, Albano, Giovanni, Cardamone, Giulia, Bellelli, Giuseppe, Citerio, Giuseppe, Foti, Giuseppe, Lamorte, Giuseppe, Matullo, Giuseppe, Baselli, Guido, Kurihara, Hayato, Neb, Holger, My, Ilaria, Kurth, Ingo, HernÃ¡ndez, Isabel, Pink, Isabell, De Rojas, Itziar, GalvÃ¡n-FemenÃa, IvÃ¡n, Holter, Jan Cato, Afset, Jan Egil, Heyckendorf, Jan, KÃ¤ssens, Jan, DamÃ¥s, Jan Kristian, Rybniker, Jan, AltmÃ¼ller, Janine, Ampuero, Javier, MartÃn, Javier, Erdmann, Jeanette, Banales, Jesus, Badia, Joan Ramon, Dopazo, JoaquÃn, Schneider, Jochen, Bergan, Jonas, Barretina, Jordi, Walter, JÃ¶rn, HernÃ¡ndez Quero, Jose, Goikoetxea, Josune, Delgado, Juan, Guerrero, Juan M., Fazaal, Julia, Kraft, Julia, SchrÃ¶der, Julia, Risnes, Kari, Banasik, Karina, MÃ¼ller, Karl Erik, Gaede, Karoline I, Garcia-Etxebarria, Koldo, Tonby, Kristian, Heggelund, Lars, Izquierdo-Sanchez, Laura, Bettini, Laura Rachele, Sumoy, Lauro, Sander, Leif Erik, Lippert, Lena J, Terranova, Leonardo, Nkambule, Lindokuhle, Knopp, Lisa, Gustad, Lise Tuset, Garbarino, Lucia, Santoro, Luigi, TÃ©llez, Luis, Roade, Luisa, Ostadreza, Mahnoosh, Intxausti, Maider, Kogevinas, M., Riveiro Barciela, Mar, Berger, Marc M., Schaefer, Marco, Niemi, Mari E K, GutiÃ©rrez-Stampa, MarÃa A, Carrabba, Maria, Figuera Basso, Maria E, Valsecchi, Maria Grazia, Hernandez-Tejero, MarÃa, Vehreschild, Maria J G T, Manunta, Maria, Acosta-Herrera, Marialbert, D'AngiÃ², Mariella, Baldini, Marina, Cazzaniga, Marina, Grimsrud, Marit M, Cornberg, Markus, NÃ¶then, Markus M, MarquiÃ©, Marta, Castoldi, Massimo, Cordioli, Mattia, Cecconi, Maurizio, D'Amato, Mauro, Augustin, Max, Tomasi, Melissa, Boada, MercÃ¨, Dreher, Michael, Seilmaier, Michael J, Joannidis, Michael, Wittig, Michael, Mazzocco, Michela, Ciccarelli, Michele, RodrÃguez-GandÃa, Miguel, Bocciolone, Monica, Miozzo, Monica, Imaz Ayo, Natale, Blay, Natalia, Chueca, Natalia, Montano, Nicola, Braun, Nicole, Ludwig, Nicole, Marx, Nikolaus, MartÃnez, Nilda, Cornely, Oliver A, Witzke, Oliver, Palmieri, Orazio, Faverio, Paola, Preatoni, Paoletta, Bonfanti, Paolo, Omodei, Paolo, Tentorio, Paolo, Castro, Pedro, Rodrigues, Pedro M., EspaÃ±a, Pedro Pablo, Hoffmann, Per, Rosenstiel, Philip, Schommers, Philipp, Suwalski, Phillip, de Pablo, RaÃºl, Ferrer, Ricard, Bals, Robert, Gualtierotti, Roberta, Gallego-DurÃ¡n, RocÃo, Nieto, Rosa, Carpani, Rossana, Morilla, RubÃ©n, Badalamenti, Salvatore, Haider, Sammra, Ciesek, Sandra, May, Sandra, Bombace, Sara, Marsal, Sara, Pigazzini, Sara, Klein, Sebastian, Pelusi, Serena, Wilfling, Sibylle, Bosari, Silvano, Volland, Sonja, Brunak, SÃ¸ren, Raychaudhuri, Soumya, Schreiber, Stefan, Heilmann-Heimbach, Stefanie, Aliberti, Stefano, Ripke, Stephan, Dudman, Susanne, Wesse, Tanja, Zheng, Tenghao, Bahmer, Thomas, Eggermann, Thomas, Illig, Thomas, Brenner, Thorsten, Pumarola SuÃ±Ã©, TomÃ s, Feldt, Torsten, Folseraas, Trine, Gonzalez Cejudo, Trinidad, Landmesser, Ulf, Protzer, Ulrike, Hehr, Ute, Rimoldi, Valeria, Monzani, Valter, Skogen, Vegard, Keitel, Verena, Kopfnagel, Verena, Friaza, Vicente, Andrade, Victor, Moreno Aguado, VÃctor, Morros, Rosa, Albrecht, Wolfgang, Peter, Wolfgang, Poller, Wolfgang, FarrÃ©, Xavier, Yi, Xiaoli, Wang, Xiaomin, Khodamoradi, Yascha, Karadeniz, Zehra, Latiano, Anna, Goerg, Siegfried, Bacher, Petra, Koehler, Philipp, Tran, Florian, Zoller, Heinz, Schulte, Eva C, Heidecker, Bettina, Ludwig, Kerstin U, FernÃ¡ndez, Javier, Romero-GÃ³mez, Manuel, Albillos, AgustÃn, Invernizzi, Pietro, Buti, Maria, Duga, Stefano, Bujanda, Luis, Hov, Johannes R., Lenz, Tobias L, Asselta, Rosanna, de Cid, Rafael, Valenti, Luca, Karlsen, Tom H., CÃ¡ceres Aguilar, Mario, Franke, Andre
سنة النشر:	2022
المجموعة:	Universitat Autònoma de Barcelona: Dipòsit Digital de Documents de la UAB
الوصف:	Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we describe an extended genome-wide association meta-analysis of a well-characterized cohort of 3255 COVID-19 patients with respiratory failure and 12 488 population controls from Italy, Spain, Norway and Germany/Austria, including stratified analyses based on age, sex and disease severity, as well as targeted analyses of chromosome Y haplotypes, the human leukocyte antigen region and the SARS-CoV-2 peptidome. By inversion imputation, we traced a reported association at 17q21.31 to a ~0.9-Mb inversion polymorphism that creates two highly differentiated haplotypes and characterized the potential effects of the inversion in detail. Our data, together with the 5th release of summary statistics from the COVID-19 Host Genetics Initiative including non-Caucasian individuals, also identified a new locus at 19q13.33, including NAPSA, a gene which is expressed primarily in alveolar cells responsible for gas exchange in the lung.
نوع الوثيقة:	article in journal/newspaper
وصف الملف:	application/pdf
اللغة:	English
تدمد:	14602083
العلاقة:	Instituto de Salud Carlos III PI17/00535; Instituto de Salud Carlos III PI19/00589; Ministerio de EconomÃa y Competitividad PI16/01842; Instituto de Salud Carlos III PI19/01404; Agencia Estatal de InvestigaciÃ³n PID2019-107836RB-I00; Ministerio de Ciencia e InnovaciÃ³n ADE10/00026; Human Molecular Genetics; Vol. 31 (july 2022), p. 3945-3966; https://ddd.uab.cat/record/269360Test; urn:10.1093/hmg/ddac158; urn:oai:ddd.uab.cat:269360; urn:pmcid:PMC9703941; urn:pmc-uid:9703941; urn:pmid:35848942; urn:oai:pubmedcentral.nih.gov:9703941; urn:articleid:14602083v31p3945; urn:oai:egreta.uab.cat:publications/3382ef9a-a5eb-4178-9cdb-b717bb7a3caf; urn:scopus_id:85138615657
الإتاحة:	https://ddd.uab.cat/record/269360Test
حقوق:	open access ; Aquest document estÃ subjecte a una llicÃ¨ncia d'Ãºs Creative Commons. Es permet la reproducciÃ³ total o parcial, la distribuciÃ³, la comunicaciÃ³ pÃºblica de l'obra i la creaciÃ³ d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. ; https://creativecommons.org/licenses/by-nc/4.0Test/
رقم الانضمام:	edsbas.66E07A0C
قاعدة البيانات:	BASE

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تدمد:	14602083